C-Reactive Protein: Clinical and Epidemiological Perspectives

Salazar, Juan; Martínez, María Sofía; Chávez, Mervin; Toledo, Alexandra; Añez, Roberto; Torres, Yaquelín; Apruzzese, Vanessa; Silva, Carlos; Rojas, Joselyn; Bermúdez, Valmore

doi:10.1155/2014/605810

Cited by 117Lipoproteins and Cardiovascular HealthBiomarkers in Disease MechanismsInflammatory Biomarkers in Disease Prognosis

C-Reactive Protein: Clinical and Epidemiological Perspectives

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Salazar, Juan, Martínez, María Sofía, Chávez, Mervin, Toledo, Alexandra, Añez, Roberto, Torres, Yaquelín, Apruzzese, Vanessa, Silva, Carlos +2 more·2014·Cardiology Research and Practice

DOI 10.1155/2014/605810PMC PMC3932642

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Abstract

An important etiopathogenic component of cardiovascular disease is atherosclerosis, with inflammation being an essential event in the pathophysiology of all clinical pictures it comprises. In recent years, several molecules implicated in this process have been studied in order to assess cardiovascular risk in both primary and secondary prevention. C-reactive protein is a plasmatic protein of the pentraxin family and an acute phase reactant, very useful as a general inflammation marker. Currently, it is one of the most profoundly researched molecules in the cardiovascular field, yet its clinical applicability regarding cardiovascular risk remains an object of discussion, considered by some as a simple marker and by others as a true risk factor. In this sense, numerous studies propose its utilization as a predictor of cardiovascular risk through the use of high-sensitivity quantification methods for the detection of values <1 mg/L, following strict international guidelines. Increasing interest in these clinical findings has led to the creation of modified score systems including C-reactive protein concentrations, in order to enhance risk scores commonly used in clinical practice and offer improved care to patients with cardiovascular disease, which remains the first cause of mortality at the worldwide, national, and regional scenarios.

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A 50% reduction in CVD risk has been documented when lowering CRP from 1-3 mg/L to less than 1 mg/L.
“A 50% reduction in CVD risk has been documented when lowering CRP from 1 to 3 mg/L to less than 1 mg/L (Salazar et al., 2014).”
From Treatment of periodontitis and <scp>C</scp> ‐reactive protein: A systematic review and meta‐analysis of randomized clinical trials (2023) · cites this paper as Salazar et al., 2014
Section 4.1 reports that people with CRP of 1–3 mg/L had 50% greater cardiovascular risk than those below 1 mg/L. That is a comparison between groups, not evidence that lowering CRP reduces risk; it also does not translate to a 50% reduction when moving from the higher-risk group to the lower-risk group. (LLM, conf=0.88)
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[17]Amouyel P Deverly A Andrejak M Cardiovascular global risk: definition, evaluation and management strategies Therapie 2000 55 4 533 539 2-s2.0-0033693294 11098732
[20]Icaza G Núñez L Marrugat J Mujica V Escobar MC Estimación de riesgo de enfermedad coronaria mediante la función de Framingham adaptada para la población chilena Revista Médica de Chile 2009 137 1273 1282 20011933
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[59]Acevedo M Arnáiz P Barja S Relationship of C-reactive protein to adiposity, cardiovascular risk factors and subclinical atherosclerosis in healthy children Revista Espanola de Cardiologia 2007 60 10 1051 1058 2-s2.0-37349096278 17953926

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Review Article C-Reactive Protein: Clinical and Epidemiological Perspectives
Silva, C., Rojas, J., & Bermúdez, V. (2016)
Self-citation
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Authors: Salazar, J., Martínez, M. S., Chávez, M., Toledo, A., Añez, R., Torres, Y., Apruzzese, V., Silva, C., Rojas, J., & Bermúdez, V.
Affiliations: Universidad del Zulia (VE)
Endocrine-Metabolic Research Center, “Dr. Félix Gómez”, Faculty of Medicine, University of Zulia, Maracaibo 4004, Zulia, Venezuela
Corresponding author: Bermúdez, Valmore
ORCID: Salazar, Juan
Martínez, María Sofía
Chávez, Mervin
Rojas, Joselyn
Bermúdez, Valmore
Venue: Cardiology Research and Practice
Publisher: Wiley
Published: 2014
Volume: 2014
Pages: 1-10
ISSN: 2090-0597 (ISSN-L)
2090-8016
DOI: 10.1155/2014/605810
PMC: PMC3932642
OpenAlex: W1991015084
Cited by: 117
References: 113
Citations by year: 2026: 3 · 2025: 4 · 2024: 9 · 2023: 5 · 2022: 13 · 2021: 10 · 2020: 11 · 2019: 11 · 2018: 9 · 2017: 12 · 2016: 15 · 2015: 11 · 2014: 4
FWCI: 2.64
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (unspecified)
Locations: Cardiology Research and Practice (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
Keywords: C-reactive protein, cardiovascular risk, atherosclerosis, inflammation, acute phase proteins, pentraxins, high-sensitivity C-reactive protein, cardiovascular risk prediction, risk score, cardiovascular disease prevention

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C-Reactive Protein: Clinical and Epidemiological Perspectives

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