Hyperglycemia rapidly suppresses flow-mediated endothelium- dependent vasodilation of brachial artery
Open accessAbstract
Objectives We examined whether endothelial dysfunction occurs when acute hyperglycemia is induced by oral glucose loading.Background Endothelial dysfunction has been shown to occur in patients with diabetes mellitus (DM), and chronic hyperglycemia is implicated as a cause of endothelial dysfunction. However, in many patients with Type 2 DM and in those with impaired glucose tolerance (IGT), fasting blood glucose may be within normal limits, and hyperglycemia occurred only post-prandially.Methods With ultrasound technique, we measured flow-mediated endothelium-dependent vasodilation during oral glucose tolerance test in 58 subjects: (17 patients with normal glucose tolerance [NGT], 24 with IGT, and 17 with type 2 DM). In addition, we measured the levels of thiobarbituric acid reactive substances (TBARS) and nitrite/nitrate.Results Flow-mediated vasodilation decreased after glucose loading (NGT: 7.53+/-0.40, 4.24+/-0.28 and 6.35+/-0.40, in fasting, at 1- and 2-h, respectively, IGT: 6.50+/-0.48, 1.40+/-0.41** and 4.00+/-0.47*, respectively; DM: 4.77+/-0.37, 1.35+/-0.38** and 1.29+/-0.29%**, respectively; *p < 0.01 vs. fasting, **p < 0.005 vs. fasting). The TBARS concentration increased in parallel with plasma glucose level in each group (NGT: 1.43+/-0.07, 2.03+/-0.12 and 1.80+/-0.12, respectively; IGT: 1.65+/-0.11, 2.46+/-0.12** and 1.94+/-0.08*, respectively; DM: 1.73+/-0.07, 2.34+/-0.08** and 2.47+/-0.09** nmol/ml, respectively; *p < 0.05 vs. fasting, **p < 0.01 vs. fasting). Glucose loading did not change nitrite/nitrate concentration in any of the groups.Conclusions Hyperglycemia in response to oral glucose loading rapidly suppresses endothelium-dependent vasodilation, probably through increased production of oxygen-derived free radicals. These findings strongly suggest that prolonged and repeated post-prandial hyperglycemia may play an important role in the development and progression of atherosclerosis.
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Hyperglycemia has been proposed as a cause of endothelial dysfunction in both normal and diabetic subjects.
“hyperglycemia has been implicated as a cause of endothelial dysfunction in normal and diabetic subjects.”
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Cites
(1993) · New England Journal of Medicine · doi:10.1056/nejm199309303291401 · Cited by 24,667 · see citing works
Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525 · see citing works
[30] Microsomal lipid peroxidation
Buege, J. A., & Aust, S. D. (1978) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(78)52032-6 · Cited by 13,437 · see citing works
Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids
Green, L. C., Wagner, D. A., Glogowski, J. A., Skipper, P. L., Wishnok, J. S., & Tannenbaum, S. R. (1982) · Analytical Biochemistry · doi:10.1016/0003-2697(82)90118-x · Cited by 12,089 · see citing works
The pathogenesis of atherosclerosis: a perspective for the 1990s
Ross, R. (1993) · Nature · doi:10.1038/362801a0 · Cited by 10,618 · see citing works
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513 · see citing works
Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications
Flier, J. S., Underhill, L. H., Brownlee, M., Cerami, A., & Vlassara, H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805193182007 · Cited by 2,512 · see citing works
Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor
Gryglewski, R. J., Palmer, R. M. J., & Moncada, S. (1986) · Nature · doi:10.1038/320454a0 · Cited by 2,407 · see citing works
Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging.
Pignoli, P., Tremoli, E., Poli, A., Oreste, P., & Paoletti, R. (1986) · Circulation · doi:10.1161/01.cir.74.6.1399 · Cited by 2,404 · see citing works
Lipid peroxidation: its mechanism, measurement, and significance
Halliwell, B. B., & Chirico, S. (1993) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/57.5.715s · Cited by 2,355 · see citing works
Close Relation of Endothelial Function in the Human Coronary and Peripheral Circulations
Anderson, T. J., Uehata, A., Gerhard, M. D., Meredith, I. T., Knab, S., Delagrange, D., Lieberman, E. H., Ganz, P., Creager, M. A., Yeung, A. C., et al. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00327-4 · Cited by 2,033 · cited 1× · see citing works
“A close relationship was recognized between the magnitude of the endothelium-dependent vasodilation in the coronary arteries and that in the brachial arteries (16,18).”
BackgroundOxidative Stress and Diabetic Vascular Complications
Giugliano, D., Ceriello, A., & Paolisso, G. (1996) · Diabetes Care · doi:10.2337/diacare.19.3.257 · Cited by 1,938 · see citing works
Regulatory Functions of the Vascular Endothelium
Epstein, F. H., Vane, J. R., Änggård, E., & Botting, R. M. (1990) · New England Journal of Medicine · doi:10.1056/nejm199007053230106 · Cited by 1,870 · see citing works
Hyperinsulinemia as an independent risk factor for ischemic heart disease
Després, J.-P., Lamarche, B., Mauriège, P., Cantin, B., Dagenais, G. R., Moorjani, S., & Lupien, P.-J. (1996) · New England Journal of Medicine · doi:10.1056/nejm199604113341504 · Cited by 1,699 · see citing works
Joannidès, R., Haefeli, W. E., Linder, L., Richard, V. J., Bakkali, E. H., Thuillez, C., & Lüscher, T. F. (1995) · Circulation · doi:10.1161/01.cir.91.5.1314 · Cited by 1,622 · see citing works
Flow-induced release of endothelium-derived relaxing factor
Rubanyi, G. M., Romero, J. C., & Vanhoutte, P. (1986) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1986.250.6.h1145 · Cited by 1,373 · see citing works
The pathogenesis of atherosclerosis
(1972) · American Heart Journal · doi:10.1016/0002-8703(72)90090-7 · Cited by 1,329 · see citing works
Wolff, S. P., & Dean, R. T. (1987) · Biochemical Journal · doi:10.1042/bj2450243 · Cited by 1,277 · see citing works
Bucala, R., Tracey, K. J., & Cerami, A. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115014 · Cited by 1,162 · see citing works
Crucial role of endothelium in the vasodilator response to increased flow in vivo.
Pohl, U., Holtz, J., Busse, R., & Bassenge, E. (1986) · Hypertension · doi:10.1161/01.hyp.8.1.37 · Cited by 984 · see citing works
Ting, H. H., Timimi, F. K., Boles, K., Creager, S. J., Ganz, P., & Creager, M. A. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118394 · Cited by 869 · see citing works
Effect of a single high-fat meal on endothelial function in healthy subjects
Vogel, R. A., Corretti, M. C., & Plotnick, G. D. (1997) · The American Journal of Cardiology · doi:10.1016/s0002-9149(96)00760-6 · Cited by 798 · see citing works
Cosentino, F., Hishikawa, K., Katušić, Z. S., & Lüscher, T. F. (1997) · Circulation · doi:10.1161/01.cir.96.1.25 · Cited by 762 · see citing works
Nitric oxide release accounts for insulin's vascular effects in humans.
Scherrer, U., Randin, D., Vollenweider, P., Vollenweider, L., & NICOD, P. H. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117621 · Cited by 755 · see citing works
Hemodynamic actions of insulin
Baron, A. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.267.2.e187 · Cited by 608 · see citing works
Balkau, B., Shipley, M. J., Jarrett, R. J., Pyörälà, K., Pyörälä, M., Forhan, A., & Eschwège, É. (1998) · Diabetes Care · doi:10.2337/diacare.21.3.360 · Cited by 597 · see citing works
NIDDM and Its Metabolic Control Predict Coronary Heart Disease in Elderly Subjects
Kuusisto, J., Mykkänen, L. M., Pyörälà, K., & Laakso, M. (1994) · Diabetes · doi:10.2337/diab.43.8.960 · Cited by 588 · see citing works
Free radicals mediate endothelial cell dysfunction caused by elevated glucose
Tesfamariam, B., & Cohen, R. A. (1992) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1992.263.2.h321 · Cited by 558 · see citing works
Calver, A., Collier, J., & Vallance, P. J. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116149 · Cited by 522 · see citing works
Assmann, G., & Schulte, H. (1988) · American Heart Journal · doi:10.1016/0002-8703(88)90220-7 · Cited by 447 · see citing works
Oxygen-derived free radicals, endothelium, and responsiveness of vascular smooth muscle
Rubanyi, G. M., & Vanhoutte, P. M. (1986) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1986.250.5.h815 · Cited by 376 · see citing works
Beks, P. J., Mackaay, A. J. C., de Neeling, J. N. D., de Vries, H., Bouter, L. M., & Heine, R. J. (1995) · Diabetologia · doi:10.1007/bf02369357 · Cited by 296 · see citing works
Vascular dysfunction in diabetes mellitus
Feener, E. P., & King, G. L. (1997) · The Lancet · doi:10.1016/s0140-6736(97)90022-2 · Cited by 287 · see citing works
Technical aspects of evaluating brachial artery vasodilatation using high-frequency ultrasound
Corretti, M. C., Plotnick, G. D., & Vogel, R. A. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.268.4.h1397 · Cited by 283 · see citing works
Lipids and lipoproteins as coronary risk factors in non-insulin-dependent diabetes mellitus
Syvänne, M., & Taskinen, M. (1997) · The Lancet · doi:10.1016/s0140-6736(97)90024-6 · Cited by 268 · see citing works
The epidemiology of cardiovascular disease in type 2 diabetes mellitus: how sweet it is … or is it?
Nathan, D. M., Meigs, J. B., & Singer, D. E. (1997) · The Lancet · doi:10.1016/s0140-6736(97)90021-0 · Cited by 264 · see citing works
DISFUNCTION OF VASCULAR ENDOTHELIUM IN DIABETES MELLITUS
Cohen, R. A. (1993) · Cited by 254 · see citing works
High blood glucose concentration is a risk factor for mortality in middle-aged nondiabetic men
Balkau, B., Shipley, M. J., Jarrett, R. J., Pyörälà, K., Pyörälä, M., Forhan, A., & Eschwège, É. (1998) · Diabetes Care · Cited by 186 · see citing works
The role of myogenic relaxation, adenosine and prostaglandins in human forearm reactive hyperaemia.
Carlsson, I. B., Sollevi, A., & Wennmalm, Å. (1987) · The Journal of Physiology · doi:10.1113/jphysiol.1987.sp016651 · Cited by 183 · see citing works
Motoyama, T., Kawano, H., Kugiyama, K., Hirashima, O., Ohgushi, M., Tsunoda, R., Moriyama, Y., Miyao, Y., Yoshimura, M., Ogawa, H., et al. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00447-1 · Cited by 170 · see citing works
Self-citationIs there a glycemic threshold for mortality risk?
Balkau, B., Bertrais, S., Ducimetière, P., & Eschwège, É. (1999) · Diabetes Care · doi:10.2337/diacare.22.5.696 · Cited by 160 · see citing works
Topical hyperglycemia rapidly suppresses EDRF-mediated vasodilation of normal rat arterioles
Bohlen, H. G., & Lash, J. M. (1993) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1993.265.1.h219 · Cited by 145 · see citing works
Baron, A. D. (1996) · Diabetes · doi:10.2337/diab.45.1.s105 · Cited by 132 · see citing works
Biochemical and Molecular Mechanisms in the Development of Diabetic Vascular Complications
King, G. L., Kunisaki, M., Nishio, Y., Inoguchi, T., Shiba, T., & Xia, P. (1996) · Diabetes · doi:10.2337/diab.45.3.s105 · Cited by 130 · see citing works
Meigs, J. B., Singer, D. E., SULLIVAN, L. M., Dukes, K. A., D’Agostino, R. B., Nathan, D. M., Wagner, E. H., Kaplan, S. H., & Greenfield, S. (1997) · The American Journal of Medicine · doi:10.1016/s0002-9343(96)00383-x · Cited by 122 · see citing works
The Mystery of Diabetes and Atherosclerosis: Time for a New Plot
Semenkovich, C. F., & Heinecke, J. W. (1997) · Diabetes · doi:10.2337/diab.46.3.327 · Cited by 118 · see citing works
Kawano, H., Motoyama, T., Kugiyama, K., Hirashima, O., Ohgushi, M., Fujii, H., Ogawa, H., & Yasue, H. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00234-9 · Cited by 100 · see citing works
Self-citationHyperinsulinemia and Atherosclerosis
Stout, R. W. (1996) · Diabetes · doi:10.2337/diab.45.3.s45 · Cited by 98 · see citing works
Role of endothelium-derived nitric oxide in myocardial reactive hyperemia
Yamabe, H., Okumura, K., Ishizaka, H., Tsuchiya, T., & Yasue, H. (1992) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1992.263.1.h8 · Cited by 97 · see citing works
Self-citationThe Peripheral Circulation: Local Regulation
SPARKS, H. V., & Belloni, F. L. (1978) · Annual Review of Physiology · doi:10.1146/annurev.ph.40.030178.000435 · Cited by 62 · see citing works
Improved method for simultaneous determination of cholesterol in high- and low-density lipoproteins.
Noma, A., Okabe, H., Netsu-Nakayama, K., et al. (1979) · Clinical Chemistry · doi:10.1093/clinchem/25.8.1480 · Cited by 52 · see citing works
COOPER, K. E. (1962) · Annual Review of Physiology · doi:10.1146/annurev.ph.24.030162.001035 · Cited by 47 · see citing works
Is There a Glycemic Threshold for Mortality Risk?
Harris, M. I., & Eastman, R. C. (1998) · Diabetes Care · doi:10.2337/diacare.21.3.331 · Cited by 42 · see citing works
Flagged first, then by citations
Research works printed but not linked: 5
- [3]3. Meigs J.B, Singer D.E, Sullivan L.M et al: Metabolic control and prevalent cardiovascular disease in non–insulin-dependent diabetes mellitus. Am J Med 1997; 102: 38. Crossref PubMed Google Scholar
- [4]4. Semenkovich C.F and Heinecke J.W: The mystery of diabetes and atherosclerosis. Diabetes 1997; 46: 327. Crossref PubMed Google Scholar
- [20]20. Buege J.A and Aust S.D: Microsomal lipid peroxidation. Methods Enzymol 1987; 52: 302. Crossref Google Scholar
- [27]27. Assmann G and Schulte H: The Prospective Cardiovascular Münster (PROCAM) Study. Am Heart J 1988; 116: 1713. Crossref PubMed Google Scholar
- [35]35. Wolff S.P and Dean R.T: Glucose autoxidation and protein modification. Biochem J 1987; 245: 243. Crossref PubMed Google Scholar
Cited by
Sorted by citations
Chiasson, J.-L., Josse, R. G., Gomis, R., Hanefeld, M., Karasik, A., Laakso, M., & for The STOP-NIDDM Trial Research Group (2003) · JAMA · doi:10.1001/jama.290.4.486 · Cited by 1,624 · see citing works
Ceriello, A., & Motz, E. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000122852.22604.78 · Cited by 1,378 · see citing works
Ceriello, A., Esposito, K., Piconi, L., Ihnat, M. A., Thorpe, J. E., Testa, R., Boemi, M., & Giugliano, D. (2008) · Diabetes · doi:10.2337/db08-0063 · Cited by 1,310 · see citing works
Management of diabetes and hyperglycemia in hospitals.
Clement, S., Braithwaite, S. S., Magee, M. F., Ahmann, A., Smith, E. P., Schafer, R. G., Hirsch, I. B., & on behalf of the Diabetes in Hospitals Writing Committee (2004) · Diabetes Care · doi:10.2337/diacare.27.2.553 · Cited by 1,266 · see citing works
Postprandial Hyperglycemia and Diabetes Complications
Ceriello, A. (2005) · Diabetes · doi:10.2337/diabetes.54.1.1 · Cited by 945 · see citing works
Ceriello, A. (2003) · Diabetes Care · doi:10.2337/diacare.26.5.1589 · Cited by 734 · see citing works
Augustin, L. S. A., Kendall, C. W. C., Jenkins, D. J. A., Willett, W. C., Astrup, A., Barclay, A. W., Björck, I., Brand-Miller, J. C., Brighenti, F., Buyken, A. E., et al. (2015) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2015.05.005 · Cited by 707 · see citing works
Ceriello, A., Taboga, C., Tonutti, L., Quagliaro, L., Piconi, L., Bais, B., Da Ros, R., & Motz, E. (2002) · Circulation · doi:10.1161/01.cir.0000027569.76671.a8 · Cited by 655 · see citing works
Kosiborod, M., Inzucchi, S. E., Krumholz, H. M., Xiao, L., Jones, P. G., Fiske, S., Masoudi, F. A., Marso, S. P., & Spertus, J. A. (2008) · Circulation · doi:10.1161/circulationaha.107.740498 · Cited by 385 · see citing works
Microvascular complications of impaired glucose tolerance
Singleton, J. R., Smith, A. G., Russell, J. W., & Feldman, E. L. (2003) · Diabetes · doi:10.2337/diabetes.52.12.2867 · Cited by 372 · see citing works
Stranders, I., Diamant, M., van Gelder, R. E., Spruijt, H. J., Twisk, J. W. R., Heine, R. J., & Visser, F. C. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.9.982 · Cited by 353 · see citing works
Woodman, R. J., Mori, T. A., Burke, V., Puddey, I. B., Watts, G. F., & Beilin, L. J. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.5.1007 · Cited by 338 · see citing works
Ceriello, A., Assaloni, R., Da Ros, R., Maier, A., Piconi, L., Quagliaro, L., Esposito, K., & Giugliano, D. (2005) · Circulation · doi:10.1161/01.cir.0000165070.46111.9f · Cited by 298 · see citing works
Early Morning Attenuation of Endothelial Function in Healthy Humans
Otto, M. E., Svatikova, A., Barretto, R. B. D. M., Santos, S., Hoffmann, M., Khandheria, B., & Somers, V. (2004) · Circulation · doi:10.1161/01.cir.0000128207.26863.c4 · Cited by 273 · see citing works
Anderson, R. A., Evans, M. L., Ellis, G. R., Graham, J., Morris, K., Jackson, S. K., Lewis, M. J., Rees, A., & Frenneaux, M. P. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(00)00499-8 · Cited by 248 · see citing works
Raitakari, M., Ilvonen, T., Ahotupa, M., Lehtimäki, T., Harmoinen, A., Suominen, P., Elo, J., Hartiala, J., & Raitakari, O. T. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000109749.11042.7c · Cited by 198 · see citing works
Dickinson, S., Hancock, D. P., Petocz, P., Ceriello, A., & Brand-Miller, J. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1188 · Cited by 184 · see citing works
Postprandial Hyperglycemia and Glycemic Variability
Standl, E., Schnell, O., & Ceriello, A. (2011) · Diabetes Care · doi:10.2337/dc11-s206 · Cited by 183 · see citing works
Koska, J., Sands, M., Burciu, C., D’Souza, K. M., Raravikar, K., Liu, J., Truran, S., Franco, D. A., Schwartz, E. A., Schwenke, D. C., et al. (2015) · Diabetes · doi:10.2337/db14-0976 · Cited by 174 · see citing works
Ferric saccharate induces oxygen radical stress and endothelial dysfunction in vivo
Rooyakkers, T. M., Stroes, E. S. G., Kooistra, M. P., Van Faassen, E. E., Hider, R. C., Rabelink, T. J., & Marx, J. J. M. (2002) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2002.0320s1009.x · Cited by 157 · see citing works
Postprandial Myocardial Perfusion in Healthy Subjects and in Type 2 Diabetic Patients
Scognamiglio, R., Negut, C., De Kreutzenberg, S. V., Tiengo, A., & Avogaro, A. (2005) · Circulation · doi:10.1161/circulationaha.104.495127 · Cited by 153 · see citing works
Bonora, E., Corrao, G., Bagnardi, V., Ceriello, A., Comaschi, M., Montanari, P., & Meigs, J. B. (2006) · Diabetologia · doi:10.1007/s00125-006-0203-x · Cited by 141 · see citing works
Ceriello, A., Esposito, K., Testa, R., Bonfigli, A. R., Marra, M., & Giugliano, D. (2011) · Diabetes Care · doi:10.2337/dc10-1949 · Cited by 134 · see citing works
Experimental sleep restriction causes endothelial dysfunction in healthy humans
Calvin, A. D., Covassin, N., Kremers, W. K., Adachi, T., Macedo, P., Albuquerque, F. N., Bukartyk, J., Davison, D. E., Levine, J. A., Singh, P., et al. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.114.001143 · Cited by 123 · see citing works
Ihlemann, N., Rask-Madsen, C., Perner, A., Dominguez, H., Hermann, T., Køber, L., & Torp-Pedersen, C. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00008.2003 · Cited by 113 · see citing works
Giraldez, R. R., Clare, R. M., Lopes, R. D., Dalby, A. J., Prabhakaran, D., Brogan, G. X., Giugliano, R. P., James, S. K., Tanguay, J.-F., Pollack, C. V., et al. (2013) · American Heart Journal · doi:10.1016/j.ahj.2013.01.005 · Cited by 111 · see citing works
Ding, H., Aljofan, M., & Triggle, C. R. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21063 · Cited by 107 · see citing works
Kelly, A. S., Bergenstal, R. M., Gonzalez-Campoy, J., Katz, H., & Bank, A. J. (2012) · Cardiovascular Diabetology · doi:10.1186/1475-2840-11-64 · Cited by 98 · see citing works
Can Metformin Exert as an Active Drug on Endothelial Dysfunction in Diabetic Subjects
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Kendall, C. W. C., Josse, A. R., Esfahani, A., & Jenkins, D. J. A. (2011) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2011.12 · Cited by 69 · see citing works
Bellis, A., Mauro, C., Barbato, E., Ceriello, A., Cittadini, A., & Morisco, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020775 · Cited by 61 · see citing works
Siervo, M., Corander, M., Stranges, S., & Bluck, L. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.10.003 · Cited by 55 · see citing works
Why the endothelium? The endothelium as a target to reduce diabetes-associated vascular disease
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First-phase insulin secretion: can its evaluation direct therapeutic approaches?
Di Giuseppe, G., Ciccarelli, G., Soldovieri, L., Capece, U., Cefalo, C. M. A., Moffa, S., Nista, E. C., Brunetti, M., Cinti, F., Gasbarrini, A., et al. (2023) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2023.02.001 · Cited by 46 · see citing works
Ghosh, S., Lakshmanan, A. P., Hwang, M. J., Kubba, H., Mushannen, A., Triggle, C. R., & Ding, H. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.10.008 · Cited by 45 · see citing works
Saito, Y., Kajiyama, S., Nitta, A., Miyawaki, T., Matsumoto, S., Ozasa, N., Kajiyama, S., Hashimoto, Y., Fukui, M., & Imai, S. (2020) · Nutrients · doi:10.3390/nu12092767 · Cited by 31 · see citing works
- Authors
- Kawano, H., Motoyama, T., Hirashima, O., Hirai, N., Miyao, Y., Sakamoto, T., Kugiyama, K., Ogawa, H., & Yasue, H.
- Affiliations
- Kumamoto University (JP)
- Kumamoto University Hospital (JP)
- Corresponding author
- Yasue, Hirofumi
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 1999-07
- Volume
- 34
- Issue
- 1
- Pages
- 146-154
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2122648697
- Cited by
- 676
- References
- 53
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 11 · 2023: 12 · 2022: 8 · 2021: 16 · 2020: 27 · 2019: 23 · 2018: 19 · 2017: 31 · 2016: 24 · 2015: 31 · 2014: 32 · 2013: 38 · 2012: 41
- FWCI
- 7.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- hyperglycemia, endothelial dysfunction, flow-mediated dilation, brachial artery, oral glucose tolerance test, impaired glucose tolerance, type 2 diabetes, lipid peroxidation, TBARS, nitrite/nitrate, oxidative stress, postprandial blood glucose, nitric oxide bioavailability, endothelium-dependent vasodilation, endothelium-independent relaxation
- MeSH terms
- Acute Disease, Brachial Artery, Diabetes Mellitus, Diabetes Mellitus, Type 2, Endothelium, Vascular, Female, Glucose Tolerance Test, Humans, Hyperglycemia, Male, Middle Aged, Regional Blood Flow, Vasodilation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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