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The Need for Biomarkers in Diagnosis and Prognosis of Drug-Induced Liver Disease: Does Metabolomics Have Any Role?

Iruzubieta, Paula, Arias-Loste, Maria Teresa, Barbier-Torres, Lucía, Martinez-Chantar, Maria Luz, Crespo, Javier·2015·BioMed Research International
DOI 10.1155/2015/386186PMC PMC4707380
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Abstract

Drug-induced liver injury (DILI) is a potentially fatal adverse event and the leading cause of acute liver failure in the US and in the majority of Europe. The liver can be affected directly, in a dose-dependent manner, or idiosyncratically, independently of the dose, and therefore unpredictably. Currently, DILI is a diagnosis of exclusion that physicians should suspect in patients with unexplained elevated liver enzymes. Therefore, new diagnostic and prognostic biomarkers are necessary to achieve an early and reliable diagnosis of DILI and thus improve the prognosis. Although several DILI biomarkers have been found through analytical and genetic tests and pharmacokinetic approaches, none of them have been able to display enough specificity and sensitivity, so new approaches are needed. In this sense, metabolomics is a strongly and promising emerging field that, from biofluids collected through minimally invasive procedures, can obtain early biomarkers of toxicity, which may constitute specific indicators of liver damage.

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Metadata

Authors
Iruzubieta, P., Arias-Loste, M. T., Barbier-Torres, L., Martinez-Chantar, M. L., & Crespo, J.
Affiliations
  • Gastroenterology and Hepatology Department, Marqués de Valdecilla University Hospital, 39008 Santander, Spain
  • CIC bioGUNE, Metabolomics Unit, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 48160 Derio, Spain
Venue
BioMed Research International
Publisher
Hindawi Limited
Published
2015
Volume
2015
Pages
1-8
ISSN
  • 2314-6133
  • 2314-6141
DOI
10.1155/2015/386186
PMC
PMC4707380
Cited by
24
References
4
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (unspecified)

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