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Cited by 259Cardiovascular Function and Risk FactorsBlood Pressure and Hypertension StudiesCardiovascular Effects of Exercise

Effect of body size, ponderosity, and blood pressure on left ventricular growth in children and young adults in the Bogalusa Heart Study

Urbina, Elaine M., Gidding, Samuel S., Bao, Weihang, Pickoff, Arthur S., Berdusis, Kaliope, Berenson, Gerald S.·1995·Circulation
DOI 10.1161/01.cir.91.9.2400
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Abstract

Background The measurement of left ventricular mass (LVM) is important because individuals with increased LVM are at increased risk for cardiovascular diseases, including myocardial infarction and congestive heart failure. There are limited longitudinal data on the acquisition of LVM in children and young adults and the relative importance of sex, growth, excess body weight, and blood pressure (BP) on change in LVM. Methods and Results The study cohort consisted of a cross section of 160 healthy children and young adults 9 to 22 years of age at first exam in the biracial community of Bogalusa, La. All had stable BP levels recorded over a 2- to 3-year period. Repeated examinations were performed 4 to 5 years apart. At each exam, 6 BPs were obtained with a mercury sphygmomanometer by trained examiners. The mean of the observations was used, with the fourth Korotkoff phase serving as the measure of diastolic BP. Anthropometric data, including height (HT), weight (WT), and triceps skin fold thickness (TSF), were also obtained, and M-mode echocardiograms were performed. Ponderal index (PI=WT/HT 3 ) was used as a measure of weight-for-height. Tracking of HT ( r =.68 to .76), WT ( r =.73 to .82), PI ( r =.77 to .89), TSF ( r =.70 to .80), BP ( r =.47 to .60), and LVM ( r =.40 to .70) was strong in both sexes ( P <.0001). LVM indexed for linear growth (LVM/HT 2.7 ) tracked in females ( r =.56, P <.0001) but not in males. In univariate cross-sectional analyses, LVM/HT 2.7 correlated with WT, PI, and TSF in both sexes ( r =.21 to .60, P <.05) and with systolic BP (SBP) in females ( r =.23, P <.05). WT was the only independent correlate of LVM/HT 2.7 in both sexes in multivariate cross-sectional analysis in a model containing age, SBP, WT, and TSF as independent variables ( r 2 =.08 to .28, P <.02). In longitudinal univariate analyses, initial measurements of WT, PI, and TSF predicted final LVM/HT 2.7 in both sexes ( r =.28 to .56, P <.01), and SBP was significant for females ( r =.27, P <.05). In multivariate analyses, initial WT was associated with final LVM and LVM/HT 2.7 in both sexes ( r 2 =.27 to .54, P <.01). Finally, baseline LVM correlated with final SBP in both sexes ( r =.21 to .27, P <.05), and initial LVM/HT 2.7 correlated with final SBP in females ( r =.26, P <.05) with a trend for males ( r =.17). Conclusions These data indicate that linear growth is the major determinant of cardiac growth in children and that excess weight may lead to the acquisition of LVM beyond that expected from normal growth. Increased mass may also precede the development of increased BP. The development of obesity may therefore be a significant, and possibly modifiable, risk factor for developing left ventricular hypertrophy and hypertension, risk factors for cardiovascular morbidity and mortality.

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Authors
Urbina, E. M., Gidding, S. S., Bao, W., Pickoff, A. S., Berdusis, K., & Berenson, G. S.
Affiliations
Tulane University (US)
ORCID
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1995-05
Volume
91
Issue
9
Pages
2400-2406
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.91.9.2400
OpenAlex
W2159829699
Cited by
259
References
36
Citations by year
2025: 3 · 2024: 2 · 2023: 3 · 2022: 7 · 2021: 6 · 2020: 13 · 2019: 5 · 2018: 14 · 2017: 12 · 2016: 6 · 2015: 8 · 2014: 11 · 2013: 19 · 2012: 8
FWCI
7.80
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (2r01hl038844-06)
  • National Heart, Lung, and Blood Institute (5R01-HL38844)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
Keywords
left ventricular mass, left ventricular hypertrophy, body size, ponderal index, blood pressure, childhood obesity, weight gain, triceps skinfold thickness, sex differences, linear growth, children and young adults, Bogalusa Heart Study, cardiovascular risk, echocardiography, systolic blood pressure, diastolic blood pressure, anthropometry
MeSH terms
Adolescent, Adult, Blood Pressure, Body Constitution, Body Weight, Child, Female, Follow-Up Studies, Heart Diseases, Heart Ventricles, Humans, Louisiana, Male, Risk Factors, Cohort Studies

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