Fish oil reduces postprandial triglyceride concentrations without accelerating lipid emulsion removal rates
Abstract
Chronic intake of fish oil (FO) reduces postprandial lipemia. Our aim was to determine whether increased clearance of chylomicrons was the mechanism. Eight normal volunteers were randomly assigned to take 64 mg n-3 fatty acids/kg body wt or an olive oil placebo daily for 4 wk in a double-blind, crossover design. At the end of each phase, an intravenous fat-tolerance test and a four-meal, 24-h oral fat-load test were administered. The latter was designed to mimic normal eating patterns (fat provided 42% of energy). FO lowered chylomicron triglyceride and retinyl palmitate concentrations by 40% (P < 0.01) and very-low-density lipoprotein retinyl palmitate concentrations by 27% (P < 0.01). However, clearance rates of the fat emulsion were not significantly different between treatments. The results suggest that the hypochylomicronemic effect of chronic FO supplementation is not due to increased chylomicron clearance, leaving reduced chylomicron production or secretion as a more likely cause of the reduced postprandial lipemia.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Fish oil supplementation decreases the PL-TG ratio in chylomicron particles, indicating reduced chylomicron size.
“Fish oil supplementation has been shown to decrease the PL-TG ratio in the chylomicron particles, indicating reduced chylomicron size (9).”
From Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance (2003) · cites this paper as [9]
Cites
Enzymatic determination of total serum cholesterol.
Allain, C. C., Poon, L. S., Chan, C. S. G., Richmond, W., & Fu, P. C. (1974) · Clinical Chemistry · doi:10.1093/clinchem/20.4.470 · Cited by 9,845 · see citing works
Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride–methanol
Morrison, W. R., & Smith, L. M. (1964) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40190-7 · Cited by 6,005 · see citing works
Quantitative Determination of Serum Triglycerides by the Use of Enzymes
Bucolo, G., & David, H. (1973) · Clinical Chemistry · doi:10.1093/clinchem/19.5.476 · Cited by 3,202 · see citing works
Burr, M. L., Gilbert, J. F., Holliday, R. M., Elwood, P. C., Fehily, A. M., Rogers, S., Sweetnam, P. M., & Deadman, N. M. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90828-3 · Cited by 2,610 · see citing works
Statistical Principles in Experimental Design
(2003) · Wiley series in probability and statistics · doi:10.1002/0471458503.ch4 · Cited by 2,348 · see citing works
Goodman, D. S. (1988) · Archives of Internal Medicine · doi:10.1001/archinte.1988.00380010040006 · Cited by 2,292 · see citing works
The Inverse Relation between Fish Consumption and 20-Year Mortality from Coronary Heart Disease
Kromhout, D., Bosschieter, E. B., & Coulander, C. D. L. (1985) · New England Journal of Medicine · doi:10.1056/nejm198505093121901 · Cited by 2,177 · see citing works
Atherogenesis: a postprandial phenomenon.
Zilversmit, D. B. (1979) · Circulation · doi:10.1161/01.cir.60.3.473 · Cited by 1,701 · see citing works
Warnick, G. R., & Albers, J. J. (1978) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41577-9 · Cited by 1,250 · see citing works
Cardiovascular Effects of n-3 Fatty Acids
Leaf, A., & Weber, P. C. (1988) · New England Journal of Medicine · doi:10.1056/nejm198803033180905 · Cited by 1,173 · see citing works
Fish oils and plasma lipid and lipoprotein metabolism in humans: a critical review
Harris, W. S. (1989) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38310-3 · Cited by 1,127 · see citing works
Self-citationPhillipson, B. E., Rothrock, D. W., We, C., Harris, W., & Illingworth, D. R. (1985) · New England Journal of Medicine · doi:10.1056/nejm198505093121902 · Cited by 847 · see citing works
Self-citationBrunzell, J. D., Hazzard, W. R., Porte, D., & Bierman, E. L. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107334 · Cited by 484 · see citing works
Fish Consumption and Mortality from Coronary Heart Disease
(1985) · New England Journal of Medicine · doi:10.1056/nejm198509263131311 · Cited by 407 · see citing works
Weintraub, M. S., Zechner, R., Brown, A., Eisenberg, S., & Breslow, J. L. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113806 · Cited by 331 · see citing works
Reduction of postprandial triglyceridemia in humans by dietary n-3 fatty acids
Harris, W. S., Connor, W. E., Alam, N., & Illingworth, D. R. (1988) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38424-8 · Cited by 321 · see citing works
Self-citationSchneider, W. J., Kovanen, P. T., Brown, M. S., Goldstein, J. L., Utermann, G., Weber, W., Havel, R. J., Kotite, L., Kane, J. P., Innerarity, T. L., et al. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110330 · Cited by 310 · see citing works
Kagawa, Y., Nishizawa, M., Suzuki, M., Miyatake, T., HAMAOTO, T., Goto, K., Motonaga, E., IZUMIKAWA, H., HIRATA, H., & Ebihara, A. (1982) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.28.441 · Cited by 306 · see citing works
Rustan, A. C., Nossen, J. Ø., Christiansen, E. N., & Drevon, C. A. (1988) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38418-2 · Cited by 288 · see citing works
Dolecek, T. A., & Grandits, G. (2015) · World review of nutrition and dietetics · doi:10.1159/000419291 · Cited by 286 · see citing works
Chylomicron clearance in normal and hyperlipidemic man
Grundy, S. M., & Mok, H. Y. I. (1976) · Metabolism · doi:10.1016/s0026-0495(76)80006-6 · Cited by 218 · see citing works
Chylomicrons and chylomicron remnants in coronary artery disease: a case-control study
Simons, L. A., Dwyer, T., Simons, J. A., Bernstein, L., Mock, P. A., Pooma, N. S., Balasubramaniam, S., Baron, D., Branson, J., Morgan, J., et al. (1987) · Atherosclerosis · doi:10.1016/0021-9150(87)90020-7 · Cited by 205 · see citing works
Marine oils and thrombogenesis
Dyerberg, J. (1982) · Progress in Lipid Research · doi:10.1016/0163-7827(82)90011-x · Cited by 124 · see citing works
Fish oil fatty acids impair VLDL assembly and/or secretion by cultured rat hepatocytes.
Lang, C., & Davis, R. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42272-2 · Cited by 116 · see citing works
Application of a new intravenous fat tolerance test in the study of hypertriglyceridaemia in man
Boberg, J., Carlson, L. A., & Hallberg, D. (1969) · Journal of Atherosclerosis Research · doi:10.1016/s0368-1319(69)80051-7 · Cited by 102 · see citing works
Effects of a Low Saturated Fat, Low Cholesterol Fish Oil Supplement in Hypertriglyceridemic Patients
Harris, W. S., Dujovne, C. A., Zucker, M., & Johnson, B. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-109-6-465 · Cited by 101 · see citing works
Self-citationRössner, S. (1974) · PubMed · Cited by 100 · see citing works
Hallberg, D. (1965) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1965.tb04184.x · Cited by 99 · see citing works
Carlson, L. A. (1985) · Clinica Chimica Acta · doi:10.1016/0009-8981(85)90277-3 · Cited by 99 · see citing works
The effects of salmon oil upon plasma lipids, lipoproteins, and triglyceride clearance.
Harris, W. S., & CONNOR, W. E. (1980) · PubMed · Cited by 96 · see citing works
Self-citationFat emulsion particle size: influence on the clearance rate and the tissue lipolytic activity
Lutz, O., Meraïhi, Z., Mura, J.-L., et al. (1989) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/50.6.1370 · Cited by 80 · see citing works
Chung, B. H., Segrest, J. P., Smith, K. A., Griffin, F. M., & Brouillette, C. G. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114024 · Cited by 73 · see citing works
Effects of four doses of n-3 fatty acids given to hyperlipidemic patients for six months.
Harris, W. S., Windsor, S. L., & Dujovne, C. A. (1991) · Journal of the American College of Nutrition · doi:10.1080/07315724.1991.10718148 · Cited by 61 · see citing works
Self-citationMurthy, S., Albright, E., Mathur, S. N., & Field, F. J. (1988) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38490-x · Cited by 61 · see citing works
Weinberg, R. B., & Scanu, A. M. (1982) · Atherosclerosis · doi:10.1016/0021-9150(82)90109-5 · Cited by 60 · see citing works
Chylomicron triglyceride clearance: comparison of three assessment methods
Cohen, J. C. (1989) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/49.2.306 · Cited by 59 · see citing works
Parks, J. S., Johnson, F., Wilson, M., & Rudel, L. L. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43167-0 · Cited by 59 · see citing works
Apoproteins in association with intralipid incubations in rat and human plasma
Robinson, S. F., & Quarfordt, S. H. (1979) · Lipids · doi:10.1007/bf02533417 · Cited by 51 · see citing works
A monoclonal-antibody-based enzyme-linked immunosorbent assay of lipoprotein(a)
Wong, W. L., Eaton, D., Berloui, A., FENDLY, B. M., & Hass, P. (1990) · Clinical Chemistry · doi:10.1093/clinchem/36.2.192 · Cited by 47 · see citing works
Influence of eicosapentaenoic acid (20:5, n-3) on secretion of lipoproteins in CaCo-2 cells.
Ranheim, T., Gedde‐Dahl, A., Rustan, A. C., & Drevon, C. A. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40542-5 · Cited by 47 · see citing works
Carlson, L. A. (1980) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365518009093016 · Cited by 46 · see citing works
Levy, E. H., ROY, C. C., Goldstein, R. J., et al. (1991) · Journal of the American College of Nutrition · doi:10.1080/07315724.1991.10718129 · Cited by 42 · see citing works
DaCol, P., & Kostner, G. M. (1983) · Clinical Chemistry · doi:10.1093/clinchem/29.6.1045 · Cited by 39 · see citing works
Intravenous fat tolerance Correlation with very low density lipoprotein apoprotein b kinetics in man
Nicoll, A., Sigurdsson, G. T., Marsh, A. R., & Lewis, B. (1977) · Atherosclerosis · doi:10.1016/0021-9150(77)90135-6 · Cited by 30 · see citing works
Taskinen, M., Nikkilä, E., Kuusi, T., & Tulikoura, I. (1983) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.3.6.607 · Cited by 27 · see citing works
Lewis, B., Chait, A., February, A., & Mattock, M. B. (1973) · Atherosclerosis · doi:10.1016/0021-9150(73)90035-x · Cited by 26 · see citing works
Tollin, C., Ericsson, M., Johnson, O., & Backman, C. (1985) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365518509155279 · Cited by 25 · see citing works
Changes of HDL subfraction concentration and particle size by intralipid in vivo
Sakuma, N., LIN, C., MATSUMOTO, Y., et al. (1988) · Atherosclerosis · doi:10.1016/0021-9150(88)90195-5 · Cited by 15 · see citing works
Rössner, S., Rössner, S., Boberg, J., et al. (1974) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1974.tb02322.x · Cited by 13 · see citing works
Relationship between lipoproteins including HDL subfractions and the intravenous fat tolerance test
Rössner, S., & Kirstein, P. (1984) · Atherosclerosis · doi:10.1016/0021-9150(84)90058-3 · Cited by 9 · see citing works
The dietary risc rating a novel method to assess the hyperlipidemic potential of a diet
Harris, W. S., Held, S., & Dujovne, C. A. (1988) · Arteriosclerosis An Official Journal of the American Heart Association Inc · Cited by 2 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance
Park, Y., & Harris, W. S. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m200282-jlr200 · Cited by 348 · see citing works
Self-citationEicosapentaenoic acid is primarily responsible for hypotriglyceridemic effect of fish oil in humans
Rambjør, G. S., W»len, A. I., Windsor, S. L., & Harris, W. S. (1996) · Lipids · doi:10.1007/bf02637050 · Cited by 147 · see citing works
Self-citationInfluence of n-3 fatty acid supplementation on the endogenous activities of plasma lipases
Harris, W., Lu, G., Rambjør, G., Wõlen, A., Ontko, J., Cheng, Q., & Windsor, S. (1997) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.2.254 · Cited by 135 · see citing works
Self-citationAbuMweis, S., Jew, S., Tayyem, R., & Agraib, L. (2018) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12493 · Cited by 122 · see citing works
Hansen, J., Grimsgaard, S., Nilsen, H., Nordøy, A., & Bønaa, K. H. (1998) · Lipids · doi:10.1007/s11745-998-0188-8 · Cited by 91 · see citing works
Peddie, M. C., Rehrer, N. J., & Perry, T. L. (2012) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.11.002 · Cited by 75 · see citing works
N-3 fatty acids and chylomicron metabolism in the rat
Harris, W. S., Hustvedt, B. E., Hagen, E., Green, M. H., Lu, G., & Drevon, C. A. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37258-8 · Cited by 64 · see citing works
Self-citationIkeda, I., Kumamaru, J., Nakatani, N., Sakono, M., Murota, I., & Imaizumi, K. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.4.1159 · Cited by 46 · see citing works
Park, Y., Jones, P. G., & Harris, W. S. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.1.45 · Cited by 41 · see citing works
Self-citation
- Authors
- Harris, W., & Muzio, F.
- Affiliations
- University of Kansas Medical Center (US)
- Corresponding author
- Harris, WS
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 1993-07
- Volume
- 58
- Issue
- 1
- Pages
- 68-74
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W1808898926
- Cited by
- 105
- References
- 51
- Citations by year
- 2021: 2 · 2020: 1 · 2019: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 6.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r29hl040832-05, 2s07rr005373-31)
- National Heart, Lung, and Blood Institute (HL 40832)
- National Center for Research Resources (BRSG S07-RR-05373)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- fish oil, omega-3 fatty acids, postprandial lipemia, chylomicron clearance, chylomicron triglycerides, retinyl palmitate, VLDL, olive oil placebo, fat tolerance
- MeSH terms
- Olive Oil, Administration, Oral, Adult, Chylomicrons, Double-Blind Method, Female, Fish Oils, Humans, Injections, Intravenous, Male, Placebos, Plant Oils, Triglycerides, Fatty Acids, Omega-3
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review