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Cited by 339

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Effect of Exercise on Serum Estrogens in Postmenopausal Women

McTiernan, Anne, Tworoger, Shelley S., Ulrich, Cornelia M., Yasui, Yutaka, Irwin, Melinda L., Rajan, Kumar B., Sorensen, Bess, Rudolph, Rebecca E., Bowen, Deborah, Stanczyk, Frank Z., Potter, John D., Schwartz, Robert S.·2004·Cancer Research
DOI 10.1158/0008-5472.can-03-3393
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Abstract

Elevated circulating estrogens and a sedentary lifestyle increase risk for breast cancer. The effect of exercise on circulating estrogens in sedentary postmenopausal women is unknown. The objective of this study was to examine the effects of a 12-month moderate-intensity exercise intervention on serum estrogens. We randomly assigned 173 sedentary, overweight (body mass index > 24.0 kg/m2, body fat > 33%), postmenopausal women, ages 50–75 years, not using hormone therapy, living in the Seattle, Washington, area for the next year, and willing to be randomly assigned to an exercise intervention or stretching control group. The exercise intervention included facility and home-based exercise (45 min, 5 days/week moderate intensity sports/recreational exercise). A total of 170 (98.3%) women completed the study with exercisers averaging 171 min/week of exercise. After 3 months, exercisers experienced declines in estrone, estradiol, and free estradiol of 3.8, 7.7, and 8.2%, respectively, versus no change or increased concentrations in controls (P = 0.03, 0.07, and 0.02, respectively). At 12 months, the direction of effect remained the same, although the differences were no longer statistically significant. The effect was limited to women who lost body fat: women whose percentage of body fat [by dual energy x-ray absortiometry (DEXA)] decreased by ≥2% had statistically significant (comparing exercisers versus controls) decreases at 12 months of 11.9, 13.7, and 16.7% for serum estrone, estradiol, and free estradiol, respectively. We concluded that a 12-month moderate-intensity exercise intervention in postmenopausal women resulted in significant decreases in serum estrogens. The association between increased physical activity and reduced risk for postmenopausal breast cancer may be partly explained by effects on serum estrogens.

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Metadata

Authors
McTiernan, A., Tworoger, S. S., Ulrich, C. M., Yasui, Y., Irwin, M. L., Rajan, K. B., Sorensen, B., Rudolph, R. E., Bowen, D., Stanczyk, F. Z., Potter, J. D., & Schwartz, R. S.
Venue
Cancer Research
Publisher
American Association for Cancer Research (AACR)
Published
2004-04-15
Volume
64
Issue
8
Pages
2923-2928
ISSN
  • 0008-5472 (ISSN-L)
  • 1538-7445
DOI
10.1158/0008-5472.can-03-3393
OpenAlex
W2124466296
Cited by
339
References
2
FWCI
9.69
Type
journal article
Language
en
Open access
closed

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