Cited by 136Seaweed-derived Bioactive CompoundsAlgal biology and biofuel productionFood Industry and Aquatic Biology

Vitamin A, Nutrition, and Health Values of Algae: Spirulina, Chlorella, and Dunaliella

Open access
Tang, Guangwen, Suter, Paolo M.·2011·Journal of Pharmacy and Nutrition Sciences

Abstract

Spirulina, chlorella, and dunalliella are unicellular algae that are commercially produced worldwide. These algae are concentrated sources of carotenoids (especially provitamin A carotenoids) and other nutrients, such as vitamin B12. Their health benefits as a complementary dietary source for macro and micro nutrients have been studied and confirmed in various populations. The safety of human consuming these algae and products derived from these algae by humans has been widely studied. It is generally concluded that these algae and its products are safe if cultivated properly in a non-contaminated environment, and if consumed in moderation.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.6000/1927-5951.2011.01.02.04

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Dunaliella has not been used for dedicated nutritional supplementation to date, and no reliable nutritional analyses have been done.

    “It has not been used for dedicated nutritional supplementation to date, and thus no reliable nutritional analyses have been done;”

    From Biologically-Based and Physiochemical Life Support and In Situ Resource Utilization for Exploration of the Solar System—Reviewing the Current State and Defining Future Development Needs (2021) · cites this paper as [49]

    The Safety of Using Algal Products section (page not provided) discusses consumption of Dunaliella products as dietary supplements, contrary to the claim that they have not been used for supplementation. The DUNALIELLA section (page not provided) also identifies its carotenoids and quantifies β-carotene at up to 13.8% of dry weight; it does not support the assertion that no reliable nutritional analyses have been done. (LLM, conf=0.87)

    Checked by a reasoning model — may be wrong.

    Experimental — accuracy not yet measured
  • Dunaliella has been used pharmacologically for treatment of hypertension, atherosclerosis, Crohn's disease, bronchodilation, and photo damage.

    “however, it has been used pharmacologically for treatment of hypertension, atherosclerosis, Crohn’s disease, bronchodilation, and photo damage [49].”

    From Biologically-Based and Physiochemical Life Support and In Situ Resource Utilization for Exploration of the Solar System—Reviewing the Current State and Defining Future Development Needs (2021) · cites this paper as [49]

    The DUNALIELLA section describes antihypertensive and bronchodilator pharmacological functions. The Other Health Effect section reports protection against photo damage and possible effects on atherosclerosis, but says a benefit for Crohn’s disease is only possible, based on enteritis findings in rats. The claim overstates these findings as established uses for treatment of all five conditions. Page numbers are unavailable in our copy. (LLM, conf=0.88)

    Experimental — accuracy not yet measured
  • Most contaminated toxins in spirulina come from other toxic algae species that become mixed up during harvest.

    “Most contaminated toxins come from other toxic algae species that become mixed up during harvest, necessitating the study of spirulina production processes at home.”

    From Tendencies Affecting the Growth and Cultivation of Genus Spirulina: An Investigative Review on Current Trends (2022) · cites this paper as Tang and Suter [35]

    The Safety of Using Algal Products section says cyanobacterial toxins often stem from toxic species when algae are harvested from mixed phytoplankton populations, and it calls for studying cultivation techniques suitable for home growing. It does not establish that most contaminating toxins have this origin; it says “often,” not “most.” (LLM, conf=0.86)

    Experimental — accuracy not yet measured
  • Spirulina includes vitamin A (β-carotene) at 211 mg/100 g, vitamin K at 1090 μg, and vitamin B12 at 162 μg.

    “It was also reported that spirulina includes a significant amount of vitamins, including vitamin A (β-carotene) at 211 mg/100 g, vitamin K at 1090 µg, and vitamin B12 at 162 µg [88].”
  • Tang and Suter noted the importance of investigating home cultivation practices for spirulina.

    “Tang and Suter [35] noted how important it is to investigate home cultivation practices for spirulina.”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 8

  1. Belay A. The potential application of spirulina (arthrospira) as a nutritional and therapeutic supplement in health management. J Am Nutriceutical Association 2002; 5: 27-48.
  2. Gershwin ME, Belay A. Spirulina in human nutrition and health. CRC Press, Boca Raton, FL, USA, 2000.
  3. Halidou DM, Degbey H, Daouda H, Leveque A, Donnen P, Hennart P, et al. The effect of spiruline during nutritional rehabilitation: systematic review. Rev. Epidemiol Sante Publique 2008; 56: 425-31. [Article in French] Source: Pédiatrie A, hôpital National de Niamey, BP 238, Niamey, Niger. mhalidou2002@yahoo.fr
  4. FAO Fisheries and Aquaculture Circular C1034, A review on culture, production and use of spirulina as food for humans and feeds for domestic animals. 2009; Available from: ftp://ftp.fao.org/docrep/fao/011/i0424e/i0424e00.pdf
  5. Halperin SA, Smith B, Nolan C. Nolan C, Shay J, Kralovec J. Safety and immunoenhancing effect of a chlorella-derived dietary supplement in healthy adults undergoing influenza vaccination: randomized, double-blind, placebo-controlled trial. CMAJ 2003; 169: 111-7.
  6. Fujii Y, Sakamoto S, Ben-Amotz A, Nagasawa H. Effects of β-carotene-rich algae dunaliella bardawil on the dynamic changes of normal and neoplastic mammary cells and general metabolism in mice. Anticancer Res 1993; 13: 389- 93.
  7. Nagasawa H, Fujii Y, Kageyama Y, Segawa T, Ben-Amotz A Suppression by β-carotene-rich algae dunaliella bardawil of the progression, but not the development, of spontaneous mammary tumours in SHN virgin mice. Anticancer Res 1991; 11: 713-7.
  8. Kim C-J, Jung Y-H, Ko S-R, Kim H-I, Park Y-H, Oh H-M. Raceway cultivation of spirulina platensis using underground water. J Microbiol Biotechnol 2007; 17: 853-7.

Cited by

Sorted by citations

Authors
Tang, G., & Suter, P. M.
Affiliations
  • Tufts University (US)
  • University Hospital Zurich (CH)
Venue
Journal of Pharmacy and Nutrition Sciences
Published
2011-01-05
Volume
1
Issue
2
Pages
111-118
ISSN
1927-5951 (ISSN-L)
OpenAlex
W3140237773
Cited by
136
References
38
Citations by year
2026: 4 · 2025: 10 · 2024: 8 · 2023: 12 · 2022: 20 · 2021: 10 · 2020: 14 · 2019: 11 · 2018: 16 · 2017: 11 · 2016: 6 · 2015: 8 · 2014: 2 · 2013: 1 · 2012: 2
FWCI
2.43
Type
journal article
Language
en
Open access
Locations
  • Journal of Pharmacy and Nutrition Sciences (publishedVersion, cc-by-nc)
  • Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
  • Zurich Open Repository and Archive (University of Zurich)
  • Journal of Pharmacy and Nutrition Sciences
Topics
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Food Industry and Aquatic Biology
Keywords
Spirulina, Chlorella, Dunaliella, microalgae, vitamin A, provitamin A carotenoids, vitamin B12, health benefits, dietary supplements, food safety, nutrient composition

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review