The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Lipoprotein Particles in Cerebrospinal Fluid
Abstract
The brain is the most lipid-rich organ in the body, and the intricate interplay between lipid metabolism and pathologies associated with neurodegenerative disorders is being increasingly recognized. The brain is bathed in cerebrospinal fluid (CSF), which, like plasma, contains lipid-protein complexes called lipoproteins that are responsible for extracellular lipid transport. Multiple CSF lipoprotein populations exist, some of which are produced de novo in the central nervous system and others that appear to be generated from protein constituents that are produced in the periphery. These CSF lipoproteins are thought to play key roles in maintaining lipid homeostasis in the central nervous system, while little else is known due to their limited accessibility and their low abundance in CSF. Recent work has provided new insights into the compositional complexity of CSF lipoprotein families and their metabolism in cerebral circulation. The purpose of this review is to summarize our current state of knowledge on the composition, origin, and metabolism of CSF lipoproteins.
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“In addition to ApoE: ApoJ, ApoA1, ApoA2, and ApoA4 are major structural apolipoproteins in the CSF; ApoH and ApoD are also present in human CSF but are not classical apolipoproteins with amphipathic α-helical structure [8–10].”
From ApoE lipoproteins in the central nervous system under homeostasis and role in Alzheimer’s disease and related disorders (2026) · cites this paper as [8]
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Apolipoprotein E controls cerebrovascular integrity via cyclophilin A
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Lack of ABCA1 Considerably Decreases Brain ApoE Level and Increases Amyloid Deposition in APP23 Mice
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Nascent astrocyte particles differ from lipoproteins in CSF
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Cited by
Sorted by citations
Strickland, M. R., & Holtzman, D. M. (2026) · Molecular Neurodegeneration · doi:10.1186/s13024-026-00970-0
Metadata
- Authors
- Tsujita, M., Melchior, J. T., & Yokoyama, S.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2024-05
- Volume
- 44
- Issue
- 5
- Pages
- 1042-1052
- ISSN
- 1079-5642
- 1524-4636
- PMC
- PMC11342562
- Cited by
- 24
- References
- 17
- Language
- en
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