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Cited by 47Diet and metabolism studiesDietary Effects on HealthDiabetes Management and Research

Low-Carbohydrate Diets: A Matter of Love or Hate

Frigolet, María-Eugenia, Ramos Barragán, Victoria-Eugenia, Tamez González, Martha·2011·Annals of Nutrition and Metabolism
DOI 10.1159/000331994
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Abstract

Low-carbohydrate diets (LChD) have become very popular among the general population. These diets have been used to lose body weight and to ameliorate various abnormalities like diabetes, nonalcoholic fatty liver disease, polycystic ovary syndrome, narcolepsy, epilepsy, and others. Reports suggest that body weight reduction and glycemic control could be attained while following LChD. However, these advantages are more notably found in short periods of time consuming an LChD. Indeed, the safety and efficacy of the latter diets in the long term have not been sufficiently explored. In contrast to what has been proposed, other mentioned pathologies are not improved or are even worsened by carbohydrate restriction. Therefore, the aim of this review is to define the concept of LChD and to explain their clinical effects in the short and long term, their influence on metabolism, and the opinion of nutrition or health authorities. Finally, evincing the research gaps of LChD that are here exposed will later allow us to reach a consensus with regard to their utilization.

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  • Since ~73% of lean mass is water, the observed reduction of LELM in the first year of intervention may have arisen from natriuresis and water loss that occurs during keto-adaptation.

    “Since ~73% of lean mass is water, the observed reduction of LELM in the first year of intervention may have arisen from natriuresis and water loss that occurs during keto-adaptation (96, 97).”

    From Long-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-Year Non-randomized Clinical Trial (2019) · cites this paper as [96]

    The Effects of LChD section (page unavailable) says ketonuria can increase renal sodium and water loss, supporting the proposed mechanism. It does not give the ~73% water figure or address the observed first-year reduction in LELM. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Frigolet, M.-E., Ramos Barragán, V.-E., & Tamez González, M.
Affiliations
Hospital General Dr. Manuel Gea Gonzalez (MX)
Venue
Annals of Nutrition and Metabolism
Publisher
S. Karger AG
Published
2011
Volume
58
Issue
4
Pages
320-334
ISSN
  • 0250-6807 (ISSN-L)
  • 1421-9697
DOI
10.1159/000331994
OpenAlex
W1963989993
Cited by
47
References
20
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 3 · 2014: 3 · 2013: 5 · 2012: 1
FWCI
0.31
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Annals of Nutrition and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Diet and metabolism studies
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
low-carbohydrate diet, carbohydrate restriction, weight loss, glycemic control, diabetes mellitus, non-alcoholic fatty liver disease, polycystic ovary syndrome, epilepsy, narcolepsy, long-term efficacy and safety, metabolism, dietary recommendations
MeSH terms
Animals, Diabetes Mellitus, Epilepsy, Fatty Liver, Humans, Hyperglycemia, Ketosis, Obesity, Weight Loss, Practice Guidelines as Topic, Carbohydrate Metabolism, Diet, Carbohydrate-Restricted

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