Cited by 94Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

Neuroplasticity in stroke recovery. The role of microglia in engaging and modifying synapses and networks

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Sandvig, Ioanna, Augestad, Ingrid Lovise, Håberg, Asta Kristine, Sandvig, Axel·2018·European Journal of Neuroscience

Abstract

Neuroplasticity after ischaemic injury involves both spontaneous rewiring of neural networks and circuits as well as functional responses in neurogenic niches. These events involve complex interactions with activated microglia, which evolve in a dynamic manner over time. Although the exact mechanisms underlying these interactions remain poorly understood, increasing experimental evidence suggests a determining role of pro‐ and anti‐inflammatory microglial activation profiles in shaping both synaptogenesis and neurogenesis. While the inflammatory response of microglia was thought to be detrimental, a more complex profile of the role of microglia in tissue remodelling is emerging. Experimental evidence suggests that microglia in response to injury can rapidly modify neuronal activity and modulate synaptic function, as well as be beneficial for the proliferation and integration of neural progenitor cells (NPC s) from endogenous neurogenic niches into functional networks thereby supporting stroke recovery. The manner in which microglia contribute towards sculpting neural synapses and networks, both in terms of activity‐dependent and homeostatic plasticity, suggests that microglia‐mediated pro‐ and/or anti‐inflammatory activity may significantly contribute towards spontaneous neuronal plasticity after ischaemic lesions. In this review, we first introduce some of the key cellular and molecular mechanisms underlying neuroplasticity in stroke and then proceed to discuss the crosstalk between microglia and endogenous neuroplasticity in response to brain ischaemia with special focus on the engagement of synapses and neural networks and their implications for grey matter integrity and function in stroke repair.

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Crossref · 10.1111/ejn.13959

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Authors
Sandvig, I., Augestad, I. L., Håberg, A. K., & Sandvig, A.
Affiliations
  • Norwegian University of Science and Technology (NO)
  • Faculty of Medicine and Health Sciences Department of Neuromedicine and Movement Science Norwegian University of Science and Technology (NTNU) Trondheim Norway
Corresponding author
Sandvig, Ioanna
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
2018-06
Volume
47
Issue
12
Pages
1414-1428
ISSN
  • 0953-816X (ISSN-L)
  • 1460-9568
OpenAlex
W2803968036
Cited by
94
References
159
Citations by year
2026: 2 · 2025: 12 · 2024: 11 · 2023: 13 · 2022: 14 · 2021: 14 · 2020: 10 · 2019: 15 · 2018: 2
FWCI
0.97
Type
journal article
Language
en
Open access
Locations
  • European Journal of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
Funders
  • The Liaison Committee for Education, Research, and Innovation in Central Norway (Helse Midt-Norge RHF)
  • Joint Research Committee between St Olav´s Hospital and the Faculty of Medicine and Health Sciences, NTNU (Felles Forskingsutvalg)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
neuroplasticity, stroke recovery, microglia, ischemic brain injury, synaptogenesis, neurogenesis, neural progenitor cells, neurogenic niche, microglial activation, inflammation, synaptic plasticity, tissue remodeling
MeSH terms
Animals, Brain Ischemia, Humans, Nerve Net, Neuronal Plasticity, Synapses, Microglia, Stroke, Neurogenesis, Gray Matter

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