Cited by 52Gut microbiota and healthGastrointestinal motility and disordersParkinson's Disease Mechanisms and Treatments

Influence of commensal microbiota on the enteric nervous system and its role in neurodegenerative diseases

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Endres, Kristina, Schäfer, Karl-Herbert·2018·Journal of Innate Immunity

Abstract

When thinking about neurodegenerative diseases, the first symptoms that come to mind are loss of memory and learning capabilities, which all resemble hallmarks of manifestation of such diseases in the central nervous system (CNS). However, the gut comprises the largest nervous system outside the CNS that is autonomously active and in close interplay with its microbiota. Therefore, the enteric nervous system (ENS) might serve as an indicator of degenerative pathomechanisms that also affect the CNS. On the other hand, it might offer an entry point for devastating influences from the microbial community or - conversely - for therapeutic approaches via gut commensals. Within the last years, the ENS and gut microbiota therefore have sparked the interest of researchers of CNS diseases and we here report on recent findings and open questions, especially with regard to Alzheimer and Parkinson diseases.

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  • The enteric nervous system is made up of different neural networks in the intestinal wall, where individual small ganglia are connected by dense bundles of fibres.

    “Unlike the CNS, the enteric nervous system is made up of different neural networks in the intestinal wall, where individual small ganglia are connected by dense bundles of fibres.70”

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Research works printed but not linked: 3

  1. Goldblum JR, Whyte RI, Orringer MB, Ap- pelman HD: Achalasia: a morphologic study of 42 resected specimens. Am J Surg Pathol 1994; 18: 327-337.
  2. Banerji NK, Hurwitz LJ: Neurological mani- festations in adult steatorrhoea (probable glu- ten enteropathy). J Neurol Sci 1971; 14: 125- 141.
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Authors
Endres, K., & Schäfer, K.-H.
Affiliations
  • Johannes Gutenberg University Mainz (DE)
  • University of Applied Sciences Kaiserslautern (DE)
Venue
Journal of Innate Immunity
Publisher
S. Karger AG
Published
2018
Volume
10
Issue
3
Pages
172-180
ISSN
  • 1662-811X (ISSN-L)
  • 1662-8128
OpenAlex
W2801921383
Cited by
52
References
69
Citations by year
2026: 3 · 2025: 1 · 2023: 8 · 2022: 6 · 2021: 12 · 2020: 11 · 2019: 8 · 2018: 3
FWCI
0.83
Type
journal article
Language
en
Open access
Locations
  • Journal of Innate Immunity (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords
enteric nervous system, gut microbiota, commensal microorganisms, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, gut-brain axis, therapeutic target
MeSH terms
Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Alzheimer Disease, Animals, Gastrointestinal Diseases, Humans, Parkinson Disease, Enteric Nervous System, Neuroprotective Agents, Neurodegenerative Diseases

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