Arterial stiffness or endothelial dysfunction as a surrogate marker of vascular risk
Open accessAbstract
The understanding of the pathophysiology of atherosclerosis has advanced greatly in the past decade. Cardiovascular risk factors increase the likelihood of an adverse event by having a detrimental effect on the blood vessel wall. Abnormal interactions among cholesterol, inflammatory mediators, platelets and the vascular wall lead to atherogenesis and cardiac events. In an effort to better understand this process, develop surrogate end points for clinical trials and, ultimately, better risk stratify individuals, a variety of measures of arterial function have been studied. These include measures of endothelial health and arterial compliance. The current paper reviews the various techniques available for the study of vascular health. While not yet routinely used for clinical care, these measurements provide important insights into the pathophysiology and treatment of atherosclerosis.
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The clinical relevance of acute changes in endothelial function and arterial compliance following an intervention is unclear, particularly when simultaneous changes in blood pressure occur.
“The clinical relevance of acute changes in endothelial function and arterial compliance following an intervention is unclear, particularly when simultaneous changes in BP occur (Anderson, 2006;McCall et al., 2011).”
From Scientific Opinion on the safety of caffeine (2015) · cites this paper as Anderson, 2006
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- Authors
- Anderson, T. J.
- Affiliations
- University of Alberta (CA)
- Corresponding author
- Anderson, Todd J.
- ORCID
- Anderson, Todd J.
- Venue
- Canadian Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 22
- Pages
- 72B-80B
- ISSN
- 0828-282X (ISSN-L)
- PMC
- PMC2780833
- OpenAlex
- W1994138576
- Cited by
- 178
- References
- 127
- Citations by year
- 2026: 1 · 2025: 10 · 2024: 8 · 2023: 11 · 2022: 8 · 2021: 13 · 2020: 11 · 2019: 14 · 2018: 10 · 2017: 22 · 2016: 15 · 2015: 14 · 2014: 11 · 2013: 4 · 2012: 6
- FWCI
- 0.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Canadian Journal of Cardiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
- Keywords
- arterial stiffness, endothelial dysfunction, surrogate markers, vascular risk, atherosclerosis, arterial compliance, cardiovascular risk stratification, surrogate endpoints, atherogenesis
- MeSH terms
- Arteries, Blood Pressure, Cardiovascular Diseases, Compliance, Elasticity, Endothelium, Vascular, Humans, Prognosis, Risk Factors, Biomarkers, Atherosclerosis
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