Cited by 105Fatty Acid Research and HealthLipid metabolism and disordersLipid metabolism and biosynthesis

Fish oil reduces postprandial triglyceride concentrations without accelerating lipid emulsion removal rates

Harris, WS, Muzio, F·1993·The American Journal of Clinical Nutrition

Abstract

Chronic intake of fish oil (FO) reduces postprandial lipemia. Our aim was to determine whether increased clearance of chylomicrons was the mechanism. Eight normal volunteers were randomly assigned to take 64 mg n-3 fatty acids/kg body wt or an olive oil placebo daily for 4 wk in a double-blind, crossover design. At the end of each phase, an intravenous fat-tolerance test and a four-meal, 24-h oral fat-load test were administered. The latter was designed to mimic normal eating patterns (fat provided 42% of energy). FO lowered chylomicron triglyceride and retinyl palmitate concentrations by 40% (P < 0.01) and very-low-density lipoprotein retinyl palmitate concentrations by 27% (P < 0.01). However, clearance rates of the fat emulsion were not significantly different between treatments. The results suggest that the hypochylomicronemic effect of chronic FO supplementation is not due to increased chylomicron clearance, leaving reduced chylomicron production or secretion as a more likely cause of the reduced postprandial lipemia.

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Crossref · 10.1093/ajcn/58.1.68

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Authors
Harris, W., & Muzio, F.
Affiliations
University of Kansas Medical Center (US)
Corresponding author
Harris, WS
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
1993-07
Volume
58
Issue
1
Pages
68-74
ISSN
0002-9165 (ISSN-L)
OpenAlex
W1808898926
Cited by
105
References
51
Citations by year
2021: 2 · 2020: 1 · 2019: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 1 · 2012: 3
FWCI
6.91
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r29hl040832-05, 2s07rr005373-31)
  • National Heart, Lung, and Blood Institute (HL 40832)
  • National Center for Research Resources (BRSG S07-RR-05373)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords
fish oil, omega-3 fatty acids, postprandial lipemia, chylomicron clearance, chylomicron triglycerides, retinyl palmitate, VLDL, olive oil placebo, fat tolerance
MeSH terms
Olive Oil, Administration, Oral, Adult, Chylomicrons, Double-Blind Method, Female, Fish Oils, Humans, Injections, Intravenous, Male, Placebos, Plant Oils, Triglycerides, Fatty Acids, Omega-3

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