Molecular Pathways and Mechanisms of BRAF in Cancer Therapy

Poulikakos, Poulikos I.; Sullivan, Ryan J.; Yaeger, Rona

doi:10.1158/1078-0432.ccr-21-2138

Cited by 145Melanoma and MAPK PathwaysProtein Kinase Regulation and GTPase SignalingLung Cancer Treatments and Mutations

The DOI matches its Crossref record; 125 of the 125 references it cites were found in a registry or an index.

Molecular Pathways and Mechanisms of BRAF in Cancer Therapy

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Poulikakos, Poulikos I., Sullivan, Ryan J., Yaeger, Rona·2022·Clinical Cancer Research

DOI 10.1158/1078-0432.ccr-21-2138PMC PMC9616966

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Abstract

With the identification of activating mutations in BRAF across a wide variety of malignancies, substantial effort was placed in designing safe and effective therapeutic strategies to target BRAF. These efforts have led to the development and regulatory approval of three BRAF inhibitors as well as five combinations of a BRAF inhibitor plus an additional agent(s) to manage cancer such as melanoma, non–small cell lung cancer, anaplastic thyroid cancer, and colorectal cancer. To date, each regimen is effective only in patients with tumors harboring BRAFV600 mutations and the duration of benefit is often short-lived. Further limitations preventing optimal management of BRAF-mutant malignancies are that treatments of non-V600 BRAF mutations have been less profound and combination therapy is likely necessary to overcome resistance mechanisms, but multi-drug regimens are often too toxic. With the emergence of a deeper understanding of how BRAF mutations signal through the RAS/MAPK pathway, newer RAF inhibitors are being developed that may be more effective and potentially safer and more rational combination therapies are being tested in the clinic. In this review, we identify the mechanics of RAF signaling through the RAS/MAPK pathway, present existing data on single-agent and combination RAF targeting efforts, describe emerging combinations, summarize the toxicity of the various agents in clinical testing, and speculate as to where the field may be headed.

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BRAFV600E mutations are present in around 10% of advanced CRC patients and lead to constitutive activation of the MAPK pathway, drug resistance and a poor prognosis.
“BRAFV600E mutations are present in around 10% of advanced CRC patients and lead to constitutive activation of the MAPK pathway, drug resistance and a poor prognosis [1–4].”
From Co-targeting SRC overcomes resistance to BRAF inhibitors in colorectal cancer (2025) · cites this paper as [4]
The Introduction/Background states that BRAF V600 mutations occur in CRC and constitutively activate the RAS/MAPK pathway. The Clinical Implications section describes resistance to RAF inhibition in BRAFV600E CRC. Our copy does not establish that the mutation occurs in around 10% of advanced CRC patients or that it causes a poor prognosis; the reported short progression-free survival is for a treated trial cohort, not a general prognostic comparison. (LLM, conf=0.88)
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Tunable-Combinatorial Mechanisms of Acquired Resistance Limit the Efficacy of BRAF/MEK Cotargeting but Result in Melanoma Drug Addiction
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Dabrafenib, trametinib and pembrolizumab or placebo in BRAF-mutant melanoma
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Combined BRAF and MEK inhibition with PD-1 blockade immunotherapy in BRAF-mutant melanoma
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Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy
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Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers
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c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma
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Pilot Trial of Combined BRAF and EGFR Inhibition in BRAF -Mutant Metastatic Colorectal Cancer Patients
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The Mammalian MAPK/ERK Pathway Exhibits Properties of a Negative Feedback Amplifier
Sturm, O. E., Orton, R. J., Grindlay, J., Birtwistle, M. R., Vyshemirsky, V., Gilbert, D., Muffy Calder, A., Pitt, A. R., Kholodenko, B. Ν., & Kölch, W. (2010) · Science Signaling · doi:10.1126/scisignal.2001212 · Cited by 248
Atezolizumab plus cobimetinib and vemurafenib in BRAF-mutated melanoma patients
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A Phase Ib Dose-Escalation Study of Encorafenib and Cetuximab with or without Alpelisib in Metastatic BRAF -Mutant Colorectal Cancer
van Geel, R. M. J. M., Tabernero, J., Elez, E., Bendell, J. C., Spreafico, A., Schuler, M., Yoshino, T., Delord, J.-P., Yamada, Y., Lolkema, M. P., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0795 · Cited by 232
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SHP2 drives adaptive resistance to ERK signaling inhibition in molecularly defined subsets of ERK-dependent tumors
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Chapter 1 Ras Signaling and Therapies
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Effects of Raf Dimerization and Its Inhibition on Normal and Disease-Associated Raf Signaling
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An Integrated Model of RAF Inhibitor Action Predicts Inhibitor Activity against Oncogenic BRAF Signaling
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Ras-Mediated Activation of the Raf Family KinasesPreprint
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RAF inhibitor PLX8394 selectively disrupts BRAF dimers and RAS-independent BRAF-mutant-driven signaling
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Oncogenic BRAF Deletions That Function as Homodimers and Are Sensitive to Inhibition by RAF Dimer Inhibitor LY3009120
Chen, S.-H., Zhang, Y., Van Horn, R. D., Yin, T., Buchanan, S., Yadav, V., Mochalkin, I., Wong, S. S., Yue, Y. G., Huber, L., et al. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0896 · Cited by 171
Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation
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Mutant-selective degradation by BRAF-targeting PROTACs
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ARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma
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Functional characterization of a PROTAC directed against BRAF mutant V600E
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Antitumor Activity of the Selective Pan-RAF Inhibitor TAK-632 in BRAF Inhibitor-Resistant Melanoma
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Continuous versus intermittent BRAF and MEK inhibition in patients with BRAF-mutated melanoma: a randomized phase 2 trial
Algazi, A. P., Othus, M. K. D., DAUD, A. I., Lo, R. S., Mehnert, J. M., Truong, T., Conry, R. M., Kendra, K. L., Doolittle, G. C., Clark, J. I., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-1060-8 · Cited by 121
Combined PD-1, BRAF and MEK inhibition in advanced BRAF-mutant melanoma: safety run-in and biomarker cohorts of COMBI-i
Dummer, R., Lebbé, C., Atkinson, V. G., Mandalà, M., Nathan, P., Arance, A. M., Richtig, E., Yamazaki, N., Robert, C., Schadendorf, D., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-1082-2 · Cited by 120
Phase I, Open-Label, Dose-Escalation/Dose-Expansion Study of Lifirafenib (BGB-283), an RAF Family Kinase Inhibitor, in Patients With Solid Tumors
Desai, J., Gan, H. K., Barrow, C., Jameson, M. B., Atkinson, V. G., Haydon, A. M., Millward, M., Begbie, S. D., Brown, M. P., Markman, B., et al. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.19.02654 · Cited by 117
Complete regression of advanced pancreatic ductal adenocarcinomas upon combined inhibition of EGFR and C-RAF
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Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses
Botton, T., Talevich, E., Mishra, V. K., Zhang, T., Shain, A. H., Berquet, C., Gagnon, A., Judson, R. L., Ballotti, R., Ribas, A., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.009 · Cited by 113
Phase 2 results: Encorafenib (ENCO) and cetuximab (CETUX) with or without alpelisib (ALP) in patients with advanced BRAF-mutant colorectal cancer (BRAFm CRC).
Tabernero, J. M., van Geel, R. M. J. M., Guren, T. K., Yaeger, R. D., Spreafico, A., Faris, J. E., Yoshino, T., Yamada, Y., Kim, T. W., Bendell, J. C., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2016.34.15_suppl.3544 · Cited by 99
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Non-V600 BRAF mutations recurrently found in lung cancer predict sensitivity to the combination of Trametinib and Dabrafenib
Noeparast, A., Teugels, E., Giron, P., Verschelden, G., Brakeleer, S. D., Decoster, L., & Grève, J. D. (2016) · Oncotarget · doi:10.18632/oncotarget.11635 · Cited by 98
Mechanisms of Acquired Resistance to BRAF V600E Inhibition in Colon Cancers Converge on RAF Dimerization and Are Sensitive to Its Inhibition
Yaeger, R., Yao, Z., Hyman, D. M., Hechtman, J. F., Vakiani, E., Zhao, H., Su, W., Wang, L., Joelson, A., Cercek, A., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0768 · Cited by 94
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PD-L1 blockade in combination with inhibition of MAPK oncogenic signaling in patients with advanced melanoma
Ribas, A., Algazi, A. P., Ascierto, P. A., Butler, M. O., Chandra, S., Gordon, M. S., Hernandez-Aya, L. F., Lawrence, D. P., Lutzky, J., Miller, W. H., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19810-w · Cited by 92
LXH254, a Potent and Selective ARAF-Sparing Inhibitor of BRAF and CRAF for the Treatment of MAPK-Driven Tumors
Monaco, K., Delach, S. M., Yuan, J., Mishina, Y. M., Fordjour, P., Labrot, E., McKay, D., Guo, R., Higgins, S., Wang, H. Q., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-2563 · Cited by 91
Trametinib Activity in Patients with Solid Tumors and Lymphomas Harboring BRAF Non-V600 Mutations or Fusions: Results from NCI-MATCH (EAY131)
Johnson, D. B., Zhao, F., Noel, M. S., Riely, G. J., Mitchell, E. P., Wright, J. J., Chen, H. X., Gray, R. J., Li, S., McShane, L. M., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-3443 · Cited by 90
BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF -Mutated Colorectal Cancers
Tang, Z., Yuan, X., Du, R., Cheung, S.-H., Zhang, G., Wei, J., Zhao, Y., Feng, Y., Peng, H., Zhang, Y., et al. (2015) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0262 · Cited by 82
Genetic and Genomic Characterization of 462 Melanoma Patient-Derived Xenografts, Tumor Biopsies, and Cell Lines
Garman, B., Anastopoulos, I. N., Krepler, C., Brafford, P. A., Sproesser, K., Jiang, Y., Wubbenhorst, B. S., Amaravadi, R. K., Bennett, J., Beqiri, M., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.052 · Cited by 79
Convergent Therapeutic Strategies to Overcome the Heterogeneity of Acquired Resistance in BRAF V600E Colorectal Cancer
Hazar-Rethinam, M. H., Kleyman, M., Han, G. C., Liu, D., Ahronian, L. G., Shahzade, H. A., Chen, L., Parikh, A. R., Allen, J. N., Clark, J. W., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-1227 · Cited by 77
Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors
Yen, I., Shanahan, F., Merchant, M. A., Orr, C., Hunsaker, T., Durk, M. R., La, H., Zhang, X., Martin, S. E., Lin, E., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.09.002 · Cited by 77
Dual MAPK Inhibition Is an Effective Therapeutic Strategy for a Subset of Class II BRAF Mutant Melanomas
Dankner, M., Lajoie, M., Moldoveanu, D., Nguyen, T.-T., Savage, P., Rajkumar, S., Huang, X., Lvova, M., Protopopov, A. I., Vuzman, D., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-3384 · Cited by 76
Combined BRAF and HSP90 Inhibition in Patients with Unresectable BRAF V600E-Mutant Melanoma
Eroglu, Z., Chen, Y. A., Gibney, G. T., Weber, J. S., Kudchadkar, R. R., Khushalani, N. I., Markowitz, J., Brohl, A. S., Tetteh, L. F., Ramadan, H., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-0565 · Cited by 74
RAF inhibitor LY3009120 sensitizes RAS or BRAF mutant cancer to CDK4/6 inhibition by abemaciclib via superior inhibition of phospho-RB and suppression of cyclin D1
Chen, S.-H., Gong, X., Zhang, Y., Horn, R. D. V., Yin, T., Huber, L., Burke, T., Manro, J. R., Iversen, P. W., Wu, W., et al. (2017) · Oncogene · doi:10.1038/onc.2017.384 · Cited by 73
In Vivo E2F Reporting Reveals Efficacious Schedules of MEK1/2–CDK4/6 Targeting and mTOR–S6 Resistance Mechanisms
Teh, J. L. F., Cheng, P. F., Purwin, T. J., Nikbakht, N., Patel, P. S., Chervoneva, I., Ertel, A., Fortina, P. M., Kleiber, I., HooKim, K., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-0699 · Cited by 73
Exploiting Allosteric Properties of RAF and MEK Inhibitors to Target Therapy-Resistant Tumors Driven by Oncogenic BRAF Signaling
Adamopoulos, C., Ahmed, T. A., Tucker, M. R., Ung, P. M. U., Xiao, M., Karoulia, Z., Amabile, A., Wu, X., Aaronson, S. A., Ang, C., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1351 · Cited by 71
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LBA43 Spartalizumab plus dabrafenib and trametinib (Sparta-DabTram) in patients (pts) with previously untreated BRAF V600–mutant unresectable or metastatic melanoma: Results from the randomized part 3 of the phase III COMBI-i trial
Nathan, P., Dummer, R., Long, G. V., Ascierto, P. A., Tawbi, H., Robert, C., Rutkowski, P. L., Леонов, О. В., Dutriaux, C., Mandalà, M., et al. (2020) · Annals of Oncology · doi:10.1016/j.annonc.2020.08.2273 · Cited by 67
Belvarafenib, a novel pan-RAF inhibitor, in solid tumor patients harboring BRAF, KRAS, or NRAS mutations: Phase I study.
Kim, T. W., Lee, J., Shin, S. J., Kim, J.-S., Kim, Y. J., Han, H. S., Lee, S. J., Lim, H., Hong, Y.-H., Noh, Y. S., et al. (2019) · Journal of Clinical Oncology · doi:10.1200/jco.2019.37.15_suppl.3000 · Cited by 49
A Phase Ib/II Study of the BRAF Inhibitor Encorafenib Plus the MEK Inhibitor Binimetinib in Patients with BRAFV600E/K -mutant Solid Tumors
Sullivan, R. J., Weber, J. S., Patel, S. P., Dummer, R., Carlino, M. S., Tan, D. S.-W., Lebbé, C., Siena, S., Élez, E., Wollenberg, L. A., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-3550 · Cited by 48
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Efficacy and Safety of Trametinib in Non-V600 BRAF Mutant Melanoma: A Phase II Study
Nebhan, C. A., Johnson, D. B., Sullivan, R. J., Amaria, R., Flaherty, K. T., Sosman, J. A., & Davies, M. A. (2021) · The Oncologist · doi:10.1002/onco.13795 · Cited by 45
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RAF dimer inhibition enhances the antitumor activity of MEK inhibitors in K‐RAS mutant tumors
Yuan, X., Tang, Z., Du, R., Yao, Z., Cheung, S., Zhang, X., Wei, J., Zhao, Y., Du, Y., Liu, Y., et al. (2020) · Molecular Oncology · doi:10.1002/1878-0261.12698 · Cited by 40
A Multicenter Phase I Study Evaluating Dual PI3K and BRAF Inhibition with PX-866 and Vemurafenib in Patients with Advanced BRAF V600–Mutant Solid Tumors
Yam, C., Xu, X., Davies, M. A., Gimotty, P. A., Morrissette, J. J. D., Tetzlaff, M. T., Wani, K., Liu, S., Deng, W., Buckley, M. E., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-1807 · Cited by 38
Phase 1b/2 trial of ribociclib+binimetinib in metastatic NRAS-mutant melanoma: Safety, efficacy, and recommended phase 2 dose (RP2D).
Schüler, M., Ascierto, P. A., Vos, F. D., Postow, M. A., van Herpen, C. M. L., Carlino, M. S., Sosman, J. A., Berking, C., Long, G. V., Weise, A. M., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2017.35.15_suppl.9519 · Cited by 36
Targeting CDK4/6 Represents a Therapeutic Vulnerability in Acquired BRAF/MEK Inhibitor–Resistant Melanoma
Nassar, K. W., Hintzsche, J. D., Bagby, S. M., Espinoza, V. L., Langouët-Astrié, C. J., Amato, C. M., Chimed, T.-S., Fujita, M., Robinson, W. A., Tan, A. C., et al. (2021) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-20-1126 · Cited by 36
A phase Ib/II dose-escalation study evaluating triple combination therapy with a BRAF (encorafenib), MEK (binimetinib), and CDK 4/6 (ribociclib) inhibitor in patients (Pts) with BRAF V600-mutant solid tumors and melanoma.
Ascierto, P. A., Bechter, O. E., Wolter, P., Lebbé, C., Élez, E., Miller, W. H., Long, G. V., Omlin, A. G., Siena, S., Calvo, E., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2017.35.15_suppl.9518 · Cited by 32
FREQUENT SUBCLINICAL MACULAR CHANGES IN COMBINED BRAF/MEK INHIBITION WITH HIGH-DOSE HYDROXYCHLOROQUINE AS TREATMENT FOR ADVANCED METASTATIC BRAF MUTANT MELANOMA: Preliminary Results From a Phase I/II Clinical Treatment Trial
Nti, A. A., Serrano, L. W., Sandhu, H. S., Uyhazi, K. E., Edelstein, I. D., Zhou, E. J., Bowman, S., Song, D., Gangadhar, T. C., Schuchter, L. M., et al. (2019) · Retina · doi:10.1097/iae.0000000000002027 · Cited by 31
An In Vivo Reporter to Quantitatively and Temporally Analyze the Effects of CDK4/6 Inhibitor-Based Therapies in Melanoma
Teh, J. L. F., Purwin, T. J., Greenawalt, E. J., Chervoneva, I., Goldberg, A. F., Davies, M. A., & Aplin, A. E. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-3384 · Cited by 31
A phase Ib trial of belvarafenib in combination with cobimetinib in patients with advanced solid tumors: Interim results of dose-escalation and patients with NRAS-mutant melanoma of dose-expansion.
Shin, S. J., Lee, J., Kim, T. M., Kim, J.-S., Kim, Y. J., Hong, Y. S., Kim, S. Y., Kim, J. E., Lee, D. H., Hong, Y.-H., et al. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.2021.39.15_suppl.3007 · Cited by 31
Abstract PR06: Phase 1b dose-escalation study of trametinib (MEKi) plus palbociclib (CDK4/6i) in patients with advanced solid tumors
Sullivan, R. J., Amaria, R. N., Lawrence, D. P., Brennan, J., Leister, C. A., Singh, R. P., Legos, J., Thurm, H. C., Li, Y., Flaherty, K. T., et al. (2015) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.targ-15-pr06 · Cited by 23
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Dual MAPK/CDK Targeting in Melanoma: New Approaches, New Challenges
Sullivan, R. J. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0224 · Cited by 12
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Dose‐escalation trial of combination dabrafenib, trametinib, and AT13387 in patients with BRAF‐mutant solid tumors
Mooradian, M. J., Cleary, J. M., Giobbie‐Hurder, A., Darville, L. N. F., Parikh, A. R., Buchbinder, E. I., Cohen, J. V., Lawrence, D. P., Shapiro, G. I., Keer, H. N., et al. (2023) · Cancer · doi:10.1002/cncr.34730 · Cited by 10
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1387P Phase Ib study of LXH254 + LTT462 in patients with KRAS- or BRAF-mutant NSCLC
Wolf, J. M., Planchard, D., Heist, R. S., Solomon, B., Sebastian, M., Santoro, A., Reguart, N., Stammberger, U. M., Manganelli, L., Wu, H., et al. (2020) · Annals of Oncology · doi:10.1016/j.annonc.2020.08.1701 · Cited by 9
Abstract LB-B30: First in human, dose escalation trial of the combination of dabrafenib, trametinib, and navitoclax in patients with BRAF mutant solid tumors
Sullivan, R. J., Mehnert, J. M., Tawbi, H., Lawrence, D. P., Flaherty, K. T., Chen, H., Takabe, N., & Davies, M. A. (2018) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.targ-17-lb-b30 · Cited by 5
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CTEP 9557: A dose-escalation trial of combination dabrafenib, trametinib, and AT13387 in patients with BRAF mutant solid tumors.
Mooradian, M. J., Cleary, J. M., Cohen, J. V., Lawrence, D. P., Buchbinder, E. I., Giobbie‐Hurder, A., Parikh, A. R., Shapiro, G. I., Darville, L. N. F., Smalley, K. S. M., et al. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.2020.38.15_suppl.3609 · Cited by 4
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Evaluating clinical activity of MAPK targeted therapies (TT) in cancer patients (pts) with non-V600 BRAF mutations: A systematic scoping review and meta-analysis.
Dankner, M., Wang, Y., Fazelzad, R., Spreafico, A., Cescon, D. W., Zogopoulos, G., & Rose, A. A. N. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.2021.39.15_suppl.3089 · Cited by 3
Abstract CT212: Expanded phase 1/2a study of PLX8394, a novel next generation BRAF inhibitor in patients with advanced, unresectable solid tumors with alterations in BRAF
Jankú, F., Sherman, E. J., Yaeger, R. D., Parikh, A., Sullivan, R. J., Feun, L. G., de la Fuente, M. I., Tsai, F. Y.-C., Gordon, M. S., Allen, C. E., et al. (2021) · Cancer Research · doi:10.1158/1538-7445.am2021-ct212 · Cited by 2
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Research works printed but not linked: 2

Corcoran, 2020, Clinical efficacy of combined BRAF, MEK, and PD-1 inhibition in BRAFV600E colorectal cancer patients [abstract]
Janku, 2020, Interim results from a phase 1/2 precision medicine study of PLX8394- a next generation BRAF inhibitor [abstract], S2—3

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Protein degraders enter the clinic — a new approach to cancer therapy
Chirnomas, D., Hornberger, K. R., & Crews, C. M. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-023-00736-3 · Cited by 658
BRAF — a tumour-agnostic drug target with lineage-specific dependencies
Hanrahan, A. J., Chen, Z., Rosen, N., & Solit, D. B. (2024) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-023-00852-0 · Cited by 136
Circulating Tumor DNA Enables Sensitive Detection of Actionable Gene Fusions and Rearrangements Across Cancer Types
Kasi, P. M., Lee, J., Pasquina, L. W., Decker, B. J., Borre, P. V., Pavlick, D. C., Allen, J. M., Parachoniak, C. A., Quintanilha, J. C. F., Graf, R. P., et al. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-2693 · Cited by 53
The Pan-RAF–MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS–MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers
Ryan, M. B., Quade, B., Schenk, N., Fang, Z., Zingg, M., Cohen, S. E., Swalm, B. M., Li, C., Özen, A., Ye, C., et al. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-24-0139 · Cited by 51
VSIG4+ tumor-associated macrophages mediate neutrophil infiltration and impair antigen-specific immunity in aggressive cancers through epigenetic regulation of SPP1
Pan, Z., Chen, J., Xu, T. C., Cai, A., Han, B., Li, Y., Fang, Z., Yu, D., Wang, S., Zhou, J., et al. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03303-z · Cited by 56
Targeting PD-1/PD-L1 in tumor immunotherapy: Mechanisms and interactions with host growth regulatory pathways
Shen, S., Hong, Y., Huang, J., Qu, X., Sooranna, S. R., Lu, S., Li, T. X., & Niu, B. (2024) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2024.08.001 · Cited by 46
Prognostic and predictive biomarkers in non-small cell lung carcinoma
Odintsov, I., & Sholl, L. M. (2023) · Pathology · doi:10.1016/j.pathol.2023.11.006 · Cited by 47
Mechanisms of Melanoma Progression and Treatment Resistance: Role of Cancer Stem-like Cells
Hmada, Y. A., Brodell, R. T., Kharouf, N., Flanagan, T. W., AlAmodi, A. A., Hassan, S.-Y., Shalaby, H., Hassan, S.-L., Haïkel, Y., Megahed, M., et al. (2024) · Cancers · doi:10.3390/cancers16020470 · Cited by 44
Ferroptosis as a promising therapeutic strategy for melanoma
Ta, N., Jiang, X., Zhang, Y., & Wang, H. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1252567 · Cited by 38
Biomarker discovery and application—An opportunity to resolve the challenge of liver cancer diagnosis and treatment
Chen, J., Niu, C., Yang, N., Liu, C., Zou, S., & Zhu, S. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106674 · Cited by 35
Pathogenesis of Oral Toxicities Associated with Targeted Therapy and Immunotherapy
Villa, A., & Kuten‐Shorrer, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098188 · Cited by 35
Approved Small-Molecule ATP-Competitive Kinases Drugs Containing Indole/Azaindole/Oxindole Scaffolds: R&D and Binding Patterns Profiling
Zhang, H., He, F., Gao, G., Sheng, L., Wei, Q., Hu, H., Wu, Z., Fang, M., & Wang, X. (2023) · Molecules · doi:10.3390/molecules28030943 · Cited by 35
Langerhans cell histiocytosis: NACHO update on progress, chaos, and opportunity on the path to rational cures
Bielamowicz, K., Dimitrion, P. M., Abla, O., Bomken, S. N., Campbell, P. K., Collin, M. P., Degar, B. A., Diamond, E. L., Eckstein, O. S., El‐Mallawany, N. K., et al. (2024) · Cancer · doi:10.1002/cncr.35301 · Cited by 32
Molecular Docking: An Emerging Tool for Target-Based Cancer Therapy
Uppathi, P., Rajakumari, S., & Saritha, K. V. (2024) · Critical Reviews™ in Oncogenesis · doi:10.1615/critrevoncog.2024056533 · Cited by 26
Colorectal cancer with BRAF V600E mutation: Trends in immune checkpoint inhibitor treatment
Liu, M., Liu, Q., Hu, K., Dong, Y., Sun, X., Zou, Z., Ji, D., Liu, T., & Yu, Y. (2024) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2024.104497 · Cited by 24
Personalized prediction of postoperative complication and survival among Colorectal Liver Metastases Patients Receiving Simultaneous Resection using machine learning approaches: A multi-center study
Chen, Q., Chen, J., Deng, Y., Bi, X., Zhao, J., Zhou, J., Huang, Z. K., Cai, J., Xing, B., Li, Y., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216967 · Cited by 22
Established and Emerging Cancer Therapies and Cardiovascular System: Focus on Hypertension—Mechanisms and Mitigation
Butel-Simoes, L. E., Haw, T. J., Williams, T. D., Sritharan, S., Gadre, P., Herrmann, S. M., Herrmann, J., Ngo, D. T. M., & Sverdlov, A. L. (2023) · Hypertension · doi:10.1161/hypertensionaha.122.17947 · Cited by 23
Tumor-Type Agnostic, Targeted Therapies: BRAF Inhibitors Join the Group
Vranić, S., Basu, G. D., Hall, D. W., & Gatalica, Z. (2023) · Acta Medica Academica · doi:10.5644/ama2006-124.392 · Cited by 23
Genetic, Epidemiological, Clinical, and Therapeutic Trajectories in Colon and Rectal Cancers
Capuozzo, M., Picone, C., Sabbatino, F., Santorsola, M., Caraglia, F., Iervolino, D., Sirica, R., Gualillo, O., Mauro, G. D., Castiello, R., et al. (2025) · Cancers · doi:10.3390/cancers17213438 · Cited by 24
Mutations in the Serine/Threonine Kinase BRAF: Oncogenic Drivers in Solid Tumors
Roa, P., Bremer, N. V., Foglizzo, V., & Cocco, E. (2024) · Cancers · doi:10.3390/cancers16061215 · Cited by 24
Protein kinase A and local signaling in cancer
Rosenthal, K. J., Gordan, J. D., & Scott, J. D. (2024) · Biochemical Journal · doi:10.1042/bcj20230352 · Cited by 18
The Prognostic Significance of BRAF Gene Analysis in Children and Adolescents with Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis
Kotanidou, E. P., Giza, S., Tsinopoulou, V. R., Margaritis, K., Papadopoulou, A., Sakellari, E. I., Kolanis, S., Litou, E., Serbis, A., & Galli‐Τsinopoulou, A. (2023) · Diagnostics · doi:10.3390/diagnostics13061187 · Cited by 18
Paediatric Strategy Forum for medicinal product development in mitogen-activated protein kinase pathway inhibitors
Pearson, A. D. J., Allen, C. E., Fangusaro, J., Hutter, C., Witt, O., Weiner, S. L., Reaman, G. H., Russo, M., Bandopadhayay, P., Ahsan, S., et al. (2022) · European Journal of Cancer · doi:10.1016/j.ejca.2022.09.036 · Cited by 17
Analysis of RAS and drug induced homo- and heterodimerization of RAF and KSR1 proteins in living cells using split Nanoluc luciferase
Rohrer, L., Spohr, C., Beha, C., Griffin, R., Braun, S. L., Halbach, S., & Brummer, T. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01146-9 · Cited by 17
RAF and MEK Inhibitors in Non-Small Cell Lung Cancer
Adamopoulos, C., Papavassiliou, K. A., Poulikakos, P. I., & Papavassiliou, A. G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094633 · Cited by 18
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Melanoma’s New Frontier: Exploring the Latest Advances in Blood-Based Biomarkers for Melanoma
Prkačin, I., Mokos, M., Ferara, N., & Šitum, M. (2024) · Cancers · doi:10.3390/cancers16244219 · Cited by 16
Combined RAF and MEK Inhibition to Treat Activated Non-V600 BRAF-Altered Advanced Cancers
Rustgi, N., Maria, A., Toumbacaris, N., Zhao, H., Kargus, K. E., Bryant, M., Waksmundzki, A., Aricescu, I., Lefkowitz, R. A., Li, B. T., et al. (2023) · The Oncologist · doi:10.1093/oncolo/oyad247 · Cited by 15
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Novel RAF ‐directed approaches to overcome current clinical limits and block the RAS / RAF node
Scardaci, R., Berlinska, E., Scaparone, P., Michelina, S. V., Garbo, E., Novello, S., Santamarı́a, D., & Ambrogio, C. (2024) · Molecular Oncology · doi:10.1002/1878-0261.13605 · Cited by 14
Clinical Use of Molecular Biomarkers in Canine and Feline Oncology: Current and Future
Aupperle‐Lellbach, H., Kehl, A., de Brot, S., & van der Weyden, L. (2024) · Veterinary Sciences · doi:10.3390/vetsci11050199 · Cited by 20
A comprehensive overview of the molecular features and therapeutic targets in BRAF V600E ‐mutant colorectal cancer
Gu, R., Fang, H., Wang, R., Dai, W., & Cai, G. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1764 · Cited by 14
Fisetin as a chemoprotective and chemotherapeutic agent: mechanistic insights and future directions in cancer therapy
Fatima, R., Soni, P., Sharma, M., Prasher, P., Kaverikana, R., Shetty, M. S., Sharifi‐Rad, J., & Călina, D. C. (2025) · Medical Oncology · doi:10.1007/s12032-025-02664-x · Cited by 12
Drug-Induced Sarcoid-like Reactions Associated to Targeted Therapies and Biologic Agents
Andolfi, F., Caffarri, L., Neviani, M., Rubini, S., Andrisani, D., Gozzi, F., Beghé, B., Clini, E. M., Tonelli, R., & Cerri, S. (2025) · Diagnostics · doi:10.3390/diagnostics15131658 · Cited by 11
Unveiling the Dynamic Interplay between Cancer Stem Cells and the Tumor Microenvironment in Melanoma: Implications for Novel Therapeutic Strategies
Limonta, P., Chiaramonte, R., & Casati, L. (2024) · Cancers · doi:10.3390/cancers16162861 · Cited by 11
Global trends and emerging insights in BRAF and MEK inhibitor resistance in melanoma: a bibliometric analysis
Bai, J., Wan, Z., Zhou, W., Wang, L., Lou, W., Zhang, Y., & Jin, H. (2025) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2025.1538743 · Cited by 10
Effective detection of BRAFV595E mutation in canine urothelial and prostate carcinomas using immunohistochemistry
Aeschlimann, L., Kehl, A., Guscetti, F., Posthaus, C., Aupperle‐Lellbach, H., Rottenberg, S., & de Brot, S. (2024) · Veterinary and Comparative Oncology · doi:10.1111/vco.12978 · Cited by 10
Fibronectin Contributes to a BRAF Inhibitor–driven Invasive Phenotype in Thyroid Cancer through EGR1, Which Can Be Blocked by Inhibition of ERK1/2
Hicks, H. M., Pozdeyev, N. V., Sams, S. B., Pugazhenthi, U., Bales, E. S., Hofmann, M.-C. C., McKenna, L. R., & Schweppe, R. E. (2023) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-22-1031 · Cited by 10
Greasing the Wheels of Pharmacotherapy for Colorectal Cancer: the Role of Natural Polyphenols
Niu, C., Zhang, J., & Okolo, P. I., III (2023) · Current Nutrition Reports · doi:10.1007/s13668-023-00512-w · Cited by 9
NOVEL INSIGHTS IN ADVANCED THYROID CARCINOMA: FROM MECHANISMS TO TREATMENTS: Molecular insights into the origin, biology, and treatment of anaplastic thyroid carcinoma
Karimi, A. H., Zeng, P. Y., Cecchini, M. J., Barrett, J. W., Pan, H., Ying, S., Le, N., Mymryk, J. S., Ailles, L., & Nichols, A. C. (2025) · European Thyroid Journal · doi:10.1530/etj-25-0057 · Cited by 11
BRAF inhibitors in Melanoma: Structural Insights, Therapeutic Resistance, and Biological Evaluation of Quinazoline Derivatives
Paik, A., Matada, G. S. P., Ghara, A., Pal, R., Pavani, G., & Hemalatha, K. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.117866 · Cited by 9
Current and Emerging Therapies for Targeting the ERK1/2 & PI3K Pathways in Cancer
Abizadeh, E., Berglas, E., Abizadeh, A., Glatman, J., Lavi, A. B., Spivak, M., Sapir, T., & Shifteh, D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178696 · Cited by 12
Adamantinoma-like Ewing sarcoma of the salivary glands: a case report and systematic literature review
Lauricella, E., Manicone, A., Cavallo, F., Dagrada, G. P., Centonze, G., Bertulli, R., Quattrone, P., Porta, C., & Cives, M. (2023) · Therapeutic Advances in Medical Oncology · doi:10.1177/17588359231165979 · Cited by 9
Integrated Single-Cell and Transcriptome Sequencing Analyses Identify Dipeptidase 2 as an Immune-Associated Prognostic Biomarker for Lung Adenocarcinoma
Zhang, X., Zhang, Y., Gao, X., Zhang, Y., & Chen, Y. (2023) · Pharmaceuticals · doi:10.3390/ph16060871 · Cited by 8
2,3-Dihydro-1,3,4-thiadiazoles as dual B-Raf / VEGFR-2 inhibitors: Design, synthesis, and anti-breast cancer assessment
Elgammal, W. E., Elkady, H., Mahdy, H. A., Elwan, A., Husein, D. Z., Amin, F. G., Alsfouk, B. A. A., Elkaeed, E. B., Eissa, I. H., & Metwaly, A. M. (2025) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2025.144717 · Cited by 8
Sensitivities and Dependencies of BRAF Mutant Colorectal Cancer Cell Lines with or without PIK3CA Mutations for Discovery of Vulnerabilities with Therapeutic Potential
Voutsadakis, I. A. (2022) · Medicina · doi:10.3390/medicina58101498 · Cited by 8
The Role of T-Cadherin (CDH13) in Treatment Options with Garcinol in Melanoma
Staebler, S., Hoechst, S., Thongmao, A., Schneider, N., Bosserhoff, A., & Kuphal, S. (2024) · Cancers · doi:10.3390/cancers16101853 · Cited by 8
Co-targeting SRC overcomes resistance to BRAF inhibitors in colorectal cancer
Rubio-Cuesta, B., Carretero-Puche, C., Llamas, P., Sarmentero, J., Gil-Calderon, B., Lens-Pardo, A., Antón-Pascual, B., Rubio-González, E., Cámara-Jurado, M., Salamanca, J., et al. (2025) · British Journal of Cancer · doi:10.1038/s41416-025-03058-6 · Cited by 7
The mechanism and consequences of BRAF inhibitor resistance in melanoma
Golub, K., Bai, W., Zhang, Z., Xiao, H., Sun, R., Shen, J., & Sun, J. (2023) · Genome Instability & Disease · doi:10.1007/s42764-023-00105-5 · Cited by 6
TCF12 Activates TGFB2 Expression to Promote the Malignant Progression of Melanoma
Tian, Y., Jiang, Z., Chai, X., Ping, Z., Zhao, Y., Xu, X., Luo, C., & Sheng, J. (2023) · Cancers · doi:10.3390/cancers15184505 · Cited by 7
Clinical and genetic drivers of oligo-metastatic disease in colon cancer
Ottaiano, A., Santorsola, M., Sirica, R., Mauro, A. D., Carlo, A. D., Ianniello, M., Sabbatino, F., Castiello, R., Peschio, F. D., Cascella, M., et al. (2024) · Neoplasia · doi:10.1016/j.neo.2024.101111 · Cited by 6
Decoding driver and phenotypic genes in cancer: Unveiling the essence behind the phenomenon
Liu, D., Liu, L., Zhang, X., Zhao, X., Li, X., Che, X., & Wu, G. (2025) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2025.101358 · Cited by 6
Dabrafenib-Trametinib and Radiotherapy for Oligoprogressive BRAF Mutant Advanced Melanoma
Rossi, E., Schinzari, G., Cellini, F., Balducci, M., Pasqualoni, M., Maiorano, B. A., Fionda, B., Longo, S., Deodato, F., Stefani, A. D., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11020394 · Cited by 6
Developing pioneering pharmacological strategies with CRISPR/Cas9 library screening to overcome cancer drug resistance
He, Y., Li, H., Ju, X., & Gong, B. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189212 · Cited by 6
Targeting All BRAF Alterations: The (Re)-Search Continues
Bhamidipati, D., Pellatt, A. J., & Subbiah, V. (2024) · JCO Precision Oncology · doi:10.1200/po.23.00670 · Cited by 7
Microbiota dysbiosis impact on the metabolism of T3 and T4 hormones and its association with thyroid cancer
Cadena-Ullauri, S., Guevara‐Ramírez, P., Paz‐Cruz, E., Ruiz‐Pozo, V. A., Tamayo‐Trujillo, R., & Zambrano, A. K. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1589726 · Cited by 6
Investigation of novel nimesulide derivatives against breast cancer
Birgül, K., Atlıhan, İ., Dere, D., Yelekçi, K., Tiber, P. M., Orun, O., & Küçükgüzel, Ş. G. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.108850 · Cited by 6
Human biomarker navigator
Li, M., Zhang, Q., Wang, Z., Gui, Z., Liu, J., Li, J., Jiang, M., Chang, Z., Han, Q., Yang, B., et al. (2026) · iMeta · doi:10.1002/imt2.70157 · Cited by 6
Mannose enhances anti-tumor effect of PLX4032 in anaplastic thyroid cancer
Li, Z., Song, L., Yang, Y., Zhao, Y., & Ma, S. (2025) · Endocrine Related Cancer · doi:10.1530/erc-24-0209 · Cited by 5
PTRF Confers Melanoma‐Acquired Drug Resistance Through the Upregulation of EGFR
Wang, M., Cao, Y., Ren, C., Wang, K., Wang, Y., Wu, X., Mao, J., Liang, Q., Zhang, Q., Lu, H., et al. (2025) · Cell Proliferation · doi:10.1111/cpr.70086 · Cited by 6
BRAF D594A mutation defines a unique biological and immuno-modulatory subgroup associated with functional CD8+ T cell infiltration in colorectal cancer
Li, W., Zhao, C., Li, W., Gong, Y., Ma, K., Lu, Y., Liu, X., Zhang, L., & Guo, F. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04606-5 · Cited by 5
Interfering Nuclear Protein Laminb1 Induces DNA Damage and Reduces Vemurafenib Resistance in Melanoma Cells In Vitro
Li, Y., Feng, Y., & Chen, D. (2024) · Cancers · doi:10.3390/cancers16234060 · Cited by 5
Exploring the clinical complexity of cardio-facio-cutaneous syndrome: insights from a pediatric case series
Ou, Y., Cao, J., Duan, Y., Chen, F., Zhou, J., Li, J., & Gan, X. (2024) · Frontiers in Pediatrics · doi:10.3389/fped.2024.1355277 · Cited by 4
Generation of a genetically engineered porcine melanoma model featuring oncogenic control through conditional Cre recombination
Oh, D., Hong, N., Eun, K., Lee, J., Cai, L., Kim, M., Choi, H., Jawad, A., Ham, J., Park, M. G., et al. (2025) · Scientific Reports · doi:10.1038/s41598-024-82554-w · Cited by 4
Novel CDK2/CDK9 inhibitor fadraciclib targets cell survival and DNA damage pathways and synergizes with encorafenib in human colorectal cancer cells with BRAF(V600E)
Mohiuddin, M., Póvoa, V., Fior, R., & Sinicrope, F. A. (2025) · Oncogenesis · doi:10.1038/s41389-025-00574-1 · Cited by 4
Hybrid chalcone-pyrazoline derivatives: synthesis and in silico evaluation for anticancer potential
Saha, P., Yasmin, A., Jha, R., Passi, A., Monga, V., Jindal, S., & Goyal, K. (2025) · Future Medicinal Chemistry · doi:10.1080/17568919.2025.2561464 · Cited by 4
Versatile Xenopus tropicalis model with targeted integration of human BRAF V600E
Ran, R., Li, L., Chen, P., Li, S., Wang, P., Zhu, Z., Wang, X., Chen, Y., Hang, J., & Liang, W. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2426981122 · Cited by 4
USP7 inhibitor P5091 enhances the antitumor efficacy of vemurafenib in BRAFV600E-mutant thyroid cancer via ferroptosis
Hu, C., Tian, W., Tang, Y., Wang, P., Kuan, T., Wei, W., Chen, D., Li, P., & Su, X. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117522 · Cited by 4
The dual fate of DYRK2 in cancer: balancing the light and dark side of tumorigenesis
Suanes-Cobos, L., Torres-Ramos, M., Aguilera-Ventura, I., Serrano-Yubero, A., & Calzado, M. A. (2026) · Cancer and Metastasis Reviews · doi:10.1007/s10555-025-10311-0 · Cited by 4
BRAF/MEK-targeted therapy in BRAF ex15 p.T599dup mutation-driven NSCLC: a case report
Jiang, L., Yang, P., Liu, Y., & Li, J. (2024) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-024-05675-9 · Cited by 4
Combined BRAF and PIM1 inhibitory therapy for papillary thyroid carcinoma based on BRAFV600E regulation of PIM1: Synergistic effect and metabolic mechanisms
Xu, Q.-Q., Wang, J., Mao, Y., Xuan, Z., Ke, Y., Tang, X., & Zhu, X. (2024) · Neoplasia · doi:10.1016/j.neo.2024.100996 · Cited by 4
Regorafenib in patients with pretreated advanced melanoma: a single-center case series
Mijnsbrugge, A.-S. V., Cerckel, J., Dirven, I., Tijtgat, J., Vounckx, M., Claes, N., & Neyns, B. (2024) · Melanoma Research · doi:10.1097/cmr.0000000000000977 · Cited by 4
Unveiling the BRAF fusion structure variations through DNA and RNA sequencing
Yang, Q., Wang, B., Meng, X., Ma, T., Qian, Z., Cai, X., Sun, X., Xu, Y., Luo, Q., Yang, T., et al. (2025) · British Journal of Cancer · doi:10.1038/s41416-025-02998-3 · Cited by 4
Tumor-infiltrating immune cells based TMEscore and related gene signature is associated with the survival of CRC patients and response to fluoropyrimidine-based chemotherapy
Guo, X., Li, S., Lei, R., Ding, Z., Hu, B.-L., & Lin, R. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.953321 · Cited by 4
Driver and targetable alterations in Chinese patients with small bowel carcinoma
Li, J., Li, X., Dong, N., Shu, Y., Jing, C., Ma, T., Li, W., Zhang, C., Cai, Y., & Deng, W. (2023) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-022-04521-0 · Cited by 5
73880 Molecular and Genetic Markers for Malignant Melanoma: Implications for Prognosis and Therapy
Fleshner, L., Sayegh, A., Atak, M. F., Hirani, R., Farabi, B., Safai, B., & Marmon, S. (2025) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2026.04.1223 · Cited by 3
DDX21 Links BRAF V600E and TERT to Promote Thyroid Cancer Progression
Chen, M., Jiang, K., Zhang, Q., Xiao, X. O., Zhu, L., Sang, Y., Hu, G., Yu, S., Hong, S., Lv, W., et al. (2026) · Thyroid · doi:10.1177/10507256261417697 · Cited by 3
Cancer treatment–related cognitive impairment
Neth, B. J., Schagen, S. B., & Wefel, J. S. (2026) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdag064 · Cited by 4
Germline Variants in Proto-Oncogenes and Tumor Suppressor Genes in Women with Cervical Cancer
Lenkova, K., Khusainova, R. I., Minyazeva, R. K., Zaripova, A. R., Gilyazova, I. R., Mokrysheva, N. G., & Minniakhmetov, I. R. (2024) · Biomedicines · doi:10.3390/biomedicines12112454 · Cited by 3
Role of contrast-enhanced ultrasound with time-intensity curve analysis about thyroid nodule and parenchyma for differentiating BRAF V600E mutation status
Hu, Z., Xue, R., Liu, Z., Liu, L., & Gong, Z. (2025) · PeerJ · doi:10.7717/peerj.19006 · Cited by 3
New 1,3,4‐Thiadiazole‐Based Dual B‐Raf/VEGFR‐2 Inhibitors With Potential Anti‐Breast Activity: Design, Synthesis, In Vitro and In Silico Evaluations
Elgammal, W. E., Elkady, H., Mahdy, H. A., Alsfouk, B. A. A., Husein, D. Z., Amin, F. G., Abuelkhir, A. A., Elkaeed, E. B., Metwaly, A. M., & Eissa, I. H. (2025) · Archiv der Pharmazie · doi:10.1002/ardp.70097 · Cited by 3
AI-driven de novo design of BRAF inhibitors with enhanced binding affinity and optimized drug-likeness
Lu, Z., & Zhang, A. (2026) · PeerJ · doi:10.7717/peerj.20541 · Cited by 4
Navigating the complexity of BRAF mutations in non-small cell lung cancer: current insights and future prospects
Ibrahim, S., Shenoy, S., Kateel, R., Hegde, S., Parida, A., & Samantaray, L. (2024) · Multidisciplinary Respiratory Medicine · doi:10.5826/mrm.2024.992 · Cited by 3
A panorama of lung cancer biomarkers
Mesquita, A. S. S., Maeda, M. I., Brandão, J. C. D., Gaglionone, N. C., da Silva, I. C., Mak, M. P., & do Nascimento, É. C. T. (2025) · Surgical and Experimental Pathology · doi:10.1186/s42047-025-00177-5 · Cited by 3
BRAF p.V600E mutation as a molecular boundary between genuine oligo-repeated and poly-metastatic disease in colorectal cancer
Ottaiano, A., Santorsola, M., Circelli, L., Ianniello, M., Casillo, M., Petrillo, N., Sabbatino, F., Cascella, M., Perri, F., Capuozzo, M., et al. (2023) · Neoplasia · doi:10.1016/j.neo.2023.100930 · Cited by 3
Emerging Systemic Therapy Considerations for Pancreatic Cancer
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Authors: Poulikakos, P. I., Sullivan, R. J., & Yaeger, R.
Affiliations: Icahn School of Medicine at Mount Sinai (US)
Massachusetts General Hospital (US)
Memorial Sloan Kettering Cancer Center (US)
Corresponding author: Poulikakos, Poulikos I.
Sullivan, Ryan J.
Yaeger, Rona
ORCID: Poulikakos, Poulikos I.
Sullivan, Ryan J.
Yaeger, Rona
Venue: Clinical Cancer Research
Publisher: American Association for Cancer Research (AACR)
Published: 2022-04-29
Volume: 28
Issue: 21
Pages: 4618-4628
ISSN: 1078-0432 (ISSN-L)
1557-3265
DOI: 10.1158/1078-0432.ccr-21-2138
PMC: PMC9616966
OpenAlex: W4225136170
Cited by: 145
References: 125
Citations by year: 2026: 29 · 2025: 41 · 2024: 41 · 2023: 31 · 2022: 3
FWCI: 3.02
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Clinical Cancer Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (U54 CA224068, P30 CA008748, R01 C233736, R01 CA204314, R01 CA240362, R01CA238229, R01 CA193970, R01 CA229851, UM1 CA186709)
Irma T. Hirschl Trust
Melanoma Research Alliance
Melanoma Research Foundation
Breast Cancer Alliance
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
Keywords: BRAF, BRAF inhibitors, BRAF V600 mutation, RAS/MAPK pathway, Raf signaling, combination therapy, melanoma, non-small cell lung cancer, anaplastic thyroid carcinoma, colorectal cancer, drug resistance, drug toxicity, targeted cancer therapy
MeSH terms: Antineoplastic Agents, Carcinoma, Non-Small-Cell Lung, Humans, Lung Neoplasms, Mutation, Protein Kinase Inhibitors, Proto-Oncogene Proteins B-raf

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