Cited by 502Mitochondrial Function and PathologyCardiovascular Function and Risk FactorsCardiac Ischemia and Reperfusion

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Reduced Mitochondrial Oxidative Capacity and Increased Mitochondrial Uncoupling Impair Myocardial Energetics in Obesity

Boudina, Sihem, Sena, Sandra, O’Neill, Brian T., Tathireddy, Prakash, Young, Martin E., Abel, E. Dale·2005·Circulation

DOI 10.1161/circulationaha.105.554360

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Abstract

Background— Obesity is a risk factor for cardiovascular disease and is strongly associated with insulin resistance and type 2 diabetes. Recent studies in obese humans and animals demonstrated increased myocardial oxygen consumption (MV̇ o 2 ) and reduced cardiac efficiency (CE); however, the underlying mechanisms remain unclear. The present study was performed to determine whether mitochondrial dysfunction and uncoupling are responsible for reduced cardiac performance and efficiency in ob/ob mice. Methods and Results— Cardiac function, MV̇ o 2 , mitochondrial respiration, and ATP synthesis were measured in 9-week-old ob/ob and control mouse hearts. Contractile function and MV̇ o 2 in glucose-perfused ob/ob hearts were similar to controls under basal conditions but were reduced under high workload. Perfusion of ob/ob hearts with glucose and palmitate increased MV̇ o 2 and reduced CE by 23% under basal conditions, and CE remained impaired at high workload. In glucose-perfused ob/ob hearts, mitochondrial state 3 respirations were reduced but ATP/O ratios were unchanged. In contrast, state 3 respiration rates were similar in ob/ob and control mitochondria from hearts perfused with palmitate and glucose, but ATP synthesis rates and ATP/O ratios were significantly reduced in ob/ob , which suggests increased mitochondrial uncoupling. Pyruvate dehydrogenase activity and protein levels of complexes I, III, and V were reduced in obese mice. Conclusions— These data indicate that reduced mitochondrial oxidative capacity may contribute to cardiac dysfunction in ob/ob mice. Moreover, fatty acid but not glucose-induced mitochondrial uncoupling reduces CE in obese mice by limiting ATP production and increasing MV̇ o 2 .

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The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
Randle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093
The Continuing Epidemics of Obesity and Diabetes in the United States
Mokdad, A. H. (2001) · JAMA · doi:10.1001/jama.286.10.1195 · Cited by 2,730
Superoxide activates mitochondrial uncoupling proteins
Echtay, K. S., Roussel, D., St-Pierre, J., Jekabsons, M. B., Cadenas, S., Stuart, J. A., Harper, J. A., Roebuck, S. J., Morrison, A., Pickering, S., et al. (2002) · Nature · doi:10.1038/415096a · Cited by 1,382
Lipotoxic diseases
Unger, R. H. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.104057 · Cited by 875
Energy metabolism in uncoupling protein 3 gene knockout mice
Vidal-Puig, A. J., Grujic, D., Zhang, C.-Y., Hagen, T., Boss, O., Ido, Y., Szczepanik, A., Wade, J., Mootha, V., Cortright, R., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910179199 · Cited by 677
Effect of Obesity and Insulin Resistance on Myocardial Substrate Metabolism and Efficiency in Young Women
Peterson, L. R., Herrero, P., Schechtman, K. B., Racette, S. B., Waggoner, A. D., Kisrieva-Ware, Z., Dence, C., Klein, S., Marsala, J., Meyer, T., et al. (2004) · Circulation · doi:10.1161/01.cir.0000127959.28627.f8 · Cited by 656
Abnormal Cardiac and Skeletal Muscle Energy Metabolism in Patients With Type 2 Diabetes
Scheuermann-Freestone, M., Madsen, P. L., Manners, D., Blamire, A. M., Buckingham, R. E., Styles, P., Radda, G. K., Neubauer, S., & Clarke, K. (2003) · Circulation · doi:10.1161/01.cir.0000072789.89096.10 · Cited by 525
Uncoupling Protein 2, in Vivo Distribution, Induction upon Oxidative Stress, and Evidence for Translational Regulation
Pecqueur, C., Alves‐Guerra, M., Gelly, C., Lévi-Meyrueis, C., Couplan, E., Collins, S., Ricquier, D., Bouillaud, F., & Miroux, B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006938200 · Cited by 483
Alterations in left ventricular structure and function in young healthy obese women
Peterson, L. R., Waggoner, A. D., Schechtman, K. B., Meyer, T., Gropler, R. J., Barzilai, B., & Dávila-Román, V. G. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.10.062 · Cited by 449
Myocardial triglycerides and systolic function in humans: In vivo evaluation by localized proton spectroscopy and cardiac imaging
Szczepaniak, L. S., Dobbins, R. L., Metzger, G. J., Sartoni‐D'Ambrosia, G., Arbique, D., Vongpatanasin, W., Unger, R. H., & Victor, R. G. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10372 · Cited by 441

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The link between obesity and aging - insights into cardiac energy metabolism
Owesny, P., & Grune, T. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111870 · Cited by 24
“2 Mitochondrial respiration in obesity As mitochondria play a crucial role in regulating energy metabolism, DIO significantly impacts mitochondrial morphology, leading to mitochondrial dysfunction (Boudina et al., 2005; Salvestrini et al., 2019; García-García et al., 2020; Liu & Lin et al., 2023).”
Background
Sensitivity of Cardiac Carnitine Palmitoyltransferase to Malonyl-CoA Is Regulated by Leptin: Similarities with a Model of Endogenous Hyperleptinemia
Guzmán‐Ruiz, R., Somoza, B., Gil‐Ortega, M., Merino, B., Cano, V., Attané, C., Castan‐Laurell, I., Valet, P., Fernández‐Alfonso, M. S., & Ruiz‐Gayo, M. (2010) · Endocrinology · doi:10.1210/en.2009-1170 · Cited by 21
“Dietary treatment with HF reduced on basal levels of pAMPK (F(1,17) 9,783; P 0.”
BackgroundMethod
Mitochondrial Oxidative Phosphorylation Function and Mitophagy in Ischaemic/Reperfused Hearts from Control and High-Fat Diet Rats: Effects of Long-Term Melatonin Treatment
Dhanabalan, K., Mzezewa, S., Huisamen, B., & Lochner, A. (2020) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-020-06997-9 · Cited by 21
Nutritional Aspects of Breath Testing Based on Stable Isotopes
Parra, M. D., & Martínez, J. A. (2006) · Nutrition Reviews · doi:10.1111/j.1753-4887.2006.tb00218.x · Cited by 21
Methylene blue decreases mitochondrial lysine acetylation in the diabetic heart
Berthiaume, J. M., Hsiung, C., Austin, A. B., McBrayer, S. P., Depuydt, M. M., Chandler, M. P., Miyagi, M., & Rosca, M. G. (2017) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-017-2993-1 · Cited by 22
Lessons that can be learned from patients with diabetogenic mutations in mitochondrial DNA: implications for common type 2 diabetes
Maassen, J. A., Hart, L. M. ‘., & Ouwens, D. M. (2007) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3282f0b774 · Cited by 21
Effect of exercise on improving myocardial mitochondrial function in decreasing diabetic cardiomyopathy
Zhang, F., Lin, J. J., Tian, H. N., & Wang, J. (2023) · Experimental Physiology · doi:10.1113/ep091309 · Cited by 19
“In a study of diabetic animal models, myocardial mitochondrial content and oxidative phosphorylation-related components were decreased, as well as mitochondrial oxidative phosphorylation capacity (Boudina et al., 2005; Lashin & Romani., 2004).”
Background
Astragalus polysaccharides repress myocardial lipotoxicity in a PPARalpha-dependent manner in vitro and in vivo in mice
Chen, W., Lai, Y., Wang, L., Xia, Y., Chen, W., Zhao, X., Mao-hua, Y., Li, Y., Zhang, Y., & Ye, H. (2014) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2014.11.007 · Cited by 22
“…ultrastructural analyses revealed increased mitochondrial proliferation in models of type 1 and type 2 diabetesmellitus and even inmousemodels of themetabolic syndrome, whichmight be driven in part by activation of the PPARα/PGC1-α gene regulatory pathways (Boudina et al., 2005; Yang et al., 2007).”
Background
Obesity Stresses Cardiac Mitochondria Even When You Are Young
Abel, E. D. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.09.039 · Cited by 20
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Diabetic cardiomyopathy revisited: The interplay between diabetes and heart failure
Mann, C., Braunwald, E., & Zelniker, T. A. (2025) · International Journal of Cardiology · doi:10.1016/j.ijcard.2025.133554 · Cited by 23
Myocardial tissue phase mapping reveals impaired myocardial tissue velocities in obesity
Rider, O. J., Ajufo, E. C., Ali, M. K., Petersen, S. E., Nethononda, R. M., Francis, J. M., & Neubauer, S. (2014) · International journal of cardiac imaging · doi:10.1007/s10554-014-0548-z · Cited by 19
“[17,30-32] Using TPM, patients with left ventricular hypertrophy due to hypertensive heart 17 disease have previously been shown to have reduced systolic and diastolic velocities in both radial and 18 longitudinal directions, as well as reduced circumferential basal rotation.”
Method
Differences in the prognostic relevance of myocardial ischaemia and scar by cardiac magnetic resonance in patients with and without diabetes mellitus
Giuşcă, S., Kelle, S., Nagel, E. C., Buss, S. J., Voss, A., Püntmann, V. O., Fleck, E., Katus, H. A., & Korosoglou, G. (2015) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jev220 · Cited by 19
“Apart from that and independent from the progression of CAD, altered fatty acid metabolism, deregulated mitochondrial phosphorylation, and decreased glucose oxidation play an additional deleterious role in the prognosis of patients with DM.(25,26) When analysing the association of DM and other risk predictors, we foun…”
Background
Mitochondrial Alterations and Enhanced Human Leukocyte/Endothelial Cell Interactions in Type 1 Diabetes
Iannantuoni, F., Marañón, A., Abad‐Jiménez, Z., Canet, F., Díaz-Pozo, P., López‐Domènech, S., Morillas, C., Rocha, M., & Víctor, V. M. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072155 · Cited by 19
Restoration of glucose metabolism in leptin-resistant mouse hearts after acute myocardial infarction through the activation of survival kinase pathways
Witham, W. G., Yester, K. A., O'Donnell, C. P., & McGaffin, K. R. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2012.03.016 · Cited by 19
Glucose Homeostasis and Cardiovascular Alterations in Diabetes
Xiang, L., Mittwede, P. N., & Clemmer, J. S. (2015) · Comprehensive physiology · doi:10.1002/cphy.c150001 · Cited by 19
Transcriptional analysis of brown adipose tissue in leptin-deficient mice lacking inducible nitric oxide synthase: evidence of the role of Med1 in energy balance
Becerril, S., Rodrı́guez, A., Catalán, V., Sáinź, N., Ramírez, B., Gómez‐Ambrosi, J., & Frühbeck, G. (2012) · Physiological Genomics · doi:10.1152/physiolgenomics.00039.2012 · Cited by 18
“In this sense, leptin has been shown to activate mitochondrial biogenesis, and leptin deficiency is associated with impaired mitochondrial function (5).”
Background
Metabolic and Biochemical Stressors in Diabetic Cardiomyopathy
Kain, V., & Halade, G. V. (2017) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00031 · Cited by 21
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König, A., Bode, C., & Bugger, H. (2012) · Heart Failure Clinics · doi:10.1016/j.hfc.2012.06.001 · Cited by 18
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Duicu, O., Lighezan, R., Sturza, A., Ceauşu, R. A., Borza, C., Văduva, A., Noveanu, L., Gaşpar, M., Ionac, A., Feier, H. B., et al. (2015) · BioMed Research International · doi:10.1155/2015/515437 · Cited by 18
NADPH Oxidase 2 Mediates Myocardial Oxygen Wasting in Obesity
Hafstad, A. D., Hansen, S. S., Lund, J., Santos, C. X. C., Boardman, N. T., Shah, A. M., & Aasum, E. (2020) · Antioxidants · doi:10.3390/antiox9020171 · Cited by 18
“Several studies have associated diabetes and obesity with cardiac mitochondrial dysfunction, although there is no complete consensus in the literature [23,24,34].”
Background
Obesity and Hypertension
Seravalle, G., & Grassi, G. M. (2024) · Springer eBooks · doi:10.1007/978-3-031-62491-9_5 · Cited by 22
In vivo creatine kinase reaction kinetics at rest and stress in type II diabetic rat heart
Bashir, A., Coggan, A. R., & Gropler, R. J. (2015) · Physiological Reports · doi:10.14814/phy2.12248 · Cited by 17
“Reduced [PCr] might indicate mitochondrial dysfunction, as previous studies in diabetic rodent hearts have demonstrated reduced mitochondrial respiration and ATP synthesis (Kuo et al. 1983, 1985; Boudina et al. 2005).”
Background
Mitochondria of mice and men: Moderate magnetic fields in obesity and fatty liver
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“A similar mitochondrial defect is seen in conventional insulin resistant ob/ob and db/db-mice [38].”
Background
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Ansari, M., & Kurian, G. A. (2019) · Cardiovascular Toxicology · doi:10.1007/s12012-019-09542-9 · Cited by 17
Elevated circulating high-sensitivity cardiac troponin t and cardiac remodeling in obesity
Huang, J., Liu, M., Su, E., Yu, P., Jiang, H., Zhao, J., & Ge, J. (2021) · BMC Cardiovascular Disorders · doi:10.1186/s12872-021-02445-0 · Cited by 17
The Diabetic Cardiorenal Nexus
D’Elia, J. A., Bayliss, G. P., & Weinrauch, L. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137351 · Cited by 17
“Following weight loss after bariatric surgery [103,104] levels of reactive oxygen species of lipid origin are corrected [105,106].”
Background
Loss of Bradykinin Signaling Does Not Accelerate the Development of Cardiac Dysfunction in Type 1 Diabetic Akita Mice
Wende, A. R., Soto, J. E., Olsen, C. D., Pires, K. M. P., Schell, J. C., Larrieu-Lahargue, F., Litwin, S. E., Kakoki, M., Takahashi, N., Smithies, O., et al. (2010) · Endocrinology · doi:10.1210/en.2010-0256 · Cited by 17
Self-citation
Myocardial Insulin Resistance: An Overview of Its Causes, Effects, and Potential Therapy
Toit, E. F. D., & Donner, D. G. (2012) · InTech eBooks · doi:10.5772/50619 · Cited by 18
“Reduced cardiac efficiency possibly contributes to cardiac dysfunction in obesity, insulin resistance and diabetes [44, 45, 213].”
Background
Sucrose Nonfermenting-Related Kinase Enzyme–Mediated Rho-Associated Kinase Signaling is Responsible for Cardiac Function
Cossette, S. M., Bhute, V. J., Bao, X., Harmann, L. M., Horswill, M. A., Sinha, I., Gastonguay, A. J., Pooya, S., Bordas, M. L., Kumar, S. N., et al. (2016) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.116.001515 · Cited by 16
“Furthermore, accumulation of lipids (free fatty acids) in the failing heart can create additional metabolic stress by increasing energy uncoupling and proton leakage and decreasing energy production.(32,33)”
Background
Dual roles of myocardial mitochondrial AKT on diabetic cardiomyopathy and whole body metabolism
Chen, Y., TA, A., Chen, Y., Lee, H.-C., Fan, W., Chen, P., Jordan, M. C., Roos, K. P., MacGregor, G. R., Yang, Q., et al. (2023) · Cardiovascular Diabetology · doi:10.1186/s12933-023-02020-1 · Cited by 16
“Both human and animal studies have demonstrated elevated myocardial oxygen consumption and lowered cardiac respiration efficiency in diabetic hearts [5].”
Background
Significance of mitochondria on cardiometabolic syndromes
Nair, A., Sindhu, G., & Raghu, K. G. (2018) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12359 · Cited by 16
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Shin, J., Lee, S. H., Kwon, M.-C., Yang, D. K., Seo, H.-R., Kim, J., Kim, Y. Y., Im, S.-K., Abel, E. D., Kim, K., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053577 · Cited by 16
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MethodSelf-citation
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“Furthermore, an imbalance in substrate utiliza-tion—such as increased glucose uptake and altered oxidation of alternative fuels—has been recognized as a hallmark of metabolic dysregulation in HFpEF [20, 21].”
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Lkhagva, B., Lee, T., Lin, Y., Chen, Y., Chung, C., Higa, S., & Chen, Y. (2022) · Cells · doi:10.3390/cells11182915 · Cited by 17
“These findings suggest that the excess influx of reducing equivalents of the TCA cycle may enter the ETC as a compensatory mechanism, inducing higher proton leak and uncoupled oxidative phosphorylation [46,47].”
Background
Investigating the Interplay between Cardiovascular and Neurodegenerative Disease
Cousineau, J., Dawe, A. M., & Alpaugh, M. (2024) · Biology · doi:10.3390/biology13100764 · Cited by 15
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AlGhatrif, M., Watts, V. L., Niu, X., Halushka, M. K., Miller, K. L., Vandegaer, K., Bedja, D., Fox-Talbot, K., Bielawska, A. E., Gabrielson, K. L., et al. (2013) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-013-9453-4 · Cited by 15
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Lasheras, J., Vilà, M., Zamora, M., Riu, E., Pardo, R., Poncelas, M., Cases, I., Ruiz‐Meana, M., Hernández, C., Felíu, J. E., et al. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.04.004 · Cited by 15
High‐fat diet affects skeletal muscle mitochondria comparable to pressure overload‐induced heart failure
Heyne, E., Schrepper, A., Doenst, T., Schenkl, C., Kreuzer, K., & Schwarzer, M. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15325 · Cited by 15
Hypoxia Attenuates Pressure Overload‐Induced Heart Failure
Froese, N., Szaroszyk, M., Galuppo, P., Visker, J. R., Werlein, C., Korf‐Klingebiel, M., Berliner, D., Reboll, M. R., Hamouche, R., Gegel, S., et al. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.123.033553 · Cited by 14
“11 15 Importantly, aforementioned animal models do not reflect HIF-1 α – independent adaptations at high altitude and alveolar hypoxia.”
Self-citation
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Yusuf, J. A., Akanbi, S. T., Ijibadejo, M. S., Sulaiman, S. E., Olorunlowu, D. R., Akinola, A. O., Abe, A. P., Opoola, E. K., Adejobi, E. O., Adigun, T. D., et al. (2025) · Discover Neuroscience · doi:10.1186/s13064-025-00223-8 · Cited by 15
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Tedesco, L., Rossi, F., Ruocco, C., Ragni, M., Carruba, M. O., Valerio, A., & Nisoli, E. (2022) · Experimental Eye Research · doi:10.1016/j.exer.2022.109060 · Cited by 14
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“Normal MAPR It is known that mtDNA depletion may interfere with respiratory chain ATP production [27].”
BackgroundMethod
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Norris, A. W., Hirshman, M. F., Yao, J., Jessen, N., Musi, N., Chen, L., Sivitz, W. I., Goodyear, L. J., & Kahn, C. R. (2008) · Endocrinology · doi:10.1210/en.2008-0100 · Cited by 13
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Background
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Lou, P., Lucchinetti, E., Zhang, L., Affolter, A., Gandhi, M., Hersberger, M., Warren, B. E., Lemieux, H., Sobhi, H. F., Clanachan, A. S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104971 · Cited by 13
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Delayed longitudinal myocardial function recovery after dobutamine challenge as a novel presentation of myocardial dysfunction in type 2 diabetic patients without angiographic coronary artery disease
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Chen, W., Chen, W., Xia, Y., Zhao, X., Wang, H., Mao-hua, Y., Li, Y., Ye, H., & Zhang, Y. (2012) · Molecular Biology Reports · doi:10.1007/s11033-012-2325-1 · Cited by 13
“In addition, ultrastructural analyses revealed increased mitochondrial proliferation in models of type 1 and type 2 diabetes mellitus and even in mouse models of the metabolic syndrome, which might be driven in part by activation of the PPARa/PGC1-a gene regulatory pathways [32, 33].”
Background
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Background
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Saleh, S. A., Hanna, G. S., El‐Nabi, S. H., El-Domiaty, H. F., Shabaan, A., & Ewida, S. F. (2020) · Journal of Genetics · doi:10.1007/s12041-020-01196-9 · Cited by 13
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Changes in cardiac energy metabolic pathways in overweighed rats fed a high-fat diet
Modrego, J., Heras, N. D. L., Zamorano‐León, J. J., Mateos‐Cáceres, P. J., Martín‐Fernández, B., Valero‐Muñoz, M., Lahera, V., & López-Farré, A. J. (2012) · European Journal of Nutrition · doi:10.1007/s00394-012-0392-7 · Cited by 12
High fat diet altered cardiac metabolic gene profile in Psammomys obesus gerbils
Sahraoui, A., Dewachter, C., Vegh, G., Entee, K. M., Naeije, R., Bouguerra, S. A., & Dewachter, L. (2020) · Lipids in Health and Disease · doi:10.1186/s12944-020-01301-y · Cited by 13
WY14643 improves left ventricular myocardial mitochondrial and systolic functions in obese rats under chronic persistent hypoxia via the PPARα pathway
Yan, J. X., Song, K., Bai, Z., & Ge, R. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118888 · Cited by 12
Ratas Zucker como modelo experimental para el estudio de diferentes enfermedades
Aleixandre, A., & Miguel, M. (2008) · Endocrinología y Nutrición · doi:10.1016/s1575-0922(08)70670-3 · Cited by 12
Linking the Cardiomyocyte Circadian Clock to Myocardial Metabolism
Durgan, D. J., & Young, M. E. (2008) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-008-6086-y · Cited by 12
Self-citation
Amyloid beta 42 alters cardiac metabolism and impairs cardiac function in male mice with obesity
Hall, L. G., Czeczor, J. K., Connor, T., Botella, J., Jong, K. A. D., Renton, M. C., Genders, A. J., Venardos, K. M., Martin, S. D., Bond, S. T., et al. (2024) · Nature Communications · doi:10.1038/s41467-023-44520-4 · Cited by 12
“This provides further evidence that A β 42 inhibits complex I of the respiratory chain as well as reducing mitochondrial capacityincardiomyocytes,bothofwhichhavebeenobservedinheart failure 43,51 – 53 .”
High metabolic substrate load induces mitochondrial dysfunction in rat skeletal muscle microvascular endothelial cells
Hansen, C. C., Olsen, K., Pilegaard, H., Bangsbo, J., Gliemann, L., & Hellsten, Y. (2021) · Physiological Reports · doi:10.14814/phy2.14855 · Cited by 11
“| 13 of 17HANSEN Et Al. including hepatocytes (Chan & Enns, 1979; Vaartjes & Bergh, 1978), myocytes (Boudina et al., 2005; Sparks et al., 2016) as well as white (Maassen et al., 2007) and brown (Fedorenko et al., 2012) adipocytes.”
Background
Slow TCA flux implies low ATP production in tumorsPreprint
Bartman, C., Shen, Y., Lee, W. D., TeSlaa, T. A., Jankowski, C. S. R., Wang, L., Yang, L., Roichman, A., Bhatt, V. D., Lan, T., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.04.463108 · Cited by 11
PKM 2 regulates metabolic flux and oxidative stress in the murine heart
Lee, K. C. Y., Williams, A. L., Wang, L., Xie, G., Jia, W. P., Fujimoto, A., Gerschenson, M., & Shohet, R. V. (2024) · Physiological Reports · doi:10.14814/phy2.70040 · Cited by 10
“It has been linked to increased NADH and FADH 2 flux, increased fatty acid oxidation, and subsequent mitochondrial uncoupling (Boudina et al., 2005; Teshima et al., 2014; Wright et al., 2009).”
Background
Switching to a Standard Chow Diet at Weaning Improves the Effects of Maternal and Postnatal High-Fat and High-Sucrose Diet on Cardiometabolic Health in Adult Male Mouse Offspring
Merlin, A. C., Gonzalez, K., Mockler, S., Perez, Y., Jia, U.-T. A., Chicco, A. J., Ullevig, S. L., & Chung, E. (2022) · Metabolites · doi:10.3390/metabo12060563 · Cited by 10
“Genetically obese mice (ob/ob) showed decreased mitochondrial oxidative capacity and mitochondrial efficiency with fatty acid substrates but not glucose substrates [7].”
Background
Epigenetic regulation and heart failure
Cao, D. J. (2014) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.2014.942285 · Cited by 10
“However, similar PGC1adriven processes in other insulin-resistant models such as the obesity animal model (ob/ob) were not evident [105].”
Background
Letter to the Editor
How, O.-J., Aasum, E., & Larsen, T. S. (2007) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01681.x · Cited by 10
“The common way of assessing efficiency in ex vivo rodent hearts is to relate external work (i.e. stroke work, cardiac output, cardiac power, rate pressure product) to MVO2 (Sarnhoff et al. 1958, Mazumder et al. 2004, Boudina et al. 2005, Buchanan et al. 2005, Wang et al. 2005a).”
Very low-density lipoprotein receptor mediates triglyceride-rich lipoprotein-induced oxidative stress and insulin resistance
Hajri, T., Gharib, M., Fungwe, T. V., & M’Koma, A. E. (2024) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00425.2023 · Cited by 9
In silico studies on the sensitivity of myocardial PCr/ATP to changes in mitochondrial enzyme activity and oxygen concentration
Edwards, L. M., Ashrafian, H., & Korzeniewski, B. (2011) · Molecular BioSystems · doi:10.1039/c1mb05310h · Cited by 9
Experimental evidence on the efficacy of two new metabolic modulators on mitochondrial biogenesis and function in mouse cardiomyocytes
Tedesco, L., Rossi, F., Ruocco, C., Ragni, M., Carruba, M. O., Valerio, A., & Nisoli, E. (2020) · Journal of Population Therapeutics and Clinical Pharmacology · doi:10.15586/jptcp.v27isp2.740 · Cited by 9
Dysregulation of the Mitochondrial Proteome Occurs in Mice Lacking Adiponectin Receptor 1
Pepin, M. E., Koentges, C., Pfeil, K., Gollmer, J., Kersting, S., Wiese, S., Hoffmann, M. M., Odening, K. E., Mühlen, C. V. Z., Diehl, P., et al. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00872 · Cited by 10
“The HFD-feeding associated downregulation of AdipoR1 detected in heart, kidneys and liver suggests that impaired gene expression of OXPHOS proteins in diabetic complications may, at least in part, be driven by impaired AdipoR1/adiponectin signaling, in particular in diabetic cardiomyopathy (37, 38).”
Background
Mitofilin: Key factor in diabetic cardiomyopathy?
Gorr, M. W., & Wold, L. E. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.11.028 · Cited by 9
Association between glyphosate exposure and cardiovascular health using “Life’s Essential 8” metrics in US adults
Zhu, Y., Yang, Z., Chen, Y., Qian, L., Hao, C., Hao, L., Yang, B., & Duan, J. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.117559 · Cited by 8
Sleeve Gastrectomy Reduces Oxidative Stress and Reverses Mitochondrial Dysfunction Associated with Metabolic Syndrome
Rossi, M. M., Signorini, F. J., Castillo, T. A., Parada, M. D. L. P. S., Moser, F., & Báez, M. D. C. (2024) · Obesity Surgery · doi:10.1007/s11695-024-07244-y · Cited by 8
“Studies in rats and humans have shown that obesity is associated with changes in mitochondrial size and density, affecting the activity of the electron transport chain and the capacity for fatty acid oxidation [24, 25].”
Mitochondrial Coupling and Contractile Efficiency in Humans with High and Low V˙O2peaks
Layec, G., Bringard, A., Fur, Y. L., Micallef, J., Vilmen, C., Perrey, S., Cozzone, P. J., & Bendahan, D. (2015) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000858 · Cited by 8
“Changes between minute 3 and the last point of the exercise ($pH(3)) were not significantly different between groups (Mann–Whitney U: P 9 0.”
Background
Mitochondria and Heart Disease
Stoll, S., Leimena, C., & Qiu, H. (2018) · InTech eBooks · doi:10.5772/intechopen.72611 · Cited by 8
“Mouse models of type 2 diabetes (db/db and ob/ob) showed dysfunctional mitochondrial state 3 respiration and decline in ATP production [125, 126].”
Gene and drug-mediated SERCA2a activation restores cardiac function and metabolic balance in diabetic mice
Kang, S., Majid, A., Hammoudi, N., & Lebeche, D. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118617 · Cited by 8
Left Ventricular Dysfunction in Human Immunodeficiency Virus Infection
Cade, W. T. (2008) · Journal of the CardioMetabolic Syndrome · doi:10.1111/j.1559-4572.2008.07581.x · Cited by 7
Acute effects of high intensity training on cardiac function: a pilot study comparing subjects with type 2 diabetes to healthy controls
Ness, H. O., Ljones, K., Gjelsvik, R. H., Tjønna, A. E., Malmo, V., Nilsen, H. O., Hollekim-Strand, S. M., Dalen, H., & Høydal, M. A. (2022) · Scientific Reports · doi:10.1038/s41598-022-12375-2 · Cited by 7
Remodeling of cardiac metabolism in heart failure with preserved ejection fraction
Yoshii, A., & Tian, R. (2022) · Current Opinion in Physiology · doi:10.1016/j.cophys.2022.100559 · Cited by 7
Determinants of improvement of left ventricular mechano-energetic efficiency in hypertensive patients
Lembo, M., Trimarco, V., Manzi, M. V., Mancusi, C., Esposito, G., Esposito, S., Morisco, C., Izzo, R., & Trimarco, B. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.977657 · Cited by 7
Effects of altered cellular ultrastructure on energy metabolism in diabetic cardiomyopathy: an in silico study
Ghosh, S., Guglielmi, G., Orfanidis, I., Spill, F., Hickey, A. J., Hanssen, E. G., & Rajagopal, V. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0323 · Cited by 6
Mitochondrial Metabolism and Insulin Action
Turner, N. A. (2013) · InTech eBooks · doi:10.5772/56449 · Cited by 8
Close association between circulating high-sensitivity cardiac troponin I and metabolic syndrome in the general population
Sugiura, T., Dohi, Y., Takase, H., Yamashita, S., Mizoguchi, T., Fujii, S., & Ohte, N. (2019) · Hypertension Research · doi:10.1038/s41440-019-0283-x · Cited by 8
Oligomannuronate prevents mitochondrial dysfunction induced by IAPP in RINm5F islet cells by inhibition of JNK activation and cell apoptosis
Liu, X., Li, Q., Cheng, X., Liu, Z., Zhao, X., Zhang, S., Yu, G., Hao, J., & Hao, J. (2020) · Chinese Medicine · doi:10.1186/s13020-020-00310-4 · Cited by 7
Molecular basis of ventricular arrhythmogenicity in a Pgc-1α deficient murine model
Saadeh, K., Chadda, K. R., Ahmad, S., Valli, H., Nanthakumar, N., Fazmin, I. T., Edling, C. E., Huang, C. L.-H., & Jeevaratnam, K. (2021) · Molecular Genetics and Metabolism Reports · doi:10.1016/j.ymgmr.2021.100753 · Cited by 8
Diet-induced obesity obstructs insulin signaling in the heart
Young, L. H. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01088.2009 · Cited by 7
Molecular Pathways in Diabetic Cardiomyopathy and the Role of Anti-hyperglycemic Drugs Beyond Their Glucose Lowering Effect
Lee, J.-E., Kim, B. G., & Won, J. C. (2025) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2025.14.1.54 · Cited by 6
Effects of non-coding RNAs and RNA-binding proteins on mitochondrial dysfunction in diabetic cardiomyopathy
Potel, K. N., Cornelius, V. A., Yacoub, A., Chokr, A., Donaghy, C. L., Kelaini, S., Eleftheriadou, M., & Margariti, A. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1165302 · Cited by 6
Sterculia tragacantha Lindl Aqueous Leaf Extract Ameliorate Cardiomyopathy in Streptozotocin-induced Diabetic Rats via Urotensin II and FABP3 Expressions
Ajiboye, B. O., Oyinloye, B. E., Onikanni, S. A., Osukoya, O. A., Lawal, O. E., & Bamisaye, F. A. (2021) · Journal of Oleo Science · doi:10.5650/jos.ess21251 · Cited by 6
High-resolution respirometry with multiple substrates titration in permeabilized myocardial fibers.
Duicu, O., Gheorgheosu, D., Miricä, N., Trancotă, S. L., Dehelean, C. A., Firă-Mladinescu, O., & Muntean, D. M. (2012) · The Medical-Surgical Journal · Cited by 6
Correction: Cardio-Metabolic Effects of HIV Protease Inhibitors (Lopinavir/Ritonavir)
Reyskens, K. M. S. E., Fisher, T.-L., Schisler, J. C., O'Connor, W. G., Rogers, A. B., Willis, M. S., Planesse, C., Boyer, F., Rondeau, P., Bourdon, E., et al. (2013) · PLoS ONE · doi:10.1371/annotation/a1e2a42f-7f10-4654-a042-57d19de50208 · Cited by 6
The role of acetylation in obesity-induced cardiac metabolic alterations
Ketema, E. B., & Lopaschuk, G. D. (2024) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.3389/jpps.2024.13080 · Cited by 7
Resistance training improves the lipid profile, combat oxidative stress and inhibit MMP-2 activity in the left ventricle diet-induced obese rats
Lino, A. D. D. S., de Aquino, A. E., Leite, R. D., Speretta, G. F. F., de Moraes, F. D., Fabrizzi, F., Moraes, G., Selistre-de-Araújo, H. S., & Duarte, A. C. G. D. O. (2020) · Motriz Revista de Educação Física · doi:10.1590/s1980-6574202000030199 · Cited by 3
Consuming oxidative frying oil impairs cardiac energy production and calcium recycling, causing cardiac hypertrophy, fibrosis and diastolic dysfunction in male Sprague Dawley rats
Lin, Y., Chen, D.-L., Shaw, H., Wang, G., & Chao, P. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108816 · Cited by 5
Obesity and cardiac function – the role of caloric excess and its reversal
Sack, M. N. (2013) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2013.05.004 · Cited by 6
Assessing the Efficiency of the Diabetic Heart at Subcellular, Tissue and Organ Level
Han, D. S. L. J. (2014) · Journal of General Practice · doi:10.4172/2329-9126.1000168 · Cited by 4
“Those that are known result from proton conductance directly through the inner membrane, through Uncoupling Proteins (UCPs) [46,47], and the adenine nucleotide transporter (ANT, Figure 1).”
BackgroundInfluential
Alterations in Cardiac Metabolism in Heart Failure
Bugger, H., Wende, A. R., & Abel, E. D. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-60987-6.00017-x · Cited by 5
Self-citation
Distinct profiles of mitochondrial bioenergetics and redox balance in left atrial and ventricular myocardium in the healthy rat heart
Fang, T., Chan, A., Chew‐Harris, J., & Pham, T. (2025) · Experimental Physiology · doi:10.1113/ep093102 · Cited by 4
“…2014) or an unchanged P/O ratio in db / db and ob / ob mice (Boudina et al., 2005, 2007) or Type 2 diabetic rats (Pham et al., 2025) when supported with glucose-derived substrates, but the P/O ratio appeared lower when supplied with glucose plus fatty acid substrates (Boudina et al., 2005, 2007).”

Authors: Boudina, S., Sena, S., O’Neill, B. T., Tathireddy, P., Young, M. E., & Abel, E. D.
Affiliations: Baylor College of Medicine (US)
From the Division of Endocrinology, Metabolism and Diabetes and Program in Human Molecular Biology and Genetics (S.B., S.S., B.T.O., P.T., E.D.A.), University of Utah School of Medicine, Salt Lake City, Utah, and USDA/ARS Children’s Nutrition Research Center and Department of Pediatrics (M.E.Y.), Baylor College of Medicine, Houston, Tex.
ORCID: Boudina, Sihem
Young, Martin E.
Abel, E. Dale
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2005-10-25
Volume: 112
Issue: 17
Pages: 2686-2695
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/circulationaha.105.554360
OpenAlex: W2160331251
Cited by: 502
References: 31
Citations by year: 2026: 7 · 2025: 12 · 2024: 20 · 2023: 17 · 2022: 22 · 2021: 23 · 2020: 23 · 2019: 16 · 2018: 20 · 2017: 29 · 2016: 25 · 2015: 42 · 2014: 48 · 2013: 39 · 2012: 33
FWCI: 6.15
Type: journal article
Language: en
Update notices: correction (2021-12-06)
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Funders: American Diabetes Association
American Heart Association
National Institutes of Health
National Heart, Lung, and Blood Institute (R01HL073167, R01-HL-73167, UO1HL70525, U01HL070525)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK092065)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
Keywords: obesity, mitochondrial uncoupling, mitochondrial oxidative capacity, myocardial oxygen consumption, cardiac efficiency, cardiac energetics, ob/ob mice, palmitate, fatty acid metabolism, pyruvate dehydrogenase, mitochondrial respiration, ATP production, insulin resistance, type 2 diabetes, cardiac contractile function
MeSH terms: Adenosine Triphosphate, Animals, Energy Metabolism, Mice, Inbred C57BL, Mice, Obese, Mitochondria, Heart, Myocardium, Obesity, Oxidative Phosphorylation, Oxygen Consumption, Mice

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Reduced Mitochondrial Oxidative Capacity and Increased Mitochondrial Uncoupling Impair Myocardial Energetics in Obesity

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