The Reactive Oxygen Species in Macrophage Polarization: Reflecting Its Dual Role in Progression and Treatment of Human Diseases

The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function

Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481

The chemokine system in diverse forms of macrophage activation and polarization

MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534

Macrophage plasticity and polarization: in vivo veritas

Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335

Toll-Like Receptors

Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143

A role for mitochondria in nlrp3 inflammasome activation

Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602

Macrophage Diversity Enhances Tumor Progression and Metastasis

Qian, B., & Pollard, J. W. (2010) · Cell · doi:10.1016/j.cell.2010.03.014 · Cited by 5,338

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

Biswas, S. K., & Mantovani, A. (2010) · Nature Immunology · doi:10.1038/ni.1937 · Cited by 3,840

Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K., et al. (2003) · Science · doi:10.1126/science.1087262 · Cited by 3,286

Proanthocyanidins suppress NLRP3 inflammasome and M1 macrophage polarization to alleviate severe acute pancreatitis in mice

Sheng, L., Han, C., Ling, X., Guo, X., Lin, R., & Ding, Z. (2022) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23242 · Cited by 19

Is Nuclear Factor Erythroid 2-Related Factor 2 a Target for the Intervention of Cytokine Storms?

Liu, Z., Deng, P., Liu, S., Bian, Y., Xu, Y., Zhang, Q., Wang, H., & Pi, J. (2023) · Antioxidants · doi:10.3390/antiox12010172 · Cited by 21

Nonylphenol attenuates SOCS3 expression and M1 polarization in lipopolysaccharide-treated rat splenic macrophages

Pal, S., Nath, P., Biswas, S., Mukherjee, U., & Maitra, S. (2019) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2019.03.012 · Cited by 20

Investigating Low-Dose Thoracic Radiation as a Treatment for COVID-19 Patients to Prevent Respiratory Failure

Wilson, G. D., Mehta, M. P., Welsh, J. S., Chakravarti, A., Rogers, L., & Fontanesi, J. (2020) · Radiation Research · doi:10.1667/rade-20-00108.1 · Cited by 20

Targeting Multiple Signal Transduction Pathways of SARS-CoV-2: Approaches to COVID-19 Therapeutic Candidates

Fakhri, S., Nouri, Z., Moradi, S. Z., Akkol, E. K., Piri, S., Sobarzo‐Sánchez, E., Farzaei, M. H., & Echeverría, J. (2021) · Molecules · doi:10.3390/molecules26102917 · Cited by 18

Failure Analysis of TEVG’s I: Overcoming the Initial Stages of Blood Material Interaction and Stabilization of the Immune Response

Rodríguez-Soto, M. A., Vargas, N. S., Riveros, A., Muñoz-Camargo, C., Cruz, J. C., Sandoval, N. F., & Briceño, J. C. (2021) · Cells · doi:10.3390/cells10113140 · Cited by 19

SslE (YghJ), a Cell-Associated and Secreted Lipoprotein of Neonatal Septicemic Escherichia coli, Induces Toll-Like Receptor 2-Dependent Macrophage Activation and Proinflammation through NF-κB and MAP Kinase Signaling

Tapader, R., Bose, D., Dutta, P., Das, S., & Pal, A. (2018) · Infection and Immunity · doi:10.1128/iai.00399-18 · Cited by 20

MOF-mediated PRDX1 acetylation regulates inflammatory macrophage activation

Chen, H., Sun, Y., Mittler, G., Rumpf, T., Shvedunova, M., Grosschedl, R., & Akhtar, A. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114682 · Cited by 22

In Vitro Electrochemical Detection of Hydrogen Peroxide in Activated Macrophages via a Platinum Microelectrode Array

Carriere, V. M., Rodrigues, J. P., Tan, C., Arumugam, P. U., & Poh, S. (2021) · Sensors · doi:10.3390/s21165607 · Cited by 18

An ethanol extract of Aster yomena (Kitam.) Honda inhibits lipopolysaccharide-induced inflammatory responses in murine RAW 264.7 macrophages

Kang, H.-J., Jeong, J.-S., Park, N.-J., Go, G.-B., Kim, S. O., Park, C., Kim, B. W., Hong, S. H., & Choi, Y. H. (2017) · BioScience Trends · doi:10.5582/bst.2016.01217 · Cited by 18

Antibiotic-Dependent Relationships Between the Nasal Microbiome and Secreted Proteome in Nasal Polyps

KIM, Y., Han, D., Mo, J., Kim, Y. M., Kim, D. W., Choi, H. G., Park, J., & Shin, H. (2021) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2021.13.4.589 · Cited by 18

Enterocyte superoxide dismutase 2 deletion drives obesity

García‐Irigoyen, O., Bovenga, F., Piglionica, M., Piccinin, E., Cariello, M., Arconzo, M., Peres, C., Corsetto, P. A., Rizzo, A. M., Ballanti, M., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103707 · Cited by 17

Balance of Macrophage Activation by a Complex Coacervate-Based Adhesive Drug Carrier Facilitates Diabetic Wound Healing

Wang, C., Luo, S., Jia, S., Wu, W., Chang, S.-F., Feng, S., Yang, C., Lin, J.-H., & Wee, Y. (2022) · Antioxidants · doi:10.3390/antiox11122351 · Cited by 18

Shedding light on microglial dysregulation in Alzheimer’s disease: exploring molecular mechanisms and therapeutic avenues

Bhardwaj, V., Kumari, S., Dhapola, R., Sharma, P., Beura, S. K., Singh, S. K., Vellingiri, B., & HariKrishnaReddy, D. (2024) · Inflammopharmacology · doi:10.1007/s10787-024-01598-6 · Cited by 18

Inhibitory effects on the production of inflammatory mediators and reactive oxygen species by Mori folium in lipopolysaccharide-stimulated macrophages and zebrafish

Kwon, D. H., JEONG, J. W., Choi, E. O., Lee, H. W., Lee, K. W., Kim, K. Y., Kim, S. G., Hong, S. H., Kim, G., Park, C., et al. (2017) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201720160836 · Cited by 17

Biomedical applications of cerium oxide nanoparticles: a potent redox modulator and drug delivery agent

Abuid, N. J., Gattás‐Asfura, K. M., LaShoto, D. J., Poulos, A. M., & Stabler, C. L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816662-8.00017-5 · Cited by 18

Optimization of Gold Nanoparticles for Efficient Delivery of Catalase to Macrophages for Alleviating Inflammation

Fakih, F. B., Shanti, A., Stefanini, C., & Lee, S. (2020) · ACS Applied Nano Materials · doi:10.1021/acsanm.0c02234 · Cited by 17

Cardiovascular Risk Factors and Their Relationship with Vascular Dysfunction in South African Children of African Ancestry

Matjuda, E. N., Engwa, G. A., Anye, S. N. C., Nkeh-Chungag, B. N., & Goswami, N. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10020354 · Cited by 19

Role of Zerumbone, a Phytochemical Sesquiterpenoid from Zingiber zerumbet Smith, in Maintaining Macrophage Polarization and Redox Homeostasis

Yeh, W., Huang, B., Chen, G., Charoensaensuk, V., Tsai, C., Yang, L., Lu, D., Chen, M.-K., & Lin, C. (2022) · Nutrients · doi:10.3390/nu14245402 · Cited by 18

Lipopolysaccharides-stimulated macrophage products enhance Withaferin A-induced apoptosis via activation of caspases and inhibition of NF-κB pathway in human cancer cells

Piao, L., Zhao, C., Lu, W.-J., Xiaoli, C., Shi, W., & Lu, L. (2016) · Molecular Immunology · doi:10.1016/j.molimm.2016.10.010 · Cited by 17

Natural Products for Regulating Macrophages M2 Polarization

Chang, Z., Wang, Y., Liu, C., Smith, W. W., & Kong, L. (2019) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x14666190523093535 · Cited by 17

Beyond M1/M2: The role of reactive oxygen species in liver fibrosis and immune modulation

Lu, H., Huang, J., Wang, Y.-C., Casals, E., Casals, G., & Zeng, M. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103933 · Cited by 19

The promise of targeting heme and mitochondrial respiration in normalizing tumor microenvironment and potentiating immunotherapy

Akter, Z., Salamat, N., Ali, M. Y., & Li, Z. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2022.1072739 · Cited by 17

Remodeling periodontal osteoimmune microenvironment through MAPK/NFκB phosphorylation pathway of macrophage via intelligent ROS scavenging

Qiu, X., Peng, H., Zhao, Y., Yu, Y., Yang, J., Liu, C., Ren, S., & Miao, L. (2023) · Human Cell · doi:10.1007/s13577-023-00979-3 · Cited by 16

Construction of multifunctional coating with cationic amino acid-coupled peptides for osseointegration of implants

Zhao, B., Dong, Y., Shen, X., He, W., Jin, H., Yao, L., Zheng, S., Zan, X., & Liu, J. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100848 · Cited by 16

Lithium is able to minimize olanzapine oxidative-inflammatory induction on macrophage cells

Fernandes, M. S., Barbisan, F., Azzolin, V. F., do Prado‐Lima, P. A. S., Teixeira, C. F., Jung, I. E. D. C., Assmann, C. E., Riffel, R. T., Duarte, M. M. M. F., Ribeiro, E. M. A., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0209223 · Cited by 16

Optical changes in THP-1 macrophage metabolism in response to pro- and anti-inflammatory stimuli reported by label-free two-photon imaging

Smokelin, I. S., Mizzoni, C., Erndt‐Marino, J. D., Kaplan, D. L., & Georgakoudi, I. (2020) · Journal of Biomedical Optics · doi:10.1117/1.jbo.25.1.014512 · Cited by 17

Cardiac Immunology: A New Era for Immune Cells in the Heart.

Koc, A., & Cagavi, E. (2020) · Advances in Experimental Medicine and Biology · doi:10.1007/5584_2020_576 · Cited by 15

GC–MS screening and antiparasitic action of Putranjiva roxburghii leaves against sensitive and resistant strains of Leishmania donovani

Keshav, P., Goyal, D. K., & Kaur, S. (2021) · Journal of Parasitic Diseases · doi:10.1007/s12639-021-01388-9 · Cited by 16

ADSA Foundation Scholar Award: Shakin' off the rust—Oxidative stress and redox status as underlying factors of immune dysfunction in periparturient cows and preweaning calves

Abuelo, Á. (2025) · Journal of Dairy Science · doi:10.3168/jds.2025-26707 · Cited by 19

Peripheral monocyte transcriptional signatures of inflammation and oxidative stress in Parkinson’s disease

Thome, A. D., Wang, J., Atassi, F., Thonhoff, J. R., Faridar, A., Zhao, W., Beers, D. R., Lai, E. C., & Appel, S. H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1571074 · Cited by 17

cROSsing the Line: Between Beneficial and Harmful Effects of Reactive Oxygen Species in B-Cell Malignancies

Domka, K., Góral, A., & Firczuk, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01538 · Cited by 15

Cellular RNA and DNA sensing pathways are essential for the dose-dependent response of human monocytes to ionizing radiation

Mikhalkevich, N., Russ, E. U., & Iordanskiy, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1235936 · Cited by 15

A chronic pro-inflammatory environment contributes to the physiopathology of actinic lentigines

Duval, C., Bourreau, E., Warrick, E., Bastien, P., Nouveau, S., & Bernerd, F. (2024) · Scientific Reports · doi:10.1038/s41598-024-53990-5 · Cited by 16

Studies on the effects of LPS , ß‐glucan and metabolic inhibitors on the respiratory burst and gene expression in Atlantic salmon macrophages

Ulvestad, J. S., Kumari, J., Seternes, T., Chi, H., & Dalmo, R. A. (2018) · Journal of Fish Diseases · doi:10.1111/jfd.12806 · Cited by 15

Erythropoietin promotes functional recovery in a mouse model of postoperative ileus

Elfar, W., Gurjar, A. A., Talukder, M. A. H., Noble, M., Lorenzo, C. D., & Elfar, J. C. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.14049 · Cited by 15

Xenotransplantation of tannic acid‐encapsulated neonatal porcine islets decreases proinflammatory innate immune responses

Barra, J. M., Kozlovskaya, V., Kepple, J. D., Seeberger, K. L., Kuppan, P., Hunter, C. S., Korbutt, G. S., Kharlampieva, E., & Tse, H. M. (2021) · Xenotransplantation · doi:10.1111/xen.12706 · Cited by 15

Shooting yourself in the foot: How immune cells induce antibiotic tolerance in microbial pathogens

Beam, J. E., Rowe, S. E., & Conlon, B. P. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009660 · Cited by 15

Role of Base Excision Repair in Innate Immune Cells and Its Relevance for Cancer Therapy

Zhao, S., Habib, S. L., Senejani, A. G., Sebastian, M. M., & Kidane, D. (2022) · Biomedicines · doi:10.3390/biomedicines10030557 · Cited by 14

Integrated computational and in vivo models reveal Key Insights into macrophage behavior during bone healing

Baratchart, E., Lo, C. H., Lynch, C. C., & Basanta, D. (2022) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1009839 · Cited by 15

Activatable superparamagnetic iron oxide nanoparticles scavenge reactive oxygen species in macrophages and endothelial cells

Nwasike, C., Yoo, E., Purr, E., & Doiron, A. L. (2020) · RSC Advances · doi:10.1039/d0ra06683d · Cited by 15

Subcellular distribution of Prussian blue nanozymes dictates enzymatic activity and macrophage polarization for effective colitis therapy

Ding, H., Long, M., Wu, Y., Zhang, Y., Yang, Z., Yan, X., Li, Y., Shen, Y., Zhang, M., Zhang, Y., et al. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123622 · Cited by 14

IFN-γ-Driven macrophage responses in the immunity to Mycobacterium tuberculosis and Mycobacterium leprae

Imran, M., Alshrari, A. S., Khan, A., & Alzahrani, A. R. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1679691 · Cited by 14

A Viral Long Non-Coding RNA Protects against Cell Death during Human Cytomegalovirus Infection of CD14+ Monocytes

Perera, M. R., Roche, K. L., Murphy, E. A., & Sinclair, J. H. (2022) · Viruses · doi:10.3390/v14020246 · Cited by 14

Macrophage-targeted ultrasound nanobubbles for highly efficient sonodynamic therapy of atherosclerotic plaques by modulating M1-to-M2 polarization

Chen, Y., Wang, H., Pan, J., Guo, Y., Hu, Y., Huang, X., Zhou, Y., Deng, Q., & Zhou, Q. (2023) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2023.117423 · Cited by 14

Mammalian Target of Rapamycin Complex 1 Activation in Macrophages Contributes to Persistent Lung Inflammation following Respiratory Tract Viral Infection

Huckestein, B. R., Zeng, K., Westcott, R., Alder, J. K., Antos, D., Kolls, J. K., & Alcorn, J. F. (2023) · American Journal Of Pathology · doi:10.1016/j.ajpath.2023.11.017 · Cited by 14

Vibrio cholerae OmpU Mediates CD36-Dependent Reactive Oxygen Species Generation Triggering an Additional Pathway of MAPK Activation in Macrophages

Prasad, G. V. R. K., Dhar, V., & Mukhopadhaya, A. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1800389 · Cited by 15

Imbalance of Ly-6Chi and Ly-6Clo Monocytes/Macrophages Worsens Hyperoxia-Induced Lung Injury and Is Rescued by IFN-γ

Eldredge, L. C., Creasy, R. S., Tanaka, S., Lai, J.-F., & Ziegler, S. F. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801374 · Cited by 14

The effects of carvacrol on oxidative stress, inflammation, and liver function indicators in a systemic inflammation model induced by lipopolysaccharide in rats

Mortazavi, A., Kargar, H. M. P., Beheshti, F., Anaeigoudari, A., Vaezi, G., & Hosseini, M. (2021) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000711 · Cited by 14

Influences of Histidine-1 and Azaphenylalanine-4 on the Affinity, Anti-inflammatory, and Antiangiogenic Activities of Azapeptide Cluster of Differentiation 36 Receptor Modulators

Possi, K. C., Mulumba, M., Omri, S., García‐Ramos, Y., Tahiri, H., Chemtob, S., Ong, H., & Lubell, W. D. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b01209 · Cited by 14

p-Coumaroyl Anthocyanin Mixture Isolated from Tuber Epidermis of Solanum tuberosum Attenuates Reactive Oxygen Species and Pro-inflammatory Mediators by Suppressing NF-κB and STAT1/3 Signaling in LPS-Induced RAW264.7 Macrophages

Lee, H., Lee, S.-G., Shin, J., Lee, H., Yoon, K., Ji, Y. W., Jang, D. S., & Lee, K. (2017) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b17-00362 · Cited by 14

Novel insights into the regulation of cellular catabolic metabolism in macrophages through nuclear receptors

Stifel, U., Caratti, G., & Tuckermann, J. P. (2022) · FEBS Letters · doi:10.1002/1873-3468.14474 · Cited by 14

Quercus acuta Thunb. Suppresses LPS-Induced Neuroinflammation in BV2 Microglial Cells via Regulating MAPK/NF-κB and Nrf2/HO-1 Pathway

Kim, J. K., Yang, H. J., & Go, Y. (2022) · Antioxidants · doi:10.3390/antiox11101851 · Cited by 14

Increased oxidative stress responses in murine macrophages exposed at the air-liquid interface to third- and fourth-generation electronic nicotine delivery system (ENDS) aerosols

Pinkston, R., Penn, A. L., & Noël, A. (2023) · Toxicology Reports · doi:10.1016/j.toxrep.2023.06.008 · Cited by 15

Overreactive macrophages in SARS-CoV-2 infection: The effects of ACEI

Felkle, D., Zięba, K., Kaleta, K., Czaja, J., Zyzdorf, A., Sobocińska, W., Jarczyński, M., Bryniarski, K., & Nazimek, K. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110858 · Cited by 13

Gold Nanodandelions as Nanozymes and Reactive Oxygen Species Scavengers in Tumor Microenvironment Components

Lee, H., Chuang, Y.-C., Tsai, J., Chen, Y.-C., Wu, P., Lo, L., Chiou, J., & Shen, Y. (2023) · ACS Applied Nano Materials · doi:10.1021/acsanm.3c04734 · Cited by 13

Europium-Containing Nanospheres for Treating Ovariectomy-Induced Osteoporosis: Targeted Bone Remodeling and Macrophage Polarization Modulation

Wang, Y.-C., Cai, M.-T., Chen, M., Tung, F.-I., Chen, M., & Liu, T.-Y. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s472253 · Cited by 13

The role of redox system in metastasis formation

Cencioni, C., Comunanza, V., Middonti, E., Vallariello, E., & Bussolino, F. (2021) · Angiogenesis · doi:10.1007/s10456-021-09779-5 · Cited by 13

Immune Responses Are Differentially Regulated by Root, Stem, Leaf, and Flower Extracts of Female and Male CBD Hemp (Cannabis sativa L.) Plants

Esposito, L. G. A., Overbaugh, E., Xiong, J., Thirumurugan, R., Komarnytsky, S., da Silva, D. J. H., & Esposito, D. (2021) · Immuno · doi:10.3390/immuno1040025 · Cited by 13

Re-polarisation of Macrophages Within Collective Tumour Cell Migration: A Multiscale Moving Boundary Approach

Suveges, S., Eftimie, R., & Trucu, D. (2022) · Frontiers in Applied Mathematics and Statistics · doi:10.3389/fams.2021.799650 · Cited by 17

Oxidative Stress‐Mediated Overexpression of Uracil DNA Glycosylase in Leishmania donovani Confers Tolerance against Antileishmanial Drugs

Mishra, A., Khan, M. I., Jha, P. K., Kumar, A., Das, S., Das, P., Das, P. K., & Sinha, K. K. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/4074357 · Cited by 13

Monoclonal Antibody to CD14, TLR4, or CD11b: Impact of Epitope and Isotype Specificity on ROS Generation by Human Granulocytes and Monocytes

Kabanov, D. S., Grachev, S. V., & Прохоренко, И. Р. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/5708692 · Cited by 13

Omega-3 and omega-6 fatty acid differentially impact cardiolipin remodeling in activated macrophage

Chang, W.-H., Ting, H.-C., Chen, W., Chan, J.-F., & Hsu, Y. (2018) · Lipids in Health and Disease · doi:10.1186/s12944-018-0845-y · Cited by 14

Patient-Reported Health Outcomes After Treatment of COVID-19 with Nebulized and/or Intravenous Neutral Electrolyzed Saline Combined with Usual Medical Care Versus Usual Medical care alone: A Randomized, Open-Label, Controlled Trial.Preprint

Delgado‐Enciso, I., Paz-García, J., Barajas-Saucedo, C. E., Mokay-Ramírez, K. A., Meza‐Robles, C., Lopez‐Flores, R., Delgado‐Machuca, M., Murillo‐Zamora, E., Toscano-Velazquez, J. A., Delgado‐Enciso, J., et al. (2020) · doi:10.21203/rs.3.rs-68403/v1 · Cited by 14

Metal Ion Periplasmic-Binding Protein YfeA of Glaesserella parasuis Induces the Secretion of Pro-Inflammatory Cytokines of Macrophages via MAPK and NF-κB Signaling through TLR2 and TLR4

Yang, Z. L., Tang, X., Wang, K., Dai, K., Chang, Y., Du, S., Zhao, Q., Huang, X., Wu, R. J., Yan, Q., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179627 · Cited by 12

Interaction of Macrophages with Bone Healing Microenvironment: Mechanism and Biomaterials

Lu, X., Gao, J., Bao, W., Xu, J., Sun, X., Wang, Y., & Li, B. (2023) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2023.0157 · Cited by 13

Serine metabolism in macrophage polarization

Huang, X., Yang, X. F., Li, X., & Chen, Y. (2023) · Inflammation Research · doi:10.1007/s00011-023-01815-y · Cited by 14

Redefining vascular repair: revealing cellular responses on PEUU—gelatin electrospun vascular grafts for endothelialization and immune responses on in vitro models

Rodríguez-Soto, M. A., Riveros, A., Orjuela-Garzón, I. C., Fernández-Calderón, I. M., Rodríguez, C. F., Vargas, N. S., Ostos, C., Muñoz-Camargo, C., Cruz, J. C., Kim, S., et al. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1410863 · Cited by 12

Modulation of Monocyte Effector Functions and Gene Expression by Human Cytomegalovirus Infection

Khoury, J. B. E., Fishman, J. A., & Planchon, M. S. (2024) · Viruses · doi:10.3390/v16121809 · Cited by 13

Baicalin prevents experimental autoimmune uveitis by promoting macrophage polarization balance through inhibiting the HIF-1α signaling pathway

Liu, B., Peng, Y., Wang, C., Wei, H., Xu, S., Liu, Y., Yin, X., Bi, H., & Guo, D. (2025) · Scientific Reports · doi:10.1038/s41598-025-01286-7 · Cited by 12

Role of Inflammatory Cell Responses in Stimulating Fibroblasts in Diabetic Oral Ulcer after Treatment with Liquid Smoke of Coconut Endocarp: A Histological Assessment

Ernawati, D. S., Surboyo, M. D. C., Ayuningtyas, N. F., & Nagoro, A. A. B. (2020) · European Journal of Dentistry · doi:10.1055/s-0040-1715913 · Cited by 12

Diabetes and Cannabinoid CB1 receptor deficiency promote similar early onset aging-like changes in the skin

Leal, E. C., Moura, L. I. F., Pirzgalska, R. M., Marques‐da‐Silva, D., Ledent, C. A., Köfalvi, A., & Carvalho, E. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111528 · Cited by 12

Vitexin along with verapamil downregulates efflux pump P-glycoprotein in macrophages and potentiate M1 to M2 switching via TLR4-NF-κB-TNFR2 pathway in lipopolysaccharide treated mice

Kundu, A., Ghosh, P., & Bishayi, B. (2023) · Immunobiology · doi:10.1016/j.imbio.2023.152767 · Cited by 12

Sustained Hypoxia Suppresses Joint Destruction in a Rat Model of Rheumatoid Arthritis via Negative Feedback of Hypoxia Inducible Factor-1α

Kaihara, K., Nakagawa, S., Arai, Y., Inoue, H., Tsuchida, S., Fujii, Y., Kamada, Y., Kishida, T., Mazda, O., & Takahashi, K. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083898 · Cited by 12

Anti-inflammatory effect of stem cells against spinal cord injury via regulating macrophage polarization

Cheng, Z., & He, X. (2017) · Journal of Neurorestoratology · doi:10.2147/jn.s115696 · Cited by 12

The Role of Prostaglandins as Major Inflammatory Mediators in Colorectal Cancer

Macia-Guardado, M., Lutz, V., Hengstschläger, M., & Dolznig, H. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262412191 · Cited by 17

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