Cited by 106Sperm and Testicular FunctionHeavy Metal Exposure and ToxicityArsenic contamination and mitigation

Antioxidant Potential of Spirulina platensis Mitigates Oxidative Stress and Reprotoxicity Induced by Sodium Arsenite in Male Rats

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Bashandy, Samir A. E., El Awdan, Sally A., Ebaid, Hossam, Alhazza, Ibrahim M.·2016·Oxidative Medicine and Cellular Longevity

Abstract

The present study aimed to examine the protective role of Spirulina platensis ( S. platensis ) against arsenic‐induced testicular oxidative damage in rats. Arsenic (in the form of NaAsO 2 at a dose of 6.3 mg/kg body weight for 8 weeks) caused a significant accumulation of arsenic in testicular tissues as well as a decrease in the levels of testicular superoxide dismutase (SOD), catalase (CAT), reduced glutathione, and zinc. Moreover, it significantly decreased plasma testosterone, luteinizing hormone (LH), triiodothyronine (T 3 ), and thyroxine (T 4 ) levels and reduced sperm motility and sperm count. Arsenic (AS) led to a significant increase in testicular malondialdehyde (MDA), tumour necrosis factor alpha (TNF‐ α ), nitric oxide (NO), and sperm abnormalities. S. platensis at a dose of 300 mg/kg was found to attenuate As‐induced oxidative stress, testicular damage, and sperm abnormalities by its potent antioxidant activity. S. platensis may represent a potential therapeutic option to protect the testicular tissue from arsenic intoxication.

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  • Antioxidant activity accounts for the protective role of Spirulina against toxicity induced by carbon tetrachloride, metals, deltamethrin, and drugs in animal models.

    “It has been suggested that the antioxidant activity accounts for the protective role of Spirulina against the toxicity induced by carbon tetrachloride (CCl4) [40], by metals (arsenic, mercuric chloride, chromium, cadmium, and fluoride) [34, 41–44], by the insecticide deltamethrin in mice [39] and rats [45]”

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Authors
Bashandy, S. A. E., El Awdan, S. A., Ebaid, H., & Alhazza, I. M.
Affiliations
  • National Research Centre (EG)
  • King Saud University (SA)
Corresponding author
Bashandy, Samir A. E.
Venue
Oxidative Medicine and Cellular Longevity
Publisher
Wiley
Published
2016-01
Volume
2016
Issue
1
Pages
7174351-7174351
ISSN
  • 1942-0994 (ISSN-L)
  • 1942-0900
OpenAlex
W2234087843
Cited by
106
References
55
Citations by year
2026: 8 · 2025: 7 · 2024: 7 · 2023: 11 · 2022: 13 · 2021: 16 · 2020: 13 · 2019: 8 · 2018: 11 · 2017: 9 · 2016: 3
FWCI
13.74
Type
journal article
Language
en
Open access
Locations
  • Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
King Saud University (RGP-1435-093)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
  • Physical Sciences › Environmental Science › Environmental Chemistry › Arsenic contamination and mitigation
Keywords
Spirulina platensis, sodium arsenite, arsenic toxicity, testicular oxidative stress, reproductive toxicity, antioxidant activity, sperm abnormalities, superoxide dismutase, catalase, reduced glutathione, testosterone, luteinizing hormone, thyroxine, TNF-α, nitric oxide, zinc
MeSH terms
Animals, Antioxidants, Arsenic, Catalase, Glutathione, Luteinizing Hormone, Male, Malondialdehyde, Nitric Oxide, Organ Size, Random Allocation, Sperm Motility, Spermatozoa, Superoxide Dismutase, Testis, Testosterone, Thyroxine, Triiodothyronine, Tumor Necrosis Factor-alpha, Zinc, Rats, Wistar, Sodium Compounds, Arsenites, Oxidative Stress, Rats, Spirulina

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