CoChat
Sign Up
Cited by 166Blood Pressure and Hypertension StudiesHeart Rate Variability and Autonomic ControlCardiovascular Syncope and Autonomic Disorders

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Catheter-Based Renal Nerve Ablation and Centrally Generated Sympathetic Activity in Difficult-to-Control Hypertensive Patients: Prospective Case Series

Brinkmann, Julia, Heusser, Karsten, Schmidt, Bernhard M., Menne, Jan, Klein, Gunnar, Bauersachs, Johann, Haller, Hermann, Sweep, Fred C., Diedrich, Andre, Jordan, Jens, Tank, Jens·2012·Hypertension
DOI 10.1161/hypertensionaha.112.201186
Open this paper in CoChat — free account

Abstract

Endovascular renal nerve ablation has been developed to treat resistant hypertension. In addition to lowering efferent renal sympathetic activation, the intervention may attenuate central sympathetic outflow through decreased renal afferent nerve traffic, as evidenced by a recent case report. We tested the hypothesis in 12 nonpreselected patients with difficult-to-control hypertension (aged 45–74 years) admitted for renal nerve ablation. All patients received ≥3 antihypertensive medications at full doses, including a diuretic. Electrocardiogram, respiration, brachial and finger arterial blood pressure, and muscle sympathetic nerve activity were recorded before and 3 to 6 months after renal nerve ablation. Heart rate and blood pressure variability were analyzed in the time and frequency domain. Pharmacological baroreflex slopes were determined using the modified Oxford bolus technique. Resting heart rate was 61±3 bpm before and 58±2 bpm after ablation ( P =0.4). Supine blood pressure was 157±7/85±4 mm Hg before and 157±6/85±4 mm Hg after ablation ( P =1.0). Renal nerve ablation did not change resting muscle sympathetic nerve activity (before, 34±2 bursts per minute; after, 32±3 bursts per minute P =0.6), heart rate variability, or blood pressure variability. Pharmacological baroreflex control of heart rate and muscle sympathetic nerve activity did not change. We conclude that reduced central sympathetic inhibition may be the exception rather than the rule after renal nerve ablation in unselected patients with difficult-to-control arterial hypertension.

Overview

Integrity signals

Registry

Crossref · 10.1161/hypertensionaha.112.201186

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Cited by

Sorted by citations

See all 166

Related

See all

Metadata

Authors
Brinkmann, J., Heusser, K., Schmidt, B. M., Menne, J., Klein, G., Bauersachs, J., Haller, H., Sweep, F. C., Diedrich, A., Jordan, J., & Tank, J.
Affiliations
  • Vanderbilt University (US)
  • From the Institute of Clinical Pharmacology (J.B., K.H., J.J., J.T.), Department of Nephrology and Hypertension (B.M.S., J.M., H.H.), and Department of Cardiology and Angiology (G.K., J.B.), Hannover Medical School, Hannover, Germany; Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, TN (A.D.); Department of Chemical Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands (F.C.S.).
ORCID
Venue
Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2012-12
Volume
60
Issue
6
Pages
1485-1490
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
DOI
10.1161/hypertensionaha.112.201186
OpenAlex
W2104599770
Cited by
166
References
35
Citations by year
2026: 2 · 2025: 2 · 2023: 5 · 2021: 3 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 7 · 2016: 14 · 2015: 23 · 2014: 41 · 2013: 49 · 2012: 7
FWCI
24.69
Type
journal article
Language
en
Open access
closed
Locations
  • Hypertension (publishedVersion)
  • PubMed (publishedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
Funders
  • Deutsche Forschungsgemeinschaft
  • National Heart, Lung, and Blood Institute (P01HL056693)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
Keywords
renal nerve ablation, resistant hypertension, muscle sympathetic nerve activity, baroreflex sensitivity, heart rate variability, blood pressure variability, renal afferent nerves, sympathetic nervous system
MeSH terms
Aged, Antihypertensive Agents, Blood Pressure, Female, Heart Rate, Humans, Hypertension, Kidney, Male, Middle Aged, Prospective Studies, Sympathectomy, Sympathetic Nervous System, Treatment Outcome, Catheter Ablation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review