Cited by 2,852Atrial Fibrillation Management and OutcomesCardiac Arrhythmias and TreatmentsCardiac pacing and defibrillation studies

The DOI matches its Crossref record; 33 of the 34 references it cites were found in a registry or an index.

Updated Worldwide Survey on the Methods, Efficacy, and Safety of Catheter Ablation for Human Atrial Fibrillation

Cappato, Riccardo, Calkins, Hugh, Chen, Shih-Ann, Davies, Wyn, Iesaka, Yoshito, Kalman, Jonathan, Kim, You-Ho, Klein, George, Natale, Andrea, Packer, Douglas, Skanes, Allan, Ambrogi, Federico, Biganzoli, Elia·2010·Circulation Arrhythmia and Electrophysiology

DOI 10.1161/circep.109.859116

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Abstract

BACKGROUND: The purpose of this study was to provide an updated worldwide report on the methods, efficacy, and safety of catheter ablation of atrial fibrillation (AF). METHODS AND RESULTS: A questionnaire with 46 questions was sent to 521 centers from 24 countries in 4 continents. Complete interviews were collected from 182 centers, of which 85 reported to have performed 20,825 catheter ablation procedures on 16,309 patients with AF between 2003 and 2006. The median number of procedures per center was 245 (range, 2 to 2715). All centers included paroxysmal AF, 85.9% also included persistent and 47.1% also included long-lasting AF. Carto-guided left atrial circumferential ablation (48.2% of patients) and Lasso-guided ostial electric disconnection (27.4%) were the most commonly used techniques. Efficacy data were analyzed with centers representing the unit of analysis. Of 16,309 patients with full disclosure of outcome data, 10 488 (median, 70.0%; interquartile range, 57.7% to 75.4%) became asymptomatic without antiarrhythmic drugs and another 2047 (10.0%; 0.5% to 17.1%) became asymptomatic in the presence of previously ineffective antiarrhythmic drugs over 18 (range, 3 to 24) months of follow-up. Success rates free of antiarrhythmic drugs and overall success rates were significantly larger in 9590 patients with paroxysmal AF (74.9% and 83.2%) than in 2800 patients with persistent AF (64.8% and 75.0%) and 1108 patients with long-lasting AF (63.1% and 72.3%) (P<0.0001). Major complications were reported in 741 patients (4.5%). CONCLUSIONS: When analyzed in a large number of electrophysiology laboratories worldwide, catheter ablation of AF shows to be effective in approximately 80% of patients after 1.3 procedures per patient, with approximately 70% of them not requiring further antiarrhythmic drugs during intermediate follow-up.

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10.1161/circ.95.3.572 · DOI
10.1161/circ.100.11.1203 · DOI
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Background
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Result
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Result
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Result
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Background
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Symptomatic and Asymptomatic Atrial Fibrillation after Pulmonary Vein Ablation and the Impact on Quality of Life
Pontoppidan, J., Nielsen, J. C., Poulsen, S. H., & HANSEN, P. S. (2009) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2009.02357.x · Cited by 40
Design and evaluation of a transesophageal HIFU probe for ultrasound-guided cardiac ablation: simulation of a HIFU mini-maze procedure and preliminary ex vivo trials
Constanciel, É., N’Djin, W. A., Bessière, F., Chavrier, F., Grinberg, D., Vignot, A., Chevalier, P., Chapelon, J. Y., & Lafon, C. (2013) · IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control · doi:10.1109/tuffc.2013.2772 · Cited by 40
Complications of transseptal catheterization for different cardiac procedures
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“31% in 2010 [6,7].”
Background
A randomized trial to compare atrial fibrillation ablation using a steerable vs. a non-steerable sheath
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Improving safety in the electrophysiology laboratory using a simple radiation dose reduction strategy: a study of 1007 radiofrequency ablation procedures
Rogers, D. P. S., England, F., Lozhkin, K., LOWE, M. D., Lambiase, P. D., & CHOW, A. W. C. (2010) · Heart · doi:10.1136/hrt.2010.204222 · Cited by 40
Catheter ablation for atrial fibrillation: Should it be first-line therapy?
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Pulmonary vein anatomy and long-term outcome after multi-electrode pulmonary vein isolation with phased radiofrequency energy for paroxysmal atrial fibrillation
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Complication Rates of Catheter Ablation of Atrial Fibrillation in Patients Aged ≥75 Years versus <75 Years—Results from the German Ablation Registry
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Incidence and Predictors of Left Atrial Appendage Thrombus in Patients Treated With Nonvitamin K Oral Anticoagulants Versus Warfarin Before Catheter Ablation for Atrial Fibrillation
Wyrembak, J., Campbell, K. B., Steinberg, B. A., Bahnson, T. D., Daubert, J. P., Velazquez, E. J., Samad, Z. Z., & Atwater, B. D. (2017) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2016.12.008 · Cited by 40
First-in-Man Analysis of the Relationship Between Electrical Rotors From Noninvasive Panoramic Mapping and Atrial Fibrosis From Magnetic Resonance Imaging in Patients With Persistent Atrial Fibrillation
Sohns, C., Lemeš, C., Metzner, A., Fink, T., Chmelevsky, M., Maurer, T., Budanova, M., Solntsev, V., Schulze, W., Staab, W., et al. (2017) · Circulation: Arrhythmia and Electrophysiology · doi:10.1161/circep.116.004419 · Cited by 35
Catheter Ablation of the Superolateral Mitral Isthmus Line
Maurer, T., Metzner, A., Ho, S. Y., Wohlmuth, P., Reißmann, B., Heeger, C.-H. H., Lemeš, C., Hayashi, K., Saguner, A. M., Riedl, J., et al. (2017) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.117.005191 · Cited by 40
Nonfluoroscopic catheter ablation of paroxysmal atrial fibrillation
Lyan, E., Tsyganov, A., Abdrakhmanov, A. S., Morozov, A., Bakytzhanuly, A., Tursunbekov, A., Nuralinov, O., Mironovich, S., Klukvin, A., Алексеевич, М. В., et al. (2018) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.13321 · Cited by 40
Obesity is associated with impaired long-term success of pulmonary vein isolation: a plea for risk factor management before ablation
Maat, G. E. D., Mulder, B. A., Berretty, W. L., Al-Jazairi, M. I. H., Tan, Y. E. S., Wiesfeld, A. C. P., Mariani, M. A., Gelder, I. C. V., Rienstra, M., & Blaauw, Y. (2018) · Open Heart · doi:10.1136/openhrt-2017-000771 · Cited by 40
“Minor adverse events were defined as bleeding from the femoral artery/vein, femoral aneurysm not requiring intervention, pericardial effusion not requiring intervention and asymptomatic pulmonary vein stenosis.(16)”
Background
Treatment of atrial fibrillation: a comprehensive review and practice guide
Li, J., Gao, M., Zhang, M., Liu, D., Li, Z., Du, J., & Hou, Y. (2020) · Cardiovascular journal of South Africa/Cardiovascular journal of Southern Africa · doi:10.5830/cvja-2019-064 · Cited by 42
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Incidence and outcomes of cerebrovascular events complicating catheter ablation for atrial fibrillation
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“Cerebrovascular complications associated with atrial fibrillation ablation The 2010 worldwide survey of AF ablation reported an overall incidence of 0.94% thrombo-embolic events including 37 (0.23% per patient) strokes and 115 (0.71% per patient) TIAs.2 In a single-centre study on periprocedural complications occurred…”
BackgroundInfluential
State of the Art Imaging Review of Blunt and Penetrating Cardiac Trauma
Qamar, S. R., Wu, Y., Nicolaou, S., & Murray, N. (2020) · Canadian Association of Radiologists Journal · doi:10.1177/0846537119899200 · Cited by 39
How to Learn Pulmonary Vein Isolation with a Novel Ablation Device: Learning Curve Effects Using the Endoscopic Ablation System
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Oral anticoagulant therapy for stroke prevention in patients with atrial fibrillation undergoing ablation: results from the First European Snapshot Survey on Procedural Routines for Atrial Fibrillation Ablation (ESS-PRAFA)
Potpara, T., Larsen, T. B., Deharo, J. C., Rossvoll, O., Dagres, N., Todd, D., Pison, L., Proclemer, A., Purefellner, H., Blomstrom-Lundqvist, C., et al. (2015) · EP Europace · doi:10.1093/europace/euv132 · Cited by 39
“This is an increase compared with previous reports showing that as many as 27% of patients underwent AF ablation without pre-procedural OAC, and 12–15% were not prescribed OAC post AF ablation.(1,5) Indeed, randomized trials are lacking to support the common practice of giving OAC at least 3 weeks beforeAF ablation to…”
Result
Current Status of Catheter Ablation for Atrial Fibrillation
Inoue, K., Murakawa, Y., Nogami, A., Shoda, M., Naito, S., Kumagai, K., Miyauchi, Y., Yamane, T., Morita, N., Okumura, K., et al. (2014) · Circulation Journal · doi:10.1253/circj.cj-13-1179 · Cited by 39
Whole Exome Sequencing in Atrial Fibrillation
Lubitz, S. A., Brody, J. A., Bihlmeyer, N. A., Roselli, C., Weng, L.-C. C., Christophersen, I. E., Alonso, Á., Boerwinkle, E., Gibbs, R. A., Bis, J. C., et al. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006284 · Cited by 40
“Current treatments for AF have limited efficacy and can cause significant adverse effects [8, 9].”
Background
Comparative Effectiveness of Hybrid Ablation Versus Endocardial Catheter Ablation Alone in Patients With Persistent Atrial Fibrillation
Kress, D. C., Erickson, L., Choudhuri, I., Zilinski, J. L., Mengesha, T., Krum, D. P., & Sra, J. S. (2016) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2016.10.010 · Cited by 39
Should We Perform Catheter Ablation for Asymptomatic Atrial Fibrillation?
Kalman, J. M., Sanders, P., Rosso, R., & Calkins, H. G. (2017) · Circulation · doi:10.1161/circulationaha.116.024926 · Cited by 42
Power, Lesion Size Index and Oesophageal Temperature Alerts During Atrial Fibrillation Ablation
Leo, M., Pedersen, M. E. F., Rajappan, K., Ginks, M., Hunter, R. J., Bowers, R., Kalla, M., Bashir, Y., & Betts, T. R. (2020) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.120.008316 · Cited by 39
Peri-procedural anticoagulation in patients undergoing ablation for atrial fibrillation
Vazquez, S. R., Johnson, S. A., & Rondina, M. T. (2010) · Thrombosis Research · doi:10.1016/j.thromres.2009.11.031 · Cited by 40
Continuous Nonfluoroscopic Localization of the Esophagus During Radiofrequency Catheter Ablation of Atrial Fibrillation
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New Ablation Techniques for Atrial Fibrillation and the Minimally Invasive Cryo-Maze Procedure in Patients with Lone Atrial Fibrillation
Moten, S., Rodríguez, E., Cook, R., Nifong, L. W., & Chitwood, W. R. (2007) · Heart Lung and Circulation · doi:10.1016/j.hlc.2007.05.005 · Cited by 39
The Medical ANtiarrhythmic Treatment or Radiofrequency Ablation in Paroxysmal Atrial Fibrillation (MANTRA-PAF) Trial: clinical rationale, study design, and implementation
Jøns, C., HANSEN, P. S., Johannessen, A. C., Hindricks, G., Raatikainen, P. M. J., Kongstad, O., Walfridsson, H., Pehrson, S. M., Almroth, H., Hartikainen, J. E. K., et al. (2009) · EP Europace · doi:10.1093/europace/eup122 · Cited by 39
The pre-ablation triglyceride-glucose index predicts late recurrence of atrial fibrillation after radiofrequency ablation in non-diabetic adults
Tang, Q.-H., GUO, X., Sun, Q., & Ma, J. (2022) · BMC Cardiovascular Disorders · doi:10.1186/s12872-022-02657-y · Cited by 38
Efficacy and safety of pulsed‐field versus conventional thermal ablation for atrial fibrillation: A systematic review and meta‐analysis
Amin, A. M., Nazir, A., Abuelazm, M. T., Ibrahim, A. A. A., Elbenawi, H., Aboutaleb, A. M., Ellabban, M., Arnaout, M., Turkmani, M. M., Abdelazeem, B., et al. (2024) · Journal of Arrhythmia · doi:10.1002/joa3.13118 · Cited by 39
Prevention of atrial–esophageal fistula after catheter ablation of atrial fibrillation
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Persistent iatrogenic atrial septal defect after pulmonary vein isolation by cryoballoon: an under-recognized complication
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Class I Histone Deacetylase Inhibition for the Treatment of Sustained Atrial Fibrillation
Seki, M., LaCanna, R., Powers, J. C., Vrakas, C. N., Liu, F., Berretta, R. M., Chacko, G., Holten, J., Jadiya, P., Wang, T., et al. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.234591 · Cited by 38
“This may explain why most patients with permanent AF are less responsive to current antiarrhythmic or catheter-based therapies (Gaita et al., 2008; Cappato et al., 2010), which do not prevent or reduce atrial remodeling.”
Background
Long-term outcomes after ablation of persistent atrial fibrillation: an observational study over 6 years
Wynn, G. J., Kadri, M. E., Haq, I. J., Das, M., Modi, S. S., SNOWDON, R. L., Hall, M. C. S., Waktare, J. E. P., TODD, D. M., & Gupta, D. (2016) · Open Heart · doi:10.1136/openhrt-2015-000394 · Cited by 39
“1% incidence of major complications, with no thromboembolic events, compares favourably with that reported in worldwide registries and other studies.(5) 13–16 Second, recurrence after the initial CA is the norm rather than the exception.”
BackgroundResultInfluential
Concomitant ablation for atrial fibrillation during septal myectomy in patients with hypertrophic obstructive cardiomyopathy
Bogachev-Prokophiev, A. V., Afanasyev, A. V., Иванович, Ж. С., Pivkin, A. N., Фоменко, М. С., Махарамович, Ш. Р., & Karaskov, A. M. (2017) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2017.08.063 · Cited by 38
Very long-term clinical outcomes after radiofrequency catheter ablation for atrial fibrillation: A large single-center experience
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Relationship between procedural volume and complication rates for catheter ablation of atrial fibrillation: a systematic review and meta-analysis
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Ablation of Atrial Fibrillation in Humans Using a Balloon‐Based Ablation System: Identification of the Site of Phrenic Nerve Damage Using Pacing Maneuvers and CARTO
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Feasibility of Real-Time MRI With a Novel Carbon Catheter for Interventional Electrophysiology
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Favorable Long-Term Outcome of Maze Surgery in Patients With Lone Atrial Fibrillation
Hemels, M. E. W., Gu, Y. L., Tuinenburg, A. E., Boonstra, P. W., Wiesfeld, A. C. P., van den Berg, M. P., van Veldhuisen, D. J., & Gelder, I. C. V. (2006) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2005.10.007 · Cited by 38
The Role Of Renin Angiotensin System In Atrial Fibrillation.
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“Other investigators have published similar results, reporting freedom from AF in 56% and 92% of patients, depending on the ablation strategy and intensity of follow-up [7, 11, 13, 23].”
BackgroundResult
Catheter ablation of atrial fibrillation in very young adults: a 5-year follow-up study
Saguner, A. M., Maurer, T., Wißner, E., Santoro, F., Lemeš, C., Mathew, S., Sohns, C., Heeger, C.-H. H., Reißmann, B., Riedl, J., et al. (2016) · EP Europace · doi:10.1093/europace/euw378 · Cited by 36
Ten-year ablation outcomes of patients with paroxysmal atrial fibrillation undergoing pulmonary vein isolation
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Safety and efficacy of catheter ablation of atrial fibrillation in patients with diabetes mellitus—single center experience
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Early cerebral thromboembolic complications after radiofrequency catheter ablation of atrial fibrillation: incidence, characteristics, and risk factors
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Radiofrequency catheter ablation maintains its efficacy better than antiarrhythmic medication in patients with paroxysmal atrial fibrillation: On-treatment analysis of the randomized controlled MANTRA-PAF trial
Raatikainen, M. J. P., Hakalahti, A., Uusimaa, P., Nielsen, J. C., Johannessen, A. C., Hindricks, G., Walfridsson, H., Pehrson, S. M., Englund, A., Hartikainen, J. E. K., et al. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.06.160 · Cited by 35

Authors: Cappato, R., Calkins, H., Chen, S.-A., Davies, W., Iesaka, Y., Kalman, J., Kim, Y.-H., Klein, G., Natale, A., Packer, D., Skanes, A., Ambrogi, F., & Biganzoli, E.
Affiliations: The Royal Melbourne Hospital (AU)
ORCID: Cappato, Riccardo
Calkins, Hugh
Chen, Shih-Ann
Kalman, Jonathan
Kim, You-Ho
Klein, George
Natale, Andrea
Packer, Douglas
Skanes, Allan
Ambrogi, Federico
Biganzoli, Elia
Venue: Circulation Arrhythmia and Electrophysiology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2010-02
Volume: 3
Issue: 1
Pages: 32-38
ISSN: 1941-3084 (ISSN-L)
1941-3149
DOI: 10.1161/circep.109.859116
OpenAlex: W2146673314
Cited by: 2,852
References: 34
Citations by year: 2026: 26 · 2025: 42 · 2024: 51 · 2023: 68 · 2022: 81 · 2021: 110 · 2020: 126 · 2019: 125 · 2018: 141 · 2017: 177 · 2016: 199 · 2015: 184 · 2014: 220 · 2013: 246 · 2012: 218
FWCI: 156.54
Type: journal article
Language: en
Open access: closed
Locations: Circulation Arrhythmia and Electrophysiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Keywords: catheter ablation, atrial fibrillation, paroxysmal atrial fibrillation, persistent atrial fibrillation, ablation efficacy, ablation safety, procedural complications, CARTO system
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Anticoagulants, Atrial Fibrillation, Data Collection, Female, Humans, Male, Middle Aged, Surveys and Questionnaires, Treatment Outcome, Catheter Ablation, Young Adult

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Updated Worldwide Survey on the Methods, Efficacy, and Safety of Catheter Ablation for Human Atrial Fibrillation

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