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Cited by 159Chemotherapy-induced cardiotoxicity and mitigationChemotherapy-induced organ toxicity mitigationBioactive Compounds and Antitumor Agents

Protective effect ofSpirulina against doxorubicin-induced cardiotoxicity

Khan, Mahmood, Shobha, Jagdish Chandra, Mohan, Iyyapu Krishna, Naidu, Madireddi Umamaheswara Rao, Sundaram, Challa, Singh, Shashi, Kuppusamy, Periannan, Kutala, Vijay Kumar·2005·Phytotherapy Research
DOI 10.1002/ptr.1783
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Abstract

The generation of reactive oxygen species and mitochondrial dysfunction has been implicated in doxorubicin (DOX)-induced cardiotoxicity. The aim of the present study was to determine whether Spirulina, a blue-green algae, could serve as a cardioprotective agent during DOX treatment in a mouse model. Mice were treated with DOX (4 mg/kg bw, intraperitoneally), weekly, for 4 weeks. Spirulina was administered orally for 3 days twice daily, then for 7 weeks along with the four equal injections of DOX. Cardiotoxicity was assessed, at 3 weeks after the end of the DOX-treatment period, by mortality, volume of ascites, liver congestion, oxidative stress and ultrastructural changes of heart tissue. The DOX-treated animals showed higher mortality (53%) and more ascites. Myocardial damage, as assessed by ultrastructural changes, showed loss of myofibrils, cytoplasmic vacuolization and mitochondrial swelling. Myocardial superoxide dismutase and glutathione peroxidase activities were decreased and lipid peroxidation was increased. Pretreatment with Spirulina significantly protected the mice from DOX-induced cardiotoxic effects as evidenced from lower mortality (26%), less ascites, lower levels of lipid peroxidation, normalization of antioxidant enzymes and ultrastructural studies showing minimal damage to the heart. In vitro cytotoxic studies using ovarian cancer cells demonstrated that Spirulina did not compromise the anti-tumor activity of doxorubicin. These results suggest that Spirulina has a protective effect against cardiotoxicity induced by DOX and it may, therefore, improve the therapeutic index of DOX.

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  • C-phycocyanin attenuated ischemia-reperfusion-induced cardiac dysfunction through its antioxidant and antiapoptotic actions.

    “Khan et al. investigated the cardioprotective effect of C-phycocyanin (PC) (an antioxidant biliprotein pigment of a blue–green algae Arthrospira platensis) against ischemia–reperfusion (I/R)-induced myocardial injury and show that PC attenuated I/R-induced cardiac dysfunction through its antioxidant and antiapoptotic actions [112].”

    From Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature (2023) · cites this paper as [112]

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Authors
Khan, M., Shobha, J. C., Mohan, I. K., Naidu, M. U. R., Sundaram, C., Singh, S., Kuppusamy, P., & Kutala, V. K.
Affiliations
  • Nizam's Institute of Medical Sciences (IN)
  • The Ohio State University (US)
Corresponding author
Kutala, Vijay Kumar
ORCID
Venue
Phytotherapy Research
Publisher
Wiley
Published
2005
Volume
19
Issue
12
Pages
1030-1037
ISSN
  • 0951-418X (ISSN-L)
  • 1099-1573
DOI
10.1002/ptr.1783
OpenAlex
W1998318428
Cited by
159
References
78
Citations by year
2026: 1 · 2025: 5 · 2024: 4 · 2023: 9 · 2022: 11 · 2021: 15 · 2020: 5 · 2019: 7 · 2018: 17 · 2017: 7 · 2016: 7 · 2015: 10 · 2014: 9 · 2013: 12 · 2012: 6
FWCI
3.65
Type
journal article
Language
en
Open access
closed
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 3895 d)
Locations
  • Phytotherapy Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Prevent Cancer Foundation
  • National Institutes of Health
  • National Cancer Institute (CA102264, R01CA102264)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Chemotherapy-induced cardiotoxicity and mitigation
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Chemotherapy-induced organ toxicity mitigation
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
Keywords
Spirulina, doxorubicin, cardiotoxicity, cardioprotection, oxidative stress, lipid peroxidation, antioxidant enzymes, mitochondrial dysfunction, reactive oxygen species, ovarian cancer, chemotherapy side effects, cyanobacteria
MeSH terms
Cyanobacteria, Animals, Antibiotics, Antineoplastic, Bacterial Proteins, Cardiomyopathy, Dilated, Doxorubicin, Drug Interactions, Female, Heart, Myocardium, Phycocyanin, Superoxides, Oxidative Stress, Mice, Spirulina

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