Cited by 345Pregnancy and preeclampsia studiesMicroRNA in disease regulationNeurological Complications and Syndromes

Differential expression profile of microRNAs in human placentas from preeclamptic pregnancies vs normal pregnancies

Zhu, Xiao-ming, Han, Tao, Sargent, Ian L., Yin, Guo-wu, Yao, Yuan-qing·2009·American Journal of Obstetrics and Gynecology

Abstract

Objective The purpose of this study was to perform a comprehensive analysis of the microRNA expression profile in placentas from preeclamptic pregnancies vs normal placentas.Study design Placentas were obtained from patients with (1) mild preeclampsia (n = 8) and (2) severe preeclampsia (n = 15) and (3) in a normal control group (n = 11) with elective cesarean delivery. The microRNA expression profile was assessed by microRNA microarray and real-time reverse transcriptase-polymerase chain reaction analysis.Results Thirty-four microRNAs were expressed differentially in preeclamptic placentas, compared with normal placentas. Of these, 11 microRNAs were overexpressed, and 23 microRNAs were underexpressed in preeclamptic pregnancies. Notably, several microRNA clusters on human chromosome 19q13.42, 13q31.3, Xq26.2, Xq26.3, and 14q32.31 (a human imprinted region) were expressed differentially in preeclamptic placentas. These results were confirmed with the use of real-time polymerase chain reaction for selected microRNAs (miR-210, -152, -411, and so on).Conclusion The results show that 34 microRNAs are deregulated in preeclamptic pregnancies, which suggests the involvement of these microRNAs in the pathogenesis of preeclampsia.

Integrity signals

Registry

Crossref · 10.1016/j.ajog.2008.12.045

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Zhu, X.-M., Han, T., Sargent, I. L., Yin, G.-W., & Yao, Y.-Q.
Affiliations
  • Chinese People's Liberation Army (CN)
  • John Radcliffe Hospital (GB)
  • Tang Du Hospital (CN)
Venue
American Journal of Obstetrics and Gynecology
Publisher
Elsevier BV
Published
2009-06
Volume
200
Issue
6
Pages
661.e1-661.e7
ISSN
0002-9378 (ISSN-L)
OpenAlex
W2057477277
Cited by
345
References
28
Citations by year
2026: 4 · 2025: 10 · 2024: 7 · 2023: 11 · 2022: 14 · 2021: 18 · 2020: 23 · 2019: 31 · 2018: 33 · 2017: 24 · 2016: 21 · 2015: 33 · 2014: 23 · 2013: 27 · 2012: 29
FWCI
24.87
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
Keywords
preeclampsia, microRNA expression, placenta, differential gene expression, miR-210, miR-152, miRNA clusters, preeclampsia pathogenesis
MeSH terms
Adult, Female, Humans, Placenta, Pre-Eclampsia, Pregnancy, Severity of Illness Index, Gene Expression, MicroRNAs

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review