Cited by 362Musculoskeletal pain and rehabilitationPsychosomatic Disorders and Their TreatmentsPain Mechanisms and Treatments

Persistent pain and depression: A biopsychosocial perspective

Campbell, Lisa C, Clauw, Daniel J, Keefe, Francis J·2003·Biological Psychiatry

Abstract

This review highlights recent research findings on the relationship between persistent pain and depression and discusses the implications of these findings for future research in persons who suffer from both pain and depression. First, we briefly discuss advances in theories of pain that underscore the important role that depression can play in the chronic pain experience. Second, we discuss depression in persons suffering from chronic pain from a biopsychosocial perspective that takes into account both biological and psychosocial mechanisms linking pain and depression. Third, we address biomedical, psychosocial, and combined medical-psychosocial approaches to treatment in persons with persistent pain and depression. We conclude by highlighting future directions for research related to screening and diagnosis of depression in persons having persistent pain, treatment of comorbid pain and depression, and individual and subgroup differences in the experience of persistent pain and depression.

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Crossref · 10.1016/s0006-3223(03)00545-6

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113 of 113 references verified0 citation errors · 0 not checkable

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  • In the general population, depression is associated with a wide range of health, mental health, and neurological conditions, such as chronic pain, headaches and migraines, diabetes, low testosterone, cardiovascular/cerebrovascular/small vessel ischemic disease, PD, MCI, and AD.

    “In the general population, depression is associated with a wide range of health, mental health, and neurological conditions, such as 1) chronic pain [71–75]; 2) headaches and migraines [76–79]; 3) diabetes [80–82]; 4) low testosterone [83–85]; 5) cardiovascular, cerebrovascular, and small vessel ischemic disease [86–92]; 6) PD [93]; 7) MCI [94–96]; and 8) AD [97].”

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Authors
Campbell, L. C., Clauw, D. J., & Keefe, F. J.
Affiliations
Duke University (US)
Corresponding author
Keefe, Francis J
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2003-08
Volume
54
Issue
3
Pages
399-409
ISSN
0006-3223 (ISSN-L)
OpenAlex
W1992795892
Cited by
362
References
116
Citations by year
2026: 10 · 2025: 16 · 2024: 6 · 2023: 13 · 2022: 8 · 2021: 9 · 2020: 9 · 2019: 14 · 2018: 16 · 2017: 19 · 2016: 12 · 2015: 28 · 2014: 30 · 2013: 24 · 2012: 17
FWCI
1.26
Type
journal article
Language
en
Open access
closed
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (63429)
Topics
  • Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Keywords
chronic pain, depression, biopsychosocial model, pain theories, pain-depression comorbidity, psychosocial mechanisms, biological mechanisms, pain management, subgroup differences
MeSH terms
Depression, Depressive Disorder, Humans, Pain, Pain Management

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