The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Atherosclerosis in the Apolipoprotein E–Deficient Mouse: A Decade of Progress
Abstract
Arguably the most critical advancement in the elucidation of factors affecting atherogenesis has been the development of mouse models of atherosclerosis. Among available models, the apolipoprotein E–deficient (apoE−/−) mouse is particularly popular because of its propensity to spontaneously develop atherosclerotic lesions on a standard chow diet. A Medline search reveals over 645 articles dedicated to studies using this reliable and convenient “super” animal model since its inception (Piedrahita JA et al, Proc Natl Acad Sci U S A 1992;89:4471–4475; Plump AS et al, Cell 1992;71:343–353) with a more or less steady increase from year to year. This review will examine our present understanding of the pathology and progression of plaques in this animal and highlight some of the nutritional, pharmacological, and genetic studies that have enhanced this understanding.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Plump, A. S., Smith, J. D., Hayek, T., Aalto-Setälä, K., Walsh, A., Verstuyft, J. G., Rubin, E. M., & Breslow, J. L. (1992) · Cell · doi:10.1016/0092-8674(92)90362-g · Cited by 2,263
Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E
Zhang, S. H., Reddick, R. L., Piedrahita, J. A., & Maeda, N. (1992) · Science · doi:10.1126/science.1411543 · Cited by 2,237
ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.
Nakashima, Y., Plump, A. S., Raines, E. W., Breslow, J. L., & Ross, R. (1994) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.14.1.133 · Cited by 1,693
Moulton, K. S., Heller, E., Konerding, M. A., Flynn, E., Palinski, W., & Folkman, J. (1999) · Circulation · doi:10.1161/01.cir.99.13.1726 · Cited by 688
Moulton, K. S., Vakili, K., Zurakowski, D., Soliman, M., Butterfield, C., Sylvin, E., Lo, K.-M., Gillies, S., Javaherian, K., & Folkman, J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0730843100 · Cited by 652
Increased Atherosclerosis in Hyperlipidemic Mice With Inactivation of ABCA1 in Macrophages
Aiello, R. J., Brees, D., Bourassa, P.-A., Royer, L., Lindsey, S., Coskran, T., Haghpassand, M., & Francone, O. L. (2002) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000014804.35824.da · Cited by 390
Increased ABCA1 activity protects against atherosclerosis
Singaraja, R. R., Fievet, C., Castro, G., James, E. R., Hennuyer, N., Clee, S. M., Bissada, N., Choy, J. C., Fruchart, J.-C., McManus, B. M., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15748 · Cited by 250
von der Thüsen, J. H., van Vlijmen, B. J. M., Hoeben, R. C., Kockx, M. M., Havekes, L. M., van Berkel, T. J. C., & Biessen, E. A. L. (2002) · Circulation · doi:10.1161/01.cir.0000015502.97828.93 · Cited by 203
Guo, Z., Mitchell-Raymundo, F., Yang, H., Ikeno, Y., Nelson, J., Diaz, V., Richardson, A., & Reddick, R. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00008-8 · Cited by 121
Mezdour, H., Jones, R., Dengremont, C., Castro, G., & Maeda, N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.21.13570 · Cited by 113
Research works printed but not linked: 93
- 10.1016/0021-9150(87)90202-4 · DOI · Paper page
- 10.1097/00041433-200006000-00004 · DOI · Paper page
- 10.1073/pnas.97.7.3433 · doi:10.1073/pnas.97.7.3433
- 10.1073/pnas.89.10.4471 · DOI · Paper page
- 10.1161/atv91.14.1.8274470 · doi:10.1161/atv91.14.1.8274470
- 1995, J Lipid Res, 36, 2320, 10.1016/S0022-2275(20)39713-3 · DOI · Paper page
- 10.1161/atv91.14.1.8274468 · doi:10.1161/atv91.14.1.8274468
- 10.1161/atvb.20.12.2587 · doi:10.1161/atvb.20.12.2587
- 10.1161/atvb.19.10.2368 · doi:10.1161/atvb.19.10.2368
- 10.1161/circ.103.12.1681 · doi:10.1161/circ.103.12.1681
- 10.1093/ajcn/79.1.123 · DOI
- 10.1093/ajcn/79.1.54 · DOI
- 10.1038/2685 · DOI · Paper page
- 10.1079/BJN2003870 · DOI
- 10.1073/pnas.240462697 · DOI · Paper page
- 10.1161/01.cir.0000012142.69612.25 · DOI
- 10.1016/0021-9150(94)90192-9 · DOI
- 10.1161/circ.99.9.1222 · doi:10.1161/circ.99.9.1222
- 10.1172/JCI7664 · DOI
- 10.1093/jn/133.3.744 · DOI
- 10.1093/jn/131.8.2082 · DOI · Paper page
- 10.1161/atvb.21.9.1470 · doi:10.1161/atvb.21.9.1470
- 10.1161/atvb.21.12.2032 · doi:10.1161/atvb.21.12.2032
- 10.1006/bbrc.1997.6844 · DOI
- 10.1097/00005344-199804000-00011 · DOI
- 10.1016/S0167-5273(01)00542-3 · DOI
- 10.1161/01.atv.0000042232.42883.56 · DOI
- 10.1002/jcb.10492 · DOI
- 10.1016/S0006-291X(03)00819-2 · DOI
- 10.1161/atvb.21.3.372 · doi:10.1161/atvb.21.3.372
- 10.1161/01.cir.0000092886.52404.50 · DOI
- 10.1046/j.1463-1326.2003.00240.x · DOI
- 10.1016/S0024-3205(00)00950-4 · DOI
- 10.1073/pnas.210394497 · DOI
- 10.1080/140174302762659094 · DOI
- 10.1016/S0008-6363(03)00464-4 · DOI
- 10.1016/S0735-1097(03)00304-8 · DOI
- 10.1073/pnas.93.19.10022 · DOI · Paper page
- 10.1161/01.ATV.17.11.2679 · DOI
- 10.1016/S0021-9150(98)00325-6 · DOI
- 10.1007/s11745-002-0922-2 · DOI
- 10.1161/atvb.21.10.1577 · doi:10.1161/atvb.21.10.1577
- 10.1073/pnas.182199799 · DOI · Paper page
- 10.1073/pnas.98.2.507 · DOI · Paper page
- 10.1073/pnas.112059299 · DOI · Paper page
- 10.1161/circ.103.21.2604 · doi:10.1161/circ.103.21.2604
- 10.1161/circ.103.13.1778 · doi:10.1161/circ.103.13.1778
- 10.1038/sj.bjp.0704160 · DOI
- 10.1161/01.atv.0000057807.28754.7f · DOI · Paper page
- 10.1161/circ.99.13.1726 · doi:10.1161/circ.99.13.1726
- 10.1073/pnas.0336398100 · DOI · Paper page
- 10.1172/JCI9021 · DOI · Paper page
- 10.1172/JCI200316484 · DOI
- 10.1161/01.atv.0000078520.89539.77 · DOI · Paper page
- 10.1172/JCI0215748 · doi:10.1172/jci0215748 · Paper page
- 10.1073/pnas.012587699 · DOI · Paper page
- 10.1172/JCI117412 · DOI · Paper page
- 10.1161/circ.99.1.105 · doi:10.1161/circ.99.1.105
- 10.1161/atvb.21.11.1790 · doi:10.1161/atvb.21.11.1790
- 10.1161/circ.104.20.2447 · doi:10.1161/circ.104.20.2447
- 10.1016/S0891-5849(02)01429-6 · DOI · Paper page
- 10.1074/jbc.M910376199 · DOI · Paper page
- 10.1016/S0002-9440(10)65540-X · DOI · Paper page
- 10.1074/jbc.272.34.20963 · DOI · Paper page
- 10.1038/386292a0 · DOI · Paper page
- 10.1161/atvb.20.12.2600 · doi:10.1161/atvb.20.12.2600
- 10.1172/JCI9259 · DOI · Paper page
- 10.1161/01.atv.0000091363.28501.84 · DOI · Paper page
- 10.1161/res.90.3.270 · doi:10.1161/res.90.3.270
- 10.1161/01.ATV.17.11.2333 · DOI · Paper page
- 10.1161/01.cir.0000093189.97429.9d · DOI · Paper page
- 10.1097/00041433-199710000-00009 · DOI · Paper page
- 1997, J Clin Invest, 6, 1575
- 10.1172/JCI200111380 · DOI
- 10.1161/01.cir.0000114526.50618.24 · DOI · Paper page
- 10.1161/circ.101.19.2290 · doi:10.1161/circ.101.19.2290
- 10.1161/circ.103.25.3099 · doi:10.1161/circ.103.25.3099
- 10.1161/circ.104.4.448 · doi:10.1161/circ.104.4.448
- 10.1161/circ.103.18.2277 · doi:10.1161/circ.103.18.2277
- 10.1172/JCI9626 · DOI · Paper page
- 10.1161/01.atv.0000064374.15232.c3 · DOI · Paper page
- 10.1007/BF03402102 · DOI · Paper page
- 10.1016/S0008-6363(03)00343-2 · DOI · Paper page
- 10.1161/01.cir.0000057548.68243.42 · DOI · Paper page
- 10.1161/01.cir.0000038140.80105.ad · DOI · Paper page
- 10.1038/nm810 · DOI · Paper page
- 10.1172/JCI1461 · DOI
- 1997, Proc Natl Acad Sci U S A, 97, 10335
- 10.1161/atvb.20.3.846 · doi:10.1161/atvb.20.3.846
- 10.1161/atvb.22.3.499 · doi:10.1161/atvb.22.3.499
- 10.1182/blood-2002-07-2131 · DOI
- 10.1161/circ.98.15.1541 · doi:10.1161/circ.98.15.1541
- 10.1002/mrm.10360 · DOI
Cited by
Nahrendorf, M., Jaffer, F. A., Kelly, K. A., Sosnovik, D. E., Aikawa, E., Libby, P., & Weissleder, R. (2006) · Circulation · doi:10.1161/circulationaha.106.646380 · Cited by 602
Nanoparticle PET-CT Imaging of Macrophages in Inflammatory Atherosclerosis
Nahrendorf, M., Zhang, H., Hembrador, S., Panizzi, P., Sosnovik, D. E., Aikawa, E., Libby, P., Swirski, F. K., & Weissleder, R. (2008) · Circulation · doi:10.1161/circulationaha.107.741181 · Cited by 559
Animal models of atherosclerosis
Emini Veseli, B., Perrotta, P., De Meyer, G. R. A., Roth, L., Van der Donckt, C., Martinet, W., & De Meyer, G. R. Y. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.05.010 · Cited by 548
Mouse Models for Atherosclerosis and Pharmaceutical Modifiers
Zadelaar, S., Kleemann, R., Verschuren, L., de Vries-Van der Weij, J., van der Hoorn, J., Princen, H. M., & Kooistra, T. (2007) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.107.142570 · Cited by 527
den Hartigh, L. (2019) · Nutrients · doi:10.3390/nu11020370 · Cited by 371
Metadata
- Authors
- Meir, K. S., & Leitersdorf, E.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2004-06
- Volume
- 24
- Issue
- 6
- Pages
- 1006-1014
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2101096780
- Cited by
- 498
- References
- 10
- FWCI
- 7.90
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Atherosclerosis in the Apolipoprotein E–Deficient Mouse: A Decade of Progress. https://app.cochat.ai/papers/10.1161/01.atv.0000128849.12617.f4
- The paper
- Meir, K. S., & Leitersdorf, E. (2004). Atherosclerosis in the Apolipoprotein E–Deficient Mouse: A Decade of Progress. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/01.atv.0000128849.12617.f4
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
