The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Syncope Evaluation in the Emergency Department Study (SEEDS): A Multidisciplinary Approach to Syncope Management
Open accessAbstract
Background— The primary aim and central hypothesis of the study are that a designated syncope unit in the emergency department improves diagnostic yield and reduces hospital admission for patients with syncope who are at intermediate risk for an adverse cardiovascular outcome. Methods and Results— In this prospective, randomized, single-center study, patients were randomly allocated to 2 treatment arms: syncope unit evaluation and standard care. The 2 groups were compared with χ 2 test for independence of categorical variables. Wilcoxon rank sum test was used for continuous variables. Survival was estimated with the Kaplan-Meier method. One hundred three consecutive patients (53 women; mean age 64±17 years) entered the study. Fifty-one patients were randomized to the syncope unit. For the syncope unit and standard care patients, the presumptive diagnosis was established in 34 (67%) and 5 (10%) patients ( P <0.001), respectively, hospital admission was required for 22 (43%) and 51 (98%) patients ( P <0.001), and total patient-hospital days were reduced from 140 to 64. Actuarial survival was 97% and 90% ( P =0.30), and survival free from recurrent syncope was 88% and 89% ( P =0.72) at 2 years for the syncope unit and standard care groups, respectively. Conclusions— The novel syncope unit designed for this study significantly improved diagnostic yield in the emergency department and reduced hospital admission and total length of hospital stay without affecting recurrent syncope and all-cause mortality among intermediate-risk patients. Observations from the present study provide benchmark data for improving patient care and effectively utilizing healthcare resources.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“In this setting, a structured ED protocol can be effective as an alternative to inpatient admission (107–110).”
From 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope (2017) · cites this paper as [107]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Incidence and Prognosis of Syncope
Soteriades, E. S., Evans, J. C., Larson, M. G., Chen, M. H., Chen, L., Benjamin, E. J., & Levy, D. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012407 · Cited by 1,364
Guidelines on management (diagnosis and treatment) of syncope
Brignole, M. (2001) · European Heart Journal · doi:10.1053/euhj.2001.2739 · Cited by 951
A Prospective Evaluation and Follow-up of Patients with Syncope
Kapoor, W. N., Karpf, M., Wieand, S., Peterson, J. R., & Levey, G. S. (1983) · New England Journal of Medicine · doi:10.1056/nejm198307283090401 · Cited by 779
Evaluation and outcome of emergency room patients with transient loss of consciousness
Day, S. C., Cook, E. F., Funkenstein, H., & Goldman, L. (1982) · The American Journal of Medicine · doi:10.1016/0002-9343(82)90913-5 · Cited by 587
Tilt table testing for assessing syncope
Benditt, D. G., Ferguson, D. W., Grubb, B. P., Kapoor, W. N., Kugler, J., Lerman, B. B., Maloney, J. D., Ravielle, A., Ross, B. A., Sutton, R., et al. (1996) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(96)00236-7 · Cited by 574
Guidelines on management (diagnosis and treatment) of syncope-update 2004. Executive Summary.
Brignole, M., Alboni, P., Benditt, D. G., Bergfeldt, L., Blanc, J., Thomsen, P. E. B., van Dijk, J. G., Fitzpatrick, A. P., Hohnloser, S. H., Janoušek, J., et al. (2004) · European Heart Journal · doi:10.1016/j.ehj.2004.09.004 · Cited by 566
Evaluation and Outcome of Patients with Syncope
KAPOOR, W. N. (1990) · Medicine · doi:10.1097/00005792-199005000-00004 · Cited by 539
A Clinical Trial of a Chest-Pain Observation Unit for Patients with Unstable Angina
Farkouh, M. E., Smars, P. A., Reeder, G. S., Zinsmeister, A. R., Evans, R. W., Meloy, T. D., Kopecky, S. L., Allen, M., Allison, T. G., Gibbons, R. J., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199812243392603 · Cited by 516
Self-citationDiagnostic value of history in patients with syncope with or without heart disease
Alboni, P., Brignole, M., Menozzi, C., Raviele, A., Del Rosso, A., Dinelli, M., Solano, A., & Bottoni, N. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01241-4 · Cited by 444
Linzer, M., Yang, E. H., Estes III, N. A. M., Wang, P., Vorperian, V. R., & Kapoor, W. N. (1997) · Annals of Internal Medicine · doi:10.7326/0003-4819-126-12-199706150-00012 · Cited by 437
Colivicchi, F. (2003) · European Heart Journal · doi:10.1016/s0195-668x(02)00827-8 · Cited by 359
CLINICAL GUIDELINE: Diagnosing Syncope: Part 2: Unexplained Syncope
Linzer, M., Yang, E. H., Estes, N. A. M., Wang, P., Vorperian, V. R., & Kapoor, W. N. (1997) · Annals of Internal Medicine · doi:10.7326/0003-4819-127-1-199707010-00014 · Cited by 313
Syncope in advanced heart failure: high risk of sudden death regardless of origin of syncope
Middlekauff, H. R., Stevenson, W. G., Stevenson, L. W., & Saxon, L. A. (1993) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(93)90724-f · Cited by 311
Risk stratification of patients with syncope
Martin, T. P., Hanusa, B. H., & Kapoor, W. N. (1997) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(97)70217-8 · Cited by 285
Calkins, H. G., Shyr, Y., Frumin, H., Schork, A. M., & Morady, F. (1995) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)80315-5 · Cited by 231
Long-term outcome of paced and nonpaced patients with severe carotid sinus syndrome
Brignole, M., Menozzi, C., Lolli, G., Bottoni, N., & Gaggioli, G. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)90860-2 · Cited by 210
Syncope: Current Diagnostic Evaluation and Management
Manolis, A. S., Linzer, M., Salem, D. N., & Estes, N. A. M. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-112-11-850 · Cited by 209
Ammirati, F. (2000) · European Heart Journal · doi:10.1053/euhj.1999.1910 · Cited by 205
Is syncope a risk factor for poor outcomes? comparison of patients with and without syncope
Kapoor, W. N., & Hanusa, B. H. (1996) · The American Journal of Medicine · doi:10.1016/s0002-9343(95)00052-6 · Cited by 180
Fenton, A. M., Hammill, S. C., Rea, R. F., Low, P. A., & Shen, W.-K. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-9-200011070-00014 · Cited by 158
Self-citationManagement of patients with syncope referred urgently to general hospitals
Disertori, M. (2003) · Europace · doi:10.1016/s1099-5129(03)00049-7 · Cited by 153
Current Evaluation and Management of Syncope
Kapoor, W. N. (2002) · Circulation · doi:10.1161/01.cir.0000031168.96232.ba · Cited by 135
Syncope: Mechanisms and Management
(2005) · Wiley eBooks · doi:10.1002/9780470994801 · Cited by 127
Management of syncope referred urgently to general hospitals with and without syncope units
Brignole, M. (2003) · Europace · doi:10.1016/s1099-5129(03)00047-3 · Cited by 118
Does the use of a syncope diagnostic protocol improve the investigation and management of syncope?
Farwell, D. J., & Sulke, A. N. (2004) · Heart · doi:10.1136/heart.90.1.52 · Cited by 109
Pires, L. A., Ganji, J. R., Jarandila, R., & Steele, R. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.15.1889 · Cited by 106
Croci, F. (2002) · Europace · doi:10.1053/eupc.2002.0267 · Cited by 105
The economic burden of unrecognized vasodepressor syncope
Calkins, H. G., Byrne, M., El-Atassi, R., Kalbfleisch, S., Langberg, J. J., & Morady, F. (1993) · The American Journal of Medicine · doi:10.1016/0002-9343(93)90329-n · Cited by 101
RICHARDSON, D. A., BEXTON, R. S., SHAW, F. E., & KENNY, R. A. (1997) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.1997.tb03912.x · Cited by 100
Risk stratification of patients with syncope in an accident and emergency department
Crane, S. (2002) · Emergency Medicine Journal · doi:10.1136/emj.19.1.23 · Cited by 98
Krahn, A. D., Klein, G. J., Yee, R., & Mandab, V. (1999) · American Heart Journal · doi:10.1016/s0002-8703(99)70411-4 · Cited by 95
(2001) · Annals of Emergency Medicine · doi:10.1067/mem.2001.114838 · Cited by 89
Kenny, R. A. (2003) · Journal of Cardiovascular Electrophysiology · doi:10.1046/j.1540-8167.14.s9.8.x · Cited by 88
The impact of diagnostic tests in evaluating patients with syncope.
Eagle, K. A., & Hr, B. (1983) · PubMed · Cited by 85
Prevalence and clinical outcomes of patients with multiple potential causes of syncope
Chen, L. Y., Gersh, B. J., Hodge, D. O., Wieling, W., Hammill, S. C., & Shen, W.-K. (2003) · Mayo Clinic Proceedings · doi:10.4065/78.4.414 · Cited by 81
Self-citationEpidemiology of syncope in hospitalized patients
Getchell, W. S., Larsen, G. C., Morris, C. D., & McAnulty, J. H. (1999) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.1999.03199.x · Cited by 77
Elesber, A. A., Decker, W. W., Smars, P. A., Hodge, D. O., & Shen, W.-K. (2005) · American Heart Journal · doi:10.1016/j.ahj.2004.07.024 · Cited by 56
Self-citationKlein, G. J., Gersh, B. J., & Yee, R. K. (1995) · Circulation · doi:10.1161/01.cir.92.5.1332 · Cited by 50
Self-citationVasovagal syncope interrupting sleep?
Krediet, C. T. P., Jardine, D. L., Cortelli, P., Visman, A. G. R., & Wieling, W. (2004) · Heart · doi:10.1136/hrt.2003.031294 · Cited by 42
Distinct hemodynamic profiles in patients with vasovagal syncope: a heterogeneous population
Shen, W.-K., Low, P. A., Rea, R. F., Lohse, C. M., Hodge, D. O., & Hammill, S. C. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00567-2 · Cited by 37
Self-citationDel Greco, M., Cozzio, S., Scillieri, M., Caprari, F., Scivales, A., & Disertori, M. (2003) · PubMed · Cited by 36
Admission for syncope: evaluation, cost and prognosis.
Schillinger, M., Domanovits, H., Müllner, M., Herkner, H., & Laggner, A. N. (2000) · PubMed · Cited by 32
Syncope: Overview and Approach to Management
Olshansky, B. (2005) · Wiley eBooks · doi:10.1002/9780470994801.ch1 · Cited by 22
The clinical spectrum and diagnosis of syncope.
Manolis, A. S. (1993) · PubMed · Cited by 14
Cunningham, R. M., & Mikhail, M. G. (2001) · Emergency Medicine Clinics of North America · doi:10.1016/s0733-8627(05)70170-x · Cited by 13
Long-term survival after transient loss of consciousness
Lee, R. T., Cook, E. F., Day, S. C., & Goldman, L. (1988) · Journal of General Internal Medicine · doi:10.1007/bf02595791 · Cited by 10
Role of Invasive Electrophysiologic Testing in the Evaluation and Management of Syncope
Shen, W.-K. (1997) · Cardiac Electrophysiology Review · doi:10.1023/a:1009962028083 · Cited by 6
Self-citation
Research works printed but not linked: 6
- 1993, Herz, 18, 143
- 2003, Ital Heart J, 4, 99
- 1983, Yale J Biol Med, 56, 1
- 10.1161/circ.92.5.1332 · DOI
- 1997, Card Electrophysiol Rev, 4, 478
- 2000, Wien Klin Wochenschr, 112, 835
Cited by
Sorted by citations
Developed in collaboration with, European Heart Rhythm Association (EHRA), Heart Failure Association (HFA), and Heart Rhythm Society (HRS), societies, E. B. T. F., European Society of Emergency Medicine (EuSEM), European Federation of Internal Medicine (EFIM), European Union Geriatric Medicine Society (EUGMS), American Geriatrics Society (AGS), European Neurological Society (ENS), et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp298 · Cited by 2,040
Self-citation2018 ESC Guidelines for the diagnosis and management of syncope
Brignole, M., Moya, A., de Lange, F. J., Deharo, J.-C., Elliott, P. M., Fanciulli, A., Fedorowski, A., Furlan, R., Kenny, R. A., Martín, A., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy037 · Cited by 1,951
Self-citation2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope
Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.03.004 · Cited by 478
Self-citation2018 ESC Guidelines for the diagnosis and management of syncope
Brignole, M., Moya‐Mitjans, À., de Lange, F. J., Deharo, J., Elliot, P. M., Fanciulli, A., Fedorowski, A., Furlan, R., Kenny, R. A., Martiın, A., et al. (2018) · Kardiologia Polska · doi:10.5603/kp.2018.0161 · Cited by 475
Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000499 · Cited by 463
Self-citation
Metadata
- Authors
- Shen, W. K., Decker, W. W., Smars, P. A., Goyal, D. G., Walker, A. E., Hodge, D. O., Trusty, J. M., Brekke, K. M., Jahangir, A., Brady, P. A., Munger, T. M., Gersh, B. J., Hammill, S. C., & Frye, R. L.
- Affiliations
- Mayo Clinic (US)
- ORCID
- Venue
- Circulation
- Published
- 2004-12-14
- Volume
- 110
- Issue
- 24
- Pages
- 3636-3645
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2116521722
- Cited by
- 318
- References
- 47
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 6 · 2023: 9 · 2022: 8 · 2021: 11 · 2020: 12 · 2019: 11 · 2018: 19 · 2017: 23 · 2016: 11 · 2015: 20 · 2014: 18 · 2013: 24 · 2012: 19
- FWCI
- 11.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- Mayo Foundation for Medical Education and Research
- National Institutes of Health
- National Institute on Aging (R01AG021201, AG-21201)
- National Heart, Lung, and Blood Institute (R01HL070302)
- National Institute of Neurological Disorders and Stroke (P50NS032352)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Emergency Medicine › Emergency and Acute Care Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Keywords
- syncope, syncope unit, emergency department, diagnostic yield, hospitalization, length of hospital stay, intermediate cardiovascular risk, recurrent syncope, all-cause mortality, healthcare resource utilization
- MeSH terms
- Aged, Ambulatory Care, Electrocardiography, Emergency Medical Services, Emergency Service, Hospital, Female, Follow-Up Studies, Hospitalization, Humans, Length of Stay, Male, Middle Aged, Prospective Studies, Recurrence, Syncope, Risk Assessment, Tilt-Table Test, Endpoint Determination
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
