Cited by 2,082Aortic Disease and Treatment ApproachesConnective tissue disorders researchAortic aneurysm repair treatments

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2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines

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Isselbacher, Eric M., Preventza, Ourania, Hamilton Black, James, Augoustides, John G., Beck, Adam W., Bolen, Michael A., Braverman, Alan C., Bray, Bruce E., Brown-Zimmerman, Maya M., Chen, Edward P., Collins, Tyrone J., DeAnda, Abe, Fanola, Christina L., Girardi, Leonard N., Hicks, Caitlin W., Hui, Dawn S., Schuyler Jones, William, Kalahasti, Vidyasagar, Kim, Karen M., Milewicz, Dianna M., Oderich, Gustavo S., Ogbechie, Laura, Promes, Susan B., Gyang Ross, Elsie, Schermerhorn, Marc L., Singleton Times, Sabrina, Tseng, Elaine E., Wang, Grace J., Woo, Y. Joseph, Faxon, David P., Upchurch, Gilbert R., Aday, Aaron W., Azizzadeh, Ali, Boisen, Michael, Hawkins, Beau, Kramer, Christopher M., Luc, Jessica G.Y., MacGillivray, Thomas E., Malaisrie, S. Christopher, Osteen, Kathryn, Patel, Himanshu J., Patel, Parag J., Popescu, Wanda M., Rodriguez, Evelio, Sorber, Rebecca, Tsao, Philip S., Santos Volgman, Annabelle·2022·Circulation

DOI 10.1161/cir.0000000000001106PMC PMC9876736

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Abstract

AIM: The "2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease" provides recommendations to guide clinicians in the diagnosis, genetic evaluation and family screening, medical therapy, endovascular and surgical treatment, and long-term surveillance of patients with aortic disease across its multiple clinical presentation subsets (ie, asymptomatic, stable symptomatic, and acute aortic syndromes). METHODS: A comprehensive literature search was conducted from January 2021 to April 2021, encompassing studies, reviews, and other evidence conducted on human subjects that were published in English from PubMed, EMBASE, the Cochrane Library, CINHL Complete, and other selected databases relevant to this guideline. Additional relevant studies, published through June 2022 during the guideline writing process, were also considered by the writing committee, where appropriate. Structure: Recommendations from previously published AHA/ACC guidelines on thoracic aortic disease, peripheral artery disease, and bicuspid aortic valve disease have been updated with new evidence to guide clinicians. In addition, new recommendations addressing comprehensive care for patients with aortic disease have been developed. There is added emphasis on the role of shared decision making, especially in the management of patients with aortic disease both before and during pregnancy. The is also an increased emphasis on the importance of institutional interventional volume and multidisciplinary aortic team expertise in the care of patients with aortic disease.

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Czerny, M., Grabenwöger, M., Berger, T., Aboyans, V., Corte, A. D., Chen, E. P., Desai, N. D., Dumfarth, J., Elefteriades, J. A., Etz, C. D., et al. (2024) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2024.01.021 · Cited by 375
2025 ESC Guidelines for the management of cardiovascular disease and pregnancy
Backer, J. F. A. D., Haugaa, K. H., Hasselberg, N. E., de Hosson, M., Brida, M., Castelletti, S., Cauldwell, M., Cerbai, E., Crotti, L., de Groot, N. M. S., et al. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf193 · Cited by 380
2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines
Jones, D. W., Ferdinand, K. C., Taler, S. J., Johnson, H. M., Shimbo, D., Abdalla, M., Altieri, M. M., Bansal, N., Bello, N. A., Bress, A. P., et al. (2025) · Hypertension · doi:10.1161/hyp.0000000000000249 · Cited by 424
2026 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association
Palaniappan, L. P., Allen, N. B., Almarzooq, Z., Anderson, C. A. M., Arora, P. K., Avery, C. L., Baker-Smith, C. M., Bansal, N., Currie, M. E., Earlie, R. S., et al. (2026) · Circulation · doi:10.1161/cir.0000000000001412 · Cited by 343
2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults
Jones, D. W., Ferdinand, K. C., Taler, S. J., Johnson, H. M., Shimbo, D., Abdalla, M., Altieri, M. M., Bansal, N., Bello, N. A., Bress, A. P., et al. (2025) · JACC · doi:10.1016/j.jacc.2025.05.007 · Cited by 280
2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines
Jones, D. W., Ferdinand, K. C., Taler, S. J., Johnson, H. M., Shimbo, D., Abdalla, M., Altieri, M. M., Bansal, N., Bello, N. A., Bress, A. P., et al. (2025) · Circulation · doi:10.1161/cir.0000000000001356 · Cited by 335
Clinical practice guidelines for the care of girls and women with Turner syndrome.
Gravholt, C. H., Andersen, N. H., Christin-Maitre, S., Davis, S. M., Duijnhouwer, A., Gawlik, A., Maciel-Guerra, A. T., Gutmark-Little, I., Fleischer, K., Hong, D., et al. (2024) · European Journal of Endocrinology · doi:10.1093/ejendo/lvae050 · Cited by 224
Mendelian Randomization as a Tool for Cardiovascular Research
Levin, M. G., & Burgess, S. (2023) · JAMA Cardiology · doi:10.1001/jamacardio.2023.4115 · Cited by 123
The dietary inflammatory index and its association with the prevalence of hypertension: A cross-sectional study
Zhou, N., Xie, Z.-P., Liu, Q., Xu, Y., Dai, S.-C., Lu, J., Weng, J., & Wu, L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1097228 · Cited by 87
Fate of the unoperated ascending thoracic aortic aneurysm: three-decade experience from the Aortic Institute at Yale University
Wu, J., Zafar, M. A., Liu, Y., Chen, J. F., Li, Y., Ziganshin, B. A., Ellauzi, H., Mukherjee, S. K., Rizzo, J. A., & Elefteriades, J. A. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad148 · Cited by 76
Clinical Considerations for Competitive Sports Participation for Athletes With Cardiovascular Abnormalities: A Scientific Statement From the American Heart Association and American College of Cardiology
Kim, J. H., Baggish, A. L., Levine, B. D., Ackerman, M. J., Day, S. M., Dineen, E. H., Guseh, J. S., Gerche, A. L., Lampert, R. J., Martinez, M. W., et al. (2025) · Circulation · doi:10.1161/cir.0000000000001297 · Cited by 83
Cardiovascular Management of Aortopathy in Children: A Scientific Statement From the American Heart Association
Morris, S. A., Flyer, J. N., Yetman, A. T., Quezada, E., Cappella, E., Dietz, H. C., Milewicz, D. M., Ouzounian, M., Rigelsky, C. M., Tierney, E. S. S., et al. (2024) · Circulation · doi:10.1161/cir.0000000000001265 · Cited by 74
Unveiling cellular and molecular aspects of ascending thoracic aortic aneurysms and dissections
Ganizada, B., Veltrop, R. J. A., Akbulut, A. C., Koenen, R. R., Accord, R. E., Lorusso, R., Maessen, J. G., Reesink, K. D., Bidar, E., & Schurgers, L. J. (2024) · Basic Research in Cardiology · doi:10.1007/s00395-024-01053-1 · Cited by 59
Early and Late Aortic-Related Mortality and Rupture After Fenestrated-Branched Endovascular Aortic Repair of Thoracoabdominal Aortic Aneurysms: A Prospective Multicenter Cohort Study
Oderich, G. S., Huang, Y., Harmsen, W. S., Tenorio, E. R., Schanzer, A. S., Timaran, C. H., Schneider, D. B., Mendes, B. C., Eagleton, M. J., Farber, M. A., et al. (2024) · Circulation · doi:10.1161/circulationaha.123.068234 · Cited by 59
Aortic aneurysms in a general population cohort: prevalence and risk factors in men and women
Pham, M. H. C., Sigvardsen, P. E., Fuchs, A., Kühl, J. T., Sillesen, H. H., Afzal, S., Nordestgaard, B. G., Køber, L., & Kofoed, K. F. (2024) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jeae103 · Cited by 55
Coarctation of the Aorta: Modern Paradigms Across the Lifespan
Salciccioli, K. B., & Zachariah, J. P. V. (2023) · Hypertension · doi:10.1161/hypertensionaha.123.19454 · Cited by 57
The effectiveness of tocilizumab and its comparison with tumor necrosis factor alpha inhibitors for Takayasu Arteritis: A systematic review and meta-analysis
Misra, D. P., Singh, K., Rathore, U., Patro, P., Tomelleri, A., Campochiaro, C., Agarwal, V., & Sharma, A. (2023) · Autoimmunity Reviews · doi:10.1016/j.autrev.2023.103275 · Cited by 49
Gene Therapy in Cardiovascular Disease: Recent Advances and Future Directions in Science: A Science Advisory From the American Heart Association
Kim, Y., Landstrom, A. P., Shah, S. H., Wu, J. C., & Seidman, C. E. (2024) · Circulation · doi:10.1161/cir.0000000000001296 · Cited by 51
Evaluation and management of hypertensive emergency
Miller, J. B., Hrabec, D., Krishnamoorthy, V., Kinni, H. A., & Brook, R. D. (2024) · BMJ · doi:10.1136/bmj-2023-077205 · Cited by 48
Imaging Methods for Evaluation of Chronic Aortic Regurgitation in Adults
Ranard, L. S., Bonow, R. O., Nishimura, R. A., Mack, M. J., Thourani, V. H., Bavaria, J. E., O’Gara, P. T., Bax, J. J., Blanke, P., Delgado, V., et al. (2023) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2023.08.051 · Cited by 47
SurgeryLLM: a retrieval-augmented generation large language model framework for surgical decision support and workflow enhancement
Ong, C. S., Obey, N. T., Zheng, Y., Cohan, A., & Schneider, E. B. (2024) · npj Digital Medicine · doi:10.1038/s41746-024-01391-3 · Cited by 54
Marfan Syndrome: Enhanced Diagnostic Tools and Follow-up Management Strategies
Marelli, S., Micaglio, E., Taurino, J., Salvi, P., Rurali, E., Perrucci, G. L., Dolci, C., Udugampolage, N. S., Caruso, R., Gentilini, D., et al. (2023) · Diagnostics · doi:10.3390/diagnostics13132284 · Cited by 52
Outcomes of Elective and Non-elective Fenestrated-branched Endovascular Aortic Repair for Treatment of Thoracoabdominal Aortic Aneurysms
Dias‐Neto, M., Vacirca, A., Huang, Y., Baghbani‐Oskouei, A., Jakimowicz, T., Mendes, B. C., Kölbel, T., Sobocinski, J., Bertoglio, L., Mees, B., et al. (2023) · Annals of Surgery · doi:10.1097/sla.0000000000005986 · Cited by 43
2023 ACC/AHA/SCAI Advanced Training Statement on Interventional Cardiology (Coronary, Peripheral Vascular, and Structural Heart Interventions): A Report of the ACC Competency Management Committee
Bass, T. A., Abbott, J. D., Mahmud, E., Parikh, S. A., Aboulhosn, J., Ashwath, M. L., Baranowski, B. J., Bergersen, L. J., Chaudry, H. I., Coylewright, M. J., et al. (2023) · Circulation Cardiovascular Interventions · doi:10.1161/hcv.0000000000000088 · Cited by 43
Thoracic Aorta: Anatomy and Pathology
Gioia, C. R. T. D., Ascione, A., Carletti, R., & Giordano, C. (2023) · Diagnostics · doi:10.3390/diagnostics13132166 · Cited by 41
Sex differences in type A acute aortic dissection: a systematic review and meta-analysis
Carbone, A., Ranieri, B., Castaldo, R., Franzese, M., Rega, S., Cittadini, A., Czerny, M., & Bossone, E. (2023) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwad009 · Cited by 39
Association between the non-HDL-cholesterol to HDL- cholesterol ratio and abdominal aortic aneurysm from a Chinese screening program
Lin, W., Luo, S., Li, W., Liu, J., Zhou, T., Yang, F., Zhou, D., Liu, Y., Huang, W., Feng, Y., et al. (2023) · Lipids in Health and Disease · doi:10.1186/s12944-023-01939-4 · Cited by 39
Targeting metabolism in aortic aneurysm and dissection: from basic research to clinical applications
Wang, Q., Yesitayi, G., Liu, B., Siti, D., Ainiwan, M., Aizitiaili, A., & Ma, X. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.85467 · Cited by 43
Type A aortic dissection: optimal annual case volume for surgery
Kawczynski, M. J., van Kuijk, S. M. J., Olsthoorn, J. R., Maessen, J. G., Kats, S., Bidar, E., & Heuts, S. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad551 · Cited by 35
Oxidative stress drives vascular smooth muscle cell damage in acute Stanford type A aortic dissection through HIF-1α/HO-1 mediated ferroptosis
Song, W., Chen, Y., Qin, L., Xu, X., Sun, Y., Zhong, M., Lu, Y., Hu, K. R., Wei, L., & Chen, J. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e22857 · Cited by 34
Management of aortic disease in children with FBN1-related Marfan syndrome
Mosquera, L. M., Cervi, E., Groote, K. D., Dewals, W., Fejzic, Z., Kazamia, K., Mathur, S., Milleron, O., Mir, T. S., Nielsen, D. G., et al. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae526 · Cited by 34
“22 Kaiser and colleagues 55 published a data set to calculate z -scores for thoracic aorta diameters derived from MRI in children.”
BackgroundMethodInfluential
Bicuspid aortic valve associated aortopathy: 2022 guideline update
Verma, R., Cohen, G. N., Colbert, J. D., & Fedak, P. W. M. (2022) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000001020 · Cited by 33
Hemodynamic effects of entry and exit tear size in aortic dissection evaluated with in vitro magnetic resonance imaging and fluid–structure interaction simulation
Zimmermann, J., Bäumler, K., Loecher, M., Cork, T. E., Marsden, A. L., Ennis, D. B., & Fleischmann, D. (2023) · Scientific Reports · doi:10.1038/s41598-023-49942-0 · Cited by 33
“According to latest guidelines 6 , preventive thoracic endovascular aortic repair (TEVAR) may be considered for TBAD; nevertheless, the role and timing of TEVAR remains an evolving matter of debate.”
Aging aggravates aortic aneurysm and dissection via miR-1204-MYLK signaling axis in mice
Liu, Z.-L., Li, Y., Lin, Y.-J., Shi, M., Fu, M., Li, Z., Ning, D.-S., Zeng, X.-M., Liu, X., Cui, Q.-H., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50036-2 · Cited by 38
“Aortic dissection (AD) and aneurysms, including thoracic aortic aneurysms (TAAs) and abdominal aortic aneurysms (AAAs), are potentially fatal diseases 1,2 .”
Sex Differences in Peripheral Vascular Disease: A Scientific Statement From the American Heart Association
Kim, E. S. H., Arya, S., Bryce, Y. C. D., Gornik, H. L., Long, C. A., McDermott, M. M., Pollak, A. W., Rowe, V. L., Sullivan, A. E., & Whipple, M. O. (2025) · Circulation · doi:10.1161/cir.0000000000001310 · Cited by 33
Editor's Choice – European Society for Vascular Surgery (ESVS) 2025 Clinical Practice Consensus Statement on Ascending Thoracic Endovascular Aortic Repair
Trimarchi, S., Czerny, M., Haulon, S., van Herwaarden, J. A., de Kort, J. F., Roselli, E. E., Schermerhorn, M. L., Upchurch, G. R., Wanhainen, A., Boyle, J. R., et al. (2025) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2025.05.023 · Cited by 33
ATP7A ‐related copper transport disorders: A systematic review and definition of the clinical subtypes
Feyter, S. D., Beyens, A., & Callewaert, B. L. (2023) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12590 · Cited by 32
The AORTA Gene score for detection and risk stratification of ascending aortic dilation
Pirruccello, J. P., Khurshid, S. S., Lin, H., Weng, L.-C. C., Zamirpour, S., Kany, S., Raghavan, A., Koyama, S., Vasan, R. S., Benjamin, E. J., et al. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae474 · Cited by 31
CIS-UNet: Multi-class segmentation of the aorta in computed tomography angiography via context-aware shifted window self-attention
Imran, M. A., Krebs, J. R., Gopu, V. R. R., Fazzone, B. J., Sivaraman, V. B., Kumar, A., Viscardi, C., Heithaus, R. E., Shickel, B., Zhou, Y., et al. (2024) · Computerized Medical Imaging and Graphics · doi:10.1016/j.compmedimag.2024.102470 · Cited by 39
Exploring Drug Re-Purposing for Treatment of Abdominal Aortic Aneurysms: a Systematic Review and Meta-analysis
Skovbo, J. S., Krasniqi, L., Obel, L. M., Kavaliūnaitė, E., Liisberg, M., & Lindholt, J. S. (2023) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2023.11.037 · Cited by 31
2025 ACC/AHA/HRS/ISACHD/SCAI Guideline for the Management of Adults With Congenital Heart Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines
Gurvitz, M. Z., Krieger, E. V., Fuller, S., Davis, L. L., Kittleson, M. M., Aboulhosn, J., Bradley, E. A., Buber, J., Daniels, C. J., Dimopoulos, K., et al. (2025) · Circulation · doi:10.1161/cir.0000000000001402 · Cited by 44
Advantages of Photon-Counting Detector CT in Aortic Imaging
Zanon, C., Cademartiri, F., Toniolo, A., Bini, C., Clemente, A., Colacchio, E. C., Cabrelle, G., Mastro, F. R., Antonello, M., Quaia, E., et al. (2023) · Tomography · doi:10.3390/tomography10010001 · Cited by 30
“ELs was the most common complication (53% of all complications), with an incidence of 11.7% [34,35].”
BackgroundInfluential
Selenium as a Modulator of Redox Reactions in the Prevention and Treatment of Cardiovascular Diseases
Leszto, K., Biskup, L., Korona, K., Marcinkowska, W., Możdżan, M., Węgiel, A., Młynarska, E., Rysz, J., & Franczyk, B. (2024) · Antioxidants · doi:10.3390/antiox13060688 · Cited by 31
“Arterial stiffness, which also plays a significant role in hypertension, is associated with vascular remodeling characterized by changes in vessel structure and function [72].”
Background
Lifetime Management for Aortic Stenosis: Strategy and Decision-Making in the Current Era
Chen, S., Pop, A. M., Dasi, L. P., & George, I. (2024) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2024.05.047 · Cited by 32
Antiplatelet Therapy, Abdominal Aortic Aneurysm Progression, and Clinical Outcomes
Hariri, E. H., Matta, M., Layoun, H., Badwan, O. Z., Braghieri, L., Owens, A. P., Burton, R., Bhandari, R., Mix, D., Bartholomew, J. R., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.47296 · Cited by 29
NINJ1 Facilitates Abdominal Aortic Aneurysm Formation via Blocking TLR4‐ANXA2 Interaction and Enhancing Macrophage Infiltration
Wu, Z., Xu, Z., Pu, H., Ding, A., Hu, J., Lei, J., Zeng, C., Qiu, P., Qin, J., Wu, X., et al. (2024) · Advanced Science · doi:10.1002/advs.202306237 · Cited by 33
Valve-sparing aortic root replacement using the reimplantation (David) technique: a systematic review and meta-analysis on survival and clinical outcome
Mastrobuoni, S., Govers, P. J., Veen, K. M., Jahanyar, J., van Saane, S., Segreto, A., Zanella, L., de Kerchove, L., Takkenberg, J. J. M., & Arabkhani, B. (2023) · Annals of Cardiothoracic Surgery · doi:10.21037/acs-2023-avs1-0038 · Cited by 28
Genetic Basis, New Diagnostic Approaches, and Updated Therapeutic Strategies of the Syndromic Aortic Diseases: Marfan, Loeys–Dietz, and Vascular Ehlers–Danlos Syndrome
Asta, L., D’Angelo, G. A., Marinelli, D., & Benedetto, U. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20166615 · Cited by 33
Soluble glycoprotein VI predicts abdominal aortic aneurysm growth rate and is a novel therapeutic target
Benson, T. W., Pike, M., Spuzzillo, A. R., Hicks, S. M., Ali, S. A., Pham, M., Mix, D., Brunner, S. I., Wadding-Lee, C., Conrad, K. A., et al. (2024) · Blood · doi:10.1182/blood.2023021655 · Cited by 28
Cerebral Protection Strategies and Stroke in Surgery for Acute Type A Aortic Dissection
Pitts, L., Kofler, M., Montagner, M., Heck, R., Iske, J., Buz, S., Kurz, S. D., Starck, C. T., Falk, V., & Kempfert, J. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12062271 · Cited by 28
Association of triglyceride-glucose index with the risk of incident aortic dissection and aneurysm: a large-scale prospective cohort study in UK Biobank
Tian, C., Chen, Y., Xu, B., Tan, X., & Zhu, Z. (2024) · Cardiovascular Diabetology · doi:10.1186/s12933-024-02385-x · Cited by 27
“The incidence of abdominal AA in men from 65 to 75 years of age is approximately 1.9% [8], while thoracic AA occurs at a rate of 5–10 per 100,000 person-years in the general population [9].”
BackgroundInfluential
A novel hybrid prosthesis for open repair of acute DeBakey type I dissection with malperfusion: Early results from the PERSEVERE trial
Szeto, W. Y., Fukuhara, S., Fleischman, F., Sultan, I. S., Brinkman, W. T., Arnaoutakis, G. J., Takayama, H., Eudailey, K. W., Brinster, D. R., Jassar, A. S., et al. (2024) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2024.07.059 · Cited by 27
Emergency Department Triage Accuracy and Delays in Care for High-Risk Conditions
Sax, D. R., Warton, E. M., Mark, D. G., & Reed, M. E. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.8498 · Cited by 27
Global, Regional, and National Burden of Cardiovascular Diseases and Risk Factors in 204 Countries and Territories, 1990-2023Preprint
Collaborators, G., & Roth, G. A. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5392535 · Cited by 27
Multi-modality imaging evaluation and pre-surgical planning for aortic valve-sparing operations in patients with aortic root aneurysm
Tretter, J. T., Burbano-Vera, N. H., & Najm, H. K. (2023) · Annals of Cardiothoracic Surgery · doi:10.21037/acs-2023-avs2-0040 · Cited by 26
Depression and cardiovascular disease: mind the gap in the guidelines
Armon, D. B., Buhayer, A., Miteva, K., Meinlschmidt, G., Dobretz, K., Zuccarella‐Hackl, C., Appenzeller‐Herzog, C., Mach, F., & Battegay, E. J. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf479 · Cited by 30
HTAD patient pathway: Strategy for diagnostic work-up of patients and families with (suspected) heritable thoracic aortic diseases (HTAD). A statement from the HTAD working group of VASCERN
Caruana, M., Baars, M. J. H., Bashiardes, E., Benke, K., Björck, E., Codreanu, A., Rubio, E. D. M., Dumfarth, J., Evangelista, A., Groenink, M., et al. (2022) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2022.104673 · Cited by 26
Midterm Outcomes of Endovascular vs. Medical Therapy for Uncomplicated Type B Aortic Dissection: Meta-Analysis of Reconstructed Time to Event Data
Sá, M. P., Jacquemyn, X., den Eynde, J. V., Chu, D., Serna-Gallegos, D. R., Singh, M. J., Chaer, R. A., & Sultan, I. S. (2023) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2023.07.004 · Cited by 26
Immune cell dynamics and their role in cardiac injury: Mechanisms and therapeutic implications
Liu, C., Wu, R., Yang, H., & Yao, Y.-M. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118608 · Cited by 30
Blunt Thoracic Aortic Injury
Mazzaccaro, D. P., Righini, P., Fancoli, F., Giannetta, M., Modafferi, A., Malacrida, G., & Nano, G. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12082903 · Cited by 25
Comparison of open and endovascular left subclavian artery revascularization for zone 2 thoracic endovascular aortic repair
Mandigers, T. J., Allievi, S., Jabbour, G., Gómez-Mayorga, J. L., Caron, E., Giles, K. A., Wang, G. J., van Herwaarden, J. A., Trimarchi, S., Scali, S. T., et al. (2024) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2024.06.018 · Cited by 24
ANK Deficiency-Mediated Cytosolic Citrate Accumulation Promotes Aortic Aneurysm
Wu, H., Li, Z., Yang, L., He, L., Liu, H., Yang, S., Xu, Q., Li, Y., Li, W., Li, Y., et al. (2024) · Circulation Research · doi:10.1161/circresaha.124.325152 · Cited by 25
The Role of Genetic Testing in Patients with Heritable Thoracic Aortic Diseases
Monda, E., Lioncino, M., Verrillo, F., Rubino, M., Caiazza, M., Mauriello, A., Guarnaccia, N., Fusco, A., Cirillo, A., Covino, S., et al. (2023) · Diagnostics · doi:10.3390/diagnostics13040772 · Cited by 26
Aortic Size at the Time of Type A and Type B Dissections
Perez, Z. G., Zafar, M. A., Velasco, J. J., Sonsino, A., Ellauzi, H., John, C., Kalyanasundaram, A., Ziganshin, B. A., & Elefteriades, J. A. (2023) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2023.03.037 · Cited by 24
Use of Artificial Intelligence With Deep Learning Approaches for the Follow-up of Infrarenal Endovascular Aortic Repair
Coatsaliou, Q., Lareyre, F., Raffort, J., Webster, C., Bicknell, C. D., Pouncey, A. L., Ducasse, É., & Caradu, C. (2024) · Journal of Endovascular Therapy · doi:10.1177/15266028241252097 · Cited by 24
ESVS 2024 Clinical Practice Guidelines on the Management of Abdominal Aorto-iliac Artery Aneurysms: A North American Perspective
Zettervall, S. L., & Schanzer, A. S. (2023) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2023.10.036 · Cited by 24
Association Between Genetic Diagnosis and Clinical Outcomes in Patients With Heritable Thoracic Aortic Disease
Yagyu, T., Noguchi, T., Asano, Y., Ida, K., Ogata, S., Nishimura, K., & Matsuda, H. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.122.028625 · Cited by 23
Recent advances in the treatment of giant cell arteritis
Springer, J. M., & Kermani, T. A. (2023) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2023.101830 · Cited by 23
Diagnosis of acute aortic syndromes with ultrasound and d-dimer: the PROFUNDUS study
Morello, F., Bima, P., Castelli, M., Capretti, E., Soeiro, A. D. M., Cipriano, A., Costantino, G., Vanni, S., Leidel, B. A., Kaufmann, B. A., et al. (2024) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2024.05.029 · Cited by 23
Role of macrophages in aortic dissection pathogenesis: insights from preclinical studies to translational prospective
Li, S., Fu, W., & Wang, L. (2024) · Science China Life Sciences · doi:10.1007/s11427-024-2693-5 · Cited by 23
Editor's Choice – Outcomes of Endovascular Repair Confined to the Ascending Thoracic Aorta: A Systematic Review and Meta-Analysis
de Kort, J. F., Mandigers, T. J., Bissacco, D., Domanin, M., Piffaretti, G., Twine, C. P., Wanhainen, A., van Herwaarden, J. A., Trimarchi, S., & Vincentiis, C. D. (2024) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2024.10.049 · Cited by 23
Thoracic aortic aneurysm
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“According to the American College of Cardiology/ American Heart Association (ACC/AHA) 80 and European Society of Cardiology (ESC) guidelines, 11 treatment of AAAs with angiotensin-converting enzyme inhibitor (ACEI) and beta-blockers is a Class IIa recommendation, meaning the benefits of the…”

Authors: Isselbacher, E. M., Preventza, O., Hamilton Black, J., Augoustides, J. G., Beck, A. W., Bolen, M. A., Braverman, A. C., Bray, B. E., Brown-Zimmerman, M. M., Chen, E. P., Collins, T. J., DeAnda, A., Fanola, C. L., Girardi, L. N., Hicks, C. W., Hui, D. S., Schuyler Jones, W., Kalahasti, V., Kim, K. M., Milewicz, D. M., Oderich, G. S., Ogbechie, L., Promes, S. B., Gyang Ross, E., Schermerhorn, M. L., Singleton Times, S., Tseng, E. E., Wang, G. J., Woo, Y. J., Faxon, D. P., Upchurch, G. R., Aday, A. W., Azizzadeh, A., Boisen, M., Hawkins, B., Kramer, C. M., Luc, J. G. Y., MacGillivray, T. E., Malaisrie, S. C., Osteen, K., Patel, H. J., Patel, P. J., Popescu, W. M., Rodriguez, E., Sorber, R., Tsao, P. S., & Santos Volgman, A.
Affiliations: SCA representative.
ACR representative.
American Heart Association (US)
Lay stakeholder representative.
Fraunhofer Institute for Algorithms and Scientific Computing (DE)
AATS representative.
American Hospital Association (US)
AHA/ACC Joint Committee on Clinical Practice Guidelines liaison.
STS representative.
SVS representative.
AHA/ACC staff representative.
ORCID: Isselbacher, Eric M.
Preventza, Ourania
Augoustides, John G.
Beck, Adam W.
Bolen, Michael A.
Braverman, Alan C.
Bray, Bruce E.
Chen, Edward P.
DeAnda, Abe
Fanola, Christina L.
Girardi, Leonard N.
Hicks, Caitlin W.
Hui, Dawn S.
Kalahasti, Vidyasagar
Kim, Karen M.
Milewicz, Dianna M.
Oderich, Gustavo S.
Promes, Susan B.
Schermerhorn, Marc L.
Tseng, Elaine E.
Upchurch, Gilbert R.
Aday, Aaron W.
Azizzadeh, Ali
Boisen, Michael
Kramer, Christopher M.
Luc, Jessica G.Y.
MacGillivray, Thomas E.
Osteen, Kathryn
Patel, Himanshu J.
Patel, Parag J.
Popescu, Wanda M.
Sorber, Rebecca
Tsao, Philip S.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2022-12-13
Volume: 146
Issue: 24
Pages: e334-e482
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/cir.0000000000001106
PMC: PMC9876736
OpenAlex: W4307934708
Cited by: 2,082
References: 1,104
Citations by year: 2026: 600 · 2025: 569 · 2024: 554 · 2023: 348 · 2022: 9
FWCI: 239.09
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
Locations: Circulation (publishedVersion, cc-by)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Veterans Affairs
American Heart Association
Massachusetts General Hospital
American College of Cardiology Foundation
University of Pennsylvania
CryoLife
Office of Science
National Institute of Diabetes and Digestive and Kidney Diseases (K23DK124515)
Division of Cardiothoracic Surgery, University of Colorado School of Medicine, Anschutz Medical Campus
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Aortic Disease and Treatment Approaches
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
Health Sciences › Medicine › Surgery › Aortic aneurysm repair treatments
Keywords: aortic disease, thoracic aortic disease, acute aortic syndrome, aortic aneurysm, aortic dissection, bicuspid aortic valve disease, peripheral arterial disease, genetic evaluation, family screening, endovascular repair, aortic surgery, long-term surveillance, shared decision-making, pregnancy
MeSH terms: Bicuspid Aortic Valve Disease, American Heart Association, Aortic Diseases, Cardiology, Female, Humans, Pregnancy, United States, Research Report

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2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines

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