Cited by 2,082Aortic Disease and Treatment ApproachesConnective tissue disorders researchAortic aneurysm repair treatments

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2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines

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Isselbacher, Eric M., Preventza, Ourania, Hamilton Black, James, Augoustides, John G., Beck, Adam W., Bolen, Michael A., Braverman, Alan C., Bray, Bruce E., Brown-Zimmerman, Maya M., Chen, Edward P., Collins, Tyrone J., DeAnda, Abe, Fanola, Christina L., Girardi, Leonard N., Hicks, Caitlin W., Hui, Dawn S., Schuyler Jones, William, Kalahasti, Vidyasagar, Kim, Karen M., Milewicz, Dianna M., Oderich, Gustavo S., Ogbechie, Laura, Promes, Susan B., Gyang Ross, Elsie, Schermerhorn, Marc L., Singleton Times, Sabrina, Tseng, Elaine E., Wang, Grace J., Woo, Y. Joseph, Faxon, David P., Upchurch, Gilbert R., Aday, Aaron W., Azizzadeh, Ali, Boisen, Michael, Hawkins, Beau, Kramer, Christopher M., Luc, Jessica G.Y., MacGillivray, Thomas E., Malaisrie, S. Christopher, Osteen, Kathryn, Patel, Himanshu J., Patel, Parag J., Popescu, Wanda M., Rodriguez, Evelio, Sorber, Rebecca, Tsao, Philip S., Santos Volgman, Annabelle·2022·Circulation

DOI 10.1161/cir.0000000000001106PMC PMC9876736

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Abstract

AIM: The "2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease" provides recommendations to guide clinicians in the diagnosis, genetic evaluation and family screening, medical therapy, endovascular and surgical treatment, and long-term surveillance of patients with aortic disease across its multiple clinical presentation subsets (ie, asymptomatic, stable symptomatic, and acute aortic syndromes). METHODS: A comprehensive literature search was conducted from January 2021 to April 2021, encompassing studies, reviews, and other evidence conducted on human subjects that were published in English from PubMed, EMBASE, the Cochrane Library, CINHL Complete, and other selected databases relevant to this guideline. Additional relevant studies, published through June 2022 during the guideline writing process, were also considered by the writing committee, where appropriate. Structure: Recommendations from previously published AHA/ACC guidelines on thoracic aortic disease, peripheral artery disease, and bicuspid aortic valve disease have been updated with new evidence to guide clinicians. In addition, new recommendations addressing comprehensive care for patients with aortic disease have been developed. There is added emphasis on the role of shared decision making, especially in the management of patients with aortic disease both before and during pregnancy. The is also an increased emphasis on the importance of institutional interventional volume and multidisciplinary aortic team expertise in the care of patients with aortic disease.

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Lin, X., Gao, H., Wu, Q., Xie, Y., Chen, L., & Xie, L.-F. (2025) · Annals of Medicine · doi:10.1080/07853890.2025.2457530 · Cited by 7
Cardiac Tamponade Complicating Type A Acute Aortic Dissection
Gilon, D., Korach, A., Carbone, A., Evangelista, A., Brinster, D. R., Estrera, A. L., Peterson, M. D., Chen, E. P., Bekeredjian, R., Pai, C.-W., et al. (2025) · JACC Advances · doi:10.1016/j.jacadv.2025.101632 · Cited by 7
Non-canonical splice variants in thoracic aortic dissection cases and Marfan syndrome with negative genetic testing
Murdock, D. R., Guo, D., DePaolo, J. S., Schwarze, U., Duan, X., Cecchi, A. C., Marin, I. C., Tang, Y., Chong, J. X., Bamshad, M. J., et al. (2025) · npj Genomic Medicine · doi:10.1038/s41525-025-00472-w · Cited by 7
Phosphodiesterase 5 inactivation in vascular smooth muscle cells aggravates aortic aneurysm and dissection
Feng, Y., Xue, Y., Feng, X., Li, Z., Ren, L., Guo, W., Hou, Y., Shu, T., Zhang, W., Yang, Y., et al. (2025) · The Journal of Pathology · doi:10.1002/path.6411 · Cited by 7
Point of care ultrasound for monitoring and resuscitation in patients with shock
Martínez, Á. R., Luordo, D., Rodríguez-Moreno, J., Esteban, A. D. P., & Arrese, M. T. (2025) · Internal and Emergency Medicine · doi:10.1007/s11739-025-03898-3 · Cited by 10
Aorta Wall Stress during Exercise in Patients with an Ascending Thoracic Aortic Aneurysm: Insights from a Case Series
Haykowsky, M. J., Skow, R. J., Foulkes, S., Grenier, J. G., Elefteriades, J. A., Thompson, R. B., & McMurtry, M. S. (2024) · Aorta · doi:10.1055/a-2558-4266 · Cited by 7
Optimal Management of Spontaneous Aortic Thrombus Floating in the Ascending Aorta, from a Single Case Experience to a Literature Review
Gardellini, J., Linardi, D., Nicola, V. D., Puntel, G., Puppini, G., Barozzi, L., & Luciani, G. B. (2025) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd12040146 · Cited by 7
“Guidelines about aortic pathology describe the possibility of medical management and surgical treatment of the condition, but a case-by-case evaluation is mandatory to determine the best choice between the two [56].”
Deficiency of fibroblast growth factor 2 promotes contractile phenotype of pericytes in ascending thoracic aortic aneurysm
Huang, W., Hill, J. C., Patel, S., Richards, T. D., Sultan, I. S., Kaczorowski, D. J., & Phillippi, J. A. (2025) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00834.2024 · Cited by 7
Cardiac positron emission tomography/Computed tomography (PET/CT) in current cardiology guidelines
Alwan, M., Yaman, A. E., Sayed, A., Shaikh, A., Rifai, M. A., & Al-Mallah, M. H. (2025) · Journal of Nuclear Cardiology · doi:10.1016/j.nuclcard.2025.102231 · Cited by 7
Impact of Residual Intimal Flap Displacement Post-TEVAR on TBAD Haemodynamics in Compliant, Patient-specific CFD Simulations Informed by MRI
Girardin, L., Lind, N., von Tengg‐Kobligk, H., Balabani, S., & Díaz‐Zuccarini, V. (2025) · Annals of Biomedical Engineering · doi:10.1007/s10439-025-03739-6 · Cited by 7
Intravascular Ultrasound Impact on Endovascular Treatment of Type B Aortic Dissection: A Single-Center Retrospective Study
Girolamo, A. D., Miceli, F., Dajci, A., Cangiano, R., Ascione, M., Sterpetti, A. V., di Marzo, L., & Mansour, W. (2025) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2025.04.134 · Cited by 7
A Deep Learning Model for Identifying the Risk of Mesenteric Malperfusion in Acute Aortic Dissection Using Initial Diagnostic Data: Algorithm Development and Validation
Jin, Z., Dong, J., Li, C., Jiang, Y., Yang, J., Xu, L., Li, P., Xie, Z., Li, Y., Wang, D., et al. (2025) · Journal of Medical Internet Research · doi:10.2196/72649 · Cited by 7
Endovascular repair of the ascending aorta in the Vascular Quality Initiative
de Kort, J. F., Mandigers, T. J., Jabbour, G., Allievi, S., Yadavalli, S. D., Rastogi, V., Zettervall, S. L., O’Donnell, T. F. X., van Herwaarden, J. A., Trimarchi, S., et al. (2025) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2025.06.046 · Cited by 7
Systematic Review and Meta-Analysis on the BeGraft Peripheral and BeGraft Peripheral PLUS Outcomes as Bridging Covered Stents in Fenestrated and Branched Endovascular Aortic Repair
Apostolidis, G., Nana, P., Torrealba, J. I., Panuccio, G., Katsargyris, Α., & Kölbel, T. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14155221 · Cited by 7
“The latest available guidelines recommend the application of f/bEVAR as first-line treatment in patients with complex aortic aneurysms and high surgical risk [29,30].”
Prognostic Implications of the Periaortic Fat Attenuation Index in Uncomplicated Type B Aortic Dissection
Adachi, Y., Ueda, K., Otaki, Y., Hashimoto, M., Sowa, H., Kawahara, T., Numata, G., Nakamura, S., Hinata, M., Uehara, M., et al. (2025) · Radiology Cardiothoracic Imaging · doi:10.1148/ryct.240521 · Cited by 7
Deep learning algorithm for predicting rapid progression of abdominal aortic aneurysm by integrating CT images and clinical features
Oh, S. J., Shin, J.-I., Kim, E. N., Widiastini, A., Hong, Y., Sohn, I., Jin, K. N., Lim, J. S., Kim, J. S., Choi, H.-J., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-22167-z · Cited by 9
Neurological complications post aortic arch surgery: a state of art review
Abdul‐Rahman, T., Mueller-Gomez, J. L., Gaur, A., Luna, M. L., Lisbona-Buzali, M., Herrera‐Calderón, R. E., Thaalibi, H. I., Roy, P., Mena-Guerrero, T., Arshad, M. A., et al. (2025) · Journal of Cardiothoracic Surgery · doi:10.1186/s13019-025-03706-1 · Cited by 7
Diagnosis and management of heritable thoracic aortic diseases
Backer, J. F. A. D., Mosquera, L. M., Rodríguez-Palomares, J. F., & Teixidó‐Turà, G. (2026) · Heart · doi:10.1136/heartjnl-2025-326230 · Cited by 7
Race and Socioeconomic Disparities in Proximal Aortic Surgery
Newell, P. C., Zogg, C. K., Asokan, S., Reed, A. K., Vinholo, T. F., Harloff, M. T., Hirji, S. A., Kerolos, M., Kaneko, T., & Sabe, A. A. (2023) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2023.03.032 · Cited by 7
Watch-and-wait strategy for selected patients with type A intramural hematoma
Kitamura, T., Fukuzumi, M., Mishima, T., Shikata, F., Motoji, Y., Tamura, Y., Horikoshi, R., Yokozuka, H., Ishiwaki, D., & Miyaji, K. (2023) · General Thoracic and Cardiovascular Surgery · doi:10.1007/s11748-023-01967-y · Cited by 7
Biomechanical properties of the aortic root are distinct from those of the ascending aorta in both normal and aneurysmal states
Chung, J. C.-Y., Eliathamby, D., Seo, H., Fan, C. S., Islam, R., Deol, K., Simmons, C. A., & Ouzounian, M. (2023) · JTCVS Open · doi:10.1016/j.xjon.2023.08.015 · Cited by 7
Serum Sema7A is increased in patients with acute aortic dissection
Lyu, X., Liu, X., Gong, H., Liu, Y., Zhou, Z., Hu, M., & Zhang, X. (2023) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2023.2254693 · Cited by 7
Stress Load and Ascending Aortic Aneurysms: An Observational, Longitudinal, Single-Center Study Using Computational Fluid Dynamics
de Azevedo, F. S., Almeida, G. D. C., de Azevedo, B. A., Aguilar, I. F. I., Azevedo, B., Teixeira, P., Camargo, G., Correia, M., Nieckele, A., & Oliveira, G. (2024) · Bioengineering · doi:10.3390/bioengineering11030204 · Cited by 5
“Asymptomatic, its diagnosis often occurs as an acute aortic syndrome (a life-threatening condition with aortic wall rupture), via a postmortem diagnosis or as an incidental finding when a patient undergoes imaging tests due to other causes [3].”
BackgroundMethodInfluential
Sex-based outcomes after thoracic endovascular aortic repair: A systematic review and meta-analysis
Zhang, Y., Zhang, Y., Wang, Y., Lai, H., Fu, W., Wang, C., Wang, L., & Ji, Q. (2024) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2024.04.024 · Cited by 7
Sex Comparative Analysis of Branched and Fenestrated Endovascular Aortic Arch Repair Outcomes
Nana, P., Panuccio, G., Torrealba, J. I., Rohlffs, F., Spanos, K. T., & Kölbel, T. (2024) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2024.04.030 · Cited by 7
Predictors of overall mortality after endovascular abdominal aortic repair – A single centre study
Rašiová, M., Koščo, M., Pavlíková, V., Hudák, M., Moščovič, M., & Kočan, L. (2024) · Vascular · doi:10.1177/17085381241262350 · Cited by 7
Development and Assessment of a Point-of-Care Application (Genomic Medicine Guidance) for Heritable Thoracic Aortic Disease
Patil, R., Ashraf, F., Dayeh, S. A., & Prakash, S. K. (2024) · JMIRx Med · doi:10.2196/55903 · Cited by 7
Predictors of In-Hospital Mortality in Type A Acute Aortic Syndrome: Data From the RENADA-RO Registry
Matei, D.-C., Antohi, E., Radu, R. I., Ciobanu, C. G., Geavlete, O. D., Filipescu, D., Bubenek, Ș., Moldovan, H., Iliescu, V. A., & Chioncel, O. (2024) · Heart Lung and Circulation · doi:10.1016/j.hlc.2024.02.016 · Cited by 7
Risk factors for abdominal aortic aneurysm in patients with diabetes
Cho, I. Y., Han, K., Lee, K. N., Koo, H. Y., Cho, Y. H., Lee, J. H., Park, Y., & Shin, D. W. (2024) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2024.09.007 · Cited by 7
Conventional aortic root vs valve-sparing root replacement surgery in aortic dilatation syndromes: a comparison of mortality and postoperative complications
Rashid, H. N. Z., Chehab, O., Hurrell, H., Androshchuk, V., Sularz, A., Patterson, T., Lucchese, G., & Redwood, S. R. (2022) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2023.2162039 · Cited by 7
Endovascular repair of a common iliac artery aneurysm with an iliac branch device in a patient with vascular Ehlers-Danlos syndrome due to a null COL3A1 variant
Shalhub, S., & Byers, P. H. (2023) · Journal of Vascular Surgery Cases and Innovative Techniques · doi:10.1016/j.jvscit.2023.101192 · Cited by 7
Late Outcomes of Surgery Versus Medical Therapy in Patients With Type A Aortic Intramural Hematoma: Meta-Analysis of Reconstructed Time-to-Event Data
Sá, M. P., Tasoudis, P., Jacquemyn, X., Caranasos, T. G., Ikonomidis, J. S., Serna-Gallegos, D. R., Sultan, I. S., & Chu, D. (2023) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2023.10.009 · Cited by 7
Case Report: Successful endovascular treatment of acute type A aortic dissection
Pitts, L., Heck, R., Montagner, M., Penkalla, A., Kofler, M., Falk, V., Kempfert, J., & Buz, S. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1299192 · Cited by 7
Multidisciplinary Teams: Better Together
Cormican, D. S. (2023) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2023.05.025 · Cited by 7
Genetic Problems, Diagnosis, and Cardiovascular Manifestations of Loeys-Dietz Syndrome
Dey, S., Cheikhali, R., Frishman, W. H., & Aronow, W. S. (2023) · Cardiology in Review · doi:10.1097/crd.0000000000000544 · Cited by 6
The current and future role of imaging of thoracic aortic disease: a North American society for cardiovascular imaging commentary on the 2022 AHA/ACC guidelines for the diagnosis and management of aortic disease
Hamid, A., Gupta‐Malhotra, M., Rajiah, P. S., Abbara, S., Hanneman, K. A., & Allen, B. D. (2023) · The International Journal of Cardiovascular Imaging · doi:10.1007/s10554-023-02964-1 · Cited by 6
Acute Type A Aortic Dissection Diagnosed by POCUS in a 29-year-old Man
López, V., & Blanco, P. (2023) · POCUS Journal · doi:10.24908/pocus.v8i2.16533 · Cited by 6
Effect of Asymptomatic Common Carotid Artery Dissection on the Prognosis of Patients With Acute Type A Aortic Dissection
Jia, S., Wang, M., Liu, Y., Gong, M., Jiang, W., & Zhang, H. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.123.031542 · Cited by 6
Current understanding of the genetics of thoracic aortic disease
Levy, L. E., Zak, M., & Glotzbach, J. P. (2024) · Vessel Plus · doi:10.20517/2574-1209.2023.55 · Cited by 7
Practice Patterns and Barriers to Vascular Genetic Testing Among Vascular Surgeons
Dittman, J. M., Prakash, S. K., Gupta, P. C., Wiszniewski, W. K., Singh, N. N., Smeds, M. R., & Shalhub, S. (2024) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2024.01.032 · Cited by 6
Navigating clinical appropriateness: A review of management strategies for type B aortic dissection
Afifi, R. O., & Mussa, F. F. (2024) · Seminars in Vascular Surgery · doi:10.1053/j.semvascsurg.2024.04.005 · Cited by 6
Impact of nondiameter aortic indices on surgical eligibility: Results from the Treatment in Thoracic Aortic Aneurysm: Surgery Versus Surveillance (TITAN: SvS) randomized controlled trial
Dagher, O., Appoo, J. J., Herget, E. J., Atoui, R., Baeza, C. R., Brinkman, W. T., Bozinovski, J., Chu, M. W. A., Dagenais, F., Demers, P., et al. (2024) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2024.04.010 · Cited by 6
Retrograde aortic dissection during thoracic endovascular aortic repair: How to prevent and treat
Rstum, Z. A., & Afifi, R. O. (2024) · Journal of Vascular Surgery Cases and Innovative Techniques · doi:10.1016/j.jvscit.2024.101524 · Cited by 6
The combined use of serum Raman spectroscopy and D dimer testing for the early diagnosis of acute aortic dissection
Han, X., Wang, S., Cai, R., Chen, Q., Li, J., Zhong, L., Ji, S., Mei, X., Wu, R., Yang, Y., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e32474 · Cited by 6
“Conversely, advanced imaging modalities such as computed tomography (CT) and magnetic resonance imaging (MRI) are highly accurate and are considered the preferred diagnostic techniques for AAD [1].”
BackgroundMethod
Whole aorta imaging shows increased risk for thoracic aortic aneurysms and dilatations in relatives of abdominal aortic aneurysm patients
Liu, H., IJpma, A. S., de Bruin, J. L., Verhagen, H. J. M., Roos‐Hesselink, J. W., Bekkers, J. A., Brüggenwirth, H. T., van Beusekom, H. M. M., & Majoor‐Krakauer, D. F. (2024) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2024.10.067 · Cited by 6
Biomechanical stress analysis of Type-A aortic dissection at pre-dissection, post-dissection, and post-repair states
Sun, C., Qin, T., Kalyanasundaram, A., Elefteriades, J. A., Sun, W., & Liang, L. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2024.109310 · Cited by 6
Contribution of rare chromosome 22q11.2 copy number variants to non-syndromic bicuspid aortic valve
DiGregorio, H. R., Mansoorshahi, S., Carlisle, S. G., Pensa, C. T., Watts, A., McNeely, C., Sabaté-Rotés, A., Yetman, A. T., Michelena, H. I., Backer, J. F. A. D., et al. (2024) · Heart · doi:10.1136/heartjnl-2024-324669 · Cited by 6
Protein Drug Targets for Abdominal Aortic Aneurysm and Proteomic Associations Between Modifiable Risk Factors and Abdominal Aortic Aneurysm
Qi, Y., Jiang, H., Lun, Y., Gang, Q., Shen, S., Zhang, H., Liu, M., Wang, Y., & Zhang, J. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.124.037802 · Cited by 6
Follow-up of incidentally detected mild to moderate ascending aortic dilation and risk factors for rapid progression in a Swedish middle-aged population
Kylhammar, D., Nilsson, F., Dyverfeldt, P., Hammaréus, F., Jonasson, L., Trzebiatowska‐Krzynska, A., Lindenberger, M., Nilsson, L., Nyström, F. H., Trenti, C., et al. (2025) · Heart · doi:10.1136/heartjnl-2024-325409 · Cited by 6
Aortopathy associated with bicuspid aortic valve: advances in clinical and hemodynamics research
Yang, M., Nie, Z., Yue, H., Liang, W., & Wu, Z. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1576072 · Cited by 6
Sex- and age-dependent neurovascular abnormalities linked to neuroinflammation lead to exacerbated post-ischemic brain injury in Marfan syndrome mice
Manich, G., Pérez, B., Penas, C., Dantas, A. P., Coutinho, J., Sánchez-Bernadó, P., García-Aranda, J., Fraile-Ramos, J., Benseny‐Cases, N., Martín‐Mur, B., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103662 · Cited by 6
Integrated multidisciplinary approach to aneurysm hemodynamic analysis: numerical simulation, in Vitro experiment, and deep learning
Fan, T., Wang, J., Wang, X., Chen, X., Zhao, D., Xie, F., & Chen, G. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1602190 · Cited by 6
Loss of wall stress homeostasis in ascending thoracic aortic aneurysm: histomorphometric insights into patient variants
Ganizada, B., Reesink, K. D., Parikh, S., Saraber, P. J. M. H., Cleutjens, J. P. M., Isabella, A., Krebbekx, M. Q. E., Jaminon, A. M. G., Maassen, C., Ramaekers, M. J. F. G., et al. (2025) · The Journal of Physiology · doi:10.1113/jp288734 · Cited by 6
Intra-Arterial Versus Noninvasive Blood Pressure Monitoring: A Systematic Review and Meta-Analysis
Becker, L., Bzhilyanskaya, V., Sharman, A., Moran, M., Sayal, J., Gaur, A., Shaw, A., Gorman, E. F., Pourmand, A., & Tran, Q. K. (2025) · American Journal of Critical Care · doi:10.4037/ajcc2025348 · Cited by 6
Inherited aortopathies and risk of aortic dissection and aortic syndrome in pregnancy
Chalk, T., Burns, K., & Morton, A. (2025) · Obstetric Medicine · doi:10.1177/1753495x251359834 · Cited by 6
Personalized external aortic root support: The Dutch experience
Kougioumtzoglou, A. M., Lam, B. C. Y., Bouma, B. J., Groenink, M., Scholte, A. J. H. A., Dolmaci, O. B., Corsmit, O. T., Pandey, A. K., de Blok, A. C. J., Noter, S. L., et al. (2025) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2025.07.041 · Cited by 6
Surgery Versus Surveillance: A Quality-of-Life Analysis of Patients With Moderately Dilated Aortic Root or Ascending Aorta
Guo, M. H., Appoo, J. J., Demers, P., Hafsa, E. S., Jassar, A. S., Patel, H. J., Brinkman, W. T., Ouzounian, M., Atoui, R., Grau, J. B., et al. (2025) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezaf288 · Cited by 6
Spinal cord protection in open and endovascular aortic surgery: current strategies, controversies and future directions
Torre, D. E., & Pirri, C. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1671350 · Cited by 6
Long Term Target Vessel Outcomes in Patients Treated with Fenestrated Endovascular Aortic Repair
Apostolidis, G., Nana, P., Panuccio, G., Sarhan, D. Y. A., Torrealba, J. I., & Kölbel, T. (2026) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2026.01.058 · Cited by 6
Masters Athletes With Abnormal Cardiovascular Findings
Eijsvogels, T. M. H., Kim, J. H., Aengevaeren, V. L., D’Ascenzi, F., Churchill, T., Dineen, E. H., la Garza, M. S., Gati, S., Hálasz, G., Haugaa, K. H., et al. (2026) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2026.03.025 · Cited by 9
Persistent malperfusion after central aortic repair in acute type I aortic dissections
Doenges, J. E., Reed, A. B., Huddleston, S. J., Wang, Q., & Valentine, R. J. (2023) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2023.02.004 · Cited by 6
Changes in treatment patterns of thoracoabdominal aortic aneurysms in the United States
Mohnot, J., Wang, Y., Yin, K., Malas, M. B., Edwards, N. M., Dobrilovic, N., & Zhan, Y. (2023) · JTCVS Open · doi:10.1016/j.xjon.2023.08.019 · Cited by 6
Predicting acute aortic syndrome using aortic dissection detection risk score, D-dimer, and X-ray
Song, D. H., Choi, J. H., & Lee, J. Y. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e20578 · Cited by 6
Traumatic Aortic Dissection as a Unique Clinical Entity: A Single-Center Retrospective Study
Gang, Q., Lun, Y., Pang, L., Li, X., Hou, B., Xin, S., & Zhang, J. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12247535 · Cited by 6
“The American College of Cardiology (ACC) and the American Heart Association (AHA) 2022 guidelines for the Diagnosis and Management of Aortic Disease indicate that the timing of surgical intervention remains unclear [6].”
Background
Protruding Aortic Plaque and Coronary Plaque Vulnerability
Yuki, H., Isselbacher, E. M., Niida, T., Suzuki, K., Kinoshita, D., Fujimoto, D., Lee, H., McNulty, I. A., Nakamura, S., Kakuta, T., et al. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.123.032742 · Cited by 6
Morphological risk of acute type A aortic dissection in the mildly to moderately dilated aorta
Sun, L., Li, H., Feng, X., Li, X., Wang, G., Sun, J., Zhang, X., Zhang, W., Wang, J., Niu, Z., et al. (2024) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezae016 · Cited by 6
Impact of biological sex on valvular heart disease, interventions, and outcomes
Wiens, E. J., Kawa, K. L., Kass, M., & Shah, A. H. (2024) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2023-0390 · Cited by 6
Descending Thoracic and Thoracoabdominal Aortic Aneurysm Repairs: The Society of Thoracic Surgeons Adult Cardiac Surgery Database Analysis
Chen, Q., Malas, J., Tam, D. Y., Megna, D. J., Desai, N. D., Estrera, A. L., Azizzadeh, A., Shah, A. S., Chikwe, J., & Bowdish, M. E. (2024) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2024.07.031 · Cited by 6
Enhancing Neuroprotection in Cardiac and Aortic Surgeries: A Narrative Review
Torre, D. E., & Pirri, C. (2024) · Anesthesia Research · doi:10.3390/anesthres1020010 · Cited by 6
Late diagnosis of Marfan syndrome is associated with unplanned aortic surgery and cardiovascular death
Claus, J., Schoof, L., Mir, T. S., Kammal, A. L., Schön, G., Kutsche, K., Behrendt, C., Kallenbach, K., Kölbel, T., Kubisch, C., et al. (2024) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2024.09.016 · Cited by 6
Role for Lumbar Cerebrospinal Fluid Drainage in High-risk Thoracic Endovascular Aortic Repair: A Narrative Review
Shelton, T., Gigax, B., Aly, A. H., Choi, K., Tili, E., Orion, K. C., Modarai, B., Beck, A. W., Grocott, H. P., & Awad, H. (2024) · Anesthesiology · doi:10.1097/aln.0000000000005200 · Cited by 6
Detection of Aortic Dissection and Intramural Hematoma in Non-Contrast Chest Computed Tomography Using a You Only Look Once-Based Deep Learning Model
Kim, Y.-S., Kim, J. G., Choi, H. Y., Lee, D., Kong, J.-W., Kang, G. H., Jang, Y. S., Kim, W., Lee, Y., Kim, J., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13226868 · Cited by 6
“The diagnosis of AD and IMH is generally based on imaging tests [13].”
Cardiac remodeling and antihypertensive medication changes after thoracic endovascular aortic repair vs open surgical repair
Yuan, K., Potluri, V. K., Gorantla, A., Khan, N., Helenowski, I., Soult, M. C., Schwartz, J., & Bechara, C. F. (2024) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2024.11.007 · Cited by 5
New systemic inflammatory indices as predictors of ascending aortic dilation in children with bicuspid aortic valve: A retrospective cross-sectional study
Yükçü, B., & Arslan, H. F. (2024) · Medicine · doi:10.1097/md.0000000000040904 · Cited by 6
Functional anti-inflammatory mesoporous silica nanoplatform for Synergistic and Targeted abdominal aortic aneurysm treatment.
Wu, Z.-Y., Wu, X.-Y., Meng, X.-T., Lei, J., Zeng, C., Pu, H.-J., Liu, Y.-J., Xu, Z.-J., Wu, X.-D., Huang, S., et al. (2024) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2024.12.140 · Cited by 6
Sodium Nitroprusside: The Forgotten Vasodilator? A Brief Guide for Informed and Safe Use from Heart Failure to Hypertensive Crisis and Aortic Dissection
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Authors: Isselbacher, E. M., Preventza, O., Hamilton Black, J., Augoustides, J. G., Beck, A. W., Bolen, M. A., Braverman, A. C., Bray, B. E., Brown-Zimmerman, M. M., Chen, E. P., Collins, T. J., DeAnda, A., Fanola, C. L., Girardi, L. N., Hicks, C. W., Hui, D. S., Schuyler Jones, W., Kalahasti, V., Kim, K. M., Milewicz, D. M., Oderich, G. S., Ogbechie, L., Promes, S. B., Gyang Ross, E., Schermerhorn, M. L., Singleton Times, S., Tseng, E. E., Wang, G. J., Woo, Y. J., Faxon, D. P., Upchurch, G. R., Aday, A. W., Azizzadeh, A., Boisen, M., Hawkins, B., Kramer, C. M., Luc, J. G. Y., MacGillivray, T. E., Malaisrie, S. C., Osteen, K., Patel, H. J., Patel, P. J., Popescu, W. M., Rodriguez, E., Sorber, R., Tsao, P. S., & Santos Volgman, A.
Affiliations: SCA representative.
ACR representative.
American Heart Association (US)
Lay stakeholder representative.
Fraunhofer Institute for Algorithms and Scientific Computing (DE)
AATS representative.
American Hospital Association (US)
AHA/ACC Joint Committee on Clinical Practice Guidelines liaison.
STS representative.
SVS representative.
AHA/ACC staff representative.
ORCID: Isselbacher, Eric M.
Preventza, Ourania
Augoustides, John G.
Beck, Adam W.
Bolen, Michael A.
Braverman, Alan C.
Bray, Bruce E.
Chen, Edward P.
DeAnda, Abe
Fanola, Christina L.
Girardi, Leonard N.
Hicks, Caitlin W.
Hui, Dawn S.
Kalahasti, Vidyasagar
Kim, Karen M.
Milewicz, Dianna M.
Oderich, Gustavo S.
Promes, Susan B.
Schermerhorn, Marc L.
Tseng, Elaine E.
Upchurch, Gilbert R.
Aday, Aaron W.
Azizzadeh, Ali
Boisen, Michael
Kramer, Christopher M.
Luc, Jessica G.Y.
MacGillivray, Thomas E.
Osteen, Kathryn
Patel, Himanshu J.
Patel, Parag J.
Popescu, Wanda M.
Sorber, Rebecca
Tsao, Philip S.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2022-12-13
Volume: 146
Issue: 24
Pages: e334-e482
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/cir.0000000000001106
PMC: PMC9876736
OpenAlex: W4307934708
Cited by: 2,082
References: 1,104
Citations by year: 2026: 600 · 2025: 569 · 2024: 554 · 2023: 348 · 2022: 9
FWCI: 239.09
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
Locations: Circulation (publishedVersion, cc-by)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Veterans Affairs
American Heart Association
Massachusetts General Hospital
American College of Cardiology Foundation
University of Pennsylvania
CryoLife
Office of Science
National Institute of Diabetes and Digestive and Kidney Diseases (K23DK124515)
Division of Cardiothoracic Surgery, University of Colorado School of Medicine, Anschutz Medical Campus
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Aortic Disease and Treatment Approaches
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
Health Sciences › Medicine › Surgery › Aortic aneurysm repair treatments
Keywords: aortic disease, thoracic aortic disease, acute aortic syndrome, aortic aneurysm, aortic dissection, bicuspid aortic valve disease, peripheral arterial disease, genetic evaluation, family screening, endovascular repair, aortic surgery, long-term surveillance, shared decision-making, pregnancy
MeSH terms: Bicuspid Aortic Valve Disease, American Heart Association, Aortic Diseases, Cardiology, Female, Humans, Pregnancy, United States, Research Report

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