Cited by 2,082Aortic Disease and Treatment ApproachesConnective tissue disorders researchAortic aneurysm repair treatments

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2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines

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Isselbacher, Eric M., Preventza, Ourania, Hamilton Black, James, Augoustides, John G., Beck, Adam W., Bolen, Michael A., Braverman, Alan C., Bray, Bruce E., Brown-Zimmerman, Maya M., Chen, Edward P., Collins, Tyrone J., DeAnda, Abe, Fanola, Christina L., Girardi, Leonard N., Hicks, Caitlin W., Hui, Dawn S., Schuyler Jones, William, Kalahasti, Vidyasagar, Kim, Karen M., Milewicz, Dianna M., Oderich, Gustavo S., Ogbechie, Laura, Promes, Susan B., Gyang Ross, Elsie, Schermerhorn, Marc L., Singleton Times, Sabrina, Tseng, Elaine E., Wang, Grace J., Woo, Y. Joseph, Faxon, David P., Upchurch, Gilbert R., Aday, Aaron W., Azizzadeh, Ali, Boisen, Michael, Hawkins, Beau, Kramer, Christopher M., Luc, Jessica G.Y., MacGillivray, Thomas E., Malaisrie, S. Christopher, Osteen, Kathryn, Patel, Himanshu J., Patel, Parag J., Popescu, Wanda M., Rodriguez, Evelio, Sorber, Rebecca, Tsao, Philip S., Santos Volgman, Annabelle·2022·Circulation

DOI 10.1161/cir.0000000000001106PMC PMC9876736

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Abstract

AIM: The "2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease" provides recommendations to guide clinicians in the diagnosis, genetic evaluation and family screening, medical therapy, endovascular and surgical treatment, and long-term surveillance of patients with aortic disease across its multiple clinical presentation subsets (ie, asymptomatic, stable symptomatic, and acute aortic syndromes). METHODS: A comprehensive literature search was conducted from January 2021 to April 2021, encompassing studies, reviews, and other evidence conducted on human subjects that were published in English from PubMed, EMBASE, the Cochrane Library, CINHL Complete, and other selected databases relevant to this guideline. Additional relevant studies, published through June 2022 during the guideline writing process, were also considered by the writing committee, where appropriate. Structure: Recommendations from previously published AHA/ACC guidelines on thoracic aortic disease, peripheral artery disease, and bicuspid aortic valve disease have been updated with new evidence to guide clinicians. In addition, new recommendations addressing comprehensive care for patients with aortic disease have been developed. There is added emphasis on the role of shared decision making, especially in the management of patients with aortic disease both before and during pregnancy. The is also an increased emphasis on the importance of institutional interventional volume and multidisciplinary aortic team expertise in the care of patients with aortic disease.

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Effect of Acute Resistance Exercise and Resistance Exercise Training on Central Pulsatile Hemodynamics and Large Artery Stiffness: Part I
Wakeham, D. J., Pierce, G. L., & Heffernan, K. S. (2025) · Pulse · doi:10.1159/000543313 · Cited by 4
Fluid balance and clinical outcomes in patients with aortic dissection: a retrospective case-control study based on ICU databases
Lei, J., Zhang, Z., Li, Y., Wu, Z., Pu, H., Xu, Z., Yang, X., Wang, R., Qiu, P., Chen, T., et al. (2025) · BMJ Open · doi:10.1136/bmjopen-2024-083933 · Cited by 4
Protective Effect on Spinal Cord Injury of Prophylactic Cerebrospinal Fluid Drainage in Extensive Aortic Arch Repair for Type A Aortic Dissection: A Retrospective Cohort Study
Zhou, C., Hou, B., Zhang, K., Gao, S., Cao, F., Ji, Y., Xie, E., Qiu, J., Qiu, J., & Yu, C. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.124.039427 · Cited by 4
Cardiovascular screening and long-term outcomes in aircraft pilots
Elkhatib, W. Y., Flipse, T. R., Allison, T. G., Speicher, L. L., Sledge, H. J., Li, Z., Shapiro, B. P., & Gharacholou, S. M. (2025) · Heart · doi:10.1136/heartjnl-2024-325243 · Cited by 4
Imaging-based biomechanical parameters for assessing risk of aortic dissection and rupture in thoracic aortic aneurysms
Bhatt, N., Seo, H., Hanneman, K. A., Burris, N. S., Simmons, C. A., & Chung, J. C.-Y. (2025) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezaf128 · Cited by 4
Branched endovascular aortic repair of chronic post-dissection thoracoabdominal aortic aneurysms: an institutional experience on preoperative planning, intraoperative execution, and pitfalls
Aru, R. G., Porez, F., Houérou, T. L., Palmier, M., Gaudin, A., Fabre, D., & Haulon, S. (2025) · The Journal of Cardiovascular Surgery · doi:10.23736/s0021-9509.25.13325-9 · Cited by 4
The Role of Cardiovascular Magnetic Resonance Imaging in Athletic Individuals—A Narrative Review
Grech, N., & Abela, M. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14103576 · Cited by 6
“Repeat imaging in 6 to 12 months to evaluate the disease’s progression is recommended, which will help establish a tailored surveillance strategy depending on the rate of progression and severity of the condition [9,121].”
Bicuspid Aortic Valve and Sudden Cardiac Death
Salzillo, C., Quaranta, A., Lizia, F. D., Lombardo, M., Ciccone, M. M., Santobuono, V. E., Macorano, E., Introna, F., Solarino, B., & Marzullo, A. (2025) · Life · doi:10.3390/life15060868 · Cited by 4
“Timing may also be influenced by the patient’s age, blood pressure control, and presence of symptoms [7].”
Osteosarcopenia-Aneurysm Score Predicts Long-Term Survival Following Endovascular Repair for Abdominal Aortic Aneurysm
Ozawa, H., Ohki, T., Shukuzawa, K., Fukushima, S., Ito, E., & Nakamura, K. (2025) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2025.07.012 · Cited by 4
Outcomes following extended thoracic endovascular aortic repair for Type B aortic dissection from the global registry for endovascular aortic treatment
Allievi, S., Mandigers, T. J., Weaver, F. A., Azizzadeh, A., Piffaretti, G., Schermerhorn, M. L., Magee, G. A., Gable, D. R., Lomazzi, C., & Trimarchi, S. (2025) · Interdisciplinary CardioVascular and Thoracic Surgery · doi:10.1093/icvts/ivaf156 · Cited by 4
Aortic Valve–Sparing Root Operation in Patients With Marfan and Loeys-Dietz Syndrome
Yıldız, M., Werdecker, V., Nucera, M., Mosbahi, S., Goel, N. J., Berezowski, M., Lawrence, K. M., Kapoor, S. R., Kreibich, M., Berger, T., et al. (2025) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2025.07.025 · Cited by 4
Association analysis of blood pressure with incident risks for thoracic and abdominal aortic aneurysms: an observational study of the UK Biobank cohort
Lu, K., Liu, X., Wang, Y., Tang, X., & Gao, P. (2025) · Open Heart · doi:10.1136/openhrt-2025-003240 · Cited by 4
Systematic review and meta-analysis on endovascular repair of nonelective thoracoabdominal aortic aneurysms and aneurysms involving visceral arteries
Spath, P., Campana, F., Tsilimparis, N., Gallitto, E., Caputo, S., Pini, R., Faggioli, G., & Gargiulo, M. (2025) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2025.08.030 · Cited by 4
Ten Year Clinical and Aortic Remodelling Outcomes following Endovascular Repair of Chronic Type B Aortic Dissection
Urick, D., Jensen, C. W., Vekstein, A. M., Sanaiha, Y., Moya‐Mendez, M. E., Kang, L., Long, C. A., & Hughes, G. C. (2025) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2025.09.039 · Cited by 4
Clinical characteristics and outcomes of Stanford type B aortic intramural hematoma: A single centre experience
Zhang, Z., Feng, L., He, Z., Wang, H., Zhu, X., & Cheng, T. (2023) · Frontiers in Surgery · doi:10.3389/fsurg.2022.1071600 · Cited by 4
Is female sex impactful in the pathophysiology, presentation, management, and outlook of type A acute aortic dissection?
Frati, G., Bernardi, M., Biondi‐Zoccai, G., Saade, W., & Giordano, A. (2023) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwad043 · Cited by 4
Management of acute aortic syndrome with evolving individualized precision medicine solutions: Lessons learned over two decades and literature review
Sultan, S., Acharya, Y., Long, K. C. V., Hatem, M., Hezima, M., Veerasingham, D., Soliman, O. I. I., & Hynes, N. (2023) · Frontiers in Surgery · doi:10.3389/fsurg.2023.1157457 · Cited by 4
Ten-year follow-up of dilatation of aortic structures in Fallot-type anomalies
Kim, W., Kwak, J. G., Cho, S., & Kim, W. (2023) · Pediatric Cardiology · doi:10.1007/s00246-023-03225-7 · Cited by 4
Inflammatory Biomarkers and Cardiac Surgical Risk: Hitting the Mark?
Vervoort, D., Caldonazo, T. M. M., Doenst, T., & Fremes, S. E. (2023) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2023.09.004 · Cited by 4
Case Report: It's not always about the veins; intervention of bilateral May–Thurner Syndrome secondary to iliac aneurysm
Haq, S. H., Shah, S. R., Chandra, J., Kannan, P., & Patel, S. M. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1279981 · Cited by 4
Case Report: Kommerell's diverticulum and left aberrant subclavian artery stenosis hybrid treatment with branched aortic stent-graft
Rodríguez, Á., Tello-Díaz, C., Vergara-Budding, A. C., Vinzenzi, C. F.-D., Moustafa, A.-H., Pinilla, C. A., Ginel, A., Barros-Membrilla, A. J., & Dilmé, J. F. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1309839 · Cited by 4
Thoracic Aortic Aneurysmal Disease: Comprehensive Recommendations for the Primary Care Physician
Reddy, P., Nair, K. S., Kumar, V., Bowen, J. M., Deyle, D. R., Pochettino, A. A., Connolly, H. M., & Anavekar, N. S. (2024) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2023.07.004 · Cited by 4
Sex Differences in the Histopathology of Acute Type A Aortic Dissections
Grewal, N., Dolmaci, O. B., Klautz, R. J. M., & Poelmann, R. E. (2024) · The Thoracic and Cardiovascular Surgeon · doi:10.1055/a-2239-1741 · Cited by 4
The Utility of Screening Fetal Echocardiograms Following Normal Level II Ultrasounds in Fetuses with Maternal Congenital Heart Disease
Calcara, S., Paeltz, A., Richards, B., Sisk, T., Stiver, C. A., Ogunleye, O. K., Texter, K. M., Mah, M. L., & Cua, C. L. (2024) · Cardiology and Therapy · doi:10.1007/s40119-024-00350-z · Cited by 4
The effect of obesity on the outcome of thoracic endovascular aortic repair: a systematic review and meta-analysis
Li, J., Zhang, Y., Huang, H., Zhou, Y., Wang, J., & Hu, M. (2024) · PeerJ · doi:10.7717/peerj.17246 · Cited by 4
The cardiovascular pathologist in the aortic team
Pucci, A., Rossetti, M., Lenzi, C., & Buja, L. M. (2024) · Cardiovascular Pathology · doi:10.1016/j.carpath.2024.107649 · Cited by 4
Aortic arch surgery for DeBakey type 1 aortic dissection in patients aged 60 years or younger
Biancari, F., Lega, J. R., Mariscalco, G., Peterß, S., Buech, J., Fiore, A., Perrotti, A., Rukosujew, A., Pinto, Á. G., Demal, T. J., et al. (2024) · BJS Open · doi:10.1093/bjsopen/zrae047 · Cited by 4
“…of Cardiology/American Heart Association guideline supported a policy of extended aortic repair with antegrade stenting of the proximal descending thoracic aorta in patients with acute type A aortic dissection and dissection flap extending through the arch into the descending thoracic aorta 16 .”
Background
Validating a Curvature‐Based Marker of Cervical Carotid Tortuosity for Risk Assessment in Heritable Aortopathies
Lee, J. V., Huguenard, A. L., Dacey, R. G., Braverman, A. C., & Osbun, J. W. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.124.035171 · Cited by 4
Contributions of Germline and Somatic Mosaic Genetics to Thoracic Aortic Aneurysms in Nonsyndromic Individuals
Chen, M. H., Deng, E. S., Yamada, J. M., Choudhury, S., Scotellaro, J. L., Kelley, L., Isselbacher, E. M., Lindsay, M. E., Walsh, C. A., & Doan, R. N. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.123.033232 · Cited by 4
“8,9 However, patients with sporadic TAA rarely undergo genetic testing during routine clinical care.”
Successful management of a delayed presentation of traumatic descending thoracic aorta pseudoaneurysm: a literature review based on a case report
Sadeghian, M., Ebrahimi, P., Soltani, P., Ghasemi, M., Taheri, H., & Mehrpooya, M. (2024) · International Journal of Emergency Medicine · doi:10.1186/s12245-024-00670-w · Cited by 4
A 25-Year-Old With an Incidentally Detected Ascending Thoracic Aortic Aneurysm and Bicuspid Aortic Valve
Oh, N. A., Roselli, E. E., & Vargo, P. R. (2024) · JAMA · doi:10.1001/jama.2024.12435 · Cited by 4
Importance of surgeon's experience in practicing valve-sparing aortic root replacement
Rajesh, K., Chung, M., Levine, D., Norton, E., Patel, P. M., Hohri, Y., He, C., Agarwal, P., Zhao, Y., Wang, P., et al. (2024) · JTCVS Open · doi:10.1016/j.xjon.2024.07.013 · Cited by 4
Exercise, Sports Participation, and Quality of Life in Young Patients with Heritable Thoracic Aortic Disease
Millette, T. J., Ramcharitar, R. K., Monfredi, O., Thomas, M., Conaway, M. R., & Dean, P. N. (2024) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000003570 · Cited by 4
Tabular review of contemporary fenestrated-branched endovascular aortic repair experiences for treatment of thoracoabdominal aortic aneurysms
Jobim, F., Kanamori, L. R., Cambiaghi, M., Mésnard, T., Sulzer, T. A. L., Savadi, S., Babocs, D., Schmid, B., Maximus, S., Huang, Y., et al. (2024) · The Journal of Cardiovascular Surgery · doi:10.23736/s0021-9509.24.13168-0 · Cited by 4
Early clinical outcomes in men and women undergoing proximal thoracic aortic surgery: A Swedish population-based cohort study
Braatz, E., Olsson, C., Dalén, M., Nielsen, S. J., Jeppsson, A., & Stenman, M. (2024) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2024.10.008 · Cited by 4
Effect of aortic valve phenotype and sex on aorta dilation in patients with aortic stenosis
Fleury, M., Tastet, L. L., Bernard, J., Shen, M., Capoulade, R., Abdoun, K., Bédard, É., Arsenault, M., Chétaille, P., Beaudoin, J., et al. (2024) · Open Heart · doi:10.1136/openhrt-2024-002912 · Cited by 4
Statin suppresses the development of excessive intimal proliferation in a Kawasaki disease mouse model
Motoji, Y., Fukazawa, R., Matsui, R., Watanabe, M., Hashimoto, Y., Nagi‐Miura, N., Kitamura, T., & Miyaji, K. (2024) · Physiological Reports · doi:10.14814/phy2.70096 · Cited by 6
The Frozen Elephant Trunk Procedure—8 Years of Experience from Poland
Burysz, M., Horosin, G., Olejek, W., Kowalewski, M., Bartuś, K., Słomka, A., Litwinowicz, R. A., & Batko, J. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13216544 · Cited by 4
Implementation of a Comprehensive Endovascular Aortic Programme and Maintenance of Clinical Excellence during Fenestrated Branched Endovascular Aortic Repair in Two Centres
Kanamori, L. R., Vacirca, A., Babocs, D., Tenorio, E. R., Lima, G. B. B., Mendes, B. C., Huang, Y., Maximus, S., Estrera, A. L., & Oderich, G. S. (2024) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2024.11.014 · Cited by 4
Guidelines at a crossroad: comparing European and American guidelines regarding the use of imaging in peripheral vascular arterial disease and aortic disease
Liga, R., Hostalrich, A., Gimelli, A., & Ricco, J. (2024) · European Heart Journal - Imaging Methods and Practice · doi:10.1093/ehjimp/qyae123 · Cited by 4
Presentation, management, and clinical outcomes of acute type A dissection: Does sex matter?
Meccanici, F., Thijssen, C. G. E., Gökalp, A. L., van Wijngaarden, M. H. E. J., Bierhuizen, M. F. A., Custers, G. F., Evers, J., de Veld, J. A., Notenboom, M. L., Geuzebroek, G. S. C., et al. (2024) · JTCVS Open · doi:10.1016/j.xjon.2024.12.006 · Cited by 4
Sexual dimorphism in aortic aneurysm: A review of the contributions of sex hormones and sex chromosomes
Chen, H.-N., Hu, Y., Ran, L., Wang, M., & Zhang, Z. (2024) · Vascular Pharmacology · doi:10.1016/j.vph.2024.107460 · Cited by 4
Intra-Cardiac Kinetic Energy and Ventricular Flow Analysis in Bicuspid Aortic Valve: Impact on Left Ventricular Function, Dilation Severity, and Surgical Referral
Hassanabad, A. F., & García, J. (2024) · Fluids · doi:10.3390/fluids10010005 · Cited by 4
“Broadly, aortic valve disease can be acquired or be congenital [1].”
The effect of aneurysm diameter on perioperative outcomes following complex endovascular repair
van Galen, I. F., Guetter, C. R., Caron, E., Darling, J. D., Park, J., Davis, R. B., Kricfalusi, M., Patel, V. I., van Herwaarden, J. A., O’Donnell, T. F. X., et al. (2025) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2024.12.129 · Cited by 4
Sex differences in patterns of cardiovascular referral in patients with Marfan, Ehlers-Danlos, and Loeys-Dietz syndromes
Waldron, C. J., Nasir, A., Wang, K., Chou, A., Erez, E., Vallabhajosyula, P., & Assi, R. (2025) · JTCVS Open · doi:10.1016/j.xjon.2025.01.002 · Cited by 4
Time is Aorta in Uncomplicated Type B Aortic Dissection
Civilini, E., Pascucci, M. G., Jubouri, M., Bashir, M., D’Oria, M., & Piffaretti, G. (2025) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2025.01.028 · Cited by 4
Effect of lower-body ischemia duration in aortic arch surgery under mild-to-moderate hypothermic circulatory arrest
Murana, G., Nocera, C., Zanella, L., Marco, L. D., Snaidero, S., Castagnini, S., Mariani, C., & Pacini, D. (2025) · JTCVS Open · doi:10.1016/j.xjon.2025.01.015 · Cited by 4
The relationship between regional mechanical properties and hemodynamic indices of the aortic arch: a preliminary study
Zhao, Y., Cao, Y., Fen, L., Zhang, C., Shi, Y., Song, H., Chen, L., & Chen, W. (2025) · Biomechanics and Modeling in Mechanobiology · doi:10.1007/s10237-025-01927-w · Cited by 4
Multicenter Prospective Evaluation of Patient Radiation Exposure During Fenestrated-branched Endovascular Aortic Repair
Mésnard, T., Huang, Y., Schanzer, A. S., Timaran, C. H., Schneider, D. B., Mendes, B. C., Eagleton, M. J., Farber, M. A., Parodi, F. E., Gasper, W. J., et al. (2025) · Annals of Surgery · doi:10.1097/sla.0000000000006676 · Cited by 4
Exploring Disparities in Atherosclerosis Comorbidity with Aortic Aneurysm
Николаевна, К. А., Koroleva, I. A., & Nazarenko, M. S. (2025) · Biomedicines · doi:10.3390/biomedicines13030593 · Cited by 4
“BAV is characterised by a significant genetic component, and monogenic forms have been identified in multiple studies [14,75,76].”
Influential
Evaluation of a novel compliance-matching aortic graft in a swine model
Rovas, G., Reymond, P., van Steenberghe, M., Diaper, J., Bikia, V., Çıkırıkçıoğlu, M., Habre, W., Huber, C. H., & Stergiopulos, N. (2025) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2025.112629 · Cited by 4
Real World Sex Differences in Patients Undergoing Ascending Aortic Aneurysm Surgery—A Systematic Review and Meta-Analysis of Reconstructed Time-to-Event Data
Al‐Tawil, M., Geragotellis, A., Alroobi, A., Aboabdo, M., Alaila, D., Sulaiman, W. A., Ghaben, N., Salim, H. T., Friedrich, C., Rusch, R., et al. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14061908 · Cited by 4
“However, current guidelines do not address sex-specific differences in AscAA, including possible variations in progression rates, perioperative evaluation, and post-surgery prognosis [13,14].”
Aortic dissection in the ED: a medico-legal perspective on diagnostic delays and failures
Fortier, J. H., Mostafapour, M., Ohle, R., Barbosa, K., Liu, R., Guo, M. H., Garber, G. E., & Murray, H. E. (2025) · Canadian Journal of Emergency Medicine · doi:10.1007/s43678-025-00999-y · Cited by 4
Value of aortic volumes assessed by automated segmentation of 3D MRI data in patients with thoracic aortic dilatation: A case-control study
Dietenbeck, T., Bouaou, K., Houriez—Gombaud-Saintonge, S., Guo, J., Gencer, U., Charpentier, E., Giron, A., Cesare, A. D., Nguyen, V., Gallo, A., et al. (2023) · Diagnostic and Interventional Imaging · doi:10.1016/j.diii.2023.04.004 · Cited by 4
Emergency vascular surgical care in populations with unique physiologic characteristics: Pediatric, pregnant, and frail populations
Warner, D. L., Holmes, K. W., Afifi, R., Russo, M. L., & Shalhub, S. (2023) · Seminars in Vascular Surgery · doi:10.1053/j.semvascsurg.2023.04.015 · Cited by 4
The usefulness of the genetic panel in the classification and refinement of diagnostic accuracy of Mexican patients with Marfan syndrome and other connective tissue disorders
Fuentevilla-Álvarez, G., Soto, M. E., Torres-Paz, Y. E., Meza-Toledo, S. E., Vargas‐Alarcón, G., González-Moyotl, N. J., Pérez-Torres, I., Manzano-Pech, L., Mejia, A. M., Huesca‐Gómez, C., et al. (2023) · Biomolecules and Biomedicine · doi:10.17305/bb.2023.9578 · Cited by 4
Presentation and Outcomes of Elective and Nonelective Complex Endovascular Repair for Thoracoabdominal and Juxtarenal Aortic Aneurysms
Krebs, J. R., Fazzone, B. J., Anderson, E. M., Ueland, W., Spratt, J. R., Back, M. R., Shahid, Z., Huber, T. S., Upchurch, G. R., & Cooper, M. A. (2023) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2023.09.001 · Cited by 4
Association between invasively measured central aortic pulse pressure and diameter of ascending aorta
Kim, H., Joh, H. S., Lim, W., Seo, J., Kim, S., Zo, J., & Kim, M. (2023) · Scientific Reports · doi:10.1038/s41598-023-48597-1 · Cited by 4
“Detecting aortic root dilation is crucial in clinical practice, as it is a known risk factor for serious cardiovascular conditions such as aortic regurgitation, aortic dissection, and sudden cardiac death [1].”
Background
Recapturing the Team Approach to Vascular Care
Aronow, H. D., Bonaca, M. P., Kolluri, R., & Beckman, J. A. (2023) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2023.12.004 · Cited by 4
Factors Associated with Early Mortality in Acute Type A Aortic Dissection—A Single-Centre Experience
Doukas, P., Dalibor, N., Keszei, A. P., Frankort, J., Krabbe, J., Zayat, R., Jacobs, M. J. H. M., Gombert, A., Akhyari, P., & Mehdiani, A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13041023 · Cited by 4
Pathogenetic Significance of Long Non-Coding RNAs in the Development of Thoracic and Abdominal Aortic Aneurysms
Николаевна, К. А., Koroleva, I. A., & Nazarenko, M. S. (2024) · Biochemistry (Moscow) · doi:10.1134/s0006297924010085 · Cited by 4
Current state of endovascular repair of thoracoabdominal aortic aneurysms
Rodrigues, D. V. S., Lima, G. B. B., DeMartino, R. R., & Mendes, B. C. (2024) · Vessel Plus · doi:10.20517/2574-1209.2023.109 · Cited by 4
Efficacy and Safety of Sacubitril/Valsartan in Chronic Type B Aortic Dissection Combined With Mild Hypertension
Wang, X., Song, F., Jiang, L., Huang, Z., Luo, S., Li, X., & He, X. (2024) · American Journal of Hypertension · doi:10.1093/ajh/hpae038 · Cited by 4
Considering Adverse Effects of Common Antihypertensive Medications in the ED
Wira, C., Kearns, T., Fleming‐Nouri, A., Tyrrell, J. D., Wira, C. M., & Aydin, A. (2024) · Current Hypertension Reports · doi:10.1007/s11906-024-01304-5 · Cited by 4
Controlling the nutritional status score: a new tool for predicting postoperative mortality in patients with infrarenal abdominal aortic aneurysm treated with endovascular aneurysm repair
Ye, S.-L., Xu, T.-Z., Wang, C., Han, K., Jiang, X., Tang, T., Song, B., Du, X.-L., Hu, N., & Li, X. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1351797 · Cited by 5
Deciphering the circulating immunological landscape of thoracic aortic aneurysm: Insights from a two-sample Mendelian randomization study
Gao, H., Wang, X., Gan, H., Li, M., Shi, J., & Guo, Y. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e31198 · Cited by 4
“Among all TAA, ascending aortic aneurysms and aortic root aneurysms account for about 60 %, descending aortic aneurysms account for approximately 30 %, and aortic arch aneurysms account for less than 10 % [1].”
Background
Coronary angiography following transcatheter aortic valve replacement: Insights from the SWEDEHEART registry
Louca, A., Alchay, M., Råmunddal, T., Rawshani, A., Hagström, H., Settergren, M., Nilsson, K., Shahim, B., James, S. K., Koul, S. M., et al. (2024) · Catheterization and Cardiovascular Interventions · doi:10.1002/ccd.31171 · Cited by 4
“4,5 Consequently, a substantial proportion of these patients may outlive their THV device.”
Three-year outcomes of a US pivotal trial substudy for conformable endoprosthesis in ≥10 mm nonangulated neck anatomy
Yamanouchi, D., Oderich, G. S., Han, S. M., Long, C. A., Muck, P. E., Moore, E. M., Matsumura, J. S., & Rhee, R. Y. (2024) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2024.06.166 · Cited by 4
Aortic aneurysm and cancer: What should be treated first?
Larena-Avellaneda, A. A. (2023) · VASA · doi:10.1024/0301-1526/a001046 · Cited by 4
Heritable aortic root aneurysms
Ouzounian, M., LeMaire, S. A., & Milewicz, D. M. (2023) · Annals of Cardiothoracic Surgery · doi:10.21037/acs-2023-avs1-16 · Cited by 4
Medical Management of Aortic Disease: If They Don’t Need Surgery, What Do They Need?
Saeed, M., & Malahfji, M. (2023) · Methodist DeBakey Cardiovascular Journal · doi:10.14797/mdcvj.1192 · Cited by 3
Outcomes of thoracic endovascular aortic repair with physician-manufactured partial micropore stent grafts for aortic arch pathologies
Huang, J., Tian, H., Chen, Z., Teng, B., Zhao, Y. H., & Li, F. (2023) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2023.12.043 · Cited by 3
Utility of structured follow-up imaging after aortic surgery
Chung, M., Yu, A., Zhao, Y., Wist, E., Hohri, Y., Kurlansky, P. A., Leb, J. S., O’Donnell, T. F. X., Patel, V. I., & Takayama, H. (2024) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2024.02.007 · Cited by 3
Effect of a Hypertensive Response During Exercise on Growth Rates of Aortic Diameters
van der Stouwe, J. G., Rossi, V. A., Ghidoni, C., Würzburger, L., Wiech, P., Schweiger, V., Petrasch, G., Moser, G., Schmied, C. M., Vontobel, J., et al. (2024) · American Journal of Hypertension · doi:10.1093/ajh/hpae050 · Cited by 3
Are aortic biomechanical properties early markers of dilatation in patients with Marfan syndrome? A systematic review and meta-analysis
Rosnel, C., Sivera, R., Cervi, E., Danton, M., Schievano, S., Capelli, C., & Aggarwal, A. (2024) · Biomechanics and Modeling in Mechanobiology · doi:10.1007/s10237-024-01881-z · Cited by 3
Hypertensive emergencies
Davies, E. A., Charlesworth, M., & Agarwal, S. (2024) · BJA Education · doi:10.1016/j.bjae.2024.07.002 · Cited by 3
Disparities in mortality rates from aortic aneurysm and dissection by country-level income status and sex
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Association Between Cardiac Size, Systolic Function, and Complications in Vascular Ehlers-Danlos Syndrome
Fawzy, A., Warnica, W., Hanneman, K. A., Wald, R. M., Oechslin, E. N., Thavendiranathan, P., & Karur, G. R. (2024) · Canadian Association of Radiologists Journal · doi:10.1177/08465371241278523 · Cited by 3
A rare case of IgG4-related aortitis in the thoracic aorta mimicking an intramural hematoma: navigating the diagnostic labyrinth
Alemany, V. S., Fortier, J. H., Gupta, H., Zaider, A., Grau, J. B., Burns, P. G., & Jabagi, H. (2024) · Journal of Cardiothoracic Surgery · doi:10.1186/s13019-024-03026-w · Cited by 3
Growth rates in non-syndromic aneurysms of the ascending aorta: a systematic review
Cozijnsen, L., Adriaans, B. P., Schermer, T. R., Groenink, M., Schalla, S. M., & Bekkers, S. C. A. M. (2024) · Netherlands Heart Journal · doi:10.1007/s12471-024-01911-6 · Cited by 3
Efficacy of beta-blocker agents on clinical outcomes in patients with thoracic aortic aneurysm: A systematic review and meta-analysis of randomized controlled trials
Tanrıverdi, L. H., Barrett, A., Kalyanasundaram, A., Zafar, M. A., Ziganshin, B. A., & Elefteriades, J. A. (2025) · Vascular Pharmacology · doi:10.1016/j.vph.2025.107494 · Cited by 5
Feasibility of Noncontrast 3D MR Angiography on a Commercial Wide-Bore 0.55-T System: Comparison with 1.5-T MR Angiography
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Using Genomics to Develop Personalized Cardiovascular Treatments
Sanghvi, M. M., Young, W. J., Naderi, H., Burns, R., Ramírez, J., Bell, C. G., & Munroe, P. B. (2025) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.125.319221 · Cited by 5
Early diagnosis of vascular Ehlers-Danlos syndrome through AI-powered facial analysis: Results from the Montalcino Aortic Consortium
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“1,4 Notably, vEDS is characterized by a distinct set of facial features that are part of the diagnostic criteria, 5 including prominent eyes, a narrow nose, a thin vermilion of the lips, and micrognathia 2 (Figure 1A-D), 6 which differ from those observed in the general population (Figure 1E-H).”
Ascending aortic aneurysm and dissection risk: focus on aortic height index
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Aortic root dilation in bicuspid aortic valve disease: impact on dissection risk and evaluation of guideline-based surgical thresholds — a retrospective cohort study
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Beta Blockers as Primary and Secondary Prevention for Aortic Dissections in Nonsyndromic Patients With Hypertension
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AI-Based screening for thoracic aortic aneurysms in routine breast MRI
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A systematic quantification of hemodynamic differences persisting after aortic coarctation repair
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Evaluation of a Rehabilitation Program With Blood Pressure-Guided Exercise Intensity Restrictions for Patients With Thoracic Aortic Dissection or Aneurysm
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Mechanism of distal stent graft-induced new entry and its prevention
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Cannulation Strategies for Aortic Arch Surgery
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“…artery and thus maintaining flow to the right arm and right internal carotid artery, is now established as a method of cerebral protection in aortic arch surgery [8,9], and its use has been endorsed in the latest American College of Cardiology/American Heart Association guidelines (ACC/AHA) [10].”
Risk factors for thoracic aortic aneurysm and dissection among diabetic patients: a nationwide population-based study
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Authors: Isselbacher, E. M., Preventza, O., Hamilton Black, J., Augoustides, J. G., Beck, A. W., Bolen, M. A., Braverman, A. C., Bray, B. E., Brown-Zimmerman, M. M., Chen, E. P., Collins, T. J., DeAnda, A., Fanola, C. L., Girardi, L. N., Hicks, C. W., Hui, D. S., Schuyler Jones, W., Kalahasti, V., Kim, K. M., Milewicz, D. M., Oderich, G. S., Ogbechie, L., Promes, S. B., Gyang Ross, E., Schermerhorn, M. L., Singleton Times, S., Tseng, E. E., Wang, G. J., Woo, Y. J., Faxon, D. P., Upchurch, G. R., Aday, A. W., Azizzadeh, A., Boisen, M., Hawkins, B., Kramer, C. M., Luc, J. G. Y., MacGillivray, T. E., Malaisrie, S. C., Osteen, K., Patel, H. J., Patel, P. J., Popescu, W. M., Rodriguez, E., Sorber, R., Tsao, P. S., & Santos Volgman, A.
Affiliations: SCA representative.
ACR representative.
American Heart Association (US)
Lay stakeholder representative.
Fraunhofer Institute for Algorithms and Scientific Computing (DE)
AATS representative.
American Hospital Association (US)
AHA/ACC Joint Committee on Clinical Practice Guidelines liaison.
STS representative.
SVS representative.
AHA/ACC staff representative.
ORCID: Isselbacher, Eric M.
Preventza, Ourania
Augoustides, John G.
Beck, Adam W.
Bolen, Michael A.
Braverman, Alan C.
Bray, Bruce E.
Chen, Edward P.
DeAnda, Abe
Fanola, Christina L.
Girardi, Leonard N.
Hicks, Caitlin W.
Hui, Dawn S.
Kalahasti, Vidyasagar
Kim, Karen M.
Milewicz, Dianna M.
Oderich, Gustavo S.
Promes, Susan B.
Schermerhorn, Marc L.
Tseng, Elaine E.
Upchurch, Gilbert R.
Aday, Aaron W.
Azizzadeh, Ali
Boisen, Michael
Kramer, Christopher M.
Luc, Jessica G.Y.
MacGillivray, Thomas E.
Osteen, Kathryn
Patel, Himanshu J.
Patel, Parag J.
Popescu, Wanda M.
Sorber, Rebecca
Tsao, Philip S.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2022-12-13
Volume: 146
Issue: 24
Pages: e334-e482
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/cir.0000000000001106
PMC: PMC9876736
OpenAlex: W4307934708
Cited by: 2,082
References: 1,104
Citations by year: 2026: 600 · 2025: 569 · 2024: 554 · 2023: 348 · 2022: 9
FWCI: 239.09
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
Locations: Circulation (publishedVersion, cc-by)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Veterans Affairs
American Heart Association
Massachusetts General Hospital
American College of Cardiology Foundation
University of Pennsylvania
CryoLife
Office of Science
National Institute of Diabetes and Digestive and Kidney Diseases (K23DK124515)
Division of Cardiothoracic Surgery, University of Colorado School of Medicine, Anschutz Medical Campus
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Aortic Disease and Treatment Approaches
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
Health Sciences › Medicine › Surgery › Aortic aneurysm repair treatments
Keywords: aortic disease, thoracic aortic disease, acute aortic syndrome, aortic aneurysm, aortic dissection, bicuspid aortic valve disease, peripheral arterial disease, genetic evaluation, family screening, endovascular repair, aortic surgery, long-term surveillance, shared decision-making, pregnancy
MeSH terms: Bicuspid Aortic Valve Disease, American Heart Association, Aortic Diseases, Cardiology, Female, Humans, Pregnancy, United States, Research Report

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