The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Pulse-Wave Analysis: Clinical Evaluation of a Noninvasive, Widely Applicable Method for Assessing Endothelial Function
Open accessAbstract
Currentmethods for assessing vasomotor endothelial function are impractical for use in large studies. We tested the hypothesis that pulse-wave analysis (PWA) combined with provocative pharmacological testing might provide an alternative method. Radial artery waveforms were recorded and augmentation index (AIx) was calculated from derived aortic waveforms. Thirteen subjects received sublingual nitroglycerin (NTG), inhaled albuterol, or placebo. Twelve subjects received NTG, albuterol, and placebo separately during an infusion of N G -monomethyl- l -arginine (LNMMA) or norepinephrine. Twenty-seven hypercholesterolemic subjects and 27 controls received NTG followed by albuterol. Endothelial function was assessed by PWA and forearm blood flow in 27 subjects. Albuterol and NTG both significantly and repeatably reduced AIx ( P <0.001). Only the response to albuterol was inhibited by LNMMA (−9.8±5.5% vs −4.7±2.7%; P =0.02). Baseline AIx was higher in the hypercholesterolemic subjects, who exhibited a reduced response to albuterol ( P =0.02) but not to NTG when compared with matched controls. The responses to albuterol and acetylcholine were correlated ( r =0.5, P =0.02). Consistent with an endothelium-dependent effect, the response to albuterol was substantially inhibited by LNMMA. Importantly, the response to albuterol was reduced in subjects with hypercholesterolemia and was correlated to that of intra-arterial acetylcholine. This methodology provides a simple, repeatable, noninvasive means of assessing endothelial function in vivo.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT
Martin Bland, J., & Altman, D. (1986) · The Lancet · doi:10.1016/s0140-6736(86)90837-8 · Cited by 47,965
Long-Term Follow-Up of Patients With Mild Coronary Artery Disease and Endothelial Dysfunction
Suwaidi, J. A., Hamasaki, S., Higano, S. T., Nishimura, R. A., Holmes, D. R., & Lerman, A. (2000) · Circulation · doi:10.1161/01.cir.101.9.948 · Cited by 2,043
Close Relation of Endothelial Function in the Human Coronary and Peripheral Circulations
Anderson, T. J., Uehata, A., Gerhard, M. D., Meredith, I. T., Knab, S., Delagrange, D., Lieberman, E. H., Ganz, P., Creager, M. A., Yeung, A. C., et al. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00327-4 · Cited by 2,033
Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease.
Vita, J. A., Treasure, C. B., Nabel, E. G., McLenachan, J. M., Fish, R. D., Yeung, A. C., Vekshtein, V. I., Selwyn, A. P., & Ganz, P. (1990) · Circulation · doi:10.1161/01.cir.81.2.491 · Cited by 1,173
The influence of heart rate on augmentation index and central arterial pressure in humans
Wilkinson, I. B., MacCallum, H., Flint, L., Cockcroft, J. R., Newby, D. E., & Webb, D. J. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-1-00263.x · Cited by 1,091
Self-citationImpaired vasodilation of forearm resistance vessels in hypercholesterolemic humans.
Creager, M. A., Cooke, J. P., Mendelsohn, M. E., Gallagher, S. J., Coleman, S. M., Loscalzo, J., & Dzau, V. J. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114688 · Cited by 1,017
Khaw, K.-T. (2001) · BMJ · doi:10.1136/bmj.322.7277.15 · Cited by 1,017
Simvastatin, an HMG–Coenzyme A Reductase Inhibitor, Improves Endothelial Function Within 1 Month
O'Driscoll, G., Green, D., & Taylor, R. R. (1997) · Circulation · doi:10.1161/01.cir.95.5.1126 · Cited by 952
Reproducibility of pulse wave velocity and augmentation index measured by pulse wave analysis
Wilkinson, I. B., Fuchs, S. A., Jansen, I. M., Spratt, J. C., Murray, G. D., Cockcroft, J. R., & Webb, D. J. (1998) · Journal of Hypertension · doi:10.1097/00004872-199816121-00033 · Cited by 924
Self-citationKARAMANOGLU, M., O'ROURKE, M. F., AVOLIO, A. P., & KELLY, R. P. (1993) · European Heart Journal · doi:10.1093/eurheartj/14.2.160 · Cited by 873
Cited by
Photoplethysmography and its application in clinical physiological measurement
Allen, J. (2007) · Physiological Measurement · doi:10.1088/0967-3334/28/3/r01 · Cited by 3,967
Endothelial Function and Dysfunction: Testing and Clinical Relevance
Deanfield, J. E., Halcox, J. P., & Rabelink, T. J. (2007) · Circulation · doi:10.1161/circulationaha.106.652859 · Cited by 2,710
Endothelial cell senescence in aging-related vascular dysfunction
Jia, G., Aroor, A. R., Jia, C., & Sowers, J. R. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.08.008 · Cited by 454
Sharman, J. E., Avolio, A. P., Baulmann, J., Benetos, A., Blacher, J., Blizzard, C. L., Boutouyrie, P., Chen, C.-H., Chowienczyk, P., Cockcroft, J. R., et al. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehw632 · Cited by 231
Self-citationAge-related changes in peripheral pulse timing characteristics at the ears, fingers and toes
Allen, J., & Murray, A. (2002) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1001478 · Cited by 179
Metadata
- Authors
- Wilkinson, I. B., Hall, I. R., MacCallum, H., Mackenzie, I. S., McEniery, C. M., van der Arend, B. J., Shu, Y.-E., MacKay, L. S., Webb, D. J., & Cockcroft, J. R.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2002-01
- Volume
- 22
- Issue
- 1
- Pages
- 147-152
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2121850075
- Cited by
- 371
- References
- 42
- FWCI
- 11.42
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Pulse-Wave Analysis: Clinical Evaluation of a Noninvasive, Widely Applicable Method for Assessing Endothelial Function. https://app.cochat.ai/papers/10.1161/hq0102.101770
- The paper
- Wilkinson, I. B., Hall, I. R., MacCallum, H., Mackenzie, I. S., McEniery, C. M., van der Arend, B. J., Shu, Y.-E., MacKay, L. S., Webb, D. J., & Cockcroft, J. R. (2002). Pulse-Wave Analysis: Clinical Evaluation of a Noninvasive, Widely Applicable Method for Assessing Endothelial Function. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/hq0102.101770
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
