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Updated Worldwide Survey on the Methods, Efficacy, and Safety of Catheter Ablation for Human Atrial Fibrillation
Abstract
BACKGROUND: The purpose of this study was to provide an updated worldwide report on the methods, efficacy, and safety of catheter ablation of atrial fibrillation (AF). METHODS AND RESULTS: A questionnaire with 46 questions was sent to 521 centers from 24 countries in 4 continents. Complete interviews were collected from 182 centers, of which 85 reported to have performed 20,825 catheter ablation procedures on 16,309 patients with AF between 2003 and 2006. The median number of procedures per center was 245 (range, 2 to 2715). All centers included paroxysmal AF, 85.9% also included persistent and 47.1% also included long-lasting AF. Carto-guided left atrial circumferential ablation (48.2% of patients) and Lasso-guided ostial electric disconnection (27.4%) were the most commonly used techniques. Efficacy data were analyzed with centers representing the unit of analysis. Of 16,309 patients with full disclosure of outcome data, 10 488 (median, 70.0%; interquartile range, 57.7% to 75.4%) became asymptomatic without antiarrhythmic drugs and another 2047 (10.0%; 0.5% to 17.1%) became asymptomatic in the presence of previously ineffective antiarrhythmic drugs over 18 (range, 3 to 24) months of follow-up. Success rates free of antiarrhythmic drugs and overall success rates were significantly larger in 9590 patients with paroxysmal AF (74.9% and 83.2%) than in 2800 patients with persistent AF (64.8% and 75.0%) and 1108 patients with long-lasting AF (63.1% and 72.3%) (P<0.0001). Major complications were reported in 741 patients (4.5%). CONCLUSIONS: When analyzed in a large number of electrophysiology laboratories worldwide, catheter ablation of AF shows to be effective in approximately 80% of patients after 1.3 procedures per patient, with approximately 70% of them not requiring further antiarrhythmic drugs during intermediate follow-up.
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“In patients who experience symptomatic recurrences of AF despite antiarrhythmic drug therapy, all RCTs showed better sinus rhythm maintenance with catheter ablation than on antiarrhythmic drugs.586,713,727,728”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [727]
In the citing paper
“Five to seven per cent of patients will suffer severe complications after catheter ablation of AF, and 2-3% will experience life-threatening but usually manageable complications.727,[748][749][750]”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [727]
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“Mainly using PV isolation with additional lesion sets mentioned above, a world-wide survey of catheter ablation for AF [22] from 182 centers reported on 20,825 procedures on 16,309 patients between the years 2003–2006.”
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“However, the molecular mechanisms underlying AF pathogenesis are not yet fully understood, and therapies for AF are only partially effective with substantial morbidity.(24,25) Recent advances in high-throughput technologies make large-scale molecular profiling possible.”
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“Atrial fibrillation (AF) ablation is becoming an increasingly common procedure for patients with drug-refractory, symptomatic AF [ 1 , 2]. Routine pre-procedural imaging studies, done to identify pulmonary vein anatomy and exclude left atrial (LA) thrombi, occasionally reveal anatomic variants and congenital heart dis…”
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“Although activated factor VII has been proposed as an emergency treatment for severe bleeding with these drugs [18,19], there is little experience with this agent in the setting of catheter ablation (CA) procedures.”
BackgroundLong-term events following atrial fibrillation rate control or transcatheter ablation
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“However, in clinical trials in patients with paroxysmal AF, PVI alone is insufficient in maintaining sinus rhythm in up to one third of patients [2, 6, 7], and the efficacy of this technique may be even lower in clinical practice.”
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“Catheter ablation is an effective approach for the management of patients with atrial fibrillation (AF) [1—7].”
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“Accordingly, thromboembolic and bleeding complication rates in this large survey were fairly consistent with that reported in Group 1 and 2 patients of our study [13, 18].”
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“patient to adverse events, reports from experienced centers using this approach have reported comparable complication rates with other ablation strategies.(3,6,21,22,39) In certain cases of resistant AF, termination of the arrhythmia by ablation may not be achievable.”
ResultNear-Field Ultrasound Imaging During Radiofrequency Catheter Ablation
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MethodMechanisms of Atrial Fibrillation
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“The rate of adverse events is similar as reported in literature [6,7,9], but remains significant when compared to catheter ablation [4].”
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“The overall rate of severe procedural complications may exceed 3% [1, 2 ].”
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“cular damage and thromboembolism which occurs due to the charring of the endothelium [5]–[7].”
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“This highlights the need for further studies on human tissue from patients with a history of AF.”
BackgroundInfluentialFemoral vein thrombosis after right-sided electrophysiological procedures
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Ion channel trafficking: A new therapeutic horizon for atrial fibrillation
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Catheter Ablation of Atrial Fibrillation in the Elderly
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Complications of atrial fibrillation ablation: when prevention is better than cure
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“A worldwide survey on the methods, efficacy, and safety of AF catheter ablation recently published by Cappato et al.[4] revealed that the indications for AF catheter ablation have been progressively widened.”
MethodInfluentialMulder, A. A. W., WIJFFELS, M. C. E. F., WEVER, E. F. D., & Boersma, L. V. A. (2011) · EP Europace · doi:10.1093/europace/eur204 · Cited by 23
“5%.(14) The multi-centre pilot study from Scharf et al.”
BackgroundCatheter Ablation of Atrial Fibrillation
Latchamsetty, R., & Morady, F. (2016) · Heart Failure Clinics · doi:10.1016/j.hfc.2015.08.018 · Cited by 23
Kiliszek, M., Koźluk, E., Franaszczyk, M., Lodziński, P., Piątkowska, A., Płoski, R., & Opolski, G. (2016) · Archives of Medical Science · doi:10.5114/aoms.2015.48284 · Cited by 23
“Catheter ablation is a standard therapy in many cases of atrial fibrillation (AF) [1], with well-documented efficacy (mainly with pulmonary vein isolation – PVI) [2].”
BackgroundMethodResultInfluentialAtrial Fibrillation: The Science behind Its Defiance
Czick, M. E., Shapter, C., & Silverman, D. I. (2016) · Aging and Disease · doi:10.14336/ad.2016.0211 · Cited by 26
Maurer, T., Rottner, L., Makimoto, H., Reißmann, B., Heeger, C.-H. H., Lemeš, C., Fink, T., Riedl, J., Santoro, F., Wohlmuth, P., et al. (2018) · Clinical Research in Cardiology · doi:10.1007/s00392-018-1270-y · Cited by 23
Boersma, L. V. A., Koźluk, E., Maglia, G., de Sousa, J., Grebe, O. C., Eckardt, L., Hokanson, R. B., Hemingway, L., Ostern, E., Park, H., et al. (2020) · EP Europace · doi:10.1093/europace/euaa042 · Cited by 22
Zhao, Z., Li, R., Wang, X., Li, J., Yuan, M., Liu, E., Liu, T., & Li, G. (2020) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-020-07002-z · Cited by 23
“Both are quite effective in preventing secondary episodes of AF, but still far away from curing all forms of AF [6, 7].”
BackgroundThe role of pulmonary veins in atrial fibrillation: A complex yet simple story
Chard, M., & Tabrizchi, R. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.07.002 · Cited by 23
Complications during catheter ablation of atrial fibrillation: Identification and prevention
Doppalapudi, H., Yamada, T., & Kay, G. N. (2009) · Heart Rhythm · doi:10.1016/j.hrthm.2009.07.025 · Cited by 23
Greef, Y. D., Tavernier, R., Vandekerckhove, Y. R., & Duytschaever, M. F. (2009) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2009.01646.x · Cited by 23
Periprocedural imaging and outcomes after catheter ablation of atrial fibrillation
Steinberg, B. A., Hammill, B. G., Daubert, J. P., Bahnson, T. D., Douglas, P. S., Qualls, L. G., Pokorney, S. D., Calkins, H. G., Curtis, L. H., & Piccini, J. P. (2014) · Heart · doi:10.1136/heartjnl-2014-306067 · Cited by 23
Compensatory caspase activation in MPP+-induced cell death in dopaminergic neurons
Chee, J. L. Y., Guan, X. L., Lee, J. Y., Dong, B., Leong, S. M., Ong, E. H., Liou, A. K. F., & Lim, T. M. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4413-4 · Cited by 23
Skanes, A. C., Jensen, S. M., Pap, R., Li, J., Yee, R. K., Krahn, A. D., & Klein, G. J. (2005) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2005.00287.x · Cited by 23
Callans, D. J. (2008) · Circulation · doi:10.1161/circulationaha.108.823179 · Cited by 23
Rate or Rhythm Control for Atrial Fibrillation: Update and Controversies
Chinitz, J. S., Halperin, J. L., Reddy, V. Y., & Fuster, V. (2012) · The American Journal of Medicine · doi:10.1016/j.amjmed.2012.04.007 · Cited by 22
Kalifa, J., Klos, M., Zlochiver, S., Mironov, S. F., Tanaka, K., Ulahannan, N., Yamazaki, M., Jalife, J., & Berenfeld, O. (2007) · Heart Rhythm · doi:10.1016/j.hrthm.2007.03.009 · Cited by 22
Current Hot Potatoes in Atrial Fibrillation Ablation
Roten, L., Derval, N., Pascale, P., Scherr, D., Komatsu, Y., Shah, A. J., Ramoul, K., Denis, A., Sacher, F., Hocini, M., et al. (2012) · Current Cardiology Reviews · doi:10.2174/157340312803760802 · Cited by 21
Weitz, J. I., Healey, J. S., Skanes, A. C., & Verma, A. (2014) · Circulation · doi:10.1161/circulationaha.113.005376 · Cited by 22
“Need for Anticoagulation in AF Patients Undergoing Catheter Ablation Stroke is one of the most feared complications of catheter ablation.(3) The stimulus for thromboembolism, the underlying cause of most strokes in AF patients, differs before, during, and after ablation, which may influence the optimal choice of antic…”
BackgroundInfluentialBhuriya, R., Singh, M., Sethi, A., Molnár, J., Bahekar, A., Singh, P. P., Khosla, S., & Arora, R. R. (2011) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248410389045 · Cited by 22
Complications of Atrial Fibrillation Cryoablation
Canpolat, U. (2017) · Journal of Atrial Fibrillation · doi:10.4022/jafib.1620 · Cited by 22
Greca, C. L., Cirasa, A., Modica, D. D., Sorgato, A., Simoncelli, U., & Pecora, D. (2020) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-020-00835-6 · Cited by 22
Kawakami, H., Nolan, M. T., Phillips, K. P., Scuffham, P., & Marwick, T. H. (2020) · American Heart Journal · doi:10.1016/j.ahj.2020.08.008 · Cited by 22
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Obeid, M. J., Zhou, J., Sale, A., Longacre, C. F., Zeitler, E. P., Andrade, J. G., Mittal, S., & Piccini, J. P. (2023) · Heart Rhythm · doi:10.1016/j.hrthm.2023.02.016 · Cited by 22
Italian Registry of Cardiac Computed Tomography
CCT Italian Registry Group, Cademartiri, F., Cesare, E. D., Francone, M., Ballerini, G., Ligabue, G., Maffei, E., Romagnoli, A., Argiolas, G. M., Russo, V. C., et al. (2015) · La radiologia medica · doi:10.1007/s11547-015-0518-0 · Cited by 22
Pulmonary vein isolation with a novel endoscopic ablation system using laser energy
Schade, A., Krug, J., Szöllösi, A.-G., Tarahony, M. E., & Deneke, T. (2012) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.12.86 · Cited by 22
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Biase, L. D., Perini, A. P., Mohanty, P. K., Goldenberg, A. S., Grifoni, G., Santangeli, P., Santoro, F., Sánchez, J., Horton, R., Gallinghouse, G. J., et al. (2013) · Heart Rhythm · doi:10.1016/j.hrthm.2013.11.016 · Cited by 22
Gürses, K. M., Koçyiğit, D., Yalçın, M. U., Evranos, B., Yorgun, H., ŞAHINER, L., Kaya, E. B., Oto, M. A., Ozer, N., & Aytemir, K. (2015) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-015-9989-0 · Cited by 22
“Several studies have suggested that bridging resulted in a high incidence of bleeding complications, especially at the site of vascular access [15–17].”
BackgroundAtrial fibrillation after typical atrial flutter ablation: a long-term follow-up
Bandini, A., Golia, P., Caroli, E., Biancoli, S., & Galvani, M. (2011) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0b013e3283403301 · Cited by 20
Metadata
- Authors
- Cappato, R., Calkins, H., Chen, S.-A., Davies, W., Iesaka, Y., Kalman, J., Kim, Y.-H., Klein, G., Natale, A., Packer, D., Skanes, A., Ambrogi, F., & Biganzoli, E.
- Affiliations
- The Royal Melbourne Hospital (AU)
- ORCID
- Venue
- Circulation Arrhythmia and Electrophysiology
- Published
- 2010-02
- Volume
- 3
- Issue
- 1
- Pages
- 32-38
- ISSN
- 1941-3084 (ISSN-L)
- 1941-3149
- OpenAlex
- W2146673314
- Cited by
- 2,852
- References
- 34
- Citations by year
- 2026: 26 · 2025: 42 · 2024: 51 · 2023: 68 · 2022: 81 · 2021: 110 · 2020: 126 · 2019: 125 · 2018: 141 · 2017: 177 · 2016: 199 · 2015: 184 · 2014: 220 · 2013: 246 · 2012: 218
- FWCI
- 156.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation Arrhythmia and Electrophysiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Keywords
- catheter ablation, atrial fibrillation, paroxysmal atrial fibrillation, persistent atrial fibrillation, ablation efficacy, ablation safety, procedural complications, CARTO system
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Anticoagulants, Atrial Fibrillation, Data Collection, Female, Humans, Male, Middle Aged, Surveys and Questionnaires, Treatment Outcome, Catheter Ablation, Young Adult
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