The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Extramedullary Hematopoiesis Generates Ly-6C high Monocytes That Infiltrate Atherosclerotic Lesions
Open accessAbstract
Background—: Atherosclerotic lesions are believed to grow via the recruitment of bone marrow–derived monocytes. Among the known murine monocyte subsets, Ly-6C high monocytes are inflammatory, accumulate in lesions preferentially, and differentiate. Here, we hypothesized that the bone marrow outsources the production of Ly-6C high monocytes during atherosclerosis. Methods and Results—: Using murine models of atherosclerosis and fate-mapping approaches, we show that hematopoietic stem and progenitor cells progressively relocate from the bone marrow to the splenic red pulp, where they encounter granulocyte macrophage colony-stimulating factor and interleukin-3, clonally expand, and differentiate to Ly-6C high monocytes. Monocytes born in such extramedullary niches intravasate, circulate, and accumulate abundantly in atheromata. On lesional infiltration, Ly-6C high monocytes secrete inflammatory cytokines, reactive oxygen species, and proteases. Eventually, they ingest lipids and become foam cells. Conclusions—: Our findings indicate that extramedullary sites supplement the hematopoietic function of the bone marrow by producing circulating inflammatory cells that infiltrate atherosclerotic lesions.
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Citations
Cites
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Monocytes and macrophages: developmental pathways and tissue homeostasis
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Cholesterol, inflammation and innate immunity.
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Local proliferation dominates lesional macrophage accumulation in atherosclerosis
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Metadata
- Authors
- Robbins, C. S., Chudnovskiy, A., Rauch, P. J., Figueiredo, J.-L., Iwamoto, Y., Gorbatov, R., Etzrodt, M., Weber, G. F., Ueno, T., van Rooijen, N., Mulligan-Kehoe, M. J., Libby, P., Nahrendorf, M., Pittet, M. J., Weissleder, R., & Swirski, F. K.
- Venue
- Circulation
- Published
- 2012-01-17
- Volume
- 125
- Issue
- 2
- Pages
- 364-374
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2163486647
- Cited by
- 482
- References
- 52
- FWCI
- 11.66
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Robbins, C. S., Chudnovskiy, A., Rauch, P. J., Figueiredo, J.-L., Iwamoto, Y., Gorbatov, R., Etzrodt, M., Weber, G. F., Ueno, T., van Rooijen, N., Mulligan-Kehoe, M. J., Libby, P., Nahrendorf, M., Pittet, M. J., Weissleder, R., & Swirski, F. K. (2012). Extramedullary Hematopoiesis Generates Ly-6C high Monocytes That Infiltrate Atherosclerotic Lesions. Circulation. https://doi.org/10.1161/circulationaha.111.061986
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