Cafeteria diet induces neuroplastic modifications in the nucleus accumbens mediated by microglia activation
Open accessAbstract
High-palatable and caloric foods are widely overconsumed due to hedonic mechanisms that prevail over caloric necessities leading to overeating and overweight. The nucleus accumbens (NAc) is a key brain area modulating the reinforcing effects of palatable foods and is crucially involved in the development of eating disorders. We describe that prolonged exposure to high-caloric chocolate cafeteria diet leads to overeating and overweight in mice. NAc functionality was altered in these mice, presenting structural plasticity modifications in medium spiny neurons, increased expression of neuroinflammatory factors and activated microglia, and abnormal responses after amphetamine-induced hyperlocomotion. Chronic inactivation of microglia normalized these neurobiological and behavioural alterations exclusively in mice exposed to cafeteria diet. Our data suggest that prolonged exposure to cafeteria diet produces neuroplastic and functional changes in the NAc that can modify feeding behaviour. Microglia activation and neuroinflammation play an important role in the development of these neurobiological alterations.
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Reversing neuroinflammation via targeted genetic, pharmacological, or dietary approaches that rescue behavioral anomalies supports a causal role of neuroinflammation in obesity-induced neuropathophysiology.
“Reversing neuroinflammation via targeted genetic [96,97], pharmacological [98,99], or dietary [49,100] approaches that rescue behavioral anomalies offers convincing support for a causal role of neuroinflammation in obesity-induced neuropathophysiology.”
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- Authors
- Gutiérrez‐Martos, M., Girard, B., Mendonça‐Netto, S., Perroy, J., Valjent, E., Maldonado, R., & Martin, M.
- Affiliations
- Universitat Pompeu Fabra (ES)
- Pathophysiology of Synaptic Transmission Laboratory Institut de Génomique Fonctionnelle France
- Laboratory of Neuropharmacology (DCEXS) Parc de Recerca Biomèdica de Barcelona/Universitat Pompeu Fabra (PRBB/UPF) Spain
- Institut de Génomique Fonctionnelle de Lyon (FR)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Maldonado, Rafael
- Venue
- Addiction Biology
- Publisher
- Wiley
- Published
- 2017-09-05
- Volume
- 23
- Issue
- 2
- Pages
- 735-749
- ISSN
- 1355-6215 (ISSN-L)
- 1369-1600
- OpenAlex
- W2750861738
- Cited by
- 35
- References
- 55
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 10 · 2019: 4 · 2018: 4
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- Locations
- Addiction Biology (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (acceptedVersion)
- HAL (submittedVersion)
- Repositori digital de la UPF (Universitat Pompeu Fabra) (submittedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Funders
- European Commission (#HEALTH‐F2‐2013‐602891)
- Ministerio de Economía y Competitividad (#SAF2014‐59648‐P‐FEDER)
- Instituto de Salud Carlos III (#RD12/0028/0023‐FEDER)
- Generalitat de Catalunya (#2014‐SGR‐1547)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- cafeteria diet, nucleus accumbens, microglial activation, neuroinflammation, neuroplasticity, overeating, obesity, palatable food, medium spiny neurons, amphetamine-induced hyperlocomotion, feeding behaviour
- MeSH terms
- Chocolate, Amphetamine, Central Nervous System Stimulants, Animals, Corpus Striatum, Diet, Feeding Behavior, Hyperphagia, Inflammation, Locomotion, Minocycline, Neuronal Plasticity, Neurons, Nucleus Accumbens, Cytokines, Microglia, Pyramidal Cells, Microscopy, Confocal, Dendritic Spines, Overweight, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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