Cited by 502Mitochondrial Function and PathologyCardiovascular Function and Risk FactorsCardiac Ischemia and Reperfusion

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Reduced Mitochondrial Oxidative Capacity and Increased Mitochondrial Uncoupling Impair Myocardial Energetics in Obesity

Boudina, Sihem, Sena, Sandra, O’Neill, Brian T., Tathireddy, Prakash, Young, Martin E., Abel, E. Dale·2005·Circulation

DOI 10.1161/circulationaha.105.554360

Open this paper in CoChat — free account

Abstract

Background— Obesity is a risk factor for cardiovascular disease and is strongly associated with insulin resistance and type 2 diabetes. Recent studies in obese humans and animals demonstrated increased myocardial oxygen consumption (MV̇ o 2 ) and reduced cardiac efficiency (CE); however, the underlying mechanisms remain unclear. The present study was performed to determine whether mitochondrial dysfunction and uncoupling are responsible for reduced cardiac performance and efficiency in ob/ob mice. Methods and Results— Cardiac function, MV̇ o 2 , mitochondrial respiration, and ATP synthesis were measured in 9-week-old ob/ob and control mouse hearts. Contractile function and MV̇ o 2 in glucose-perfused ob/ob hearts were similar to controls under basal conditions but were reduced under high workload. Perfusion of ob/ob hearts with glucose and palmitate increased MV̇ o 2 and reduced CE by 23% under basal conditions, and CE remained impaired at high workload. In glucose-perfused ob/ob hearts, mitochondrial state 3 respirations were reduced but ATP/O ratios were unchanged. In contrast, state 3 respiration rates were similar in ob/ob and control mitochondria from hearts perfused with palmitate and glucose, but ATP synthesis rates and ATP/O ratios were significantly reduced in ob/ob , which suggests increased mitochondrial uncoupling. Pyruvate dehydrogenase activity and protein levels of complexes I, III, and V were reduced in obese mice. Conclusions— These data indicate that reduced mitochondrial oxidative capacity may contribute to cardiac dysfunction in ob/ob mice. Moreover, fatty acid but not glucose-induced mitochondrial uncoupling reduces CE in obese mice by limiting ATP production and increasing MV̇ o 2 .

Integrity signals

Registry

Crossref · 10.1161/circulationaha.105.554360

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
Randle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093
The Continuing Epidemics of Obesity and Diabetes in the United States
Mokdad, A. H. (2001) · JAMA · doi:10.1001/jama.286.10.1195 · Cited by 2,730
Superoxide activates mitochondrial uncoupling proteins
Echtay, K. S., Roussel, D., St-Pierre, J., Jekabsons, M. B., Cadenas, S., Stuart, J. A., Harper, J. A., Roebuck, S. J., Morrison, A., Pickering, S., et al. (2002) · Nature · doi:10.1038/415096a · Cited by 1,382
Lipotoxic diseases
Unger, R. H. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.104057 · Cited by 875
Energy metabolism in uncoupling protein 3 gene knockout mice
Vidal-Puig, A. J., Grujic, D., Zhang, C.-Y., Hagen, T., Boss, O., Ido, Y., Szczepanik, A., Wade, J., Mootha, V., Cortright, R., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910179199 · Cited by 677
Effect of Obesity and Insulin Resistance on Myocardial Substrate Metabolism and Efficiency in Young Women
Peterson, L. R., Herrero, P., Schechtman, K. B., Racette, S. B., Waggoner, A. D., Kisrieva-Ware, Z., Dence, C., Klein, S., Marsala, J., Meyer, T., et al. (2004) · Circulation · doi:10.1161/01.cir.0000127959.28627.f8 · Cited by 656
Abnormal Cardiac and Skeletal Muscle Energy Metabolism in Patients With Type 2 Diabetes
Scheuermann-Freestone, M., Madsen, P. L., Manners, D., Blamire, A. M., Buckingham, R. E., Styles, P., Radda, G. K., Neubauer, S., & Clarke, K. (2003) · Circulation · doi:10.1161/01.cir.0000072789.89096.10 · Cited by 525
Uncoupling Protein 2, in Vivo Distribution, Induction upon Oxidative Stress, and Evidence for Translational Regulation
Pecqueur, C., Alves‐Guerra, M., Gelly, C., Lévi-Meyrueis, C., Couplan, E., Collins, S., Ricquier, D., Bouillaud, F., & Miroux, B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006938200 · Cited by 483
Alterations in left ventricular structure and function in young healthy obese women
Peterson, L. R., Waggoner, A. D., Schechtman, K. B., Meyer, T., Gropler, R. J., Barzilai, B., & Dávila-Román, V. G. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.10.062 · Cited by 449
Myocardial triglycerides and systolic function in humans: In vivo evaluation by localized proton spectroscopy and cardiac imaging
Szczepaniak, L. S., Dobbins, R. L., Metzger, G. J., Sartoni‐D'Ambrosia, G., Arbique, D., Vongpatanasin, W., Unger, R. H., & Victor, R. G. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10372 · Cited by 441

Flagged first, then by citations

Show all 31 references

Sorted by citations

Items 401–500 of 501

Mitochondrial remodelling—a vicious cycle in diabetic complications
Sherkhane, B., Gundu, C., Sood, A., Khatri, D. K., & Singh, S. B. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06408-8 · Cited by 5
Receptor-interacting protein 140 overexpression impairs cardiac mitochondrial function and accelerates the transition to heart failure in chronically infarcted rats
Chen, Y., Chen, S., Yue, Z., Zhang, Y., Zhou, C., Cao, W., Chen, X., Zhang, L., & Liu, P. (2016) · Translational research · doi:10.1016/j.trsl.2016.08.005 · Cited by 4
Prognosis of a malignant phenotype of obesity defined by a cardiac biomarker in hypertension: the Japan Morning Surge-Home Blood Pressure study
Watanabe, H., Hoshide, S., Kanegae, H., & Kario, K. (2023) · Hypertension Research · doi:10.1038/s41440-023-01468-8 · Cited by 4
“Although the mechanisms that underlie the association between obesity and elevated hs-cTnT are not yet known, it is likely that elevated oxidase stress and/or in ﬂ ammatory cytokines released by adipose tissue play a main role in this association [10 – 12].”
Look to the stars—Is there anything that public health and rehabilitation can learn from elite sports?
Millet, G. P., & Chamari, K. (2023) · Frontiers in Sports and Active Living · doi:10.3389/fspor.2022.1072154 · Cited by 5
HIV therapy, hepatitis C virus infection, antibiotics and obesity, a mitochondria killer mix?
Côté, H. C. F., Brumme, Z. L., Chan, J. W. H., Guillemi, S. A., Montaner, J. S. G., & Harrigan, P. R. (2006) · AIDS · doi:10.1097/01.aids.0000232250.89404.00 · Cited by 4
Metabolomics and proteomics as tools to advance the understanding of exercise responses: The emerging role of gut microbiota in athlete health and performance
Antoni, C., Boqué, N., Nuria, C., Herrero, P., Jordi, M.-P., Arola, L., & Puiggròs, F. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816193-7.00019-1 · Cited by 4
WIPI1-mediated mitophagy dysfunction in ventricular remodeling associated with long-term diabetes mellitus
Liu, D., Zhou, L., Xu, B., Tse, G., Shao, Q., & Liu, T. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111663 · Cited by 3
Comparison of the Effect of Intensive versus Conventional Insulinotherapy in Patients with Cardiac Surgery after Cardiopulmonary Bypass
Liou, H., Shih, C.-C., Chung, K.-C., & Chen, H. I. (2013) · The Chinese Journal of Physiology · doi:10.4077/cjp.2013.baa078 · Cited by 3
Compensatory actions of orexinergic neurons in the lateral hypothalamus during metabolic or cortical challenges may enable the coupling of metabolic dysfunction and cortical dysfunction
Kim, S. W., Cho, K., & Lee, B. I. (2013) · Medical Hypotheses · doi:10.1016/j.mehy.2013.02.009 · Cited by 3
“In addition, enzymes important for glycolysis, the citric acid cycle, the electron transport chain, and b-oxidation showed lower activity in humans and animals with obesity, diabetes, and insulin resistance [32–34].”
Background
Imaging Myocardial Metabolism
Gropler, R. J., & Malloy, C. R. (2017) · Springer eBooks · doi:10.1007/978-3-319-61401-4_11 · Cited by 2
A modern view on the prevention and treatment of arterial hypertension in obesity
Молчанова, О. В. (2021) · Russian Journal of Preventive Medicine · doi:10.17116/profmed20212406197 · Cited by 3
PI3K signalling at the intersection of cardio-oncology networks: cardiac safety in the era of AI
Ezeani, M., & Prabhu, S. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04627-1 · Cited by 3
“The Warburg adaptation mechanisms and metabolic rewiring occurring in risk factors-induced heart failure [32, 33] combined, glucose metabolism and PI3K growth factor Fig.”
Background
The Unrestrained Overeating Behavior and Clinical Perspective
Engin, A. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-63657-8_6 · Cited by 3
Cardioprotection and neurobehavioral impact of swimming training in ovariectomized rats
Ibañez, A. M., Coto, J. G., Martínez, V. R., Yeves, A. D. M., Dolcetti, F. J. C., Cervellini, S., Echavarría, L., Rueda, J. O. V., Lofeudo, J. M., Portiansky, E. L., et al. (2024) · GeroScience · doi:10.1007/s11357-024-01422-7 · Cited by 3
“Skeletal muscles were homogenized on ice in a 20% (weight tissue/volume) homogenization buffer containing (in mmol/L) HEPES 20, EDTA 10, and pH 7.4 [65].”
Influential
Conjugated Linoleic Acid and Weight Control
Kong, Z. (2007) · CRC Press eBooks · doi:10.1201/9781420005479.ch29 · Cited by 3
Intramuscular triglyceride content precedes impaired glucose metabolism without evidence for mitochondrial dysfunction during early development of a diabetic phenotype
Callahan, Z. J., Oxendine, M., & Schaeffer, P. J. (2017) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0685 · Cited by 3
“In addition to reduced insulin sensitivity, impairment of mitochondrial function in skeletal muscle is reported in diabetic patients (Kelley et al. 2002, Mootha et al. 2003, Patti et al. 2003) and animal models of type 2 diabetes (Boudina et al. 2005, Warren et al. 2014).”
Background
Dietary Fatty Acids, Redox Signaling, and the Heart
Beam, J., Botta, A. M., Barendregt, R., & Ghosh, S. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_44 · Cited by 3
“Mitochondrial damage has been widely reported in the hearts of obese animals (Boudina et al. 2005; Dong et al. 2006; Bugger and Abel 2008) and in human patients (Ritov et al.”
Background
Mitochondrial-derived Peptide Single-nucleotide Polymorphisms Associated with Cardiovascular Complications in Type 2 DiabetesPreprint
Gaona, E. G., García-Gregorio, A., Jiménez, C. G., López-Olaiz, M. A., Mendoza-Ramírez, P., Fernandez‐Guzman, D., Zúñiga, L. Y., Parada, M. G. S., Santiago, A. E. G., Román-Pintos, L. M., et al. (2022) · Preprints.org · doi:10.20944/preprints202210.0025.v1 · Cited by 1
Mst1 inhibition attenuates obesity cardiomyopathy via reversing FUNDC1-related mitophagy
Ding, Y., Zhu, L., Zhang, M., Li, X., Hailan, L., & Zhang, C. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.112058 · Cited by 2
Therapeutic Potential of Metformin in Diabetes Mellitus-Related Cardiovascular Complications
Tan, H., & Tao, J. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.108606 · Cited by 2
PPAR/PGC-1 Regulation of Metabolism in Cardiac Disease
Duncan, J. G., & Finck, B. N. (2012) · Humana Press eBooks · doi:10.1007/978-1-61779-891-7_4 · Cited by 2
Insulin Resistance and Cardiomyopathy
Huang, J., & Hung, L. (2012) · InTech eBooks · doi:10.5772/28235 · Cited by 2
Obesity and Diabetes
Guzzardi, M. A., & Iozzo, P. (2013) · Springer eBooks · doi:10.1007/978-3-319-01050-2_2 · Cited by 2
Early Ventricular Dysfunction in Type II Diabetes: Role of Metabolic Unbalance
Dessalvi, C. C. (2013) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.s13-004 · Cited by 2
“Several studies suggest an alteration in myocardial energetic metabolism caused by IR that could lead to impairment of myocardial ATP production [28-30].”
Facts and Artifacts in the Evaluation of the Anti-diabetic Activity of Spent Hop Extract in Rat Hearts in the“Experimental Model of Diabetes”
Łabieniec-Watała, M., Przygodzki, T., Siewiera, K., Podsędek, A., & Watała, C. W. (2015) · International Journal of Pharmaceutical Sciences Research · doi:10.15344/2394-1502/2015/106 · Cited by 2
“Additionally, it was noted that for the increased oxygen consumption and increased fatty acid (FA) utilization observed in the hearts of diabetic animals with obesity two major phanomena may be responsible: the uncoupling of mitochondrial oxidative phosphorylation (OXPHOS) and oxygen wastage [11].”
Background
Relationship Between Substrate Metabolism and Cardiac Efficiency
Aasum, E. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1227-8_7 · Cited by 2
Experimental Models of Oxidative Stress Related to Cardiovascular Diseases and Diabetes
Mesa, M. D., Aguilera, C. M., & Gil, Á. (2011) · Humana Press eBooks · doi:10.1007/978-1-60761-956-7_2 · Cited by 2
“[116] have indicated that reduced mitochondrial oxidative capacity may contribute to cardiac dysfunction in ob/ob mice.”
Background
Molecular Changes in Fatty Acid Oxidation in the Failing Heart
Jaswal, J. S., Keung, W., Wang, W., Ussher, J. R., & Lopaschuk, G. D. (2011) · Springer eBooks · doi:10.1007/978-1-4419-7130-2_12 · Cited by 2
Comparison of intrinsic exercise capacity and response to acute exercise in ICR (Institute of Cancer Research) mice derived from three different lineages
Hwang, D.-J., Kwon, K.-C., Choi, D.-H., Song, H., Kim, K., Jung, Y., Hwang, D., & Cho, J. (2021) · Laboratory Animal Research · doi:10.1186/s42826-021-00094-0 · Cited by 1
“Additionally, the difference in UCP3-mediated cardiac efficiency [30], as an element affecting the RMR by regulating the coupling efficiency, did not affect the factors associated with the RMR, such as O2 uptake, CO2 production, and respiratory exchange ratio (RER: a value obtained from the VCO2/VO2 ratio), during the…”
Background
HIV-pharmacotherapy and pathogenesis of diabetes-induced cardiovascular complications: an updated narrative review
Maswanganyi, K., Khathi, A., & Gamede, M. W. (2026) · Cardiovascular Research · doi:10.1093/cvr/cvag036 · Cited by 1
Integrative Proteomic and Bioenergetic Profiling Reveals Diet- and Strain-Specific Mitochondrial Dysfunction in Cohen Diabetic Rat Hearts
Pavelich, L., Arroum, T., Pham, L., Komnenov, D., Stemmer, P. M., Lax, R., Saada, A., Weksler‐Zangen, S., & Hüttemann, M. (2026) · Antioxidants · doi:10.3390/antiox15020248 · Cited by 1
Mitochondrial Dysfunction in Diabetic Cardiomyopathy
Ahn, J., & Kim, J. (2008) · Korean Diabetes Journal · doi:10.4093/kdj.2008.32.6.467 · Cited by 1
Mitochondria in Cardiac Disease
Gottlieb, R. A., Quarato, G., & Abel, E. D. (2012) · Humana Press eBooks · doi:10.1007/978-1-61779-891-7_3 · Cited by 1
Self-citation
Effects of Metformin Treatment on Myocardial and Endothelial Function in Insulin Resistance Patients: A Metabolomic Study
Deidda, M. (2013) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.1000279 · Cited by 1
“Moreover, alteration of the myocardial energetic metabolism caused by IR can lead to ATP production impairment and have a major role in the early longitudinal dysfunction [35-38].”
Background
Diabetic Cardiomyopathy: Distinct and Preventable Entity or Inevitable Consequence?
Schilling, J. D., & Mann, D. L. (2014) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-014-0417-2 · Cited by 1
Cardiac Metabolism and Energetic Control
Rohrbach, S., & Niemann, B. (2016) · Springer eBooks · doi:10.1007/978-3-319-31251-4_4 · Cited by 1
Diabetes-Associated Cardiomyopathy and Cell Therapy
Hochhauser, E., Morozov, M., & Arad, M. (2013) · CRC Press eBooks · doi:10.1201/b14663-16 · Cited by 1
The Metabolic Syndrome and Cardiac Function
Bugger, H., & Abel, E. D. (2008) · Advances in Pulmonary Hypertension · doi:10.21693/1933-088x-7.3.332 · Cited by 1
Self-citation
CALPASTATIN OVER-EXPRESSION REDUCES CARDIAC FIBROSIS IN A MURINE MODEL OF TYPE 2 DIABETES
Singh, M. K. (2011) · Scholarship@Western (Western University) · Cited by 1
Efectos de la obesidad en el consumo máximo de oxígeno medido indirectamente
Benavides-Castellón, R. (2023) · EID Ergonomía Investigación y Desarrollo · doi:10.29393/eid5-11eorb10011 · Cited by 1
Prolonged mean response time in older adults with cardiovascular risk compared to healthy older adults
Kominami, K., & Akino, M. (2022) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/s13102-022-00565-4 · Cited by 1
“In addition, physical inactivity [42, 43], age-related changes [44], and comorbidities [45, 46] are believed to decrease mitochondrial function and ATP synthesis capacity.”
Background
Letter to the editor: “Does a reduction in ADP-limited respiration indicate impaired mitochondrial function?”
Schwarzer, M., & Doenst, T. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00434.2009 · Cited by 1
A critical analysis of mitochondrial functioning and associated proteins in obesity-related cardiomyopathy
George, S. (2013) · SUNScholar (Stellenbosch University) · Cited by 1
Metabolic Health with Obesity: A Novel Role for Cholesteryl Ester Transfer Protein
Cappel, D. A. (2014) · Cited by 1
Amyloid beta 42 alters cardiac metabolism and impairs cardiac function in obesityPreprint
Hall, L. G., Czeczor, J. K., Connor, T., Botella, J., Jong, K. A. D., Renton, M. C., Genders, A. J., Venardos, K. M., Martin, S. D., Bond, S. T., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.02.510555 · Cited by 1
A Critical Role of Nrf2 In Protecting Cardiomyocytes Against Oxidative Stress and Ischemic Injury
Strom, J. G. (2014) · UA Campus Repository (The University of Arizona) · Cited by 1
Cardiomyopathy and muscle insulin resistance in type 2 diabetes : craving for sugars, or dying for fat?
van de Weijer, T. (2013) · Research Publications (Maastricht University) · doi:10.26481/dis.20130705tw
The Diabetic Heart: Examination of the Inner Mitochondrial Membrane
Croston, T. L. (2013) · doi:10.33915/etd.4958
The Endothelium, Cardiovascular Disease, and Therapy
Levine, T. B., & Levine, A. B. (2012) · Wiley eBooks · doi:10.1002/9781118480045.ch14
Efeitos do treinamento físico aeróbio sobre o sistema renina angiotensina cardíaco e sistêmico de ratos obesos
Barretti, D. L. M. (2010) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.5.2010.tde-04112010-093205
The effect of hexarelin in streptozotocin (STZ)-induced rat model through protective actions on islet beta cells and cardiomyocytes
Zhang, X. (2015) · The University of Queensland · doi:10.14264/uql.2015.823
“Recent studies reveal that a decreased mitochondrial respiration is closely linked to down-regulation of oxidative phosphorylated protein in diabetic mice, suggesting impaired cardiac contractility caused by reduced ATP production [158].”
Background
Fat in hearts: Uptake, storage, and turnover
Trent, C. M. (2014) · doi:10.7916/d8c53j0x
The role of melatonin in cardioprotection : an investigation into the mechanisms involved in glucose homeostasis, microvascular endothelial function and mitochondrial function in normal and insulin resistant states
Nduhirabandi, F. (2014) · SUNScholar (Stellenbosch University)
Abstract 18691: Stimulation of Glucagon-Like-Peptide-1 Receptor Through Exendin-4 Preserves Myocardial Performance and Prevents Cardiac Remodeling in Infarcted Myocardium
DeNicola, M., & Zhao, T. C. (2013) · Circulation · doi:10.1161/circ.128.suppl_22.a18691
Obesità e ipertensione arteriosa
Verdecchia, P., & Trimarco, B. (2008) · Giornale italiano di cardiologia · doi:10.1714/669.7813
Characterizing the Relationship Between Energy Metabolism and Mesenchymal Stem Cell Therapy in the Infarcted Heart
Hughey, C. C. (2013) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/25306
The impact of obesity and chronic PPAR Alpha agonist treatment on cardiac function, metabolism and ischaemic tolerance
Smith, W. T. (2012) · SUNScholar (Stellenbosch University)
Diabetes and Cardiac Mitochondria
Marı́n-Garcı́a, J. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4599-9_20
Studies on the regulation of hepatic and intestinal lipid metabolism.
Kannisto, K. (2013) · Figshare
Cardioprotection with helium and anesthetics in healthy and diseased myocardium
Huhn, R. (2009) · UvA-DARE (University of Amsterdam)
Nutritional and Environmental Influences on Cardiac Metabolism and Performance
van Bilsen, M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-802394-5.00010-8
Development of xanthohumol derivatives as mild mitochondrial uncouplers for treatment of metabolic syndrome
Stevens, J. F. (2014)
The Physiological and Pathological Role of Mitochondrial Calcium in the Diabetic Heart
Sloan, R. C. (2011)
Obesity and Cardiac Dysfunction
Sweeney, G., Litwin, S. E., & Abel, E. D. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1607-5_14
Self-citation
Targeting the mitochondrial inner membrane to improve bioenergetics in the diseased heart
Moukdar, F. (2014) · The Scholarship East Carolina University's Institutional Repository (East Carolina University)
INFLUÊNCIA DA OXIDAÇÃO DE GLICOSE SOBRE A FUNÇÃO MIOCÁRDICA DE RATOS OBESOS
Filho, J. D. M. (2010)
Cardiac and skeletal muscle adaptations in health and disease
Andersson, D. C. (2009)
The integrated function of cardiac, skeletal, and vascular smooth muscle: limitations to oxygen transport and utilization in healthy aging and disease
Park, S. (2016) · J. Willard Marriott Library · doi:10.26053/0h-5xje-g4g0
Therapeutic Effects of Selective Androgen Receptor Modulation in the Treatment of Cardiac, Metabolic and Bone Pathologies Associated with Androgen Decline and Obesity
Donner, D. G. (2015) · Griffith Research Online · doi:10.13140/rg.2.1.1191.1761
Regulation and Functions of Cardiac Lipins
Kok, B. P. (2012) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r30b09
Cardiotoxicidad del estado de tolerancia a la glucosa alterada
Sommese, L. M. (2018) · doi:10.35537/10915/66305
Evaluation of Cardiac Mitochondrial Function in the Fructose-Fed Rat
Scott, K. Y. (2016) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3r20s218
Role of Mitochondria in Cardiovascular Comorbidities Associated with Obesity and Type 2 Diabetes
Boudina, S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-811752-1.00011-0
Self-citation
Cardiac Energy Metabolism in Heart Failure Associated with Obesity and Diabetes
Lopaschuk, G. D. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1227-8_5
Functional, structural and molecular investigations into experimental type-1 and type-2 diabetes-induced cardiomyopathy
D’Souza, A. (2011) · CLOK (University of Central Lancashire)
Faculty Opinions recommendation of Mitochondrial DNA variant for complex I reveals a role in diabetic cardiac remodeling.
Beard, D. A. (2012) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.715347802.790852877
Sympathetic Nervous System and Cardiovascular Alterations Due to Food Restrictions
Shah, A. K., & Dhalla, N. S. (2021) · Advances in biochemistry in health and disease · doi:10.1007/978-3-030-84763-0_15
Kir6.1 improves cardiac dysfunction in diabetic cardiomyopathy via the AKT-Foxo1 signaling pathwayPreprint
Wang, J., Bai, J., Duan, P., Wang, H., Li, Y., & Zhu, Q. (2020) · doi:10.21203/rs.3.rs-33214/v1
“DCM and its associated mitochondrial dysfunction have been observed in ob/ob, db/db and HFDfed mice [24, 25].”
Background
Visualizing the Role of ER Stress in Diabetic Cardiomyopathy: A Bibliometric AnalysisPreprint
Ji, Y., Jin, Z., xu, Z., Zhou, L., Wen, X., Gao, L., Su, W., Xia, Z., Xia, Z., & Lei, S. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4641193
Obesity
Badimón, L., Anker, S. D., & von Haehling, S. (2023) · doi:10.1093/med/9780198891628.003.0016
Rida Herbal Bitters Improve Cardiovascular Function in High-fat Diet/Streptozotocin-induced Diabetic Rats
Ajao, F. O., Balogun, D. A., Iyedupe, M. O., Ayobami, O., Esther, O., Adeniji, L., Victor, A., & Olaleye, F. E. (2024) · Journal of Cardiology and Cardiovascular Medicine · doi:10.29328/journal.jccm.1001177
Transcriptome Analysis of One Bamboo Pest, Hippotiscus Dorsalis, Reveals Differentially Expressed Unigenes Related to Different Segment of Each SexPreprint
Zhao, M., Chen, M., Qiu, H., Wu, J., Dai, L., & Zhang, S. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4866134
Molecular Pathways in Diabetic Cardiomyopathy and the Role of Anti-hyperglycemic Drugs Beyond Their Glucose Lowering Effect
Lee, J.-E., Kim, B. G., & Won, J. C. (2025) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2025.14.1.46
Persistent Oxidation of Mitochondrial and Transmembrane Proteins in Rat Cerebrum and Heart Regardless of Age or Nutrition
Yang, W., Fan, S., Guevara, C. R., Kratochwil, M., Thilmany, S. C., Sugawa, M. D., Dencher, N. A., & Poetsch, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262211155
“The efficacy of this protective strategy is underscored by its stark contrast to the mitochondrial dysfunction and amplified oxidative damage observed in settings of metabolic overload, such as obesity [66,67].”
Cardiometabolic adaptations to altered fuel supply, Ca2+ handling and exercise
Boardman, N. T. (2011) · NORA - Norwegian Open Research Archives
The Role of Mitochondrial Uncoupling in the Development of Diabetic Nephropathy
Persson, M. F. (2012)
Additional file 2 of Dual roles of myocardial mitochondrial AKT on diabetic cardiomyopathy and whole body metabolism
Chen, Y.-H., Ta, A. P., Chen, Y., LEE, H., Fan, W., Chen, P.-L., Jordan, M. C., Roos, K. P., MacGregor, G. R., Yang, Q., et al. (2024) · Figshare · doi:10.6084/m9.figshare.24452634
Additional file 1 of Dual roles of myocardial mitochondrial AKT on diabetic cardiomyopathy and whole body metabolism
Chen, Y.-H., Ta, A. P., Chen, Y., LEE, H., Fan, W., Chen, P.-L., Jordan, M. C., Roos, K. P., MacGregor, G. R., Yang, Q., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24452412
Effet cardioprotecteur des ligands de la protéine translocatrice mitochondriale (TSPO) au cours de l'ischémie-reperfusion myocardique expérimentale : rôle du cholestérol.
Paradis, S. (2012) · theses.fr (ABES) · doi:10.70675/caf126f8zf83ez45f7z9564z293f56d2f8c9
Coeur, mitochondries, lésions d'ischémie-reperfusion : impact du diabète et du post-conditionnement par les ligands opiacés
Richer, R. (2018) · theses.fr (ABES) · doi:10.70675/4872f281z6a43z4c94z9905z0d548007c0ac
Rôles et mécanismes d’action de la protéine Epac1 mitochondriale dans les pathologies cardiaques
Laudette, M. (2019) · theses.fr (ABES) · doi:10.70675/5a24dee4ze02cz4524za612zea3224b1ea32
Du prédiabète au diabète de type 2 : quels impacts sur la santé cardiovasculaire dans le sexe féminin ? : approche thérapeutique par le Resvératrol contre les lésions myocardiques liées à l’ischémie-reperfusion dans le diabète de type 2
Fourny, N. (2019) · theses.fr (ABES) · doi:10.70675/846aa6e5z8362z45a5z8e8dz2452913634b4
Rôle de la signalisation calcique dans les troubles métaboliques associés à la dysfonction myocardique
Lacôte, M. (2018) · theses.fr (ABES) · doi:10.70675/bc9b8426z5718z40e1zadc2zaa52fb20a6fd
Homéostasie calcique mitochondriale dans le contrôle des troubles du rythme associés à la cardiomyopathie métabolique
Fossier, L. (2021) · theses.fr (ABES) · doi:10.70675/36de6f26zc009z49d6zaa35za5cfbe95b345
Rôle du stress oxydant dans le remodelage cardiaque induit par l'obésité
Masri, Y. E. (2024) · theses.fr (ABES) · doi:10.70675/8079719dzd619z4251z9b8fz80e07d39e6c9
Chronic Low-Dose Gold Nanoparticle Exposure Induces Persistent Alterations in Mitochondrial Respiration in a Physicochemical-Property Dependent Manner
Nunes, Á. M., & Falagan-Lotsch, P. (2026) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6c00848
Peripartum-Associated Heart Failure Develops Independently of RHOT Proteins
Froese, N., Sina, E., Galuppo, P., Werlein, C., Gigina, A., Hegermann, J., Geffers, R., Scholz, T., Kamp, J. C., Neubert, L., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27114991
Regular exercise improves cardiac dysfunction in Drosophila by inhibiting excessive mitochondrial fission through RalA
Huang, W., Ding, M., Yi, Q., Li, Y. M., Gu, W., Zhang, P., Tian, R., Zhang, Z., & Zheng, L. (2026) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2026.168338
The Impact of Cardiorespiratory Fitness on Cytotoxic T Cell Metabolism and Function
Crane, J. C., Hodgman, C. F., Maddux, R. M., Caslin, H. L., Laughlin, M., Gorniak, S. L., & LaVoy, E. C. P. (2026) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000004063
Lysine Acetylation as a Regulatory Mechanism in Cardiometabolic Disease: A Focus on Sirtuins
Trivedi, K., & Dolinsky, V. W. (2026) · Pharmaceuticals · doi:10.3390/ph19101557
“In the heart, mitochondrial dysfunction contributes to diabetic cardiomyopathy, where increased fatty acid utilization and reduced glucose oxidation contribute to metabolic inflexibility and reduced cardiac efficiency [24,25].”

Authors: Boudina, S., Sena, S., O’Neill, B. T., Tathireddy, P., Young, M. E., & Abel, E. D.
Affiliations: Baylor College of Medicine (US)
From the Division of Endocrinology, Metabolism and Diabetes and Program in Human Molecular Biology and Genetics (S.B., S.S., B.T.O., P.T., E.D.A.), University of Utah School of Medicine, Salt Lake City, Utah, and USDA/ARS Children’s Nutrition Research Center and Department of Pediatrics (M.E.Y.), Baylor College of Medicine, Houston, Tex.
ORCID: Boudina, Sihem
Young, Martin E.
Abel, E. Dale
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2005-10-25
Volume: 112
Issue: 17
Pages: 2686-2695
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/circulationaha.105.554360
OpenAlex: W2160331251
Cited by: 502
References: 31
Citations by year: 2026: 7 · 2025: 12 · 2024: 20 · 2023: 17 · 2022: 22 · 2021: 23 · 2020: 23 · 2019: 16 · 2018: 20 · 2017: 29 · 2016: 25 · 2015: 42 · 2014: 48 · 2013: 39 · 2012: 33
FWCI: 6.15
Type: journal article
Language: en
Update notices: correction (2021-12-06)
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Funders: American Diabetes Association
American Heart Association
National Institutes of Health
National Heart, Lung, and Blood Institute (R01HL073167, R01-HL-73167, UO1HL70525, U01HL070525)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK092065)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
Keywords: obesity, mitochondrial uncoupling, mitochondrial oxidative capacity, myocardial oxygen consumption, cardiac efficiency, cardiac energetics, ob/ob mice, palmitate, fatty acid metabolism, pyruvate dehydrogenase, mitochondrial respiration, ATP production, insulin resistance, type 2 diabetes, cardiac contractile function
MeSH terms: Adenosine Triphosphate, Animals, Energy Metabolism, Mice, Inbred C57BL, Mice, Obese, Mitochondria, Heart, Myocardium, Obesity, Oxidative Phosphorylation, Oxygen Consumption, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Reduced Mitochondrial Oxidative Capacity and Increased Mitochondrial Uncoupling Impair Myocardial Energetics in Obesity

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks