Drug Therapy of High-Risk Lipid Abnormalities in Children and Adolescents: A Scientific Statement From the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee, Council of Cardiovascular Disease in the Young, With the Council on Cardiovascular Nursing

McCrindle, Brian W.; Urbina, Elaine M.; Dennison, Barbara A.; Jacobson, Marc S.; Steinberger, Julia; Rocchini, Albert P.; Hayman, Laura L.; Daniels, Stephen R.

doi:10.1161/circulationaha.107.181946

Cited by 418Lipoproteins and Cardiovascular HealthLipid metabolism and disordersCholesterol and Lipid Metabolism

Drug Therapy of High-Risk Lipid Abnormalities in Children and Adolescents: A Scientific Statement From the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee, Council of Cardiovascular Disease in the Young, With the Council on Cardiovascular Nursing

McCrindle, Brian W., Urbina, Elaine M., Dennison, Barbara A., Jacobson, Marc S., Steinberger, Julia, Rocchini, Albert P., Hayman, Laura L., Daniels, Stephen R.·2007·Circulation

DOI 10.1161/circulationaha.107.181946

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Abstract

Despite compliance with lifestyle recommendations, some children and adolescents with high-risk hyperlipidemia will require lipid-lowering drug therapy, particularly those with familial hypercholesterolemia. The purpose of this statement is to examine new evidence on the association of lipid abnormalities with early atherosclerosis, discuss challenges with previous guidelines, and highlight results of clinical trials with statin therapy in children and adolescents with familial hypercholesterolemia or severe hypercholesterolemia. Recommendations are provided to guide decision-making with regard to patient selection, initiation, monitoring, and maintenance of drug therapy.

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Data suggest that care for type 1 diabetes has improved, as evidenced by reduced rates of microvascular disease in past decades, whereas data on cardiovascular disease suggest substantially less progress in reducing macrovascular disease rates.
“Furthermore, there are data to suggest that care for T1D has improved as evidenced by reduced rates of microvascular disease in the past decades109–111, whereas data on CVD suggest that substantially less progress has been made in reduction of macrovascular disease rates111–113.”
From Epidemiology of type 1 diabetes (2010) · cites this paper as [112]
The AHA categorizes type 1 children in the highest tier for cardiovascular risk and recommends both lifestyle and pharmacologic treatment for those with elevated LDL cholesterol levels.
“the AHA categorizes type 1 children in the highest tier for cardiovascular risk and recommends both lifestyle and pharmacologic treatment for those with elevated LDL cholesterol levels (285,286).”
From Standards of Medical Care in Diabetes—2009 (2009) · cites this paper as [286]

Implications of Recent Clinical Trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines
Grundy, S. M., Cleeman, J. I., Merz, C. N. B., Brewer, H. B., Clark, L. T., Hunninghake, D. B., Pasternak, R. C., Smith, S. C., & Stone, N. J. (2004) · Circulation · doi:10.1161/01.cir.0000133317.49796.0e · Cited by 6,902 · see citing works
Prevalence and Trends in Overweight Among US Children and Adolescents, 1999-2000
Ogden, C. L. (2002) · JAMA · doi:10.1001/jama.288.14.1728 · Cited by 4,060 · see citing works
Association between Multiple Cardiovascular Risk Factors and Atherosclerosis in Children and Young Adults
Berenson, G. S., Srinivasan, S. R., Bao, W., Newman, W. P., Tracy, R. E., & Wattigney, W. A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199806043382302 · Cited by 4,032 · see citing works
A Definition of Advanced Types of Atherosclerotic Lesions and a Histological Classification of Atherosclerosis
Stary, H. C., Chandler, A. B., Dinsmore, R. E., Fuster, V., Glagov, S. K., Insull, W., Rosenfeld, M. E., Schwartz, C. J., Wagner, W. D., & Wissler, R. W. (1995) · Circulation · doi:10.1161/01.cir.92.5.1355 · Cited by 3,506 · see citing works
The Relation of Overweight to Cardiovascular Risk Factors Among Children and Adolescents: The Bogalusa Heart Study
Freedman, D. S., Dietz, W. H., Srinivasan, S. R., & Berenson, G. S. (1999) · Pediatrics · doi:10.1542/peds.103.6.1175 · Cited by 2,456 · see citing works
Vitamin E Supplementation and Cardiovascular Events in High-Risk Patients
(2000) · New England Journal of Medicine · doi:10.1056/nejm200001203420302 · Cited by 1,957 · see citing works
Relation of Body Fat Distribution to Metabolic Complications of Obesity*
KISSEBAH, A. H., VYDELINGUM, N., MURRAY, R., EVANS, D. J., KALKHOFF, R. K., & ADAMS, P. W. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-2-254 · Cited by 1,909 · see citing works
Overweight in Children and Adolescents
Daniels, S. R., Arnett, D. K., Eckel, R. H., Gidding, S. S., Hayman, L. L., Kumanyika, S., Robinson, T. N., Scott, B. J., Jeor, S. S., & Williams, C. L. (2005) · Circulation · doi:10.1161/01.cir.0000161369.71722.10 · Cited by 1,555 · see citing works
Self-citation
Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution.
Krotkiewski, M., Björntorp, P. A., Sjöström, L., & Smith, U. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111040 · Cited by 1,448 · see citing works
Homocysteine Lowering and Cardiovascular Events after Acute Myocardial Infarction
Bønaa, K. H., Njølstad, I., Ueland, P. M., Schirmer, H., Tverdal, A., Steigen, T., Wang, H., Nordrehaug, J. E., Arnesen, E., & Rasmussen, K. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055227 · Cited by 1,442 · see citing works
Effects of Long-term Vitamin E Supplementation on Cardiovascular Events and Cancer: A Randomized Controlled Trial
(2005) · JAMA · doi:10.1001/jama.293.11.1338 · Cited by 1,209 · see citing works
Vitamin E in the Primary Prevention of Cardiovascular Disease and Cancer: The Women’s Health Study: A Randomized Controlled Trial
Lee, I.-M., Cook, N. R., Gaziano, J. M., Gordon, D., Ridker, P. M., Manson, J. E., Hennekens, C. H., & Buring, J. E. (2005) · JAMA · doi:10.1001/jama.294.1.56 · Cited by 1,137 · see citing works
Relation of Serum Lipoprotein Levels and Systolic Blood Pressure to Early Atherosclerosis
Newman, W. P., Freedman, D. S., Voors, A. W., Gard, P. D., Srinivasan, S. R., Cresanta, J. L., Williamson, G. D., Webber, L. S., & Berenson, G. S. (1986) · New England Journal of Medicine · doi:10.1056/nejm198601163140302 · Cited by 1,063 · see citing works
Report of the Expert Panel on Blood Cholesterol Levels in Children and Adolescents
(1991) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(21)07128-5 · Cited by 911 · see citing works
Passive Smoking and Impaired Endothelium-Dependent Arterial Dilatation in Healthy Young Adults
Celermajer, D. S., Adams, M. R., Clarkson, P., Robinson, J. T. C., McCredie, R. J., Donald, A. E., & Deanfield, J. E. (1996) · New England Journal of Medicine · doi:10.1056/nejm199601183340303 · Cited by 907 · see citing works
CORONARY DISEASE AMONG UNITED STATES SOLDIERS KILLED IN ACTION IN KOREA
Enos, W. F. (1953) · JAMA · doi:10.1001/jama.1953.03690120006002 · Cited by 890 · see citing works
Carotid Intimal-Medial Thickness Is Related to Cardiovascular Risk Factors Measured From Childhood Through Middle Age
Davis, P. H., Dawson, J. D., Riley, W. A., & Lauer, R. M. (2001) · Circulation · doi:10.1161/hc4601.099486 · Cited by 881 · see citing works
Presence of increased stiffness of the common carotid artery and endothelial dysfunction in severely obese children: a prospective study
Tounian, P., Aggoun, Y., Dubern, B., Varille, V., Guy-grand, B., Sidi, D., Girardet, J.-P., & Bonnet, D. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06525-4 · Cited by 813 · see citing works
A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association.
Stary, H. C., Chandler, A. B., Glagov, S. K., Guyton, J. R., Insull, W., Rosenfeld, M. E., Schaffer, S. A., Schwartz, C. J., Wagner, W. D., & Wissler, R. W. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.5.840 · Cited by 738 · see citing works
High Prevalence of Coronary Atherosclerosis in Asymptomatic Teenagers and Young Adults
Tuzcu, E. M., Kapadia, S. R., Tutar, E., Ziada, K. M., Hobbs, R. E., McCarthy, P. M., Young, J. B., & Nissen, S. E. (2001) · Circulation · doi:10.1161/01.cir.103.22.2705 · Cited by 673 · see citing works
Efficacy and Safety of Statin Therapy in Children With Familial Hypercholesterolemia
Wiegman, A., Hutten, B. A., de Groot, E., Rodenburg, J., Bakker, H. D., Büller, H. R., Sijbrands, E. J. G., & Kastelein, J. J. P. (2004) · JAMA · doi:10.1001/jama.292.3.331 · Cited by 646 · see citing works
Influence of maternal hypercholesterolaemia during pregnancy on progression of early atherosclerotic lesions in childhood: Fate of Early Lesions in Children (FELIC) study
Claudio Napoli, A., Glass, C. K., Witztum, J. L., Deutsch, R., D’Armiento, F. P., & Palinski, W. (1999) · The Lancet · doi:10.1016/s0140-6736(99)02131-5 · Cited by 645 · see citing works
The Effect of Weight Loss on the Sensitivity of Blood Pressure to Sodium in Obese Adolescents
Rocchini, A. P., Key, J., Bondie, D., Chico, R., Moorehead, C., Katch, V., & Martin, M. (1989) · New England Journal of Medicine · doi:10.1056/nejm198908313210905 · Cited by 621 · see citing works
Self-citation
Coronary Artery Disease in Combat Casualties in Vietnam
McNamara, J. (1971) · JAMA · doi:10.1001/jama.1971.03180330061012 · Cited by 607 · see citing works
Randomised trial of α-tocopherol and β-carotene supplements on incidence of major coronary events in men with previous myocardial infarction
Rapola, J., Virtamo, J. R. K., Ripatti, S., Huttunen, J. K., Albanes, D., Taylor, P. R., & Heinonen, O. P. (1997) · The Lancet · doi:10.1016/s0140-6736(97)01234-8 · Cited by 569 · see citing works
Determinants of atherosclerosis in the young
McGill, H. C., & McMahan, C. A. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00720-6 · Cited by 538 · see citing works
Role of Insulin in Endogenous Hypertriglyceridemia*
Reaven, G. M., Lerner, R. L., D, M. P. S. M., & Farquhar, J. W. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105666 · Cited by 512 · see citing works
Reappraisal of the role of insulin in hypertriglyceridemia
Olefsky, J. M., Farquhar, J. W., & Reaven, G. M. (1974) · The American Journal of Medicine · doi:10.1016/0002-9343(74)90006-0 · Cited by 483 · see citing works
Efficacy and Safety of Ezetimibe Coadministered With Atorvastatin or Simvastatin in Patients With Homozygous Familial Hypercholesterolemia
Gagné, C., Gaudet, D., & Bruckert, É. (2002) · Circulation · doi:10.1161/01.cir.0000018744.58460.62 · Cited by 480 · see citing works
Dietary Recommendations for Children and Adolescents: A Guide for Practitioners: Consensus Statement From the American Heart Association
Gidding, S. S., Dennison, B. A., Birch, L. L., Daniels, S. R., Gilman, M. W., Lichtenstein, A. H., Rattay, K. T., Steinberger, J., Stettler, N., & Van Horn, L. (2005) · Circulation · doi:10.1161/circulationaha.105.169251 · Cited by 465 · see citing works
Self-citation
Flavonoid-Rich Dark Chocolate Improves Endothelial Function and Increases Plasma Epicatechin Concentrations in Healthy Adults
Engler, M. B., Engler, M. M., Chen, C. Y., Malloy, M. J., Browne, A., Chiu, E. Y., Kwak, H., Milbury, P. E., Paul, S. M., Blumberg, J. B., et al. (2004) · Journal of the American College of Nutrition · doi:10.1080/07315724.2004.10719361 · Cited by 465 · see citing works
Relationship of Atherosclerosis in Young Men to Serum Lipoprotein Cholesterol Concentrations and Smoking
(1990) · JAMA · doi:10.1001/jama.1990.03450230054029 · Cited by 405 · see citing works
Relationship of body fat topography to insulin sensitivity and metabolic profiles in premenopausal women
Evans, D. J., Hoffman, R. G., Kalkhoff, R. K., & Kissebah, A. H. (1984) · Metabolism · doi:10.1016/0026-0495(84)90164-1 · Cited by 389 · see citing works
Early statin therapy restores endothelial function in children with familial hypercholesterolemia
de Jongh, S., Liliën, M. R., Roodt, J. O. ’., Stroes, E. S. G., Bakker, H. D., & Kastelein, J. J. P. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02593-7 · Cited by 366 · see citing works
Influence of Leptin on Arterial Distensibility
Singhal, A., Farooqi, I. S., Cole, T. J., O’Rahilly, S., Fewtrell, M. S., Kattenhorn, M., Lucas, A., & Deanfield, J. E. (2002) · Circulation · doi:10.1161/01.cir.0000033219.24717.52 · Cited by 363 · see citing works
Elevated Serum C-Reactive Protein Levels and Early Arterial Changes in Healthy Children
Järvisalo, M. J., Harmoinen, A. P. T., Hakanen, M., Paakkunainen, U., Viikari, J. S. A., Hartiala, J., Lehtimäki, T. J., Simell, O., & Raitakari, O. T. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000024222.06463.21 · Cited by 315 · see citing works
Risk Factors Related to Carotid Intima-Media Thickness and Plaque in Children With Familial Hypercholesterolemia and Control Subjects
Tonstad, S., Joakimsen, O., Stensland-Bugge, E., Leren, T. P., Ose, L., Russell, D., & Bønaa, K. H. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.8.984 · Cited by 314 · see citing works
The importance of physical activity in the prevention of overweight and obesity in childhood: a review and an opinion
Steinbeck, K. S. (2001) · Obesity Reviews · doi:10.1046/j.1467-789x.2001.00033.x · Cited by 312 · see citing works
Do Upper-Body and Centralized Adiposity Measure Different Aspects of Regional Body-Fat Distribution? Relationship to Non-Insulin-Dependent Diabetes Mellitus, Lipids, and Lipoproteins
Haffner, S. M., D, M. P. S. M., Hazuda, H. P., Pugh, J. A., & Patterson, J. K. (1987) · Diabetes · doi:10.2337/diab.36.1.43 · Cited by 312 · see citing works
Efficacy and Safety of Statin Therapy in Children With Familial Hypercholesterolemia
de Jongh, S., Ose, L., Szamosi, T., Gagné, C., Lambert, M. A., Scott, R. S., Perron, P., Dobbelaere, D., Saborio, M., Tuohy, M. B., et al. (2002) · Circulation · doi:10.1161/01.cir.0000035247.42888.82 · Cited by 308 · see citing works
Determinants of human adipose tissue lipoprotein lipase. Effect of diabetes and obesity on basal- and diet-induced activity.
Pykälistö, O., Smith, P. H., & Brunzell, J. D. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108185 · Cited by 284 · see citing works
Efficacy and Safety of Lowering Dietary Intake of Fat and Cholesterol in Children With Elevated Low-Density Lipoprotein Cholesterol
Kwiterovich, P. O. (1995) · JAMA · doi:10.1001/jama.1995.03520420045036 · Cited by 284 · see citing works
Adiposity in childhood predicts obesity and insulin resistance in young adulthood
Steinberger, J., Moran, A., Hong, C.-P., Jacobs, D. R., & Sinaiko, A. R. (2001) · The Journal of Pediatrics · doi:10.1067/mpd.2001.112658 · Cited by 276 · see citing works
Self-citation
Long-Term Safety and Efficacy of a Cholesterol-Lowering Diet in Children With Elevated Low-Density Lipoprotein Cholesterol: Seven-Year Results of the Dietary Intervention Study in Children (DISC)
Obarzanek, E., Kimm, S. Y. S., BARTON, B. A., Horn, L. V., Kwiterovich, P. O., Simons‐Morton, D. G., Hunsberger, S., Lasser, N. L., Robson, A. M., Franklin, F. A., et al. (2001) · PEDIATRICS · doi:10.1542/peds.107.2.256 · Cited by 275 · see citing works
Insulin and renal sodium retention in obese adolescents.
Rocchini, A. P., Katch, V. L., Kveselis, D. A., Moorehead, C., Martin, M., Lampman, R. M., & Gregory, M. (1989) · Hypertension · doi:10.1161/01.hyp.14.4.367 · Cited by 274 · see citing works
Self-citation
Efficacy and Safety of Lovastatin in Adolescent Males With Heterozygous Familial Hypercholesterolemia
Stein, E. A., Illingworth, D. R., Kwiterovich, P. O., Liacouras, C. A., Siimes, M. A., Jacobson, M. S., Brewster, T. G., Hopkins, P. N., Davidson, M. H., Graham, K. J., et al. (1999) · JAMA · doi:10.1001/jama.281.2.137 · Cited by 271 · see citing works
Self-citation
Efficacy and safety of atorvastatin in children and adolescents with familial hypercholesterolemia or severe hyperlipidemia: a multicenter, randomized, placebo-controlled trial
McCrindle, B. W., Ose, L., & Marais, A. (2003) · The Journal of Pediatrics · doi:10.1016/s0022-3476(03)00186-0 · Cited by 270 · see citing works
Self-citation
Effects of Nonlipid Risk Factors on Atherosclerosis in Youth With a Favorable Lipoprotein Profile
McGill, H. C., McMahan, C. A., Zieske, A. W., Malcom, G. T., Tracy, R. E., & Strong, J. P. (2001) · Circulation · doi:10.1161/01.cir.103.11.1546 · Cited by 262 · see citing works
Hyperinsulinemia, upper body adiposity, and cardiovascular risk factors in non-diabetics
Haffner, S. M., Fong, D. S., Hazuda, H. P., Pugh, J. A., & Patterson, J. K. (1988) · Metabolism · doi:10.1016/0026-0495(88)90133-3 · Cited by 254 · see citing works
Antioxidant Vitamins C and E Improve Endothelial Function in Children With Hyperlipidemia: Endothelial Assessment of Risk from Lipids in Youth (EARLY) Trial
Engler, M. M., Engler, M. B., Malloy, M. J., Chiu, E. Y., Schloetter, M. C., Paul, S. M., Stuehlinger, M., Lin, K. Y., Cooke, J. P., Morrow, J. D., et al. (2003) · Circulation · doi:10.1161/01.cir.0000086345.09861.a0 · Cited by 253 · see citing works
Arterial Mechanical Changes in Children With Familial Hypercholesterolemia
Aggoun, Y., Bonnet, D., Sidi, D., Girardet, J. P., Brucker, E., Polak, M., Safar, M. E., & Levy, B. I. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.9.2070 · Cited by 233 · see citing works
Risk Scores Predict Atherosclerotic Lesions in Young People
McMahan, C. A. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.8.883 · Cited by 219 · see citing works
Garlic Powder and Plasma Lipids and Lipoproteins
Isaacsohn, J. L., Moser, M., Stein, E. A., Dudley, K., Davey, J. A., Liskov, E., & Black, H. R. (1998) · Archives of Internal Medicine · doi:10.1001/archinte.158.11.1189 · Cited by 217 · see citing works
Insulin resistance syndrome in childhood: Associations of the euglycemic insulin clamp and fasting insulin with fatness and other risk factors
Sinaiko, A. R., Jacobs, D. R., Steinberger, J., Moran, A., Luepker, R. V., Rocchini, A. P., & Prineas, R. J. (2001) · The Journal of Pediatrics · doi:10.1067/mpd.2001.118535 · Cited by 213 · see citing works
Self-citation
Distribution of Lipoproteins by Age and Gender in Adolescents
Jolliffe, C. J., & Janssen, I. (2006) · Circulation · doi:10.1161/circulationaha.106.620864 · Cited by 211 · see citing works
Increases in Physical Fitness During Childhood Improve Cardiovascular Health During Adolescence: The Muscatine Study
Janz, K. F., Dawson, J. D., & Mahoney, L. T. (2002) · International Journal of Sports Medicine · doi:10.1055/s-2002-28456 · Cited by 208 · see citing works
Effect of a Garlic Oil Preparation on Serum Lipoproteins and Cholesterol Metabolism
Berthold, H. K., Sudhop, T., & von Bergmann, K. (1998) · JAMA · doi:10.1001/jama.279.23.1900 · Cited by 208 · see citing works
Pathobiological Determinants of Atherosclerosis in Youth Risk Scores Are Associated With Early and Advanced Atherosclerosis
McMahan, C. A., Gidding, S. S., Malcom, G. T., Tracy, R. E., Strong, J. P., & McGill, H. C. (2006) · PEDIATRICS · doi:10.1542/peds.2006-0970 · Cited by 207 · see citing works
Cardiovascular Risk Factors and Atherosclerosis in Young Males
Knoflach, M., Kiechl, S. J., Kind, M., Said, M., Sief, R., Gisinger, M., van der Zee, R., Gaston, H., Jarosch, E., Willeit, J., et al. (2003) · Circulation · doi:10.1161/01.cir.0000085996.95532.ff · Cited by 204 · see citing works
Sitostanol ester margarine in dietary treatment of children with familial hypercholesterolemia.
Gylling, H., Siimes, M. A., & Miettinen, T. A. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41499-3 · Cited by 201 · see citing works
Arterial Abnormalities in the Offspring of Patients with Premature Myocardial Infarction
Gaeta, G. B., Michele, M. D., Cuomo, S., Guarini, P., Foglia, M. C., Bond, M. G., & Trevisan, M. (2000) · New England Journal of Medicine · doi:10.1056/nejm200009213431203 · Cited by 195 · see citing works
Short-Term Efficacy and Safety of Pravastatin in 72 Children with Familial Hypercholesterolemia
Knipscheer, H., Boelen, C. C. A., Kastelein, J., van Diermen, D. V., Groenemeijer, B. E., van den Ende, A., Büller, H., & Bakker, H. D. (1996) · Pediatric Research · doi:10.1203/00006450-199605000-00021 · Cited by 174 · see citing works
Efficacy and safety of cholestyramine therapy in peripubertal and prepubertal children with familial hypercholesterolemia
Tonstad, S., Knudtzon, J., Sivertsen, M., Refsum, H., & Ose, L. (1996) · The Journal of Pediatrics · doi:10.1016/s0022-3476(96)70188-9 · Cited by 161 · see citing works
Treatment of Familial Hypercholesterolemia in Children and Adolescents: Effect of Lovastatin
Lambert, M. A., Lupien, P.-J., Gagné, C., Levy, E. H., Blaichman, S., Langlois, S., Hayden, M. R., Rose, V., Clarke, J. T. R., Wolfe, B. M. J., et al. (1996) · PEDIATRICS · doi:10.1542/peds.97.5.619 · Cited by 158 · see citing works
High Density Lipoprotein (HDL) Metabolism in Noninsulin-Dependent Diabetes Mellitus: Measurement of HDL Turnover Using Tritiated HDL*
Golay, A., Zech, L. A., SHI, M.-Z., Chiou, Y.-A. M., Reaven, G. M., & Chen, Y. I. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-65-3-512 · Cited by 154 · see citing works
Overview and Summary
(1992) · PEDIATRICS · doi:10.1542/peds.89.3.525 · Cited by 153 · see citing works
Docosahexaenoic acid restores endothelial function in children with hyperlipidemia: results from the EARLY Study
Engler, M. M., Engler, M. B., Malloy, M. J., Chiu, E., Besio, D., Paul, S. M., Stuehlinger, M., Morrow, J. D., Ridker, P. M., Rifai, N., et al. (2004) · International Journal of Clinical Pharmacology and Therapeutics · doi:10.5414/cpp42672 · Cited by 150 · see citing works
Low-density lipoproteins and risk for coronary artery disease
Ballantyne, C. M. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00769-3 · Cited by 145 · see citing works
Family History and Cardiovascular Risk in Familial Hypercholesterolemia
Wiegman, A., Rodenburg, J., de Jongh, S., Defesche, J. C., Bakker, H. D., Kastelein, J. J. P., & Sijbrands, E. J. G. (2003) · Circulation · doi:10.1161/01.cir.0000058166.99182.54 · Cited by 142 · see citing works
Differential effects of short-term lipid lowering with ezetimibe and statins on endothelial function in patients with CAD: clinical evidence for ‘pleiotropic’ functions of statin therapy
Fichtlscherer, S., Schmidt‐Lucke, C., Bojunga, S., Rössig, L., Heeschen, C., Dimmeler, S., & Zeiher, A. M. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehi881 · Cited by 141 · see citing works
Evidence for an independent relationship between plasma insulin and concentration of high density lipoprotein cholesterol and triglyceride
Zavaroni, I., Dall’Aglio, E., Alpi, O., Bruschi, F., Bonora, E., Pezzarossa, A., & BUTTURINI, U. (1985) · Atherosclerosis · doi:10.1016/0021-9150(85)90105-4 · Cited by 138 · see citing works
Effect of Obesity and High Blood Pressure on Plasma Lipid Levels in Children and Adolescents
Boyd-Woschinko, G. S., Koenigsberg, J., Falkner, B. E., Gidding, S. S., & Hassink, S. G. (2005) · PEDIATRICS · doi:10.1542/peds.2004-1877 · Cited by 137 · see citing works
Safety of rosuvastatin
Shepherd, J., Hunninghake, D. B., Stein, E. A., Kastelein, J. J. P., Harris, S., Pears, J. S., & Hutchinson, H. G. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2004.06.049 · Cited by 137 · see citing works
Physical Activity, Physical Fitness, and Coronary Heart Disease Risk Factors in Youth: The Québec Family Study
Katzmarzyk, P. T., Malina, R. M., & Bouchard, C. (1999) · Preventive Medicine · doi:10.1006/pmed.1999.0592 · Cited by 132 · see citing works
Garlic Extract Therapy in Children With Hypercholesterolemia
McCrindle, B. W., Helden, E., & Conner, W. T. (1998) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.152.11.1089 · Cited by 131 · see citing works
Self-citation
Relationship between lipoprotein levels and in vivo insulin action in normal young white men
Garg, A., Helderman, J. H., Koffler, M., Ayuso, R. M. A., Rosenstock, J., & Raskin, P. (1988) · Metabolism · doi:10.1016/0026-0495(88)90157-6 · Cited by 130 · see citing works
The Effect of Aerobic Exercise Training on the Lipid-Lipoprotein Profile of Children and Adolescents
Tolfrey, K., Jones, A. M., & Campbell, I. G. (2000) · Sports Medicine · doi:10.2165/00007256-200029020-00003 · Cited by 125 · see citing works
Efficacy and Safety of Lovastatin Therapy in Adolescent Girls With Heterozygous Familial Hypercholesterolemia
Clauss, S. B., Holmes, K. W., Hopkins, P. N., Stein, E. A., Cho, M., Tate, A. C., Johnson‐Levonas, A. O., & Kwiterovich, P. O. (2005) · PEDIATRICS · doi:10.1542/peds.2004-2090 · Cited by 123 · see citing works
Pediatric Precursors of Adult Cardiovascular Disease: Noninvasive Assessment of Early Vascular Changes in Children and Adolescents
Groner, J. A., Joshi, M. S., & Bauer, J. A. (2006) · PEDIATRICS · doi:10.1542/peds.2005-2992 · Cited by 122 · see citing works
Endothelial dysfunction occurs in children with two genetic hyperlipidemias: Improvement with antioxidant vitamin therapy
Mietus‐Snyder, M., & Malloy, M. J. (1998) · The Journal of Pediatrics · doi:10.1016/s0022-3476(98)70174-x · Cited by 118 · see citing works
Cholesterol and Arterial Distensibility in the First Decade of Life
Leeson, C. P. M., Whincup, P. H., Cook, D. G., Mullen, M. J., Donald, A. E., Seymour, C. A., & Deanfield, J. E. (2000) · Circulation · doi:10.1161/01.cir.101.13.1533 · Cited by 116 · see citing works
Garlic powder, effect on plasma lipids, postprandial lipemia, low-density lipoprotein particle size, high-density lipoprotein subclass distribution and lipoprotein(a)
Superko, H. R., & Krauss, R. M. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)90541-7 · Cited by 112 · see citing works
Prospective Randomized Trial of Low-Saturated-Fat, Low-Cholesterol Diet During the First 3 Years of Life
Niinikoski, H., Viikari, J. S. A., ̈nnemaa, T. R., Lapinleimu, H., Jokinen, E. V., Salo, P., Seppänen, R., Leino, A. E., Tuominen, J., Välimäki, I. A. T., et al. (1996) · Circulation · doi:10.1161/01.cir.94.6.1386 · Cited by 108 · see citing works
Insulin Responsiveness of Adipose Tissue Lipoprotein Lipase Is Delayed but Preserved in Obesity*
SADUR, U. N., Yost, T. J., & Eckel, R. H. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-59-6-1176 · Cited by 106 · see citing works
Niacin Treatment of Hypercholesterolemia in Children
Colletti, R. B., Roff, N. K., Neufeld, E. J., Baker, A., Newburger, J. W., & McAuliffe, T. L. (1993) · PEDIATRICS · doi:10.1542/peds.92.1.78 · Cited by 106 · see citing works
Endothelial Function in Healthy 11-Year-Old Children After Dietary Intervention With Onset in Infancy
Raitakari, O. T., Rönnemaa, T., Järvisalo, M. J., Kaitosaari, T., Volanen, I., Kallio, K., Lagström, H., Jokinen, E., Niinikoski, H., Viikari, J. S. A., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.583195 · Cited by 104 · see citing works
Plant sterols lower LDL cholesterol without improving endothelial function in prepubertal children with familial hypercholesterolaemia
de Jongh, S., Vissers, M. N., Rol, P., Bakker, H. D., Kastelein, J. J. P., & Stroes, E. S. G. (2003) · Journal of Inherited Metabolic Disease · doi:10.1023/a:1025155002348 · Cited by 103 · see citing works
Relationship between plasma insulin levels and high density lipoprotein cholesterol levels in healthy men
Stalder, M., Pometta, D., & Suenram, A. (1981) · Diabetologia · doi:10.1007/bf00281546 · Cited by 102 · see citing works
A psyllium-enriched cereal for the treatment of hypercholesterolemia in children: a controlled, double-blind, crossover study
Davidson, M., Dugan, L. D., Burns, J., Sugimoto, D. H., Story, K., & Drennan, K. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/63.1.96 · Cited by 100 · see citing works
Effect of weight loss on blood pressure and insulin resistance in normotensive and hypertensive obese individuals
Su, H., Sheu, W. H., CHIN, H., Jeng, C.-Y., Chen, Y. I., & Reaven, G. M. (1995) · American Journal of Hypertension · doi:10.1016/0895-7061(95)00330-r · Cited by 97 · see citing works
Family history evaluation as a predictive screen for childhood hypercholesterolemia. Pediatric Practice Research Group.
Griffin, T. C., Christoffel, K. K., Binns, H. J., & McGuire, P. A. (1989) · PubMed · Cited by 89 · see citing works
Asymptomatic hyperglycemia is associated with lipid and lipoprotein changes favoring atherosclerosis.
Laakso, M., & Barrett-Connor, E. L. (1989) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.9.5.665 · Cited by 89 · see citing works
Acceptability and compliance with two forms of cholestyramine in the treatment of hypercholesterolemia in children: A randomized, crossover trial
McCrindle, B. W., O'Neill, M. B., Cullen-Dean, G., & Helden, E. (1997) · The Journal of Pediatrics · doi:10.1016/s0022-3476(97)70353-6 · Cited by 89 · see citing works
Self-citation
Plant stanol ester margarine lowers serum total and low-density lipoprotein cholesterol concentrations of healthy children: The STRIP project
Tammi, A., Rönnemaa, T., Gylling, H. K., Rask-Nissilä, L., Viikari, J. S. A., Tuominen, J., Pulkki, K. J., & Simell, O. (2000) · The Journal of Pediatrics · doi:10.1016/s0022-3476(00)90014-3 · Cited by 89 · see citing works
Double blind trial of bezafibrate in familial hypercholesterolaemia.
Wheeler, K., West, R., Lloyd, J. K., & Barley, J. (1985) · Archives of Disease in Childhood · doi:10.1136/adc.60.1.34 · Cited by 87 · see citing works
Forearm resistance vessel abnormalities and insulin resistance in obese adolescents.
Rocchini, A. P., Moorehead, C., Katch, V. L., Key, J., & Finta, K. M. (1992) · Hypertension · doi:10.1161/01.hyp.19.6.615 · Cited by 85 · see citing works
Self-citation
Effect of 7-Year Infancy-Onset Dietary Intervention on Serum Lipoproteins and Lipoprotein Subclasses in Healthy Children in the Prospective, Randomized Special Turku Coronary Risk Factor Intervention Project for Children (STRIP) Study
Kaitosaari, T., Rönnemaa, T., Raitakari, O. T., Talvia, S. S., Kallio, K., Volanen, I., Leino, A. E., Jokinen, E. V., Välimäki, I. A. T., Viikari, J. S. A., et al. (2003) · Circulation · doi:10.1161/01.cir.0000083723.75065.d4 · Cited by 84 · see citing works
Marked Dyslipidemia in Human Immunodeficiency Virus-Infected Children on Protease Inhibitor-Containing Antiretroviral Therapy
Lainka, E., Oezbek, S., Falck, M., Ndagijimana, J., & Niehues, T. (2002) · PEDIATRICS · doi:10.1542/peds.110.5.e56 · Cited by 83 · see citing works
Low-Density Lipoprotein Receptor Genotype and Response to Pravastatin in Children With Familial Hypercholesterolemia
Koeijvoets, K. C. M. C., Rodenburg, J., Hutten, B. A., Wiegman, A., Kastelein, J. J. P., & Sijbrands, E. J. G. (2005) · Circulation · doi:10.1161/circulationaha.105.565507 · Cited by 79 · see citing works
A Randomized Crossover Trial of Combination Pharmacologic Therapy in Children with Familial Hyperlipidemia
McCrindle, B. W., Helden, E., Cullen-Dean, G., & Conner, W. T. (2002) · Pediatric Research · doi:10.1203/00006450-200206000-00009 · Cited by 78 · see citing works
Self-citation
Plant stanols do not restore endothelial function in pre-pubertal children with familial hypercholesterolemia despite reduction of low-density lipoprotein cholesterol levels
Jakulj, L., Vissers, M. N., Rodenburg, J., Wiegman, A., Trip, M. D., & Kastelein, J. J. P. (2006) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2005.11.023 · Cited by 77 · see citing works
A 15-year physical activity pattern is positively related to aerobic fitness in young males and females (13-27 years)
Kemper, H. C. G., Twisk, J. W. R., Koppes, L. L. J., van Mechelen, W., & Post, G. B. (2001) · European Journal of Applied Physiology · doi:10.1007/s004210100392 · Cited by 76 · see citing works
A Randomized Intervention Since Infancy to Reduce Intake of Saturated Fat
Talvia, S. S., Lagström, H., Räsänen, M., Salminen, M., Räsänen, L., Salo, P., Viikari, J. S. A., Rönnemaa, T., Jokinen, E. V., Vahlberg, T. J., et al. (2004) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.158.1.41 · Cited by 76 · see citing works
Effect of docosahexaenoic acid on lipoprotein subclasses in hyperlipidemic children (the EARLY study)
Engler, M. M., Engler, M. B., Malloy, M. J., Paul, S. M., Kulkarni, K. R., & Mietus-Snyder, M. L. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2004.12.014 · Cited by 76 · see citing works
Race and gender differences in serum lipoproteins of children, adolescents, and young adults—Emergence of an adverse lipoprotein pattern in white males: The Bogalusa Heart Study
Srinivasan, S. R., Wattigney, W. A., Webber, L. S., & Berenson, G. S. (1991) · Preventive Medicine · doi:10.1016/0091-7435(91)90063-a · Cited by 74 · see citing works
Family History Evaluation as a Predictive Screen for Childhood Hypercholesterolemia
Griffin, T. C., Christoffel, K. K., Binns, H. J., & McGuire, P. A. (1989) · PEDIATRICS · doi:10.1542/peds.84.2.365 · Cited by 72 · see citing works
Plant stanol and sterol esters in prevention of cardiovascular diseases
Miettinen, T. A., & Gylling, H. K. (2004) · Annals of Medicine · doi:10.1080/07853890310021625 · Cited by 71 · see citing works
Low dose colestipol in adolescents with familial hypercholesterolaemia.
Tonstad, S., Sivertsen, M., Aksnes, L., & Ose, L. (1996) · Archives of Disease in Childhood · doi:10.1136/adc.74.2.157 · Cited by 67 · see citing works
Simvastatin use in children
Ducobu, J., Brasseur, D. J., Chaudron, J.-M., Deslypere, J.-P., Harvengt, C., Muls, E., & Thomson, M. (1992) · The Lancet · doi:10.1016/0140-6736(92)92092-t · Cited by 67 · see citing works
Exercise training induced alterations in prepubertal children's lipid-lipoprotein profile
Tolfrey, K., CAMPBELL, I. G., & Batterham, A. M. (1998) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199812000-00005 · Cited by 65 · see citing works
Randomized, double-blind, placebo-controlled, two-period crossover clinical trial of psyllium fiber in children with hypercholesterolemia
Dennison, B. A., & Levine, D. M. (1993) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)81532-x · Cited by 64 · see citing works
Self-citation
Effect of soy protein diet versus standard low fat, low cholesterol diet on lipid and lipoprotein levels in children with familial or polygenic hypercholesterolemia
Widhalm, K., Brazda, G., Schneider, B. K., & Kohl, S. (1993) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)81533-1 · Cited by 63 · see citing works
Serum Total Cholesterol Screening for the Detection of Elevated Low-Density Lipoprotein in Children and Adolescents: The Bogalusa Heart Study
Dennison, B. A., Kikuchi, D. A., Srinivasan, S. R., Webber, L. S., & Berenson, G. S. (1990) · PEDIATRICS · doi:10.1542/peds.85.4.472 · Cited by 61 · see citing works
Self-citation
Effects of a soy-protein beverage on plasma lipoproteins in children with familial hypercholesterolemia
Laurin, D., Jacques, H., Moorjani, S., Steinke, F. H., Gagné, C., Brun, D., & Lupien, P. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.1.98 · Cited by 61 · see citing works
Association of fasting insulin with blood pressure in young individuals. The Bogalusa Heart Study
Jiang, X. (1993) · Archives of Internal Medicine · doi:10.1001/archinte.153.3.323 · Cited by 61 · see citing works
PDAY risk score predicts advanced coronary artery atherosclerosis in middle-aged persons as well as youth
McMahan, C. A., McGill, H. C., Gidding, S. S., Malcom, G. T., Newman, W. P., Tracy, R. E., & Strong, J. P. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.02.008 · Cited by 59 · see citing works
Insulin-stimulated glucose utilization and borderline hypertension in young adult blacks.
Falkner, B. E., Hulman, S., & Kushner, H. (1993) · Hypertension · doi:10.1161/01.hyp.22.1.18 · Cited by 58 · see citing works
Prospective, Randomized, Infancy-Onset Trial of the Effects of a Low-Saturated-Fat, Low-Cholesterol Diet on Serum Lipids and Lipoproteins Before School Age
Rask-Nissilä, L., Jokinen, E. V., Rönnemaa, T., Viikari, J. S. A., Tammi, A., Niinikoski, H., Seppänen, R., Tuominen, J., & Simell, O. (2000) · Circulation · doi:10.1161/01.cir.102.13.1477 · Cited by 57 · see citing works
Quality of life, anxiety and concerns among statin-treated children with familial hypercholesterolaemia and their parents.
de Jongh, S., Kerckhoffs, M. C., Grootenhuis, M. A., Bakker, H. D., Heymans, H. S. A., & Last, B. F. (2003) · Acta Paediatrica · doi:10.1080/08035250310004298 · Cited by 56 · see citing works
Month-to-month variability of lipids, lipoproteins, and apolipoproteins and the impact of acute infection in adolescents
Gidding, S. S., Stone, N. J., Bookstein, L. C., Laskarzewski, P. M., & Stein, E. A. (1998) · The Journal of Pediatrics · doi:10.1016/s0022-3476(98)70227-6 · Cited by 55 · see citing works
Failure of Current Guidelines for Cholesterol Screening in Urban African-American Adolescents
Rifai, N., Neufeld, E. J., Ahlstrom, P., Rimm, E. B., D’Angelo, L. J., & Hicks, J. M. (1996) · PEDIATRICS · doi:10.1542/peds.98.3.383 · Cited by 54 · see citing works
Radial Artery Compliance in Young, Obese, Normotensive Subjects
Mangoni, A. A., Giannattasio, C., Brunani, A., Failla, M., Colombo, M., Bolla, G., Cavagnini, F., Grassi, G. M., & Mancia, G. (1995) · Hypertension · doi:10.1161/01.hyp.26.6.984 · Cited by 53 · see citing works
Seasonal Variation in Plasma Cholesterol Distributions: Implications for Screening and Referral
Råstam, L., Hannan, P. J., Luepker, R. V., Mittelmark, M. B., Murray, D. M., & Slater, J. S. (1992) · American Journal of Preventive Medicine · doi:10.1016/s0749-3797(18)30780-3 · Cited by 52 · see citing works
Lowering of plasma cholesterol levels in free-living adolescent males; use of natural and synthetic polyunsaturated foods to provide balanced fat diets
Stein, E. A., Mendelsohn, D., Fleming, M., Barnard, G., Carter, K. J., du Toit, P., Hansen, J., & Bersohn, I. (1975) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/28.11.1204 · Cited by 51 · see citing works
State-of-the-art update and review: clinical trials of lipid-lowering agents.
Kwiterovich, P. (1998) · American Journal of Cardiology · doi:10.1016/s0002-9149(98)00957-6 · Cited by 50 · see citing works
The carotid artery wall thickness in teenagers is related to their diet and the typical risk factors of heart disease among adults
Sanchez, A., Barth, J. D., & Zhang, L. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(00)00532-3 · Cited by 48 · see citing works
Effect of a Rapeseed Oil Substituting Diet on Serum Lipids and Lipoproteins in Children and Adolescents with Familial Hypercholesterolemia
Gulesserian, T., & Widhalm, K. (2002) · Journal of the American College of Nutrition · doi:10.1080/07315724.2002.10719201 · Cited by 47 · see citing works
Efficacy and Safety of Pravastatin in Children and Adolescents with Heterozygous Familial Hypercholesterolemia: A Prospective Clinical Follow-Up Study
Hedman, M., Matikainen, T., Föhr, A., Lappi, M., Piippo, S., Nuutinen, M., & Antikainen, M. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1541 · Cited by 47 · see citing works
Challenges to Implementing the Current Pediatric Cholesterol Screening Guidelines Into Practice
Dennison, B. A., Jenkins, P., & Pearson, T. A. (1994) · PEDIATRICS · doi:10.1542/peds.94.3.296 · Cited by 44 · see citing works
Self-citation
Efficacy and safety of atorvastatin after pediatric heart transplantation
Chin, C. C., Gamberg, P., Miller, J. L., Luikart, H. I., & Bernstein, D. (2002) · The Journal of Heart and Lung Transplantation · doi:10.1016/s1053-2498(02)00455-2 · Cited by 40 · see citing works
Association of Fasting Insulin With Blood Pressure in Young Individuals
Jiang, X. (1993) · Archives of Internal Medicine · doi:10.1001/archinte.1993.00410030037006 · Cited by 35 · see citing works
Quality of life, anxiety and concerns among statin‐treated children with familial hypercholesterolaemia and their parents.
de Jongh, S., Kerckhoffs, M., Grootenhuis, M., et al. (2003) · Acta Paediatrica · doi:10.1111/j.1651-2227.2003.tb02584.x · Cited by 35 · see citing works
ASSESSMENT OF PLASMA TOTAL CHOLESTEROL AS A TEST TO DETECT ELEVATED LOW DENSITY (BETA) LIPOPROTEIN CHOLESTEROL LEVELS (TYPE IIa HYPERLIPOPROTEINEMIA) IN YOUNG SUBJECTS FROM A POPULATION-BASED SAMPLE
Kwiterovich, P. O., HEISS, G. M., Johnson, N. L., Chase, G. A., Tamir, I., & Rifkind, B. M. (1982) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a113291 · Cited by 33 · see citing works
Selected predictor variables and the lipid-lipoprotein profile of prepubertal girls and boys
Tolfrey, K., CAMPBELL, I. G., & JONES, A. M. (1999) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199911000-00009 · Cited by 33 · see citing works
Effects of dietary modification and fish oil supplementation on dyslipoproteinemia in pediatric systemic lupus erythematosus.
Ilowite, N. T., Copperman, N. M., Leicht, T., Kwong, T., & Jacobson, M. S. (1995) · PubMed · Cited by 32 · see citing works
Self-citation
Definition and application of the discretionary screening indicators according to the National Cholesterol Education Program for Children and Adolescents
Diller, P. M., Huster, G. A., Leach, A. D., Laskarzewski, P. M., & Sprecher, D. L. (1995) · The Journal of Pediatrics · doi:10.1016/s0022-3476(95)70446-9 · Cited by 31 · see citing works
Colestipol tablets in adolescents with familial hypercholesterolaemia
Tonstad, S., & Ose, L. (1996) · Acta Paediatrica · doi:10.1111/j.1651-2227.1996.tb14221.x · Cited by 31 · see citing works
Compliance With Childhood Cholesterol Screening Among Members of a Prepaid Health Plan
Bachman, R. P. (1993) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1993.02160280032013 · Cited by 30 · see citing works
Determinants of Endothelium-Dependent Femoral Artery Vasodilation in Youth
Treiber, F. A., Papavassiliou, D. P., Gutin, B., Malpass, D., Wang, Y., Islam, S., Davis, H., & Strong, W. B. (1997) · Psychosomatic Medicine · doi:10.1097/00006842-199707000-00007 · Cited by 30 · see citing works
Blood Lipids and Lipoproteins in Child and Adolescent Athletes
Eisenmann, J. C. (2002) · Sports Medicine · doi:10.2165/00007256-200232050-00002 · Cited by 25 · see citing works
Year-to-Year Variability of Cholesterol Levels in a Pediatric Practice
Benuck, I. (1995) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1995.02170150072013 · Cited by 25 · see citing works
Altered blood pressure reactivity in adolescent diabetics
Newkumet, K. M., Goble, M. M., Young, R. B., Kaplowitz, P. B., & Schieken, R. M. (1995) · Pediatric Nephrology · doi:10.1007/bf00858989 · Cited by 22 · see citing works
Parent and Physician Response to Children’s Cholesterol Values of 200 mg/dL or Greater: The Child and Adolescent Trial for Cardiovascular Health Experiment
Nader, P. R., Yang, M., Luepker, R. V., Parcel, G. S., Pirie, P. L., Feldman, H. A., Stone, E. J., & Webber, L. S. (1997) · PEDIATRICS · doi:10.1542/peds.99.5.e5 · Cited by 20 · see citing works
Altered Blood Pressure Reactivity in Adolescent Diabetics
Newkumet, K. M., Goble, M. M., Young, R. B., Kaplowitz, P. B., & Schieken, R. M. (1994) · PEDIATRICS · doi:10.1542/peds.93.4.616 · Cited by 19 · see citing works
Colesevelam hydrochloride in the management of dyslipidemia
Armani, A., & Toth, P. (2006) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.4.3.283 · Cited by 16 · see citing works
New Cholesterol Guidelines for Children?
Gidding, S. S. (2006) · Circulation · doi:10.1161/circulationaha.106.647891 · Cited by 15 · see citing works
Prevention of familial cardiovascular disease by screening for family history and lipids in youths.
Williams, R. R., Hunt, S. C., Barlow, G. K., Wu, L., Hopkins, P. N., Schumacher, M. C., Hasstedt, S. J., Ware, J. L., Chamberlain, R. M., & Weinberg, A. D. (1992) · PubMed · Cited by 12 · see citing works
Exercise and Lipid Abnormalities
Daniels, S. R. (1999) · Pediatric Cardiology · doi:10.1007/s002469900403 · Cited by 11 · see citing works
Self-citation
Improved lipid profile and blood sugar control in pediatric renal transplant recipients using sirolimus-tacrolimus combination
El‐Sabrout, R., Weiss, R., Butt, F., Rashid, I., DELANEY, V. B., Qadir, M., Hanson, P., & Butt, K. M. H. (2002) · Transplantation Proceedings · doi:10.1016/s0041-1345(02)03132-9 · Cited by 11 · see citing works
Primary care physicians and children's blood cholesterol
Kimm, S. Y. S., Payne, G. H., Lakatos, E., Webber, L. S., & Greenblatt, J. (1992) · Preventive Medicine · doi:10.1016/0091-7435(92)90018-d · Cited by 10 · see citing works
Childhood Cardiovascular Risk Factors and Carotid Vascular Changes in Adulthood: The Bogalusa Heart Study
Li, S., Chen, W., Srinivasan, S. R., Bond, M. G., Tang, R., Urbina, E. M., & Berenson, G. S. (2003) · JAMA · doi:10.1001/jama.290.17.2271 · Cited by 8 · see citing works
Self-citation
American Diabetes Association annual meeting, 1999: dyslipidemia, endothelial dysfunction, and glycosylation.
Bloomgarden, Z. T. (2000) · Diabetes Care · doi:10.2337/diacare.23.5.690 · Cited by 7 · see citing works
Autoimmune Hyperlipidemia in a Child With Autoimmune Hepatitis
Rumbo, C., Betzhold, J., Merati, S., & Shneider, B. L. (2002) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200208000-00014 · Cited by 7 · see citing works
Educating NPs to educate patients: Cholesterol screening in pediatric primary care
Windorski, S. K., & Kalb, K. A. (2002) · Journal of Pediatric Health Care · doi:10.1067/mph.2002.116544 · Cited by 5 · see citing works

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Standards of medical care in diabetes—2014
American Diabetes Association (2014) · Diabetes Care · doi:10.2337/dc14-s014 · Cited by 4,572 · see citing works
Standards of medical care in diabetes—2013
American Diabetes Association (2013) · Diabetes Care · doi:10.2337/dc13-s011 · Cited by 4,369 · see citing works
Standards of medical care in diabetes 2010
American Diabetes Association (2010) · Diabetes Care · doi:10.2337/dc10-s011 · Cited by 3,470 · see citing works
Standards of medical care in diabetes—2011
American Diabetes Association (2011) · Diabetes Care · doi:10.2337/dc11-s011 · Cited by 2,880 · see citing works
Standards of Medical Care in Diabetes—2012
(2012) · Diabetes Care · doi:10.2337/dc12-s011 · Cited by 2,240 · see citing works
Standards of Medical Care in Diabetes—2009
American Diabetes Association (2009) · Diabetes Care · doi:10.2337/dc09-s013 · Cited by 2,167 · see citing works
Subendothelial Lipoprotein Retention as the Initiating Process in Atherosclerosis: Update and Therapeutic Implications
Tabas, I., Williams, K. J., & Borén, J. (2007) · Circulation · doi:10.1161/circulationaha.106.676890 · Cited by 1,399 · see citing works
Lipid screening and cardiovascular health in childhood
Daniels, S. R., Greer, F. R., & and the Committee on Nutrition (2008) · Pediatrics · doi:10.1542/peds.2008-1349 · Cited by 1,178 · see citing works
Self-citation
Epidemiology of type 1 diabetes
Maahs, D. M., West, N. A., Lawrence, J. M., & Mayer-Davis, E. J. (2010) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2010.05.011 · Cited by 1,092 · see citing works
American Association of Clinical Endocrinologists and American College of Endocrinology guidelines for management of dyslipidemia and prevention of cardiovascular disease
Jellinger, P. S., Handelsman, Y., Rosenblit, P. D., Bloomgarden, Z. T., Fonseca, V. A., Garber, A. J., Grunberger, G., Guerin, C. K., Bell, D. S. H., Mechanick, J. I., et al. (2017) · Endocrine Practice · doi:10.4158/ep171764.appgl · Cited by 1,094 · see citing works
Statin Safety and Associated Adverse Events: A Scientific Statement From the American Heart Association
Newman, C. B., Preiss, D., Tobert, J. A., Jacobson, T. A., Page, R. L., II, Goldstein, L. B., Chin, C. C., Tannock, L. R., Miller, M. J., Raghuveer, G., et al. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atv.0000000000000073 · Cited by 760 · see citing works
Familial Hypercholesterolemia: Screening, diagnosis and management of pediatric and adult patients
Goldberg, A. C., Hopkins, P. N., Toth, P. P., Ballantyne, C. M., Rader, D. J., Robinson, J. G., Daniels, S. R., Gidding, S. S., de Ferranti, S. D., Ito, M. K., et al. (2011) · Journal of clinical lipidology · doi:10.1016/j.jacl.2011.03.001 · Cited by 622 · see citing works
Self-citation
Long-term Cardiovascular Toxicity in Children, Adolescents, and Young Adults Who Receive Cancer Therapy: Pathophysiology, Course, Monitoring, Management, Prevention, and Research Directions
Lipshultz, S. E., Adams, M. J., Colan, S. D., Constine, L. S., Herman, E. H., Hsu, D. T., Hudson, M. M., Kremer, L. C. M., Landy, D. C., Miller, T. L., et al. (2013) · Circulation · doi:10.1161/cir.0b013e3182a88099 · Cited by 614 · see citing works
Self-citation
American Association of Clinical Endocrinologists' Guidelines for Management of Dyslipidemia and Prevention of Atherosclerosis
Jellinger, P. S., Smith, D. A., Mehta, A., Ganda, O. P., Handelsman, Y., Rodbard, H. W., Shepherd, M. D., & Seibel, J. A. (2012) · Endocrine Practice · doi:10.4158/ep.18.s1.1 · Cited by 527 · see citing works
Type 1 Diabetes Mellitus and Cardiovascular Disease
de Ferranti, S. D., de Boer, I. H., Fonseca, V. A., Fox, C. S., Golden, S. H., Lavie, C. J., Magge, S. N., Marx, N., McGuire, D. K., Orchard, T. J., et al. (2014) · Circulation · doi:10.1161/cir.0000000000000034 · Cited by 504 · see citing works
Cardiovascular Risk Reduction in High-Risk Pediatric Patients: A Scientific Statement From the American Heart Association
de Ferranti, S. D., Steinberger, J., Ameduri, R. K., Baker, A., Gooding, H. C., Kelly, A. S., Mietus‐Snyder, M., Mitsnefes, M. M., Peterson, A. L. H., St‐Pierre, J., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000618 · Cited by 448 · see citing works
Self-citation
Type 1 Diabetes Mellitus and Cardiovascular Disease: A Scientific Statement From the American Heart Association and American Diabetes Association
de Ferranti, S. D., de Boer, I. H., Fonseca, V. A., Fox, C. S., Golden, S. H., Lavie, C. J., Magge, S. N., Marx, N., McGuire, D. K., Orchard, T. J., et al. (2014) · Diabetes Care · doi:10.2337/dc14-1720 · Cited by 434 · see citing works
14. Children and Adolescents: Standards of Medical Care in Diabetes—2022
(2021) · Diabetes Care · doi:10.2337/dc22-s014 · Cited by 379 · see citing works
Integrated guidance on the care of familial hypercholesterolaemia from the International FH Foundation
Watts, G. F., Gidding, S. S., Wierzbicki, A. S., Toth, P. P., Rodrigo Alonso, K., Brown, W. V., Bruckert, É., Defesche, J. C., Lin, K. K., Livingston, M., et al. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.11.025 · Cited by 377 · see citing works
13. Children and Adolescents: Standards of Medical Care in Diabetes−2020
American Diabetes Association (2019) · Diabetes Care · doi:10.2337/dc20-s013 · Cited by 272 · see citing works
Statins for children with familial hypercholesterolemia
Vuorio, A. F., Kuoppala, J., Kovanen, P. T., Humphries, S. E., Tonstad, S., Wiegman, A., Drogari, E., & Ramaswami, U. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006401.pub4 · Cited by 265 · see citing works
Diagnosis and Management of Prediabetes in the Continuum of Hyperglycemia—When Do the Risks of Diabetes Begin? A Consensus Statement From the American College of Endocrinology and the American Association of Clinical Endocrinologists*
Garber, A. J., Handelsman, Y., EINHORN, D. F., Bergman, D. A., Bloomgarden, Z. T., Fonseca, V. A., Garvey, W. T., Gavin, J. R., Grunberger, G., Horton, E. S., et al. (2008) · Endocrine Practice · doi:10.4158/ep.14.7.933 · Cited by 235 · see citing works
13. Children and Adolescents: <i>Standards of Medical Care in Diabetes—2021</i>
American Diabetes Association (2021) · Diabetes Care · doi:10.2337/dc21-s013 · Cited by 223 · see citing works
2018 Guidelines for the management of dyslipidemia
Rhee, E., Kim, H. C., Kim, J. H., Lee, E. Y., Kim, B. J., Kim, E. M., Song, Y., Lim, J. H., Kim, B. J., Choi, S., et al. (2019) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2019.188 · Cited by 217 · see citing works
Severe heterozygous familial hypercholesterolemia and risk for cardiovascular disease: A study of a cohort of 14,000 mutation carriers
Besseling, J., Kindt, I., Hof, M. H. P., Kastelein, J. J. P., Hutten, B. A., & Hovingh, G. K. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.12.020 · Cited by 212 · see citing works
Reduction of Risk for Cardiovascular Disease in Children and Adolescents
Daniels, S. R., PRATT, C. A., & Hayman, L. L. (2011) · Circulation · doi:10.1161/circulationaha.110.016170 · Cited by 206 · see citing works
Self-citation
Familial hypercholesterolaemia: A model of care for Australasia
Watts, G. F., SULLIVAN, D. R., Poplawski, N. K., van Bockxmeer, F., Hamilton‐Craig, I. R., Clifton, P. M., O’Brien, R. C., Bishop, W., George, P. M., Barter, P. J., et al. (2011) · Atherosclerosis Supplements · doi:10.1016/j.atherosclerosissup.2011.06.001 · Cited by 205 · see citing works
14. Children and Adolescents: Standards of Care in Diabetes—2023
ElSayed, N. A., Aleppo, G., Aroda, V. R., Bannuru, R. R., Brown, F. M., Bruemmer, D., Collins, B. S., Hilliard, M. E., Isaacs, D. M., Johnson, E. L., et al. (2022) · Diabetes Care · doi:10.2337/dc23-s014 · Cited by 210 · see citing works
13. Children and Adolescents: Standards of Medical Care in Diabetes—2019
American Diabetes Association (2018) · Diabetes Care · doi:10.2337/dc19-s013 · Cited by 200 · see citing works
A Pooled Analysis of Lacosamide Clinical Trial Data Grouped by Mechanism of Action of Concomitant Antiepileptic Drugs
Sake, J., Hebert, D., Isojärvi, J. I. T., Doty, P., Backer, M. D., Davies, K., Eggert‐Formella, A., & Zackheim, J. (2010) · CNS Drugs · doi:10.2165/11587550-000000000-00000 · Cited by 197 · see citing works
The Association of Pediatric Low- and High-Density Lipoprotein Cholesterol Dyslipidemia Classifications and Change in Dyslipidemia Status With Carotid Intima-Media Thickness in Adulthood
Magnussen, C. G., Venn, A., Thomson, R. J., Juonala, M., Srinivasan, S. R., Viikari, J. S. A., Berenson, G. S., Dwyer, T., & Raitakari, O. T. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.09.061 · Cited by 192 · see citing works
Cardiovascular Disease Risk Factors in Youth With Diabetes Mellitus
Maahs, D. M., Daniels, S. R., de Ferranti, S. D., Dichek, H. L., Flynn, J. T., Goldstein, B. I., Kelly, A. S., Nadeau, K. J., Martyn-Nemeth, P. A., Osganian, S. K., et al. (2014) · Circulation · doi:10.1161/cir.0000000000000094 · Cited by 196 · see citing works
Self-citation
12. Children and Adolescents: Standards of Medical Care in Diabetes—2018
American Diabetes Association (2017) · Diabetes Care · doi:10.2337/dc18-s012 · Cited by 196 · see citing works
2018 Guidelines for the Management of Dyslipidemia in Korea
Rhee, E., Kim, H. C., Kim, J. H., Lee, E. Y., Kim, B. J., Kim, E. M., Song, Y., Lim, J. H., Kim, B. J., Choi, S., et al. (2019) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2019.8.2.78 · Cited by 192 · see citing works
14. Children and Adolescents: Standards of Care in Diabetes—2025
American Diabetes Association Professional Practice Committee, ElSayed, N. A., McCoy, R. G., Aleppo, G., Balapattabi, K., Beverly, E. A., Briggs Early, K., Bruemmer, D., Echouffo-Tcheugui, J. B., Ekhlaspour, L., et al. (2025) · Diabetes Care · doi:10.2337/dc25-s014 · Cited by 173 · see citing works
Pediatric aspects of Familial Hypercholesterolemias: Recommendations from the National Lipid Association Expert Panel on Familial Hypercholesterolemia
Daniels, S. R., Gidding, S. S., & de Ferranti, S. D. (2011) · Journal of clinical lipidology · doi:10.1016/j.jacl.2011.03.453 · Cited by 173 · see citing works
Self-citation
Carotid Intima-Media Thickness in Children With Familial Hypercholesterolemia
Kusters, D. M., Wiegman, A., Kastelein, J. J. P., & Hutten, B. A. (2013) · Circulation Research · doi:10.1161/circresaha.114.301430 · Cited by 170 · see citing works
Efficacy and Safety of Rosuvastatin Therapy for Children With Familial Hypercholesterolemia
Avis, H. J., Hutten, B. A., Gagné, C., Langslet, G., McCrindle, B. W., Wiegman, A., Hsia, J. A., Kastelein, J. J. P., & Stein, E. A. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.10.042 · Cited by 166 · see citing works
Self-citation
14. Children and Adolescents: Standards of Care in Diabetes—2024
ElSayed, N. A., Aleppo, G., Bannuru, R. R., Bruemmer, D., Collins, B. S., Ekhlaspour, L., Hilliard, M. E., Johnson, E. L., Khunti, K. K., Lingvay, I., et al. (2023) · Diabetes Care · doi:10.2337/dc24-s014 · Cited by 178 · see citing works
Integrated guidance on the care of familial hypercholesterolemia from the International FH Foundation
Watts, G. F., Gidding, S. S., Wierzbicki, A. S., Toth, P. P., Rodrigo Alonso, K., Brown, W. V., Bruckert, É., Defesche, J. C., Lin, K. K., Livingston, M., et al. (2014) · Journal of clinical lipidology · doi:10.1016/j.jacl.2014.01.002 · Cited by 163 · see citing works
Adolescence Risk Factors Are Predictive of Coronary Artery Calcification at Middle Age
Hartiala, O., Magnussen, C. G., Kajander, S. A., Knuuti, J. M., Ukkonen, H., Saraste, A., Rinta-Kiikka, I. C., Kainulainen, S., Kähönen, M. A. P., Hutri‐Kähönen, N., et al. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.05.045 · Cited by 156 · see citing works
Utility of Currently Recommended Pediatric Dyslipidemia Classifications in Predicting Dyslipidemia in Adulthood
Magnussen, C. G., Raitakari, O. T., Thomson, R. J., Juonala, M., Patel, D. A., Viikari, J. S. A., Marniemi, J., Srinivasan, S. R., Berenson, G. S., Dwyer, T., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.718981 · Cited by 150 · see citing works
Management of familial hypercholesterolemia in children and young adults: Consensus paper developed by a panel of lipidologists, cardiologists, paediatricians, nutritionists, gastroenterologists, general practitioners and a patient organization
Descamps, O. S., Tenoutasse, S., Stéphenne, X., Gies, I., Beauloye, V., Lebrethon, M.-C., de Beaufort, C. E., Waele, K. D., Scheen, A. J., Rietzschel, E. R., et al. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.06.016 · Cited by 149 · see citing works
Efficacy and safety of coadministration of ezetimibe and simvastatin in adolescents with heterozygous familial hypercholesterolemia.
van der Graaf, A., Cuffie-Jackson, C., Vissers, M., Trip, M., Gagné, C., Shi, G., Veltri, E., Avis, H., & Kastelein, J. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.09.002 · Cited by 134 · see citing works
Primary Prevention of Cardiovascular Disease in Nursing Practice: Focus on Children and Youth
Hayman, L. L., Meininger, J. C., Daniels, S. R., McCrindle, B. W., Helden, L., Ross, J. D., Dennison, B. A., Steinberger, J., & Williams, C. L. (2007) · Circulation · doi:10.1161/circulationaha.107.184595 · Cited by 147 · see citing works
Self-citation
Familial Hypercholesterolemia
Bouhairie, V. E., & Goldberg, A. C. (2015) · Cardiology Clinics · doi:10.1016/j.ccl.2015.01.001 · Cited by 128 · see citing works
2015 Korean Guidelines for the Management of Dyslipidemia: Executive Summary (English Translation)
Committee for the Korean Guidelines for the Management of Dyslipidemia (2016) · Korean Circulation Journal · doi:10.4070/kcj.2016.46.3.275 · Cited by 124 · see citing works
Familial hypercholesterolemia and elevated lipoprotein(a): double heritable risk and new therapeutic opportunities
Vuorio, A. F., Watts, G. F., Schneider, W. J., Tsimikas, S., & Kovanen, P. T. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12981 · Cited by 118 · see citing works
American Association of Clinical Endocrinologists’ Guidelines for Management of Dyslipidemia and Prevention of Atherosclerosis: Executive Summary
Jellinger, P. S., Smith, D. A., Mehta, A., Ganda, O. P., Handelsman, Y., Rodbard, H. W., Shepherd, M. D., Seibel, J. A., Kreisberg, R. A., & Goldberg, R. B. (2012) · Endocrine Practice · doi:10.4158/ep.18.2.269 · Cited by 112 · see citing works
Childhood risk factors predict cardiovascular disease, impaired fasting glucose plus type 2 diabetes mellitus, and high blood pressure 26 years later at a mean age of 38 years: the Princeton–lipid research clinics follow-up study
Morrison, J. A., Glueck, C. J., & Wang, P. (2011) · Metabolism · doi:10.1016/j.metabol.2011.08.010 · Cited by 109 · see citing works
National Institutes of Health Hematopoietic Cell Transplantation Late Effects Initiative: The Cardiovascular Disease and Associated Risk Factors Working Group Report
Armenian, S. H., Chemaitilly, W., Chen, M. Y., Chow, E. J., Duncan, C., Jones, L. W., Pulsipher, M. A., Remaley, A. T., Rovó, A., Salooja, N., et al. (2016) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2016.08.019 · Cited by 107 · see citing works
Statins for children with familial hypercholesterolemia
Vuorio, A. F., Kuoppala, J., Kovanen, P. T., Humphries, S. E., Tonstad, S., Wiegman, A., Drogari, E., & Ramaswami, U. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006401.pub5 · Cited by 104 · see citing works
Effect of Rosuvastatin on Carotid Intima-Media Thickness in Children With Heterozygous Familial Hypercholesterolemia
Braamskamp, M. J. A. M., Langslet, G., McCrindle, B. W., Cassiman, D. M., Francis, G. A., Gagné, C., Gaudet, D., Morrison, K. M., Wiegman, A., Turner, T. A., et al. (2017) · Circulation · doi:10.1161/circulationaha.116.025158 · Cited by 103 · see citing works
Self-citation
Morphologic and metabolic abnormalities in vertically HIV-infected children and youth
Aldrovandi, G. M., Lindsey, J. C., Jacobson, D. L., Zadzilka, A., Sheeran, E., Moye, J., Borum, P. R., Meyer, W. A., Hardin, D. S., & Mulligan, K. M. (2009) · AIDS · doi:10.1097/qad.0b013e3283269dfb · Cited by 102 · see citing works
Screening for Lipid Disorders in Children: US Preventive Services Task Force Recommendation Statement
US Preventive Services Task Force (2007) · PEDIATRICS · doi:10.1542/peds.2006-1812 · Cited by 99 · see citing works
Trends in the Prevalence of Chronic Medication Use in Children: 2002–2005
Cox, E. R., Halloran, D. R., Homan, S. M., Welliver, S., & MAGER, D. E. (2008) · PEDIATRICS · doi:10.1542/peds.2008-0214 · Cited by 96 · see citing works
Familial hypercholesterolemia: A review
Varghese, M. J. (2014) · Annals of Pediatric Cardiology · doi:10.4103/0974-2069.132478 · Cited by 95 · see citing works
Statin treatment of children with familial hypercholesterolemia – Trying to balance incomplete evidence of long-term safety and clinical accountability: Are we approaching a consensus?
Vuorio, A. F., Docherty, K. F., Humphries, S. E., Kuoppala, J., & Kovanen, P. T. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.10.032 · Cited by 92 · see citing works
Management of metabolic syndrome in children and adolescents
Pacifico, L., Anania, C., Martino, F., Poggiogalle, E., Chiarelli, F., Arca, M., & Chiesa, C. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2011.01.011 · Cited by 89 · see citing works
Glucose Control Predicts 2-Year Change in Lipid Profile in Youth with Type 1 Diabetes
Maahs, D. M., Dabelea, D., D'Agostino, R. B., Andrews, J. S., SHAH, A. S., Crimmins, N. A., Mayer‐Davis, E. J., Marcovina, S. M., Imperatore, G., Wadwa, R. P., et al. (2012) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2012.06.006 · Cited by 89 · see citing works
Self-citation
Pituitary adenomas in childhood, adolescence and young adulthood: presentation, management, endocrine and metabolic outcomes
Steele, C. A., MacFarlane, I. A., Blair, J., Cuthbertson, D. J., Didi, M., Mallucci, C. L., Javadpour, M., & Daousi, C. (2010) · European Journal of Endocrinology · doi:10.1530/eje-10-0519 · Cited by 85 · see citing works
Metabolic syndrome and cardiovascular disease following hematopoietic cell transplantation: screening and preventive practice recommendations from CIBMTR and EBMT
DeFilipp, Z. M., Duarte, R. F., Snowden, J. A., Majhail, N. S., Greenfield, D., López‐Miranda, J., Arat, M., Baker, K. S., Burns, L. J., Duncan, C., et al. (2016) · Bone Marrow Transplantation · doi:10.1038/bmt.2016.203 · Cited by 84 · see citing works
Paediatric screening for hypercholesterolaemia in Europe: Table 1
Kusters, D. M., de Beaufort, C. E., Widhalm, K., Guardamagna, O., Bratina, N., Ose, L., & Wiegman, A. (2011) · Archives of Disease in Childhood · doi:10.1136/archdischild-2011-300081 · Cited by 83 · see citing works
11. Children and Adolescents
American Diabetes Association (2015) · Diabetes Care · doi:10.2337/dc16-s014 · Cited by 82 · see citing works
Lipids, lipid modifying agents and cardiovascular risk: a review of the evidence
Preiss, D., & Sattar, N. (2009) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03490.x · Cited by 92 · see citing works
Cascade Screening for Familial Hypercholesterolemia (FH)
Ned, R. M., & Sijbrands, E. J. G. (2011) · PLoS Currents · doi:10.1371/currents.rrn1238 · Cited by 81 · see citing works
Colesevelam Hydrochloride: Efficacy and Safety in Pediatric Subjects with Heterozygous Familial Hypercholesterolemia
Stein, E. A., Marais, A. D., Szamosi, T., Raal, F. J., Schurr, D., Urbina, E. M., Hopkins, P. N., Karki, S., Xu, J., Misir, S., et al. (2009) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2009.08.037 · Cited by 78 · see citing works
Self-citation
11. Children and Adolescents
American Diabetes Association (2014) · Diabetes Care · doi:10.2337/dc15-s014 · Cited by 77 · see citing works
Risk factors for cardiovascular disease and type 2 diabetes retained from childhood to adulthood predict adult outcomes: the Princeton LRC Follow-up Study
Morrison, J. A., Glueck, C. J., Woo, J. G., & Wang, P. (2012) · International Journal of Pediatric Endocrinology · doi:10.1186/1687-9856-2012-6 · Cited by 76 · see citing works
Vascular health in children and adolescents: effects of obesity and diabetes
Copeland, K. C., Short, K. R., Blackett, & Gardner (2009) · Vascular Health and Risk Management · doi:10.2147/vhrm.s7116 · Cited by 75 · see citing works
The treatment of hypercholesterolemic children: Efficacy and safety of a combination of red yeast rice extract and policosanols
Guardamagna, O., Abello, F., Baracco, V., Stasiowska, B., & Martino, F. (2010) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2009.10.015 · Cited by 74 · see citing works
Monogenic pediatric dyslipidemias: Classification, genetics and clinical spectrum
Rahalkar, A. R., & Hegele, R. A. (2007) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2007.10.007 · Cited by 74 · see citing works
Dietary interventions (plant sterols, stanols, omega-3 fatty acids, soy protein and dietary fibers) for familial hypercholesterolaemia
Malhotra, A., Shafiq, N., Arora, A., Singh, M., Kumar, R., & Malhotra, S. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001918.pub3 · Cited by 72 · see citing works
12. Children and Adolescents
American Diabetes Association (2016) · Diabetes Care · doi:10.2337/dc17-s015 · Cited by 70 · see citing works
Ezetimibe Treatment of Pediatric Patients with Hypercholesterolemia
Clauss, S. B., Wai, K., Kavey, R.-E. W., & KUEHL, K. S. (2009) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2008.12.044 · Cited by 66 · see citing works
Use of Statins for Dyslipidemia in the Pediatric Population
Eiland, L. S., & Luttrell, P. K. (2010) · The Journal of Pediatric Pharmacology and Therapeutics · doi:10.5863/1551-6776-15.3.160 · Cited by 66 · see citing works
Association of Hypercholesterolemia Incidence With Antiretroviral Treatment, Including Protease Inhibitors, Among Perinatally HIV-Infected Children
Tassiopoulos, K., Williams, P. L., Seage, G. R., Crain, M. J., Oleske, J. M., & Farley, J. J. (2008) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3181648e16 · Cited by 65 · see citing works
Metabolic Syndrome and Cardiovascular Disease after Hematopoietic Cell Transplantation: Screening and Preventive Practice Recommendations from the CIBMTR and EBMT
DeFilipp, Z. M., Duarte, R. F., Snowden, J. A., Majhail, N. S., Greenfield, D., López‐Miranda, J., Arat, M., Baker, K. S., Burns, L. J., Duncan, C., et al. (2016) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2016.05.007 · Cited by 64 · see citing works
Ezetimibe-associated adverse effects: what the clinician needs to know
Florentin, M., Liberopoulos, E. N., & Elisaf, M. (2007) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2007.01592.x · Cited by 64 · see citing works
Spectrum and Management of Hypertriglyceridemia Among Children in Clinical Practice
Manlhiot, C., Larsson, P., Gurofsky, R. C., Smith, R. W., Fillingham, C., Clarizia, N. A., Chahal, N., Clarke, J., & McCrindle, B. W. (2009) · PEDIATRICS · doi:10.1542/peds.2008-0367 · Cited by 64 · see citing works
Self-citation
Identification and treatment of metabolic complications in pediatric obesity
Ode, K. L., Frohnert, B. I., & Nathan, B. M. (2009) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-009-9115-7 · Cited by 63 · see citing works
2015 Korean Guidelines for Management of Dyslipidemia
Committee for Guidelines for Management of Dyslipidemia (2015) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2015.4.1.61 · Cited by 64 · see citing works
Long-Term Statin Treatment in Children with Familial Hypercholesterolemia: More Insight into Tolerability and Adherence
Braamskamp, M. J. A. M., Kusters, D. M., Avis, H. J., Smets, E. M. A., Wijburg, F. A., Kastelein, J. J. P., Wiegman, A., & Hutten, B. A. (2015) · Pediatric Drugs · doi:10.1007/s40272-014-0116-y · Cited by 60 · see citing works
An update on the assessment and management of metabolic syndrome, a growing medical emergency in paediatric populations
Mameli, C., Zuccotti, G., Carnovale, C., Galli, E., Nannini, P., Cervia, D., & Perrotta, C. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.01.017 · Cited by 60 · see citing works
Altered Clock and Lipid Metabolism-Related Genes in Atherosclerotic Mice Kept with Abnormal Lighting Condition
Zhu, Z., Hua, B., Shang, Z., Yuan, G., Xu, L., Li, E., Li, X., Sun, N., Yan, Z., Qian, R., et al. (2016) · BioMed Research International · doi:10.1155/2016/5438589 · Cited by 59 · see citing works
Statins for children with familial hypercholesterolemia
Vuorio, A. F., Kuoppala, J., Kovanen, P. T., Humphries, S. E., Strandberg, T. E., Tonstad, S., & Gylling, H. K. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006401.pub2 · Cited by 59 · see citing works
Maternal-foetal epigenetic interactions in the beginning of cardiovascular damage
Claudio Napoli, A., Infante, T., & Casamassimi, A. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr201 · Cited by 57 · see citing works
Dyslipidemia in Youth with Diabetes: To Treat or Not to Treat?
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Authors: McCrindle, B. W., Urbina, E. M., Dennison, B. A., Jacobson, M. S., Steinberger, J., Rocchini, A. P., Hayman, L. L., & Daniels, S. R.
Affiliations: Hospital for Sick Children (CA)
ORCID: McCrindle, Brian W.
Urbina, Elaine M.
Dennison, Barbara A.
Steinberger, Julia
Hayman, Laura L.
Daniels, Stephen R.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2007-04-10
Volume: 115
Issue: 14
Pages: 1948-1967
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/circulationaha.107.181946
OpenAlex: W2070344375
Cited by: 418
References: 153
Citations by year: 2026: 5 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 8 · 2020: 19 · 2019: 11 · 2018: 7 · 2017: 12 · 2016: 18 · 2015: 23 · 2014: 26 · 2013: 32 · 2012: 36
FWCI: 53.43
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Keywords: familial hypercholesterolemia, severe hypercholesterolemia, lipid-lowering therapy, statins, early atherosclerosis, children and adolescents, patient selection, treatment monitoring
MeSH terms: Contraindications, Adolescent, Adult, Age Factors, Anticholesteremic Agents, Hypolipidemic Agents, Arteriosclerosis, Child, Child, Preschool, Cholesterol, Dietary, Clinical Trials as Topic, Combined Modality Therapy, Dietary Fats, Exercise Therapy, Female, Humans, Hyperlipoproteinemia Type II, Hyperlipoproteinemias, Infant, Cholesterol, LDL, Male, Phytotherapy, Middle Aged, Obesity, Risk Factors, Ultrasonography, HIV Infections, HIV Protease Inhibitors, Age of Onset, Disease Progression, Diet, Fat-Restricted, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Metabolic Syndrome, Diabetes Complications, Dyslipidemias

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Drug Therapy of High-Risk Lipid Abnormalities in Children and Adolescents: A Scientific Statement From the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee, Council of Cardiovascular Disease in the Young, With the Council on Cardiovascular Nursing

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