Cited by 2,082Aortic Disease and Treatment ApproachesConnective tissue disorders researchAortic aneurysm repair treatments

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2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines

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Isselbacher, Eric M., Preventza, Ourania, Hamilton Black, James, Augoustides, John G., Beck, Adam W., Bolen, Michael A., Braverman, Alan C., Bray, Bruce E., Brown-Zimmerman, Maya M., Chen, Edward P., Collins, Tyrone J., DeAnda, Abe, Fanola, Christina L., Girardi, Leonard N., Hicks, Caitlin W., Hui, Dawn S., Schuyler Jones, William, Kalahasti, Vidyasagar, Kim, Karen M., Milewicz, Dianna M., Oderich, Gustavo S., Ogbechie, Laura, Promes, Susan B., Gyang Ross, Elsie, Schermerhorn, Marc L., Singleton Times, Sabrina, Tseng, Elaine E., Wang, Grace J., Woo, Y. Joseph, Faxon, David P., Upchurch, Gilbert R., Aday, Aaron W., Azizzadeh, Ali, Boisen, Michael, Hawkins, Beau, Kramer, Christopher M., Luc, Jessica G.Y., MacGillivray, Thomas E., Malaisrie, S. Christopher, Osteen, Kathryn, Patel, Himanshu J., Patel, Parag J., Popescu, Wanda M., Rodriguez, Evelio, Sorber, Rebecca, Tsao, Philip S., Santos Volgman, Annabelle·2022·Circulation

DOI 10.1161/cir.0000000000001106PMC PMC9876736

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Abstract

AIM: The "2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease" provides recommendations to guide clinicians in the diagnosis, genetic evaluation and family screening, medical therapy, endovascular and surgical treatment, and long-term surveillance of patients with aortic disease across its multiple clinical presentation subsets (ie, asymptomatic, stable symptomatic, and acute aortic syndromes). METHODS: A comprehensive literature search was conducted from January 2021 to April 2021, encompassing studies, reviews, and other evidence conducted on human subjects that were published in English from PubMed, EMBASE, the Cochrane Library, CINHL Complete, and other selected databases relevant to this guideline. Additional relevant studies, published through June 2022 during the guideline writing process, were also considered by the writing committee, where appropriate. Structure: Recommendations from previously published AHA/ACC guidelines on thoracic aortic disease, peripheral artery disease, and bicuspid aortic valve disease have been updated with new evidence to guide clinicians. In addition, new recommendations addressing comprehensive care for patients with aortic disease have been developed. There is added emphasis on the role of shared decision making, especially in the management of patients with aortic disease both before and during pregnancy. The is also an increased emphasis on the importance of institutional interventional volume and multidisciplinary aortic team expertise in the care of patients with aortic disease.

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Thunström, S., Bech‐Hanssen, O., Krantz, E., Bryman, I., & Landin‐Wilhelmsen, K. (2023) · International Journal of Cardiology Congenital Heart Disease · doi:10.1016/j.ijcchd.2023.100489 · Cited by 1
Timing of Intervention and Long-Term Outcomes of Type B Aortic Intramural Hematoma with Intimal Disruption at Admission
Chen, D., Fang, K., Luo, M., & Shu, C. (2023) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2023.10.007 · Cited by 1
Acute Type B Intramural Hematoma: Novel Insights in the Endovascular Era
D’Orleans, C. C., Duwayri, Y. M., Zellner, A. B., Binongo, J., Farrington, W. J., Keeling, W. B., Jordan, W. D., & Leshnower, B. G. (2024) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2023.11.029 · Cited by 1
The real-world incidence and predictors of sac regression in patients with infrarenal abdominal aortic aneurysm after standard EVAR
Ding, Y., Zhou, M., Xu, L., Xie, T., Zhou, Z., Fang, S., Shi, Z., & Fu, W. (2024) · Asian Journal of Surgery · doi:10.1016/j.asjsur.2024.01.141 · Cited by 1
Evaluation of intramural hematoma: a novel use of 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging
Yang, F., Chen, Y., Zhou, Y., Shao, D., & Luo, J. (2024) · Journal of Cardiothoracic Surgery · doi:10.1186/s13019-024-02598-x · Cited by 1
A highly selective mPGES-1 inhibitor to block abdominal aortic aneurysm progression in the angiotensin mouse model
Weaver, L. M., Stewart, M. J., Ding, K., Loftin, C. D., Zheng, F., & Zhan, C. (2024) · Scientific Reports · doi:10.1038/s41598-024-57437-9 · Cited by 1
The irruption of endovascular techniques in aortic repair: A personal view
Riambau, V. (2024) · Cirugía Cardiovascular · doi:10.1016/j.circv.2024.03.003 · Cited by 1
Rapid Diagnosis of Acute Type A Aortic Dissection Through Multimodality Imaging
Soudah, C., DeAnda, A., & Abdulla, A. (2024) · CASE · doi:10.1016/j.case.2024.02.007 · Cited by 1
Abnormal Cardiac Magnetic Resonance–Derived Ascending Aortic Area Strain Demonstrates Altered Ventriculo-Vascular Function in Marfan Syndrome
Jacquemyn, X., Cordrey, K., den Eynde, J. V., Guerrerio, A. L., MacCarrick, G. L., Dietz, H., & Kutty, S. (2024) · Journal of Thoracic Imaging · doi:10.1097/rti.0000000000000784 · Cited by 1
“11 Unfortunately, many dissections still occur in patients with MFS whose aortic diameters do not meet the threshold for preventive surgery, and it remains controversial to suggest a size criterion below this threshold, since it is likely that many asymptomatic patients have a maximum aortic…”
Appropriate management of the small abdominal aortic aneurysm
Dansey, K. D., & Zettervall, S. L. (2024) · Seminars in Vascular Surgery · doi:10.1053/j.semvascsurg.2024.05.001 · Cited by 1
Enhanced expression of miR-20a driven by nanog exacerbated the degradation of extracellular matrix in thoracic aortic dissection
An, Z., Sun, Y., Yang, X., Zhou, J., Yu, Y., Zhang, B., Xu, Z., Zhu, Y., & Wang, G. (2024) · Non-coding RNA Research · doi:10.1016/j.ncrna.2024.05.006 · Cited by 1
“TAD is a deadly medical emergency with very high mortality, especially Stanford type A TAD, the mortality of which was 1 – 2% per hour in the first 24 h and almost 50 % within the first week [31].”
Background
A Case Report of Aortic Intramural Hematoma: From Diagnosis to Endovascular Treatment Guided by Transesophageal Echocardiography
Benedetti, G., Trimarchi, G., Palmieri, C., Paradossi, U., Berti, S., & Rizza, A. (2024) · Journal of Cardiovascular Echography · doi:10.4103/jcecho.jcecho_21_24 · Cited by 1
Ruptured Aortic Aneurysm in Pregnancy, Anesthetic Management of Endovascular Procedure
Chauhan, R., Balakrishnan, I., Mishra, K., & Kumar, V. (2024) · Annals of Cardiac Anaesthesia · doi:10.4103/aca.aca_111_23 · Cited by 1
“[5,6] This case was very unusual since the patient presented with an aneurysm that had ruptured in the early second trimester in the absence of common risk factors.”
Background
Ascending Aortic Progression After Isolated Aortic Valve Replacement Among Patients with Bicuspid and Tricuspid Aortic Valves
Zheng, H., Liu, X., Yu, S., Li, J., He, P., & Cheng, W. (2024) · Brazilian Journal of Cardiovascular Surgery · doi:10.21470/1678-9741-2023-0438 · Cited by 1
Cerebral protection: Antegrade cerebral perfusion in the modern era. Does temperature matter?
Hughes, G. C., Browndyke, J. N., & Mathew, J. P. (2024) · JTCVS Techniques · doi:10.1016/j.xjtc.2024.08.011 · Cited by 1
Impact of Clevidipine Versus Nicardipine on Time in Range when Lowering Blood Pressure
Armstrong, K., Shepard, K., Horsfield, M., Levine, A. R., O’Sullivan, D. M., & Zeiner, A. L. (2024) · Journal of Pharmacy Practice · doi:10.1177/08971900241279638 · Cited by 1
Quantitative aortic Na[18F]F positron emission tomography computed tomography as a tool to associate vascular calcification with major adverse cardiovascular events
Lieverse, T. T. G. F., van Praagh, G. D., Mulder, D. J., Heerspink, H. J. L., Wolterink, J. M., & Slart, R. H. J. A. (2024) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-024-06901-9 · Cited by 2
Three-dimensional morphometry of the human thoracic aorta using centerline analysis based on least-squares plane fitting
Nagamine, H., Kishita, K., Tsukada, Y., Nagano, H., & Asano, M. (2024) · JTCVS Open · doi:10.1016/j.xjon.2024.09.016 · Cited by 1
Echocardiography for Management of Cardiovascular Disease in Pregnancy
Ziccardi, M. R., & Briller, J. E. (2024) · Current Cardiology Reports · doi:10.1007/s11886-024-02126-2 · Cited by 1
Successful endovascular treatment for acute type A aortic dissection in a Jehovah's Witness patient
Mukawa, K., Shibata, T., Iba, Y., Arihara, A., Yoshikawa, K., & Kawaharada, N. (2024) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2024.10.023 · Cited by 1
4D computed tomography assessment of ruptured triple-lumen type B aortic dissection: a case report
Li, Y., Li, J., Chen, J., & Zhao, P. Q. (2024) · European Heart Journal - Case Reports · doi:10.1093/ehjcr/ytae613 · Cited by 1
Novel variant alters splicing of TGFB2 in family with features of Loeys-Dietz syndrome
Gordon, E. R., Felker, S. A., Coleman, T. F., Sosonkina, N., Pugh, J., Cochran, M. E., Hurst, A., & Cooper, S. J. (2024) · Frontiers in Genetics · doi:10.3389/fgene.2024.1435734 · Cited by 1
The association of reduced ejection fraction with the outcomes of endovascular abdominal aortic aneurysm repair
Bellamkonda, K. S., Zogg, C. K., Desai, N., Strosberg, D. S., Stone, D. H., Guzman, R. J., & Chaar, C. I. O. (2024) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2024.12.039 · Cited by 1
Pregnancy‐Related Aortic Dissection—A Rare Complication of Pregnancy
Shaikh, M. B., Stafford, R. M., Ogburn, E. A., & Tyagi, S. C. (2025) · Clinical Case Reports · doi:10.1002/ccr3.70090 · Cited by 1
Does computed tomography angiography for the Adamkiewicz artery add value over standard scanning in thoracic endovascular aortic repair planning?
Nishii, T., Horinouchi, H., Kotoku, A., Koda, Y., Sakai, R., Okura, Y., Morikawa, T., Ohta, Y., Matsuda, H., & Fukuda, T. (2025) · JTCVS structural and endovascular. · doi:10.1016/j.xjse.2025.100043 · Cited by 1
Robot-assisted anterior resection of rectal cancer in a patient with abdominal aortic aneurysm using a monitoring laparoscope: a case report
Takashima, J., Kobayashi, H., Koizumi, A., Shigehara, F., Yamazaki, K., Fujimoto, D., Miura, F., & Taniguchi, K. (2025) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000002936 · Cited by 1
Rupture of huge thoracic aortic aneurysm in a young man: Case report and literature review
Raniero, D., Tatriele, N., Trevisan, E., & Turrina, S. (2025) · Journal of Forensic and Legal Medicine · doi:10.1016/j.jflm.2025.102805 · Cited by 1
Pregnancy-related chronic type A aortic dissection highlights the importance of thorough prenatal maternal examination
Șulea, C. M., Kiss, A. B., Ágg, B., Benke, K., Bartha, E., Szilveszter, B., Stengl, R., Csonka, M., Szabolcs, Z., & Pólos, M. (2025) · Journal of Cardiothoracic Surgery · doi:10.1186/s13019-025-03357-2 · Cited by 1
Successful resuscitation of acute type A aortic dissection with pulmonary embolism using long-term venoarterial extracorporeal membrane oxygenation: a case report
Zhu, G., Yue, W., Li, Y., Wang, H., Li, J., Zhou, X., Zhang, Q., & Zhang, J. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1530566 · Cited by 1
Aortic Wall Biomechanical Assessment Depends on Ultrasound Probe Pressure: In-Vivo and In-Silico Insights
Bracco, M. I., Eiberg, J., Lorenzen, U. S., Avril, S., & Rouet, L. (2025) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2025.3537278 · Cited by 1
Thoracic Endovascular Aortic Repair for Aortic Arch Penetrating Atherosclerotic Ulcer Using Castor Single-Branched Stent-Graft With Zone 2 Landing
Li, X., Fan, J., Zhang, L., Song, C., Zhang, H., Xia, S., Li, H., & Lu, Q. (2025) · Journal of Endovascular Therapy · doi:10.1177/15266028251315015 · Cited by 1
Multi-layered electrospun grafts for surgical repair: Biomimicking physiological ascending aortic compliance
Krammer, J., Pichlmaier, M. A., Stana, J., Hagl, C. M., Peterß, S., Grab, M., & Grefen, L. (2025) · Journal of Applied Biomaterials & Functional Materials · doi:10.1177/22808000251316728 · Cited by 1
Slowing Thoracic Aortic Aneurysm Growth with Statins: A Meta-Analysis
Kolimas, A., Malla, G., Chadha, A., Sainbayar, E., Sethi, J., Hindosh, Z., Hadvani, P., Pham, H. N., & Sordia, J. (2025) · Current Cardiology Reviews · doi:10.2174/011573403x343512250127075044 · Cited by 1
Dynamic Local Conformal Reinforcement Network (DLCR) for Aortic Dissection Centerline Tracking
Zhao, J., Zeng, A., Ye, J., & Pan, D. (2025) · IEEE Journal of Biomedical and Health Informatics · doi:10.1109/jbhi.2025.3547744 · Cited by 1
Totally endoscopic replacement of the ascending aorta with 3-dimensional visualization: Defining “totally endoscopic?” A case report
Chuong, P. T. V., Thuan, P. Q., Thang, H. D., Lam, D. H., Luan, T. M. B., & Định, N. H. (2025) · JTCVS Techniques · doi:10.1016/j.xjtc.2025.02.010 · Cited by 1
Exploration of the Causal Roles of Immune Cells and Inflammatory Proteins in Aortic Dissection via Mendelian Randomization
Chen, Y. X., Chen, Y. E., Zhu, J., Uzokov, J., Li, Y., Feng, J., Miyakawa, A. A., Liu, K., & Han, Y. (2025) · Cardiovascular Innovations and Applications · doi:10.15212/cvia.2025.0002 · Cited by 3
“Aortic dissection (AD) is a serious cardiovascular disease characterized by a tear in the inner layer of the aorta [1, 2].”
Comparative Analysis of Perivascular Adipose Tissue Attenuation on Chest Computed Tomography Angiography in Patients with Marfan Syndrome: A Case–Control Study
Tuttolomondo, D., Secchi, F., Gaibazzi, N., Udugampolage, N. S., Pini, A., Filippo, M. D., Spagnolo, P., Caruso, R., & Taurino, J. (2025) · Diagnostics · doi:10.3390/diagnostics15060673 · Cited by 1
“Moreover, CTA is also recommended for first-degree relatives as it is essential to detect unrecognized asymptomatic aortic aneurysms [13].”
The impact of preoperative maintaining antithrombotic therapy in patients undergoing non-coronary endovascular interventions
Li, J., Fu, L., Zhang, Y., Qiao, T., & Wang, B. (2025) · BMC Cardiovascular Disorders · doi:10.1186/s12872-025-04625-8 · Cited by 1
Association of Subclavian Artery Blood Flow with Stroke After Thoracic Endovascular Aortic Repair with Single-Branch Stent Graft
Zhang, C., Ma, L., & Jin, Y. (2025) · Journal of Endovascular Therapy · doi:10.1177/15266028251326737 · Cited by 1
Utilizing CO 2 Cone Beam Computed Tomography for Post-Procedure Completion Control Following Fenestrated Endovascular Repair of Complex Aortic Aneurysm With a Standardized CO 2 Protocol
Esposito, D., Bastianon, M., Melani, C., Mozzetta, G., Sila, E., Grimaldi, F., Bosisio, E., Savio, A., Baldino, G., & Pratesi, G. (2025) · Journal of Endovascular Therapy · doi:10.1177/15266028251327041 · Cited by 1
“11 Approval of the local Ethical Committee was deemed unnecessary owing to the retrospective nature of the present study and in accordance with national law.”
Prognostic Value of Biomarkers in Acute Aortic Dissection: Analysis of Clinical Outcomes and Mortality
Turan, Ö. F., Işık, N. İ., Dönmez, S., Çalı, H. H., Ateş, K., Baysar, F., Szarpak, Ł., Smereka, J., & Katipoğlu, B. (2025) · Emergency Medicine International · doi:10.1155/emmi/6664490 · Cited by 1
Aortic Dissections—Postoperative Care and Considerations
Lam, S., Villegas-Bravo, L., & Lester, L. (2025) · Cardiology Clinics · doi:10.1016/j.ccl.2024.12.013 · Cited by 1
Through the gap: a case series on managing Type B aortic dissection with multiple lumens and tears
Kumar, S. S., Nagraj, S., Abittan, N., Beilin, A., Kaushik, S., Starosta, S. M., & Guelfguat, M. (2025) · Future Cardiology · doi:10.1080/14796678.2025.2482369 · Cited by 1
Practical approach to measuring vessels and reporting z-scores in children
Dyar, D., LaSalle, E. E., Ostler, H., Degner, S. C., Augustyn, R., Gholami, P., Potersnak, A. G., Koning, J. L., Schuchardt, E. L., Narayan, H. K., et al. (2025) · Pediatric Radiology · doi:10.1007/s00247-025-06217-2 · Cited by 1
Aortic injury and physiologically difficult airway: A case report
Khan, M. J., Baykuziyev, T., Karmakar, A., Hussein, M. I. H., & Ahmed, Y. E. (2025) · JCA advances. · doi:10.1016/j.jcadva.2025.100108 · Cited by 1
Changes in Abdominal Artery Diameter in Patients Treated for Acute Aortic Dissection
Burysz, M., Litwinowicz, R. A., Kowalewski, M., Walocha, J. A., & Batko, J. (2025) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd12040129 · Cited by 1
“We did not analyze the impact of arterial changes on long-term complications or mortality.”
Anesthetic Management for Endovascular Repair of the Thoracic Aorta
Shaikh, M.-A., Cheruku, S., Aguirre, M., & Bellomy, M. L. (2025) · Anesthesiology Clinics · doi:10.1016/j.anclin.2025.02.001 · Cited by 1
Spinal cord protection by normothermic artery bypass and visceral-anastomosis-first strategy in thoracoabdominal aortic aneurysm repair
Zhang, S., Li, Y., Zhou, Y., Yu, C., Sun, X., Guo, H., Chang, Y., Zhao, D. B., Sun, J., & Qian, X. (2025) · BMC Cardiovascular Disorders · doi:10.1186/s12872-025-04710-y · Cited by 1
Open Repair of Isolated Internal Iliac Artery Aneurysm in a Young Patient With Loeys–Dietz Syndrome
Koh, E. Y., Milewicz, D. M., Macedo, T. A., & Oderich, G. S. (2025) · EJVES Vascular Forum · doi:10.1016/j.ejvsvf.2025.04.006 · Cited by 1
Predictive Value of the White Blood Cells Count for the Prognosis of Hospitalized Patients with Acute Aortic Dissection
Suolang, Y., Gao, Y., Sun, C., & Zhang, S. (2025) · Reviews in Cardiovascular Medicine · doi:10.31083/rcm26347 · Cited by 1
Multicenter retrospective observational study of conservative management for acute type A intramural hematoma
Naito, N., Motoji, Y., Tamura, T., Okada, H., Miura, Y., Matsushita, H., & Kitamura, T. (2025) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2025.03.013 · Cited by 1
Emergency Department Blood Pressure Management in Type B Aortic Dissection: An Analysis with Machine Learning
Chen, N., Downing, J. V., Epstein, J. N., Mudd, S., Chan, A., Kuppireddy, S., Tehrani, R., Vashee, I., Hart, E., Esposito, E. C., et al. (2025) · Western Journal of Emergency Medicine · doi:10.5811/westjem.25005 · Cited by 1
Sex-stratified outcome differences between fenestrated endovascular aneurysm repair and open repair for juxtarenal abdominal aortic aneurysms
Manchella, M. K., Rastogi, V., Gaston, B., Kermani, S. S., Zacharias, N., Bellomo, T. R., & Dua, A. (2025) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2025.05.011 · Cited by 1
Surgical Management of Type A Aortic Intramural Hematoma With Cerebral Malperfusion: Carotid Revascularization and Arch Replacement
Fortich, S., de Elguea-Lizárraga, J. I. O., Tsukagoshi, J., Cox, M. W., Son, A. Y., & DeAnda, A. (2025) · Annals of Thoracic Surgery Short Reports · doi:10.1016/j.atssr.2025.04.012 · Cited by 1
Successful aortic valve and ascending aorta replacement during pregnancy
Dalen, C. T.-V., Fairley, S. L., & Lodge, J. S. (2025) · Obstetric Medicine · doi:10.1177/1753495x251339843 · Cited by 1
Diagnostic Yield and Outcomes of Incidental Thoracic Aortic Dilatation in the National Health Service Targeted Lung Health Check Program: Novel Insights from a Regional Tertiary Center in the United Kingdom
Ahmed, D., Khalid, N., Shrivastava, V., Philips, C., Tariq, K., Sunderji, I. D., Byass, O., & Bhatia, R. (2025) · Circulation · doi:10.1161/circulationaha.124.073264 · Cited by 1
Emergency 33-Week Cesarean Section With 3.4 cm Type A Aortic Dissection Repair in a Patient With Marfan Syndrome: A Multidisciplinary Approach
Jones, A., Bcharah, G., Islam, N., Pan, H., & Smiley, S. (2025) · Cureus · doi:10.7759/cureus.84648 · Cited by 1
“Large registry analyses report that up to 6.4% of type A dissections can be asymptomatic, with multiple case reports published on painless type A dissections [7-11].”
Influential
Biodynamic Characteristics and Blood Pressure Effects of Stanford Type B Aortic Dissection Based on an Accurate Constitutive Model
Wang, Y., Xin, L., Zhou, L., Wu, X., Zhang, J., & Wang, Z. (2025) · Applied Sciences · doi:10.3390/app15115853 · Cited by 1
Association of Shift Work and Lifestyle With Aortic Aneurysm Incidence: A Large Prospective Cohort Study in the UK Biobank
Liu, X., Zhang, X., Gong, C., Hu, H., Qiao, Z., Li, C., Ge, Y., & Zhu, J. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.124.040481 · Cited by 1
Three-dimensional characterization of ascending aortic strain, motion and growth in patients undergoing thoracic endovascular aortic repair
Tjahjadi, N., Jorge, C. C., Marway, P. S., Kim, T., Baker, T., Hazenberg, C. E. V. B., van Herwaarden, J. A., Figueroa, C. A., Patel, H. J., & Burris, N. S. (2025) · JVS Vascular Science · doi:10.1016/j.jvssci.2025.100293 · Cited by 1
“21 We excluded patients with: (1) history of ascending aortic repair, intramural hematoma, or aortitis; (2) poor CTA image quality or VDM analysis failure; and (3) lack of blood pressure data within 1 month of CTA.”
Hospital volume and outcomes of surgical repair in type A acute aortic dissection: A nationwide cohort study
Ayala, I. A. D. L., Chang, F., Chen, C., Cheng, Y.-T., Chan, Y., Wu, V. C., Liu, K., Yeh, C., Chu, P., & Chen, S. (2025) · PLoS ONE · doi:10.1371/journal.pone.0325689 · Cited by 1
“Without surgery, medical treatment has nearly a 60% mortality within the first 24 hours after diagnosis [1].”
Critical Issues in the Evaluation and Management of Adult Patients With Suspected Acute Nontraumatic Thoracic Aortic Dissection
Promes, S. B., Westafer, L. M., Byyny, R. L., Diercks, D. B., Diercks, D. B., Anderson, J., Byyny, R. L., Carpenter, C. R., Finnell, J. T., Friedman, B. W., et al. (2025) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2025.04.002 · Cited by 1
Ten Commandments on Decision Making for Open, Hybrid, and Endovascular Arch Repair
Fazzini, S., Cibin, G., Martelli, E., & D’Onofrio, A. (2025) · Innovations Technology and Techniques in Cardiothoracic and Vascular Surgery · doi:10.1177/15569845251350673 · Cited by 1
Connective tissue disorder and high risk pregnancy: a case series with personalised external aortic root support (PEARS)
Montanaro, C., Kačar, P., Iannaccone, G., Pepper, J., Wander, G., Nienaber, C. A., Hoschtitzky, A. J., Petrou, M., Douglas, H., Johnson, M. R., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-61241-y · Cited by 1
“Medical therapy, in particular beta blockers and ARBs, is recommended according to the recent guidelines 3,8 , but ARBs are not recommended during pregnancy.”
Arterial Tortuosity Syndrome: A Longitudinal Assessment of Cardiovascular Features and Interventions From the Collaborative for Longitudinal Aortic Research in the Young (CLARITY)
Salamat, B., Stephens, S. B., Britt, J. J., Beecroft, T., Taylor, A., Mosquera, L. M., Callewaert, B. L., Beyens, A., Channing, A., DiLorenzo, M. P., et al. (2025) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.64159 · Cited by 1
Two-year outcomes of endovascular repair of isolated thoracic aortic lesions using a single-branch thoracic endograft with left subclavian artery preservation
Hughes, G. C., Dake, M. D., Patel, H. J., Matsumura, J. S., Panneton, J. M., Azizzadeh, A., Lee, J. T., Brinkman, W. T., Lumsden, A. B., & Long, C. A. (2025) · JTCVS Open · doi:10.1016/j.xjon.2025.06.022 · Cited by 1
Secondary Open Surgery for Type a Aortic Dissection Following Thoracic Endovascular Aortic Repair
Xu, W., Wang, C., Wang, G., Zou, Z., Tan, S., Yu, C., & Fan, X. (2025) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2025.06.043 · Cited by 1
Polycystin-1 as a Novel Biomarker for Peripheral Artery Disease: Findings from a Pilot Prospective Study
Pg, T., Georgopoulos, S., Bakoyiannis, C. N., Davos, K., Varela, A., Efentakis, P., Dimopoulos, C., Antoniadis, P. N., Bisdas, T., & Klonaris, C. N. (2025) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2025.07.023 · Cited by 1
Follow up Imaging Protocols after Endovascular Aneurysm Repair: Results of the International FOREVAR Survey
Tran, B. L., Zwetsloot, S. L. M., Teraa, M., Lareyre, F., Kukulski, L., Jongkind, V., Gratl, A., Enzmann, F., de Borst, G. J., Meecham, L., et al. (2025) · EJVES Vascular Forum · doi:10.1016/j.ejvsvf.2025.07.005 · Cited by 1
Extended arch repair with aortic-femoral/iliac bypass if necessary for treating lower extremity malperfusion secondary to acute type A aortic dissection
Chen, Q., Wang, Y., Shao, K., Lai, H., Wang, C., & Ji, Q. (2025) · Asian Journal of Surgery · doi:10.1016/j.asjsur.2025.05.254 · Cited by 1
The association of repair timing on outcomes following thoracic endovascular aortic repair for intramural hematoma
Manchella, M. K., Rastogi, V., Bellomo, T. R., Summers, S., Gaston, B., Kermani, S. S., Dua, A., & Eagleton, M. J. (2025) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2025.08.004 · Cited by 1
Serial [ 18 F]AlF-NOTA-FAPI PET/CT and CT Angiography in Type B Aortic Dissection Before and After Thoracic Endovascular Aortic Repair
Wang, S., Lu, Y., Xue, Y., Han, H., Han, T., Chen, H., Wang, M., Luo, W., Li, H., & Zhang, X. (2025) · Journal of Nuclear Medicine · doi:10.2967/jnumed.125.270511 · Cited by 1
Empfehlungen zur Prävention und Risikooptimierung beim Bauchaortenaneurysma: eine evidenzbasierte und laienverständliche Informationsbroschüre
Behrendt, C., Trenner, M., Busch, A., Rother, U., Dorweiler, B., Adili, F., Hinterseher, I., Pfeiffer, M., Pfeiffer-Krahl, M., & Larena-Avellaneda, A. A. (2025) · Gefässchirurgie · doi:10.1007/s00772-025-01244-7 · Cited by 1
REBECGA: Brazilian Registry of Heart Disease and Pregnancy. Multicenter Epidemiological Study of Heart Diseases in Pregnancy: Retrospective Cohort
Ávila, W. S., de Lucena, A. J. G., Freire, C. M. V., da Silva, F. B., Rivera, I. R., Oliveira, J. R. S., Rivera, M. A. M., de Carvalho, R. C. M., Neto, V. Á., & Tarasoutchi, F. (2025) · Arquivos Brasileiros de Cardiologia · doi:10.36660/abc.20240807 · Cited by 7
Automated quantification of abdominal aortic calcification using 3D nnU-Net: a novel approach to assess AAA rupture risk
Luo, Y.-L., Liu, Y.-F., Huang, Z., Wang, C., Zhang, L., & Huang, S.-C. (2025) · BMC Medical Imaging · doi:10.1186/s12880-025-01911-x · Cited by 1
In vitro characterization of hemodynamics in bicuspid aortic valves: The impact of valve and ascending aortic morphologies
Hattori, K., Nakama, N., Takada, J., Nagao, M., Goto, Y., Niinami, H., & Iwasaki, K. (2025) · Magnetic Resonance in Medicine · doi:10.1002/mrm.70064 · Cited by 1
Preoperative patient education in vascular surgery
Cohen, I. C., Watson, S., Sweeney, P. R., Reilly, M. A., & Ho, K. J. (2025) · Health Education Research · doi:10.1093/her/cyaf031 · Cited by 1
Progression of Ascending Aortic Dimensions in Masters Endurance Athletes
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Authors: Isselbacher, E. M., Preventza, O., Hamilton Black, J., Augoustides, J. G., Beck, A. W., Bolen, M. A., Braverman, A. C., Bray, B. E., Brown-Zimmerman, M. M., Chen, E. P., Collins, T. J., DeAnda, A., Fanola, C. L., Girardi, L. N., Hicks, C. W., Hui, D. S., Schuyler Jones, W., Kalahasti, V., Kim, K. M., Milewicz, D. M., Oderich, G. S., Ogbechie, L., Promes, S. B., Gyang Ross, E., Schermerhorn, M. L., Singleton Times, S., Tseng, E. E., Wang, G. J., Woo, Y. J., Faxon, D. P., Upchurch, G. R., Aday, A. W., Azizzadeh, A., Boisen, M., Hawkins, B., Kramer, C. M., Luc, J. G. Y., MacGillivray, T. E., Malaisrie, S. C., Osteen, K., Patel, H. J., Patel, P. J., Popescu, W. M., Rodriguez, E., Sorber, R., Tsao, P. S., & Santos Volgman, A.
Affiliations: SCA representative.
ACR representative.
American Heart Association (US)
Lay stakeholder representative.
Fraunhofer Institute for Algorithms and Scientific Computing (DE)
AATS representative.
American Hospital Association (US)
AHA/ACC Joint Committee on Clinical Practice Guidelines liaison.
STS representative.
SVS representative.
AHA/ACC staff representative.
ORCID: Isselbacher, Eric M.
Preventza, Ourania
Augoustides, John G.
Beck, Adam W.
Bolen, Michael A.
Braverman, Alan C.
Bray, Bruce E.
Chen, Edward P.
DeAnda, Abe
Fanola, Christina L.
Girardi, Leonard N.
Hicks, Caitlin W.
Hui, Dawn S.
Kalahasti, Vidyasagar
Kim, Karen M.
Milewicz, Dianna M.
Oderich, Gustavo S.
Promes, Susan B.
Schermerhorn, Marc L.
Tseng, Elaine E.
Upchurch, Gilbert R.
Aday, Aaron W.
Azizzadeh, Ali
Boisen, Michael
Kramer, Christopher M.
Luc, Jessica G.Y.
MacGillivray, Thomas E.
Osteen, Kathryn
Patel, Himanshu J.
Patel, Parag J.
Popescu, Wanda M.
Sorber, Rebecca
Tsao, Philip S.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2022-12-13
Volume: 146
Issue: 24
Pages: e334-e482
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/cir.0000000000001106
PMC: PMC9876736
OpenAlex: W4307934708
Cited by: 2,082
References: 1,104
Citations by year: 2026: 600 · 2025: 569 · 2024: 554 · 2023: 348 · 2022: 9
FWCI: 239.09
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
Locations: Circulation (publishedVersion, cc-by)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Veterans Affairs
American Heart Association
Massachusetts General Hospital
American College of Cardiology Foundation
University of Pennsylvania
CryoLife
Office of Science
National Institute of Diabetes and Digestive and Kidney Diseases (K23DK124515)
Division of Cardiothoracic Surgery, University of Colorado School of Medicine, Anschutz Medical Campus
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Aortic Disease and Treatment Approaches
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
Health Sciences › Medicine › Surgery › Aortic aneurysm repair treatments
Keywords: aortic disease, thoracic aortic disease, acute aortic syndrome, aortic aneurysm, aortic dissection, bicuspid aortic valve disease, peripheral arterial disease, genetic evaluation, family screening, endovascular repair, aortic surgery, long-term surveillance, shared decision-making, pregnancy
MeSH terms: Bicuspid Aortic Valve Disease, American Heart Association, Aortic Diseases, Cardiology, Female, Humans, Pregnancy, United States, Research Report

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