Cited by 1,045Sex and Gender in HealthcareCardiovascular Health and Risk FactorsMenopause: Health Impacts and Treatments

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Sex/Gender Differences in Cardiovascular Disease Prevention: What a Difference a Decade Makes

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Mosca, Lori, Barrett-Connor, Elizabeth, Kass Wenger, Nanette·2011·Circulation

DOI 10.1161/circulationaha.110.968792PMC PMC3362050

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Abstract

O ver the past decade, scientists, healthcare providers, the public, and policy makers have made substantial efforts to improve understanding of the sex/gender* differences in cardiovascular disease (CVD) † and to recognize the importance of heart disease in women.Federal and American Heart Association (AHA) initiatives to raise awareness and to reduce gender disparities in research and clinical care are listed in Table 1.There was a near doubling of the rate of awareness of heart disease as the leading cause of death in women between 1997, when the AHA launched its first campaign for women, and 2009; during that same period, the death rate resulting from CVD decreased by nearly half.[2][3][4] The extent to which efforts to close research gaps and to heighten awareness of heart disease in women are causally linked to lower CVD mortality or have resulted in improved clinical outcomes for women is not established.The purposes of this article are to evaluate contemporary sex/gender differences in the burden of CVD, to assess the impact of recent clinical trials on recommendations for the prevention of CVD in women, and to examine factors that may facilitate or impede quality CVD preventive care in women.Recommendations for the design and analyses of future CVD clinical trials in women are also provided.*Gender is referred to throughout this document as a person's self-representation as male or female or how that person is responded to in social situations on the basis of the individual's gender representation.Gender is shaped by environment and experience.Sex is the classification of female or male according to reproductive organs and functions assigned by chromosomal complement. 1 †Throughout this document, CVD is inclusive of coronary heart disease, stroke, and other atherosclerotic conditions except when national statistics are provided in which CVD encompasses International Classification of Diseases, 10th revision, codes 100 to 199.

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Authors: Mosca, L., Barrett-Connor, E., & Kass Wenger, N.
Affiliations: Emory University (US)
From the Columbia University Medical Center, New York, NY (L.M.); University of California San Diego School of Medicine, La Jolla (E.B.-C.); and Emory University School of Medicine, Atlanta, GA (N.K.W.).
ORCID: Barrett-Connor, Elizabeth
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2011-11-08
Volume: 124
Issue: 19
Pages: 2145-2154
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/circulationaha.110.968792
PMC: PMC3362050
OpenAlex: W2155311570
Cited by: 1,045
References: 91
Citations by year: 2026: 53 · 2025: 97 · 2024: 93 · 2023: 82 · 2022: 106 · 2021: 127 · 2020: 91 · 2019: 79 · 2018: 75 · 2017: 83 · 2016: 40 · 2015: 47 · 2014: 32 · 2013: 27 · 2012: 11
FWCI: 22.30
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (K24HL076346, K24 2HL076346-06)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords: sex differences, gender differences, cardiovascular disease prevention, heart disease in women, cardiovascular mortality, gender disparities in research
MeSH terms: Adult, Aged, Cardiology, Coronary Disease, Female, Health Policy, Humans, Male, Middle Aged, Mortality, Risk Factors, Sex Characteristics, Prevalence, Women's Health, Risk Reduction Behavior

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Sex/Gender Differences in Cardiovascular Disease Prevention: What a Difference a Decade Makes

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