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Prevalence of Sleep Disturbances in Mild Cognitive Impairment and Dementing Disorders: A Multicenter Italian Clinical Cross-Sectional Study on 431 Patients
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Background/Aims: Sleep disturbances are common in the elderly and in persons with cognitive decline. The aim of this study was to describe frequency and characteristics of insomnia, excessive daytime sleepiness, sleep-disordered breathing, REM behavior disorder and restless legs syndrome in a large cohort of persons with mild cognitive impairment or dementia. Methods: 431 consecutive patients were enrolled in 10 Italian neurological centers: 204 had Alzheimer’s disease, 138 mild cognitive impairment, 43 vascular dementia, 25 frontotemporal dementia and 21 Lewy body dementia or Parkinson’s disease dementia. Sleep disorders were investigated with a battery of standardized questions and questionnaires. Results: Over 60% of persons had one or more sleep disturbances almost invariably associated one to another without any evident and specific pattern of co-occurrence. Persons with Alzheimer’s disease and those with mild cognitive impairment had the same frequency of any sleep disorder. Sleep-disordered breathing was more frequent in vascular dementia. REM behavior disorder was more represented in Lewy body or Parkinson’s disease dementia. Conclusion: A careful clinical evaluation of sleep disorders should be performed routinely in the clinical setting of persons with cognitive decline. Instrumental supports should be used only in selected patients.
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Patients with Alzheimer's disease have less SWS.
“Furthermore, patients with AD have less SWS, and cognitively non-impaired adults with decreased SWS exhibit increased amyloid𝛃 burden and worse sleep-mediated episodic memory consolidation [6, 7].”
From Long-Term Trazodone Use and Cognition: A Potential Therapeutic Role for Slow-Wave Sleep Enhancers (2019) · cites this paper as [7]
The Results and Discussion (page not available) compare the frequency of sleep disturbances across dementia groups, but do not report slow-wave sleep (SWS) in patients with Alzheimer’s disease. Searches for SWS, slow-wave sleep, and sleep stages found no passage addressing the claimed reduction. (LLM, conf=0.74)
Experimental — accuracy not yet measuredCognitively non-impaired adults with decreased SWS exhibit increased amyloidβ burden and worse sleep-mediated episodic memory consolidation.
“Furthermore, patients with AD have less SWS, and cognitively non-impaired adults with decreased SWS exhibit increased amyloid𝛃 burden and worse sleep-mediated episodic memory consolidation [6, 7].”
From Long-Term Trazodone Use and Cognition: A Potential Therapeutic Role for Slow-Wave Sleep Enhancers (2019) · cites this paper as [7]
The Discussion addresses sleep disturbances in patients with dementia or cognitive impairment, not the claimed association in cognitively non-impaired adults. Searches of our copy for slow-wave sleep (SWS), amyloid burden, and sleep-mediated episodic memory consolidation found no passage addressing that association. Page numbers were not available for these passages. (LLM, conf=0.76)
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Citations
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Metadata
- Authors
- Guarnieri, B., Adorni, F., Musicco, M., Appollonio, I., Bonanni, E., Caffarra, P., Caltagirone, C., Cerroni, G., Concari, L., Cosentino, F. I. I., Ferrara, S., Fermi, S., Ferri, R., Gelosa, G., Lombardi, G., Mazzei, D., Mearelli, S., Morrone, E., Murri, L., Nobili, F. M., Passero, S., Perri, R., Rocchi, R., Sucapane, P., Tognoni, G., Zabberoni, S., & Sorbi, S.
- Affiliations
- National Research Council (IT)
- Fondazione Santa Lucia (IT)
- Azienda Ospedaliera San Gerardo (IT)
- University of Pisa (IT)
- University of Parma (IT)
- Oasi Maria SS (IT)
- University of Florence (IT)
- University of Genoa (IT)
- University of L'Aquila (IT)
- Istituti Clinici Scientifici Maugeri (IT)
- University of Siena (IT)
- ORCID
- Venue
- Dementia and Geriatric Cognitive Disorders
- Publisher
- S. Karger AG
- Published
- 2012
- Volume
- 33
- Issue
- 1
- Pages
- 50-58
- ISSN
- 1420-8008 (ISSN-L)
- 1421-9824
- PMC
- PMC3696366
- OpenAlex
- W2039291573
- Cited by
- 393
- References
- 5
- Citations by year
- 2026: 30 · 2025: 26 · 2024: 39 · 2023: 43 · 2022: 45 · 2021: 40 · 2020: 44 · 2019: 29 · 2018: 17 · 2017: 19 · 2016: 24 · 2015: 21 · 2014: 9 · 2013: 7
- FWCI
- 9.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Dementia and Geriatric Cognitive Disorders (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion)
- Florence Research (University of Florence) (submittedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- Use Siena air (University of Siena) (submittedVersion)
- Funders
- Demensförbundet
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
- Keywords
- sleep disorders, mild cognitive impairment, dementia, Alzheimer's disease, vascular dementia, frontotemporal dementia, dementia with Lewy bodies, Parkinson's disease dementia, insomnia, excessive daytime sleepiness, sleep-disordered breathing, restless legs syndrome, prevalence, cognitive decline
- MeSH terms
- Aged, Cross-Sectional Studies, Dementia, Depression, Educational Status, Female, Humans, Sleep Initiation and Maintenance Disorders, Italy, Male, Neuropsychological Tests, Sleep Apnea Syndromes, Sleep Wake Disorders, Cohort Studies, Polysomnography, Diagnostic and Statistical Manual of Mental Disorders, Cognitive Dysfunction
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