The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Ogg1 -Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents Atherosclerosis
Open accessAbstract
Rationale: Activation of NLRP3 (nucleotide-binding domain and leucine-rich repeat pyrin domain containing 3) inflammasome-mediating interleukin (IL)-1β secretion has emerged as an important component of inflammatory processes in atherosclerosis. Mitochondrial DNA (mtDNA) damage is detrimental in atherosclerosis, and mitochondria are central regulators of the nucleotide-binding domain and leucine-rich repeat pyrin domain containing 3 inflammasome. Human atherosclerotic plaques express increased mtDNA damage. The major DNA glycosylase, 8-oxoguanine glycosylase (OGG1), is responsible for removing the most abundant form of oxidative DNA damage. Objective: To test the role of OGG1 in the development of atherosclerosis in mouse. Methods and Results: We observed that Ogg1 expression decreases over time in atherosclerotic lesion macrophages of low-density lipoprotein receptor ( Ldlr ) knockout mice fed a Western diet. Ogg1 −/− Ldlr −/− mice fed a Western diet resulted in an increase in plaque size and lipid content. We found increased oxidized mtDNA, inflammasome activation, and apoptosis in atherosclerotic lesions and also higher serum IL-1β and IL-18 in Ogg1 −/− Ldlr −/− mice than in Ldlr −/− . Transplantation with Ogg1 −/− bone marrow into Ldlr −/− mice led to larger atherosclerotic lesions and increased IL-1β production. However, transplantation of Ogg1 −/− Nlrp3 −/− bone marrow reversed the Ogg1 −/− phenotype of increased plaque size. Ogg1 −/− macrophages showed increased oxidized mtDNA and had greater amounts of cytosolic mtDNA and cytochrome c , increased apoptosis, and more IL-1β secretion. Finally, we found that proatherogenic miR-33 can directly inhibit human OGG1 expression and indirectly suppress both mouse and human OGG1 via AMP-activated protein kinase. Conclusions: OGG1 plays a protective role in atherogenesis by preventing excessive inflammasome activation. Our study provides insight into a new target for therapeutic intervention based on a link between oxidative mtDNA damage, OGG1, and atherosclerosis via NLRP3 inflammasome.
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Citations
Cites
Inflammation in atherosclerosis
Libby, P. (2002) · Nature · doi:10.1038/nature01323 · Cited by 8,315
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
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“mitochondrial (mt) function as the central hub for integrating these various signals.(5,8,9) We recently showed that during apoptosis/pyroptosis, mitochondrial DNA (mtDNA) damaged by oxidative stress activates the NLRP3 inflammasome, releasing active IL-1β.”
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
Vandanmagsar, B., Youm, Y.-H., Ravussin, A., Galgani, J. E., Stadler, K., Mynatt, R. L., Ravussin, E., Stephens, J. M., & Dixit, V. D. (2011) · Nature Medicine · doi:10.1038/nm.2279 · Cited by 2,655
Macrophages in atherosclerosis: a dynamic balance
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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
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“mitochondrial (mt) function as the central hub for integrating these various signals.(5,8,9) We recently showed that during apoptosis/pyroptosis, mitochondrial DNA (mtDNA) damaged by oxidative stress activates the NLRP3 inflammasome, releasing active IL-1β.”
BackgroundAMP-Activated Protein Kinase (AMPK) Controls the Aging Process via an Integrated Signaling Network
Salminen, A., & Kaarniranta, K. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2011.12.005 · Cited by 860
Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides
Rayner, K. J., Esau, C. C., Hussain, F. N., McDaniel, A. L., Marshall, S. M., van Gils, J. M., Ray, T. D., Sheedy, F. J., Goedeke, L., Liu, X., et al. (2011) · Nature · doi:10.1038/nature10486 · Cited by 706
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“Antagonizing miR-33a/b may be an effective strategy for raising plasma high-density lipoprotein levels and protecting against atherosclerosis in mice and nonhuman primates.(22,23) In this work, we show the atheroprotective role of OGG1 in a WD-induced model of atherosclerosis using Ldlr mice.”
BackgroundMitochondrial DNA mutations and human disease
Tuppen, H. A. L., Blakely, E. L., Turnbull, D. M., & Taylor, R. W. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.09.005 · Cited by 676
Cited by
Mitochondrial DNA in innate immune responses and inflammatory pathology
West, A. P., & Shadel, G. S. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.21 · Cited by 1,115
NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis
Grebe, A., Hoss, F., & Latz, E. (2018) · Circulation Research · doi:10.1161/circresaha.118.311362 · Cited by 926
Xian, H., Watari, K., Sanchez-Lopez, E., Offenberger, J., Onyuru, J., Sampath, H., Ying, W., Hoffman, H. M., Shadel, G. S., & Karin, M. (2022) · Immunity · doi:10.1016/j.immuni.2022.06.007 · Cited by 850
Cholesterol Efflux Pathways Suppress Inflammasome Activation, NETosis, and Atherogenesis
Westerterp, M., Fotakis, P., Ouimet, M., Bochem, A. E., Zhang, H., Molusky, M. M., Wang, W., Abramowicz, S., la Bastide-van Gemert, S., Wang, N., et al. (2018) · Circulation · doi:10.1161/circulationaha.117.032636 · Cited by 331
Mitochondria, Oxidative Stress and Innate Immunity
Chen, Y., Zhou, Z., & Min, W. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01487 · Cited by 315
“NLRP3 might also facilitate atherosclerosis via sensing oxidative mtDNA (Tumurkhuu et al., 2016).”
Background
Metadata
- Authors
- Tumurkhuu, G., Shimada, K., Dagvadorj, J., Crother, T. R., Zhang, W., Luthringer, D., Gottlieb, R. A., Chen, S., & Arditi, M.
- Venue
- Circulation Research
- Published
- 2016-09-02
- Volume
- 119
- Issue
- 6
- Pages
- e76-90
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2461916920
- Cited by
- 181
- References
- 17
- FWCI
- 6.77
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Tumurkhuu, G., Shimada, K., Dagvadorj, J., Crother, T. R., Zhang, W., Luthringer, D., Gottlieb, R. A., Chen, S., & Arditi, M. (2016). Ogg1 -Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents Atherosclerosis. Circulation Research. https://doi.org/10.1161/circresaha.116.308362
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