Exercise training in cancer control and treatment

Christensen, Jesper Frank; Simonsen, Casper; Hojman, Pernille

doi:10.1002/cphy.c180016

Cited by 203Cancer survivorship and carePhysical Activity and HealthCardiovascular and exercise physiology

Exercise training in cancer control and treatment

Christensen, Jesper Frank, Simonsen, Casper, Hojman, Pernille·2018·Comprehensive physiology

DOI 10.1002/cphy.c180016

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Abstract

Exercise training is playing an increasing role in cancer care, as accumulating evidence demonstrates that exercise may prevent cancer, control disease progression, interact with anti-cancer therapies, and improve physical functioning and psychosocial outcomes. In this overview article, we present the current state of the field of exercise oncology, which currently comprises of nearly 700 unique exercise intervention trials with more than 50,000 cancer patients. First, we summarize the range of these interventions with regard to diagnoses, clinical setting, timing, and type of intervention. Next, we provide a detailed discussion of the 292 trials, which have delivered structured exercise programs, outlining the impact of exercise training on cancer-specific, physiological, and psychosocial outcomes in the light of the challenges and physiological limitations cancer patients may experience. In summary, the safety and feasibility of exercise training is firmly established across the cancer continuum, and a wide range of beneficial effects on psychosocial and physiological outcomes are well documented. Many of these beneficial effects are linked to the general health-promoting properties of exercise. However, it is becoming increasing evident that exercise training can have direct effects on cancer and its treatment. This calls for future exercise oncology initiatives, which aim to target cancer-specific outcomes, and which are integrated into the concurrent cancer trajectory. Here, the field must bridge extensive knowledge of integrative exercise physiology with clinical oncology and cancer biology to provide a basis of individualized targeted approaches, which may place exercise training as an integrated component of standard cancer care. © 2019 American Physiological Society. Compr Physiol 9:165-205, 2019.

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Epidemiological studies suggest that physical activity in leisure time reduces the risk of at least 13 different cancer types.
“Epidemiological studies suggest that physical activity in leisure time reduces the risk of at least 13 different cancer types (41, 42, 222, 223).”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [223]

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Authors: Christensen, J. F., Simonsen, C., & Hojman, P.
Affiliations: Copenhagen University Hospital (DK)
ORCID: Christensen, Jesper Frank
Simonsen, Casper
Venue: Comprehensive physiology
Publisher: Wiley
Published: 2018-12-13
Volume: 9
Issue: 1
Pages: 165-205
ISSN: 2040-4603 (ISSN-L)
DOI: 10.1002/cphy.c180016
OpenAlex: W2905146028
Cited by: 203
References: 191
Citations by year: 2026: 10 · 2025: 14 · 2024: 28 · 2023: 37 · 2022: 29 · 2021: 39 · 2020: 33 · 2019: 13
Type: other
Language: en
Open access: closed
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm)
Locations: Comprehensive physiology (publishedVersion)
PubMed (publishedVersion)
Funders: Lundbeckfonden (R238-2016-2821)
Topics: Health Sciences › Medicine › Oncology › Cancer survivorship and care
Health Sciences › Medicine › Physiology › Physical Activity and Health
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords: exercise training, exercise oncology, cancer patients, cancer prevention, cancer therapy, physical function, psychosocial outcomes, exercise safety and feasibility
MeSH terms: Animals, Clinical Trials as Topic, Combined Modality Therapy, Exercise Therapy, Humans, Neoplasms

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Exercise training in cancer control and treatment

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