Activation and Signaling by the AMP-Activated Protein Kinase in Endothelial Cells

Resveratrol improves health and survival of mice on a high-calorie diet

Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.003 · Cited by 2,799

Immunol. Cell Biol.

Fitzgerald, M., Hayward, I. P., Thomas, A. C., Campbell, J. H., & CAMPBELL, G. R. (1995) · Cited by 2,552

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

Jäger, S., Handschin, C., St.-Pierre, J., & Spiegelman, B. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705070104 · Cited by 2,491

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

Hardie, D. G. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2249 · Cited by 2,261

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

Shaw, R. J., Kosmatka, M., Bardeesy, N., Hurley, R. L., Witters, L. A., DePinho, R. A., & Cantley, L. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308061100 · Cited by 1,797

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

Woods, A., Johnstone, S. R., Dickerson, K., Leiper, F. C., Fryer, L. G. D., Neumann, D., Schlattner, U., Wallimann, T., Carlson, M., & Carling, D. (2003) · Current Biology · doi:10.1016/j.cub.2003.10.031 · Cited by 1,650

Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase

Hawley, S. A., Pan, D. A., Mustard, K. J., Ross, L., Bain, J., Edelman, A. M., Frenguelli, B. G., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.009 · Cited by 1,589

AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling

Towler, M. C., & Hardie, D. G. (2007) · Circulation Research · doi:10.1161/01.res.0000256090.42690.05 · Cited by 1,262

Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

Cool, B. L., Zinker, B. A., Chiou, W. J. H., Kifle, L., Cao, N., Perham, M., Dickinson, R., Adler, A. L., Gagné, G. D., Iyengar, R., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.05.005 · Cited by 939

Transcriptional control of mitochondrial biogenesis: the central role of PGC-1

Ventura-Clapier, R., Garnier, A., & Veksler, V. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn098 · Cited by 932

The Energy Sensor AMP-activated Protein Kinase Directly Regulates the Mammalian FOXO3 Transcription Factor

Greer, E. L., Oskoui, P. R., Banko, M. R., Maniar, J. M., Gygi, M. P., Gygi, S. P., & Brunet, A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705325200 · Cited by 852

TRB3: A tribbles Homolog That Inhibits Akt/PKB Activation by Insulin in Liver

Du, K., Herzig, S., Kulkarni, R. N., & Montminy, M. (2003) · Science · doi:10.1126/science.1079817 · Cited by 842

AMP‐activated protein kinase phosphorylation of endothelial NO synthase

Chen, Z.-P., Mitchelhill, K. I., Michell, B. J., Stapleton, D., Rodríguez‐Crespo, I., Witters, L. A., Power, D. A., de Montellano, P. R. O., & Kemp, B. E. (1999) · FEBS Letters · doi:10.1016/s0014-5793(98)01705-0 · Cited by 839

SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1

Lan, F., Cacicedo, J. M., Ruderman, N., & Ido, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805711200 · Cited by 825

Adenosine 5′-Monophosphate-Activated Protein Kinase Promotes Macrophage Polarization to an Anti-Inflammatory Functional Phenotype

Sağ, D., Carling, D., Stout, R. D., & Suttles, J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.12.8633 · Cited by 803

An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans

Greer, E. L., Dowlatshahi, D., Banko, M. R., Villen, J., Hoang, K., Blanchard, D., Gygi, S. P., & Brunet, A. (2007) · Current Biology · doi:10.1016/j.cub.2007.08.047 · Cited by 801

SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

Hou, X., Xu, S., Maitland-Toolan, K. A., Sato, K., Jiang, B., Ido, Y., Lan, F., Walsh, K., Wierzbicki, M., Verbeuren, T. J., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802187200 · Cited by 778

Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells

Ouchi, N., Kobayashi, H., Kihara, S., Kumada, M., Sato, K., Inoue, T., Funahashi, T., & Walsh, K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310389200 · Cited by 759

Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade

Sanders, M. J., Grondin, P., Hegarty, B. D., Snowden, M. A., & Carling, D. (2007) · Biochemical Journal · doi:10.1042/bj20061520 · Cited by 677

Polyphenols Stimulate AMP-Activated Protein Kinase, Lower Lipids, and Inhibit Accelerated Atherosclerosis in Diabetic LDL Receptor–Deficient Mice

Zang, M., Xu, S., Maitland, K. A., Zuccollo, A., Hou, X., Jiang, B., Wierzbicki, M., Verbeuren, T. J., & Cohen, R. A. (2006) · Diabetes · doi:10.2337/db05-1188 · Cited by 672

Pleiotropic effects of statin therapy: molecular mechanisms and clinical results

Wang, C., Liu, P., & Liao, J. K. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.11.004 · Cited by 599

High Rates of Fatty Acid Oxidation during Reperfusion of Ischemic Hearts Are Associated with a Decrease in Malonyl-CoA Levels Due to an Increase in 5’-AMP-activated Protein Kinase Inhibition of Acetyl-CoA Carboxylase

Kudo, N., Barr, A., Barr, R. L., Desai, S. S., & Lopaschuk, G. D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.29.17513 · Cited by 565

Coordinated Control of Endothelial Nitric-oxide Synthase Phosphorylation by Protein Kinase C and the cAMP-dependent Protein Kinase

Michell, B. J., Chen, Z., Tiganis, T., Stapleton, D., Katsis, F., Power, D. A., Sim, A. T. R., & Kemp, B. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100122200 · Cited by 560

Knockout of the α2 but Not α1 5′-AMP-activated Protein Kinase Isoform Abolishes 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranosidebut Not Contraction-induced Glucose Uptake in Skeletal Muscle

Jørgensen, S. B., Viollet, B., Andreelli, F., Frøsig, C., Birk, J. B., Schjerling, P., Vaulont, S., Richter, E. A., & Wojtaszewski, J. F. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306205200 · Cited by 553

PGC-1 promotes insulin resistance in liver through PPAR-α-dependent induction of TRB-3

Koo, S.-H., Satoh, H., Herzig, S., Lee, C.-H., Hedrick, S., Kulkarni, R., Evans, R. M., Olefsky, J., & Montminy, M. (2004) · Nature Medicine · doi:10.1038/nm1044 · Cited by 550

Improved Endothelial Function With Metformin in Type 2 Diabetes Mellitus

Mather, K. J., Verma, S., & Anderson, T. J. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01129-9 · Cited by 513

AMPK: a metabolic gauge regulating whole-body energy homeostasis

Lage, R., Diéguez, C., Vidal‐Puig, A., & López, M. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2008.09.007 · Cited by 512

Mammalian TAK1 Activates Snf1 Protein Kinase in Yeast and Phosphorylates AMP-activated Protein Kinase in Vitro

Momcilovic, M., Hong, S. P., & Carlson, M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604399200 · Cited by 504

Activation of AMP-Activated Protein Kinase Reduces Hyperglycemia-Induced Mitochondrial Reactive Oxygen Species Production and Promotes Mitochondrial Biogenesis in Human Umbilical Vein Endothelial Cells

Kukidome, D., Nishikawa, T., Sonoda, K., Imoto, K., Fujisawa, K., Yano, M., Motoshima, H., Taguchi, T., Matsumura, T., & Araki, E. (2006) · Diabetes · doi:10.2337/diabetes.55.01.06.db05-0943 · Cited by 504

The AMP-activated protein kinase α2 catalytic subunit controls whole-body insulin sensitivity

Viollet, B., Andreelli, F., Jørgensen, S. B., Perrin, C., Geloen, A., Flamez, D., Mu, J., Lenzner, C., Baud, O., Bennoun, M., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16567 · Cited by 499

AMPK and the biochemistry of exercise: implications for human health and disease

Richter, E. A., & Ruderman, N. B. (2009) · Biochemical Journal · doi:10.1042/bj20082055 · Cited by 481

Activation of the AMP-Activated Kinase by Antidiabetes Drug Metformin Stimulates Nitric Oxide Synthesis In Vivo by Promoting the Association of Heat Shock Protein 90 and Endothelial Nitric Oxide Synthase

Davis, B. J., Xie, Z., Viollet, B., & Zou, M. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db05-1064 · Cited by 465

AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5

McGee, S. L., van Denderen, B. J. W., Howlett, K. F., Mollica, J., Schertzer, J. D., Kemp, B. E., & Hargreaves, M. (2008) · Diabetes · doi:10.2337/db07-0843 · Cited by 455

Isoform‐specific and exercise intensity‐dependent activation of 5′‐AMP‐activated protein kinase in human skeletal muscle

Wojtaszewski, J. F. P., Nielsen, P., Hansen, B. F., Richter, E. A., & Kiens, B. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-1-00221.x · Cited by 435

Purification and characterization of the AMP‐activated protein kinase

Carling, D., Clarke, P. R., Zammit, V. A., & Hardie, D. G. (1989) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1989.tb15186.x · Cited by 418

Akt Activity Negatively Regulates Phosphorylation of AMP-activated Protein Kinase in the Heart

Kovacic, S., Soltys, C.-L. M., Barr, A., Shiojima, I., Walsh, K. X., & Dyck, J. R. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305371200 · Cited by 412

Short-Term Overexpression of a Constitutively Active Form of AMP-Activated Protein Kinase in the Liver Leads to Mild Hypoglycemia and Fatty Liver

Foretz, M., Ancellin, N., Andréelli, F., Saintillan, Y., Grondin, P., Kahn, A., Thorens, B., Vaulont, S., & Viollet, B. (2005) · Diabetes · doi:10.2337/diabetes.54.5.1331 · Cited by 406

The Stimulation of Glycolysis by Hypoxia in Activated Monocytes Is Mediated by AMP-activated Protein Kinase and Inducible 6-Phosphofructo-2-kinase

Marsin, A.-S., Bouzin, C., Bertrand, L., & Hue, L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205213200 · Cited by 380

Mitochondria as signaling organelles in the vascular endothelium

Quintero, M., Colombo, S. L., Godfrey, A. R., & Moncada, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601026103 · Cited by 362

Direct Activation of AMP-activated Protein Kinase Stimulates Nitric-oxide Synthesis in Human Aortic Endothelial Cells

Morrow, V. A., Foufelle, F., Connell, J., Petrie, J. R., Gould, G. W., & Salt, I. P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212831200 · Cited by 361

A pivotal role for endogenous TGF-β-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway

Xie, M., Zhang, D., Dyck, J. R. B., Li, Y., Zhang, H., Morishima, M., Mann, D. L., Taffet, G. E., Baldini, A., Khoury, D. S., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604708103 · Cited by 358

AMP-Activated Protein Kinase in the Heart

Arad, M., Seidman, C. E., & Seidman, J. G. (2007) · Circulation Research · doi:10.1161/01.res.0000258446.23525.37 · Cited by 357

Insulin Antagonizes Ischemia-induced Thr172 Phosphorylation of AMP-activated Protein Kinase α-Subunits in Heart via Hierarchical Phosphorylation of Ser485/491

Horman, S., Vertommen, D., Heath, R. B., Neumann, D., Mouton, V., Woods, A., Schlattner, U., Wallimann, T., Carling, D., Hue, L., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506850200 · Cited by 355

AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress

Nagata, D., Mogi, M., & Walsh, K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300643200 · Cited by 331

Role of PECAM-1 in the shear-stress-induced activation of Akt and the endothelial nitric oxide synthase (eNOS) in endothelial cells

Fleming, I., Fißlthaler, B., Dixit, M., & Busse, R. (2005) · Journal of Cell Science · doi:10.1242/jcs.02541 · Cited by 328

Hyperglycemia-Induced Apoptosis in Human Umbilical Vein Endothelial Cells

Ido, Y., Carling, D., & Ruderman, N. B. (2002) · Diabetes · doi:10.2337/diabetes.51.1.159 · Cited by 323

Adiponectin-Induced Endothelial Nitric Oxide Synthase Activation and Nitric Oxide Production Are Mediated by APPL1 in Endothelial Cells

Cheng, K. K. Y., Lam, K. S. L., Wang, Y., Huang, Y., Carling, D., Wu, D., Wong, C., & Xu, A. (2007) · Diabetes · doi:10.2337/db06-1580 · Cited by 318

AMPK: Lessons from transgenic and knockout animals

Viollet, B. (2009) · Frontiers in bioscience · doi:10.2741/3229 · Cited by 314

Endothelial Dysfunction Coincides With an Enhanced Nitric Oxide Synthase Expression and Superoxide Anion Production

Bouloumié, A., Bauersachs, J. K., Linz, W., Schölkens, B. A., Wiemer, G., Fleming, I., & Busse, R. (1997) · Hypertension · doi:10.1161/01.hyp.30.4.934 · Cited by 303

Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR

Sakamoto, K., Göransson, O., Hardie, D. G., & Alessi, D. R. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00074.2004 · Cited by 299

Isoprenylated proteins

McTaggart, S. J. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5298-6 · Cited by 293

Metformin Prevents Progression of Heart Failure in Dogs

Sasaki, H., Asanuma, H., Fujita, M., Takahama, H., Wakeno, M., Ito, S., Ogai, A., Asakura, M., Kim, J., Minamino, T., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.798561 · Cited by 291

Post-translational modifications of the β-1 subunit of AMP-activated protein kinase affect enzyme activity and cellular localization

Warden, S. M., Richardson, C. A., O’Donnell, J. B., Stapleton, D., Kemp, B. E., & Witters, L. A. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3540275 · Cited by 284

Phosphorylation of LKB1 at Serine 428 by Protein Kinase C-ζ Is Required for Metformin-Enhanced Activation of the AMP-Activated Protein Kinase in Endothelial Cells

Xie, Z., Dong, Y., Scholz, R., Neumann, D., & Zou, M.-H. (2008) · Circulation · doi:10.1161/circulationaha.107.744490 · Cited by 273

AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633

Chen, Z., Peng, I.-C., Sun, W., Su, M.-I., Hsu, P.-H., Fu, Y., Zhu, Y., DeFea, K., Pan, S., Tsai, M.-D., et al. (2009) · Circulation Research · doi:10.1161/circresaha.108.187567 · Cited by 264

Statins Activate AMP-Activated Protein Kinase In Vitro and In Vivo

Sun, W., Lee, T., Zhu, M., Gu, C., Wang, Y., Zhu, Y., & Shyy, J. Y.-J. (2006) · Circulation · doi:10.1161/circulationaha.106.630194 · Cited by 264

Thienopyridone Drugs Are Selective Activators of AMP-Activated Protein Kinase β1-Containing Complexes

Scott, J. W., van Denderen, B. J. W., Jørgensen, S. B., Honeyman, J. E., Steinberg, G. R., Oakhill, J. S., Iseli, T. J., Koay, A. Z., Gooley, P. R., Stapleton, D., et al. (2008) · Chemistry & Biology · doi:10.1016/j.chembiol.2008.10.005 · Cited by 262

AMP-Activated Protein Kinase Signaling Stimulates VEGF Expression and Angiogenesis in Skeletal Muscle

Ouchi, N., Shibata, R., & Walsh, K. X. (2005) · Circulation Research · doi:10.1161/01.res.0000163633.10240.3b · Cited by 244

Liver Adenosine Monophosphate-Activated Kinase-α2 Catalytic Subunit Is a Key Target for the Control of Hepatic Glucose Production by Adiponectin and Leptin But Not Insulin

Andréelli, F., Foretz, M., Knauf, C., Cani, P. D., Perrin, C., Iglesias, M. A., Pillot, B., Bado, A., Tronche, F., Mithieux, G., et al. (2006) · Endocrinology · doi:10.1210/en.2005-0898 · Cited by 244

Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt

Chan, A. Y. M., Dolinsky, V. W., Soltys, C.-L. M., Viollet, B., Baksh, S., Light, P. E., & Dyck, J. R. B. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802869200 · Cited by 244

Adenosine Monophosphate-Activated Protein Kinase Suppresses Vascular Smooth Muscle Cell Proliferation Through the Inhibition of Cell Cycle Progression

Igata, M., Motoshima, H., Tsuruzoe, K., Kojima, K., Matsumura, T., Kondo, T., Taguchi, T., Nakamaru, K., Yano, M., Kukidome, D., et al. (2005) · Circulation Research · doi:10.1161/01.res.0000185823.73556.06 · Cited by 244

Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function

Wang, W., Yang, X., López de Silanes, I., Carling, D., & Gorospe, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300318200 · Cited by 243

AMPK inhibits fatty acid-induced increases in NF-κB transactivation in cultured human umbilical vein endothelial cells

Cacicedo, J. M., Yagihashi, N., Keaney, J. F., Ruderman, N. B., & Ido, Y. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.09.177 · Cited by 236

Epigenetic Regulation of Vascular Endothelial Gene Expression

Matouk, C. C., & Marsden, P. A. (2008) · Circulation Research · doi:10.1161/circresaha.107.171025 · Cited by 232

Activation of NF-κB by XIAP, the X Chromosome-linked Inhibitor of Apoptosis, in Endothelial Cells Involves TAK1

Hofer-Warbinek, R., Schmid, J. A., Stehlik, C., Binder, B. R., Lipp, J., & de Martin, R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910346199 · Cited by 231

Rosiglitazone Reduces Glucose-Induced Oxidative Stress Mediated by NAD(P)H Oxidase via AMPK-Dependent Mechanism

Ceolotto, G., Gallo, A., Papparella, I., Franco, L., Murphy, E. G., Iori, E., Pagnin, E., Fadini, G. P., Albiero, M., Semplicini, A., et al. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.155762 · Cited by 230

Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKα2 but not AMPKα1

Sakamoto, K., Zarrinpashneh, E., Budas, G. R., Pouleur, A., Dutta, A., Prescott, A. R., Vanoverschelde, J., Ashworth, A., Jovanović, A., Alessi, D. R., et al. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00443.2005 · Cited by 224

Thrombin Activates AMP-Activated Protein Kinase in Endothelial Cells via a Pathway Involving Ca2+/Calmodulin-Dependent Protein Kinase Kinase β

Stahmann, N., Woods, A., Carling, D., & Heller, R. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00383-06 · Cited by 214

Acute Regulation of Fatty Acid Oxidation and AMP-Activated Protein Kinase in Human Umbilical Vein Endothelial Cells

Dagher, Z., Ruderman, N. B., Tornheim, K., & Ido, Y. (2001) · Circulation Research · doi:10.1161/hh1201.092998 · Cited by 209

Agonist-modulated Regulation of AMP-activated Protein Kinase (AMPK) in Endothelial Cells

Levine, Y. C., Li, G. K., & Michel, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702182200 · Cited by 207

Skeletal Muscle-Selective Knockout of LKB1 Increases Insulin Sensitivity, Improves Glucose Homeostasis, and Decreases TRB3

Koh, H.-J., Arnolds, D. E., Fujii, N., Tran, T. T., Rogers, M. J., Jessen, N., Li, Y., Liew, C. W., Ho, R. C., Hirshman, M. F., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00979-06 · Cited by 202

AMP-Activated Protein Kinase Inhibits Angiotensin II–Stimulated Vascular Smooth Muscle Cell Proliferation

Nagata, D., Takeda, R., Sata, M., Satonaka, H., Suzuki, E., Nagano, T., & Hirata, Y. (2004) · Circulation · doi:10.1161/01.cir.0000136025.96811.76 · Cited by 197

Critical roles of AMP-activated protein kinase in constitutive tolerance of cancer cells to nutrient deprivation and tumor formation

Kato, K., Ogura, T., Kishimoto, A., Minegishi, Y., Nakajima, N., Miyazaki, M., & Esumi, H. (2002) · Oncogene · doi:10.1038/sj.onc.1205737 · Cited by 197

Inhibitors of Histone Deacetylation Downregulate the Expression of Endothelial Nitric Oxide Synthase and Compromise Endothelial Cell Function in Vasorelaxation and Angiogenesis

Rössig, L., Li, H., Fißlthaler, B., Urbich, C., Fleming, I., Förstermann, U., Zeiher, A. M., & Dimmeler, S. (2002) · Circulation Research · doi:10.1161/01.res.0000037983.07158.b1 · Cited by 197

Post-translational modifications of the β-1 subunit of AMP-activated protein kinase affect enzyme activity and cellular localization

Warden, S. M., RICHARDSON, C., O’Donnell, J. B., et al. (2001) · Biochemical Journal · doi:10.1042/bj3540275 · Cited by 195

Hyperglycemia and Insulin Resistance: Possible Mechanisms

Tomás, E., Lin, Y., Dagher, Z., Saha, A. K., Luo, Z., Ido, Y., & Ruderman, N. B. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04262.x · Cited by 177

Inhibition of Inducible Nitric-oxide Synthase by Activators of AMP-activated Protein Kinase

Pilon, G., Dallaire, P., & Marette, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401390200 · Cited by 175

AMPKα1 regulates the antioxidant status of vascular endothelial cells

Colombo, S. L., & Moncada, S. (2009) · Biochemical Journal · doi:10.1042/bj20090613 · Cited by 175

Activation of Protein Kinase Cζ by Peroxynitrite Regulates LKB1-dependent AMP-activated Protein Kinase in Cultured Endothelial Cells

Xie, Z., Dong, Y., Zhang, M., Cui, M.-Z., Cohen, R. A., Riek, U., Neumann, D., Schlattner, U., & Zou, M.-H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511178200 · Cited by 172

Effects of dietary polyphenols on gene expression in human vascular endothelial cells

Nicholson, S. K., Tucker, G. A., & Brameld, J. M. (2008) · Proceedings of The Nutrition Society · doi:10.1017/s0029665108006009 · Cited by 170

Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders

Viollet, B., Mounier, R., Leclerc, J., Yazigi, A., Foretz, M., & Andréelli, F. (2007) · Diabetes & Metabolism · doi:10.1016/j.diabet.2007.10.004 · Cited by 168

Metformin improves vascular function in insulin-resistant rats

Katakam, P. V. G., Ujhelyi, M. R., Hoenig, M., & Miller, A. W. (2000) · Hypertension · doi:10.1161/01.hyp.35.1.108 · Cited by 167

Withdrawal of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors Elicits Oxidative Stress and Induces Endothelial Dysfunction in Mice

Vecchione, C., & Brandes, R. P. (2002) · Circulation Research · doi:10.1161/01.res.0000028004.76218.b8 · Cited by 160

Posttranslational Modifications of the 5′-AMP-activated Protein Kinase β1 Subunit

Mitchelhill, K. I., Michell, B. J., House, C. M., Stapleton, D., Dyck, J. R. B., Gamble, J., Ullrich, C., Witters, L. A., & Kemp, B. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.39.24475 · Cited by 158

NF-κB-Mediated MyoD Decay during Muscle Wasting Requires Nitric Oxide Synthase mRNA Stabilization, HuR Protein, and Nitric Oxide Release

Marco, S. D., Mazrouï, R., Dallaire, P., Chittur, S. V., Tenenbaum, S. A., Radzioch, D., Marette, A., & Gallouzi, I. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.15.6533-6545.2005 · Cited by 155

Suppression of the JNK Pathway by Induction of a Metabolic Stress Response Prevents Vascular Injury and Dysfunction

Schulz, E., Dopheide, J. F., Schuhmacher, S., Thomas, S. R., Chen, K., Daiber, A., Wenzel, P., Münzel, T. F., & Keaney, J. F. (2008) · Circulation · doi:10.1161/circulationaha.108.784289 · Cited by 150

A pervasive role of histone acetyltransferases and deacetylases in an NF-κB-signaling code

Calao, M., Burny, A., Quivy, V., Dekoninck, A., & Lint, C. M. V. (2008) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2008.04.015 · Cited by 144

Energy Depletion Inhibits Phosphatidylinositol 3-Kinase/Akt Signaling and Induces Apoptosis via AMP-activated Protein Kinase-dependent Phosphorylation of IRS-1 at Ser-794

Tzatsos, A., & Tsichlis, P. N. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610101200 · Cited by 140

Metformin: Effects on Micro and Macrovascular Complications in Type 2 Diabetes

Bailey, C. J. (2008) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-008-6092-0 · Cited by 138

Increased reactive oxygen species production with antisense oligonucleotides directed against uncoupling protein 2 in murine endothelial cells

Duval, C., Nègre‐Salvayre, A., Doglio, A., Salvayre, R., Pénicaud, L., & Casteilla, L. (2002) · Biochemistry and Cell Biology · doi:10.1139/o02-158 · Cited by 138

AMP-activated Protein Kinase-regulated Phosphorylation and Acetylation of Importin α1

Wang, W., Yang, X., Kawai, T., de Silanes, I. L., Mazan-Mamczarz, K., Chen, P., Chook, Y. M., Quensel, C., Köhler, M., & Gorospe, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409014200 · Cited by 128

PGC-1α mediates exercise-induced skeletal muscle VEGF expression in mice

Leick, L., Hellsten, Y., Fentz, J., Lyngby, S. S., Wojtaszewski, J. F. P., Hidalgo, J., & Pilegaard, H. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00076.2009 · Cited by 126

Metformin normalizes endothelial function by suppressing vasoconstrictor prostanoids in mesenteric arteries from OLETF rats, a model of type 2 diabetes

Matsumoto, T., Noguchi, E., Ishida, K., Kobayashi, T., Yamada, N., & Kamata, K. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00486.2008 · Cited by 125

Adiponectin Decreases C-Reactive Protein Synthesis and Secretion From Endothelial Cells

Devaraj, S., Torok, N. J., Dasu, M. R. K., Samols, D. R., & Jialal, I. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.163303 · Cited by 125

Activation of AMP kinase α1 subunit induces aortic vasorelaxation in mice

Goirand, F., Solar, M., Athea, Y., Viollet, B., Mateo, P., Fortin, D., Leclerc, J., Hoerter, J., Ventura‐Clapier, R., & Garnier, A. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.132589 · Cited by 121

A Review of Sirt1 and Sirt1 Modulators in Cardiovascular and Metabolic Diseases

Pillarisetti, S. (2008) · Recent Advances in Cardiovascular Drug Discovery (Formerly Recent Patents on Cardiovascular Drug Discovery) · doi:10.2174/157489008786263989 · Cited by 121

AMP-activated Protein Kinase Phosphorylates and Desensitizes Smooth Muscle Myosin Light Chain Kinase

Horman, S., Morel, N., Vertommen, D., Hussain, N., Neumann, D., Beauloye, C., Najjar, N. E., Forcet, C., Viollet, B., Walsh, M. P., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802053200 · Cited by 120

Metabolic Switch and Hypertrophy of Cardiomyocytes following Treatment with Angiotensin II Are Prevented by AMP-activated Protein Kinase

Stuck, B. J., Lenski, M., Böhm, M., & Laufs, U. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801904200 · Cited by 119

High molecular weight adiponectin activates AMPK and suppresses cytokine‐induced NF‐κB activation in vascular endothelial cells

Hattori, Y., Nakano, Y., Hattori, S., Tomizawa, A., Inukai, K., & Kasai, K. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.04.037 · Cited by 119

Epoxyeicosatrienoic acids are part of the VEGF-activated signaling cascade leading to angiogenesis

Webler, A. C., Michaelis, U. R., Popp, R., Barbosa‐Sicard, E., Murugan, A., Falck, J. R., Fißlthaler, B., & Fleming, I. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00230.2008 · Cited by 115

Estradiol-Mediated Endothelial Nitric Oxide Synthase Association With Heat Shock Protein 90 Requires Adenosine Monophosphate-Dependent Protein Kinase

Schulz, E., Anter, E., Zou, M., & Keaney, J. F. (2005) · Circulation · doi:10.1161/circulationaha.105.546812 · Cited by 114

Metformin reduces blood pressure and restores endothelial function in aorta of streptozotocin-induced diabetic rats

Majithiya, J. B., & Balaraman, R. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.10.020 · Cited by 114

AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells

Li, X., Han, Y., Pang, W., Li, C., Xie, X., Shyy, J. Y.-J., & Zhu, Y. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.172452 · Cited by 113

Fenofibrate regulates retinal endothelial cell survival through the AMPK signal transduction pathway

Kim, J., Ahn, J., Kim, J., Yu, Y.-S., Kim, H., Ha, J., Shinn, S.-H., & Oh, Y.-S. (2007) · Experimental Eye Research · doi:10.1016/j.exer.2007.01.009 · Cited by 111

Resveratrol inhibits the mTOR mitogenic signaling evoked by oxidized LDL in smooth muscle cells

de Brito, P. M., Devillard, R., Nègre‐Salvayre, A., Almeida, L. M., Dinis, T. C. P., Salvayre, R., & Augè, N. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.11.011 · Cited by 107

Regulation of Endothelial Cell Cycle by Laminar Versus Oscillatory Flow

Guo, D., Chien, S., & Shyy, J. Y.-J. (2007) · Circulation Research · doi:10.1161/01.res.0000259561.23876.c5 · Cited by 107

Chronic Ethanol Intake Impairs Insulin Signaling in Rats by Disrupting Akt Association with the Cell Membrane

He, L., Simmen, F. A., Mehendale, H. M., Ronis, M. J. J., & Badger, T. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510724200 · Cited by 106

Geminivirus Infection Up-Regulates the Expression of Two Arabidopsis Protein Kinases Related to Yeast SNF1- and Mammalian AMPK-Activating Kinases

Shen, W., & Hanley-Bowdoin, L. K. (2006) · PLANT PHYSIOLOGY · doi:10.1104/pp.106.088476 · Cited by 102

AMPK and transcriptional regulation

McGee, S. L. (2007) · Frontiers in bioscience · doi:10.2741/2907 · Cited by 101

Activation of cardiac AMP-activated protein kinase by LKB1 expression or chemical hypoxia is blunted by increased Akt activity

Soltys, C.-L. M., Kovacic, S., & Dyck, J. R. B. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01206.2005 · Cited by 100

AMP-Activated Protein Kinase: Structure and Regulation

Sanz, P. (2008) · Current Protein and Peptide Science · doi:10.2174/138920308785915254 · Cited by 99

The Effect of AMP-Activated Protein Kinase and Its Activator AICAR on the Metabolism of Human Umbilical Vein Endothelial Cells

Dagher, Z., Ruderman, N. B., Tornheim, K., & Ido, Y. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1635 · Cited by 95

A769662, a novel activator of AMP‐activated protein kinase, inhibits non‐proteolytic components of the 26S proteasome by an AMPK‐independent mechanism

Moreno-Andrés, D., Knecht, E., Viollet, B., & Sanz, P. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.06.044 · Cited by 95

PPARα activators upregulate eNOS activity and inhibit cytokine-induced NF-κB activation through AMP-activated protein kinase activation

Okayasu, T., Tomizawa, A., Suzuki, K., Manaka, K., & Hattori, Y. (2008) · Life Sciences · doi:10.1016/j.lfs.2008.02.002 · Cited by 93

Inhibitory crosstalk between ERK and AMPK in the growth and proliferation of cardiac fibroblasts

Du, J., Guan, T., Zhang, H., Xia, Y., Liu, F., & Zhang, Y. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.01.099 · Cited by 93

AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production

Reihill, J. A., Ewart, M., Hardie, D. G., & Salt, I. P. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.01.110 · Cited by 91

Gab1, SHP2, and Protein Kinase A Are Crucial for the Activation of the Endothelial NO Synthase by Fluid Shear Stress

Dixit, M., Loot, A. E., Mohamed, A., Fißlthaler, B., Boulanger, C. M., Ceacareanu, B., Hassid, A., Busse, R., & Fleming, I. (2005) · Circulation Research · doi:10.1161/01.res.0000195611.59811.ab · Cited by 90

Metabolic activation of AMP kinase in vascular smooth muscle

Rubin, L. J., Magliola, L., Feng, X., JONES, A. W., & Hale, C. C. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00075.2004 · Cited by 90

Rosiglitazone Stimulates Nitric Oxide Synthesis in Human Aortic Endothelial Cells via AMP-activated Protein Kinase*

Boyle, J. G., Logan, P. J., Ewart, M., Reihill, J. A., Ritchie, S. A., Connell, J., Cleland, S. J., & Salt, I. P. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710048200 · Cited by 89

Follicle-Stimulating Hormone Inhibits Adenosine 5′-Monophosphate-Activated Protein Kinase Activation and Promotes Cell Proliferation of Primary Granulosa Cells in Culture through an Akt-Dependent Pathway

Kayampilly, P. P., & Menon, K. M. J. (2008) · Endocrinology · doi:10.1210/en.2008-1032 · Cited by 89

Stimulators of AMP‐activated protein kinase inhibit the respiratory burst in human neutrophils

Álba, G., Bekay, R. E., Álvarez-Maqueda, M., Chacón, P., Vega, A. P., Monteseirı́n, J., Santa‐María, C., Pintado, E., Bedoya, F. J., Bartrons, R., et al. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.07.077 · Cited by 89

Genetic and physiological analysis of the role of uncoupling proteins in human energy homeostasis

Pecqueur, C., Couplan, E., Bouillaud, F., & Ricquier, D. (2000) · Journal of Molecular Medicine · doi:10.1007/s001090000150 · Cited by 88

Comparison of resistance and conduit vessel nitric oxide-mediated vascular function in vivo: effects of exercise training

GREEN, D. J., Walsh, J. H., Maiorana, A., Burke, V., Taylor, R. R., & O'Driscoll, J. G. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00109.2004 · Cited by 86

In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMP-activated protein kinase

Blättler, S. M., Rencurel, F., Kaufmann, M., & Meyer, U. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610216104 · Cited by 85

Stimulation of AMP-Activated Protein Kinase Is Essential for the Induction of Drug Metabolizing Enzymes by Phenobarbital in Human and Mouse Liver

Rencurel, F., Foretz, M., Kaufmann, M., Stroka, D., Looser, R., Leclerc, I., Xavier, G. D. S., Rutter, G. A., Viollet, B., & Meyer, U. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.029421 · Cited by 85

Thrombin and histamine stimulate endothelial nitric‐oxide synthase phosphorylation at Ser1177 via an AMPK mediated pathway independent of PI3K‐Akt

Thors, B., Halldórsson, H., & Þorgeirsson, G. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.07.078 · Cited by 84

Disturbed Cross Talk between Insulin-Like Growth Factor I and AMP-Activated Protein Kinase as a Possible Cause of Vascular Dysfunction in the Amyloid Precursor Protein/Presenilin 2 Mouse Model of Alzheimer's Disease

Lopez‐Lopez, C., Dietrich, M. O., Metzger, F., Loetscher, H., & Torres‐Alemán, I. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4345-06.2007 · Cited by 83

Fenofibrate activates AMPK and increases eNOS phosphorylation in HUVEC

Murakami, H., Murakami, R., Kambe, F., Cao, X., Takahashi, R., Asai, T., Hirai, T., Numaguchi, Y., Okumura, K., Seo, H., et al. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.01.052 · Cited by 82

Activation of NAD(P)H:Quinone Oxidoreductase 1 Prevents Arterial Restenosis by Suppressing Vascular Smooth Muscle Cell Proliferation

Kim, S.-Y., Jeoung, N. H., Oh, C. J., Choi, Y., Lee, H., Kim, H., Kim, J., Hwang, J. H., Tadi, S., Yim, Y., et al. (2009) · Circulation Research · doi:10.1161/circresaha.108.189837 · Cited by 80

AMPK-Mediated Inhibition of mTOR Kinase Is Circumvented during Immediate-Early Times of Human Cytomegalovirus Infection

Kudchodkar, S. B., Prete, G. Q. D., Maguire, T. G., & Alwine, J. C. (2007) · Journal of Virology · doi:10.1128/jvi.02079-06 · Cited by 80

AMPK regulates basal skeletal muscle capillarization and VEGF expression, but is not necessary for the angiogenic response to exercise

Zwetsloot, K. A., Westerkamp, L. M., Holmes, B. F., & Gavin, T. P. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.159871 · Cited by 78

Fluid Shear Stress and NO Decrease the Activity of the Hydroxy-Methylglutaryl Coenzyme A Reductase in Endothelial Cells via the AMP-Activated Protein Kinase and FoxO1

Fißlthaler, B., Fleming, I., Keserü, B., Walsh, K., & Busse, R. (2007) · Circulation Research · doi:10.1161/01.res.0000257747.74358.1c · Cited by 75

Metformin treatment restores the altered microvascular reactivity in neonatal streptozotocin-induced diabetic rats increasing NOS activity, but not NOS expression

Sartoretto, J. L., de Melo, G. D. A. N., de Carvalho, M. H. C., Nigro, D., Tostes, R. C., Scavone, C., Cuman, R. K. N., & Fortes, Z. B. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.05.022 · Cited by 73

Exercise training enhances flow-induced vasodilation in skeletal muscle resistance arteries of aged rats: role of PGI2 and nitric oxide

Spier, S. A., Delp, M. D., Stallone, J. N., Dominguez, J. M., & Muller‐Delp, J. M. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00588.2006 · Cited by 73

Shear stress-induced activation of the AMP-activated protein kinase regulates FoxO1a and angiopoietin-2 in endothelial cells

Dixit, M., Bess, E. N., Fißlthaler, B., Härtel, F. V., Noll, T., Busse, R., & Fleming, I. (2007) · Cardiovascular Research · doi:10.1093/cvr/cvm017 · Cited by 70

Differential regulation of AMP-activated kinase and AKT kinase in response to oxygen availability in crucian carp (Carassius carassius)

Stensløkken, K., Ellefsen, S., Stecyk, J. A. W., Dahl, M. B., Nilsson, G., & Vaage, J. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90590.2008 · Cited by 69

AMP‐dependent protein kinase alpha 2 isoform promotes hypoxia‐induced VEGF expression in human glioblastoma

Neurath, K. M., Keough, M. P., Mikkelsen, T., & Claffey, K. P. (2006) · Glia · doi:10.1002/glia.20326 · Cited by 67

Activation of AMPK α- and γ-isoform complexes in the intact ischemic rat heart

Li, J., Coven, D. L., Miller, E. J., Hu, X., Young, M. E., Carling, D., Sinusas, A. J., & Young, L. H. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00251.2006 · Cited by 67

Cilostazol Activates AMP-activated Protein Kinase and Restores Endothelial Function in Diabetes

Suzuki, K., Uchida, K., Nakanishi, N., & Hattori, Y. (2008) · American Journal of Hypertension · doi:10.1038/ajh.2008.6 · Cited by 66

Regulation of Rac1 by Simvastatin in Endothelial Cells

Kou, R., Sartoretto, J. L., & Michel, T. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808664200 · Cited by 62

Bidirectional Actions of Hydrogen Peroxide on Endothelial Nitric-oxide Synthase Phosphorylation and Function

Hu, Z., Chen, J., Wei, Q., & Xia, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802455200 · Cited by 59

Inhibition of Tumor Necrosis Factor α–Stimulated Monocyte Adhesion to Human Aortic Endothelial Cells by AMP-Activated Protein Kinase

Ewart, M.-A., Kohlhaas, C. F., & Salt, I. P. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.175919 · Cited by 57

Sepsis and AMPK Activation by AICAR Differentially Regulate FoxO-1, -3 and -4 mRNA in Striated Muscle.

Nystrom, G. J., & Lang, C. H. (2008) · PubMed · Cited by 56

Caffeine Enhances Endothelial Repair by an AMPK-Dependent Mechanism

Spyridopoulos, I., Fichtlscherer, S., Popp, R., Toennes, S. W., Fißlthaler, B., Trepels, T., Zernecke, A., Liehn, E. A., Weber, C., Zeiher, A. M., et al. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.174060 · Cited by 53

Bradykinin stimulates endothelial cell fatty acid oxidation by CaMKK-dependent activation of AMPK

Mount, P. F., Lane, N., Venkatesan, S., Steinberg, G. R., Fraser, S. A., Kemp, B. E., & Power, D. A. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.12.003 · Cited by 52

Nitric Oxide Mediates the Effect of Fluvastatin on Intercellular Adhesion Molecule-1 and Platelet Endothelial Cell Adhesion Molecule-1 Expression on Human Endothelial Cells

Xenos, E. S., Stevens, S. L., Freeman, M. B., Cassada, D. C., & Goldman, M. H. (2005) · Annals of Vascular Surgery · doi:10.1007/s10016-005-0011-7 · Cited by 51

Captopril Normalizes Insulin Signaling and Insulin-Regulated Substrate Metabolism in Obese (ob/ob) Mouse Hearts

Tabbi‐Anneni, I., Buchanan, J., Cooksey, R. C., & Abel, E. D. (2008) · Endocrinology · doi:10.1210/en.2007-1646 · Cited by 46

Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR

Cai, Y., Wang, Q., Ling, Z., PIPELEERS, D. G., McDermott, P. J., Pende, M., Heimberg, H., & de Casteele, M. V. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.02.019 · Cited by 45

Human-Antigen R (HuR) Expression in Hypertension

Klöß, S., Rodenbach, D., Bordel, R., & Mülsch, A. (2005) · Hypertension · doi:10.1161/01.hyp.0000165674.58470.8f · Cited by 39

AMPK activation as a strategy for reversing the endothelial lipotoxicity underlying the increased vascular risk associated with insulin resistance syndrome

McCarty, M. F. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2004.01.042 · Cited by 35

A new constitutively active mutant of AMP-activated protein kinase inhibits anoxia-induced apoptosis of vascular endothelial cell

Nagata, D., Kiyosue, A., Takahashi, M., Satonaka, H., Tanaka, K., Sata, M., Nagano, T., Nagai, R., & Hirata, Y. (2009) · Hypertension Research · doi:10.1038/hr.2008.25 · Cited by 33

Critical roles of AMP-activated protein kinase in the carcinogenic metal-induced expression of VEGF and HIF-1 proteins in DU145 prostate carcinoma

Lee, M. Y., Hwang, J., Yun, H., Kim, E. J., Kim, M., Kim, S. S., & Ha, J. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.03.021 · Cited by 29

The involvement of AMP-activated protein kinases in the anti-inflammatory effect of nicotine in vivo and in vitro

Cheng, P., Lee, Y., Law, K.-K., Lin, C.-W., & Yen, M. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.08.004 · Cited by 28

Activators of the energy sensing kinase AMPK inhibit random cell movement and chemotaxis in U937 cells

Kanellis, J., Kandane‐Rathnayake, R., Etemadmoghadam, D., Fraser, S. A., Mount, P. F., Levidiotis, V., Kemp, B. E., & Power, D. A. (2005) · Immunology and Cell Biology · doi:10.1111/j.1440-1711.2005.01388.x · Cited by 28

AMP-activated kinase may suppress NADPH oxidase activation in vascular tissues

McCarty, M. F., Barroso-Aranda, J., & Contreras, F. (2009) · Medical Hypotheses · doi:10.1016/j.mehy.2008.12.024 · Cited by 22

Macropinocytosis is decreased in diabetic mouse macrophages and is regulated by AMPK

Guest, C. B., Chakour, K. S., & Freund, G. G. (2008) · BMC Immunology · doi:10.1186/1471-2172-9-42 · Cited by 18

Melatonin supplementation modifies experimental chronic colitis in mice

Golab, M., Dudziak, M., & Skwarlo-Sonta, K. (2008) · Proceedings of The Nutrition Society · doi:10.1017/s0029665108006514 · Cited by 7

cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action

Francis, S. H., Busch, J. L., & Corbin, J. D. (2010) · Pharmacological Reviews · doi:10.1124/pr.110.002907 · Cited by 1,059

AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan

Salminen, A., Hyttinen, J. M. T., & Kaarniranta, K. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0748-0 · Cited by 866

Mechanisms of Dysfunction in the Aging Vasculature and Role in Age-Related Disease

Donato, A. J., Machin, D. R., & Lesniewski, L. A. (2018) · Circulation Research · doi:10.1161/circresaha.118.312563 · Cited by 722

Endothelial Cell Metabolism in Normal and Diseased Vasculature

Eelen, G., de Zeeuw, P., Simons, M., & Carmeliet, P. (2015) · Circulation Research · doi:10.1161/circresaha.116.302855 · Cited by 637

Cellular and molecular biology of aging endothelial cells

Donato, A. J., Morgan, R. G., Walker, A. E., & Lesniewski, L. A. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.01.021 · Cited by 538

AMP‐ACTIVATED PROTEIN KINASE ACTIVATION AS A STRATEGY FOR PROTECTING VASCULAR ENDOTHELIAL FUNCTION

Zou, M., & Wu, Y. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04851.x · Cited by 116

The Effect of AMPK on Angiogenesis in Endothelial Cells

Xiao-ma, Y. (2014) · Medical Recapitulate · Cited by 1

Activation of AMP-Activated Protein Kinase Inhibits the Proliferation of Human Endothelial Cells

Peyton, K. J., Liu, X., Yu, Y., Yates, B., & Durante, W. (2012) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.194712 · Cited by 54

AMPK, metabolism, and vascular function

Rodríguez, C., Muñoz, M., Contreras, C., & Prieto, D. (2021) · FEBS Journal · doi:10.1111/febs.15863 · Cited by 181

AMP‐activated protein kinase activation inhibits human endothelial cell proliferation

Durante, W., Liu, X., Yu, Y., Yates, B., & Peyton, K. J. (2012) · The FASEB Journal · doi:10.1096/fasebj.26.1_supplement.1129.31