The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
Corruption of Innate Immunity by Bacterial Proteases
Open accessAbstract
The innate immune system of the human body has developed numerous mechanisms to control endogenous and exogenous bacteria and thus prevent infections by these microorganisms. These mechanisms range from physical barriers such as the skin or mucosal epithelium to a sophisticated array of molecules and cells that function to suppress or prevent bacterial infection. Many bacteria express a variety of proteases, ranging from nonspecific and powerful enzymes that degrade many proteins involved in innate immunity to proteases that are extremely precise and specific in their mode of action. Here we have assembled a comprehensive picture of how bacterial proteases affect the host’s innate immune system to gain advantage and cause infection. This picture is far from being complete since the numbers of mechanisms utilized are as astonishing as they are diverse, ranging from degradation of molecules vital to innate immune mechanisms to subversion of the mechanisms to allow the bacterium to hide from the system or take advantage of it. It is vital that such mechanisms are elucidated to allow strategies to be developed to aid the innate immune system in controlling bacterial infections.
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Cites
Yersinia YopJ Acetylates and Inhibits Kinase Activation by Blocking Phosphorylation
Mukherjee, S., Keitany, G., Li, Y., Wang, Y., Ball, H. L., Goldsmith, E. J., & Orth, K. (2006) · Science · doi:10.1126/science.1126867 · Cited by 615
Degradation of Human Antimicrobial Peptide LL-37 by Staphylococcus aureus -Derived Proteinases
Sieprawska-Lupa, M., Mydel, P., Krawczyk, K., Wójcik, K., Puklo, M., Lupa, B., Suder, P., Silberring, J., Reed, M., Pohl, J., et al. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.12.4673-4679.2004 · Cited by 551
Self-citationDisruption of Signaling by Yersinia Effector YopJ, a Ubiquitin-Like Protein Protease
Orth, K., Xu, Z., Mudgett, M. B., Bao, Z. Q., Palmer, L. E., Bliska, J. B., Mangel, W. F., Staskawicz, B., & Dixon, J. E. (2000) · Science · doi:10.1126/science.290.5496.1594 · Cited by 542
A Surface Protease and the Invasive Character of Plague
Sodeinde, O. A., Subrahmanyam, Y. V. B. K., Stark, K., Quan, T., Bao, Y., & Goguen, J. D. (1992) · Science · doi:10.1126/science.1439793 · Cited by 503
Macrophage Apoptosis by Anthrax Lethal Factor Through p38 MAP Kinase Inhibition
Park, J. M., Greten, F. R., Li, Z.-W., & Karin, M. (2002) · Science · doi:10.1126/science.1073163 · Cited by 500
Shao, F., Merritt, P. M., Bao, Z., Innes, R. W., & Dixon, J. E. (2002) · Cell · doi:10.1016/s0092-8674(02)00766-3 · Cited by 471
Kubica, M., Guzik, K., Koziel, J., Zarebski, M., Richter, W., Gajkowska, B., Golda, A., Maciag-Gudowska, A., Brix, K., Shaw, L., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001409 · Cited by 457
Self-citationProteinases of common pathogenic bacteria degrade and inactivate the antibacterial peptide LL‐37
Schmidtchen, A., Frick, I., Andersson, E., Tapper, H., & Björck, L. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03146.x · Cited by 439
Plasminogen is a critical host pathogenicity factor for group A streptococcal infection
Sun, H., Ringdahl, U., Homeister, J. W., Fay, W. P., Engleberg, N. C., Yang, A. Y., Rozek, L. S., Wang, X., Sjöbring, U., & Ginsburg, D. (2004) · Science · doi:10.1126/science.1101245 · Cited by 408
Coleman, J. L., Gebbia, J. A., Piesman, J., Degen, J. L., Bugge, T. H., & Benach, J. L. (1997) · Cell · doi:10.1016/s0092-8674(00)80298-6 · Cited by 341
Cited by
Basic biology and role of interleukin‐17 in immunity and inflammation
Zenobia, C., & Hajishengallis, G. (2015) · Periodontology 2000 · doi:10.1111/prd.12083 · Cited by 470
Porphyromonas gingivalis Periodontal Infection and Its Putative Links with Alzheimer’s Disease
Singhrao, S. K., Harding, A., Poole, S., Kesavalu, L., & Crean, S. (2015) · Mediators of Inflammation · doi:10.1155/2015/137357 · Cited by 195
Novel Fecal Biomarkers That Precede Clinical Diagnosis of Ulcerative Colitis
Galipeau, H. J., Caminero, A., Turpin, W., Bermudez-Brito, M., Santiago, A., Libertucci, J., Constante, M., Raygoza Garay, J. A., Rueda, G., Armstrong, S., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.12.004 · Cited by 190
Caminero, A., McCarville, J. L., Galipeau, H. J., Deraison, C., Bernier, S. P., Constante, M., Rolland, C., Meisel, M., Murray, J. A., Yu, X. B., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09037-9 · Cited by 139
Uriarte, S. M., Edmisson, J. S., & Jimenez‐Flores, E. (2016) · Immunological Reviews · doi:10.1111/imr.12451 · Cited by 112
Metadata
- Authors
- Potempa, J., & Pike, R. N.
- Venue
- Journal of Innate Immunity
- Publisher
- S. Karger AG
- Published
- 2008-12-02
- Volume
- 1
- Issue
- 2
- Pages
- 70-87
- ISSN
- 1662-811X (ISSN-L)
- 1662-8128
- OpenAlex
- W1999564888
- Cited by
- 276
- References
- 110
- FWCI
- 7.63
- Type
- journal article
- Language
- en
- Open access
- green
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