Cited by 260Wnt/β-catenin signaling in development and cancerHedgehog Signaling Pathway StudiesColorectal Cancer Treatments and Studies

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WNT as a Driver and Dependency in Cancer

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Parsons, Marie J., Tammela, Tuomas, Dow, Lukas E.·2021·Cancer Discovery

DOI 10.1158/2159-8290.cd-21-0190PMC PMC8487948

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Abstract

The WNT signaling pathway is a critical regulator of development and adult tissue homeostasis and becomes dysregulated in many cancer types. Although hyperactivation of WNT signaling is common, the type and frequency of genetic WNT pathway alterations can vary dramatically between different cancers, highlighting possible cancer-specific mechanisms for WNT-driven disease. In this review, we discuss how WNT pathway disruption contributes to tumorigenesis in different organs and how WNT affects the tumor cell and immune microenvironment. Finally, we describe recent and ongoing efforts to target oncogenic WNT signaling as a therapeutic strategy. Significance: WNT signaling is a fundamental regulator of tissue homeostasis and oncogenic driver in many cancer types. In this review, we highlight recent advances in our understanding of WNT signaling in cancer, particularly the complexities of WNT activation in distinct cancer types, its role in immune evasion, and the challenge of targeting the WNT pathway as a therapeutic strategy.

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Authors: Parsons, M. J., Tammela, T., & Dow, L. E.
Affiliations: Weill Cornell Medicine (US)
Memorial Sloan Kettering Cancer Center (US)
Corresponding author: Dow, Lukas E.
ORCID: Parsons, Marie J.
Tammela, Tuomas
Dow, Lukas E.
Venue: Cancer Discovery
Publisher: American Association for Cancer Research (AACR)
Published: 2021-09-13
Volume: 11
Issue: 10
Pages: 2413-2429
ISSN: 2159-8274 (ISSN-L)
2159-8290
DOI: 10.1158/2159-8290.cd-21-0190
PMC: PMC8487948
OpenAlex: W3199697997
Cited by: 257
References: 195
Citations by year: 2026: 36 · 2025: 50 · 2024: 70 · 2023: 56 · 2022: 41 · 2021: 4
FWCI: 4.56
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Cancer Discovery (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: American Cancer Society (131461-RSG-17-202-01-TBG)
NCI (1R01CA222517-01A1)
Starr Cancer Consortium (SCC I14-0023)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
Keywords: Wnt signaling, carcinogenesis, tumor immune microenvironment, immune evasion, Wnt pathway inhibitors, cancer therapy, tissue homeostasis
MeSH terms: Humans, Neoplasms, Tumor Microenvironment, Wnt Signaling Pathway, Carcinogenesis

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WNT as a Driver and Dependency in Cancer

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