Aging alters tissue resident mesenchymal stem cell properties

Alt, Eckhard U.; Senst, Christiane; Murthy, Subramanyam N.; Slakey, Douglas P.; Dupin, Charles L.; Chaffin, Abigail E.; Kadowitz, Philip J.; Izadpanah, Reza

doi:10.1016/j.scr.2011.11.002

Cited by 319Mesenchymal stem cell researchTelomeres, Telomerase, and SenescenceHematopoietic Stem Cell Transplantation

Aging alters tissue resident mesenchymal stem cell properties

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Alt, Eckhard U., Senst, Christiane, Murthy, Subramanyam N., Slakey, Douglas P., Dupin, Charles L., Chaffin, Abigail E., Kadowitz, Philip J., Izadpanah, Reza·2012·Stem Cell Research

DOI 10.1016/j.scr.2011.11.002

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Abstract

Tissue resident mesenchymal stem cells (MSCs) are known to participate in tissue regeneration that follows cell turnover, apoptosis, or necrosis. It has been long known that aging impedes an organism's repair/regeneration capabilities. In order to study the age associated changes, the molecular characteristics of adipose tissue derived MSCs (ASCs) from three age groups of healthy volunteers, i.e., young, middle aged, and aged were investigated. The number and multilineage differentiation potential of ASCs declined with age. Aging reduces the proliferative capacity along with increases in cellular senescence. A significant increase in quiescence of G2 and S phase was observed in ASCs from aged donors. The expression of genes related to senescence such as CHEK1 and cyclin-dependent kinase inhibitor p16(ink4a) was increased with age, however genes of apoptosis were downregulated. Further, an age-dependent abnormality in the expression of DNA break repair genes was observed. Global microRNA analysis revealed an abnormal expression of mir-27b, mir-106a, mir-199a, and let-7. In ubiquitously distributed adipose tissue (and ASCs), aging brings about important alterations, which might be critical for tissue regeneration and homeostasis. Our findings therefore provide a better understanding of the mechanism(s) involved in stem cell aging and regenerative potential, and this in turn may affect tissue repair that declines with aging.

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Aging is associated with decreased PCD in several cell types.
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Authors: Alt, E. U., Senst, C., Murthy, S. N., Slakey, D. P., Dupin, C. L., Chaffin, A. E., Kadowitz, P. J., & Izadpanah, R.
Affiliations: Tulane University (US)
Louisiana State University (US)
Corresponding author: Izadpanah, Reza
ORCID: Alt, Eckhard U.
Murthy, Subramanyam N.
Slakey, Douglas P.
Dupin, Charles L.
Chaffin, Abigail E.
Izadpanah, Reza
Venue: Stem Cell Research
Publisher: Elsevier BV
Published: 2012-03
Volume: 8
Issue: 2
Pages: 215-225
ISSN: 1873-5061 (ISSN-L)
DOI: 10.1016/j.scr.2011.11.002
OpenAlex: W2023538191
Cited by: 316
References: 55
Citations by year: 2026: 8 · 2025: 17 · 2024: 15 · 2023: 21 · 2022: 24 · 2021: 34 · 2020: 27 · 2019: 25 · 2018: 22 · 2017: 18 · 2016: 13 · 2015: 27 · 2014: 30 · 2013: 25 · 2012: 10
FWCI: 10.48
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 1444 d)
Locations: Stem Cell Research (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: Alliance of Cardiovascular Researchers
Topics: Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Keywords: aging, mesenchymal stem cells, adipose-derived stem cells, cellular senescence, multilineage differentiation, cell proliferation, cell cycle quiescence, DNA repair genes, microRNA expression, p16INK4a, Chk1, tissue regeneration, stem cell aging
MeSH terms: Adipose Tissue, Adolescent, Adult, Aged, Aging, Cell Count, Cell Cycle, Cell Differentiation, DNA Repair, Female, Humans, Male, Middle Aged, Apoptosis, Gene Expression Regulation, Developmental, Cell Lineage, MicroRNAs, Cell Proliferation, Young Adult, Transcriptome, Mesenchymal Stem Cells

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Aging alters tissue resident mesenchymal stem cell properties

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