Differential expression profile of microRNAs in human placentas from preeclamptic pregnancies vs normal pregnancies
Abstract
Objective The purpose of this study was to perform a comprehensive analysis of the microRNA expression profile in placentas from preeclamptic pregnancies vs normal placentas.Study design Placentas were obtained from patients with (1) mild preeclampsia (n = 8) and (2) severe preeclampsia (n = 15) and (3) in a normal control group (n = 11) with elective cesarean delivery. The microRNA expression profile was assessed by microRNA microarray and real-time reverse transcriptase-polymerase chain reaction analysis.Results Thirty-four microRNAs were expressed differentially in preeclamptic placentas, compared with normal placentas. Of these, 11 microRNAs were overexpressed, and 23 microRNAs were underexpressed in preeclamptic pregnancies. Notably, several microRNA clusters on human chromosome 19q13.42, 13q31.3, Xq26.2, Xq26.3, and 14q32.31 (a human imprinted region) were expressed differentially in preeclamptic placentas. These results were confirmed with the use of real-time polymerase chain reaction for selected microRNAs (miR-210, -152, -411, and so on).Conclusion The results show that 34 microRNAs are deregulated in preeclamptic pregnancies, which suggests the involvement of these microRNAs in the pathogenesis of preeclampsia.
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The placentas of patients with preeclampsia, as well as those from pregnancies with preeclampsia and SGA, overexpress the microRNA (miR)-210.
“the placentas of patients with preeclampsia(204), as well as those from pregnancies with preeclampsia and SGA(205), overexpress the microRNA (miR)-210”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [204]
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- Authors
- Zhu, X.-M., Han, T., Sargent, I. L., Yin, G.-W., & Yao, Y.-Q.
- Affiliations
- Chinese People's Liberation Army (CN)
- John Radcliffe Hospital (GB)
- Tang Du Hospital (CN)
- ORCID
- Han, Tao
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 200
- Issue
- 6
- Pages
- 661.e1-661.e7
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2057477277
- Cited by
- 345
- References
- 28
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 7 · 2023: 11 · 2022: 14 · 2021: 18 · 2020: 23 · 2019: 31 · 2018: 33 · 2017: 24 · 2016: 21 · 2015: 33 · 2014: 23 · 2013: 27 · 2012: 29
- FWCI
- 24.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
- Keywords
- preeclampsia, microRNA expression, placenta, differential gene expression, miR-210, miR-152, miRNA clusters, preeclampsia pathogenesis
- MeSH terms
- Adult, Female, Humans, Placenta, Pre-Eclampsia, Pregnancy, Severity of Illness Index, Gene Expression, MicroRNAs
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