Novel scenes improve recollection and recall of words
Abstract
Exploring a novel environment can facilitate subsequent hippocampal long-term potentiation in animals. We report a related behavioral enhancement in humans. In two separate experiments, recollection and free recall, both measures of hippocampus-dependent memory formation, were enhanced for words studied after a 5-min exposure to unrelated novel as opposed to familiar images depicting indoor and outdoor scenes. With functional magnetic resonance imaging, the enhancement was predicted by specific activity patterns observed during novelty exposure in parahippocampal and dorsal prefrontal cortices, regions which are known to be linked to attentional orienting to novel stimuli and perceptual processing of scenes. Novelty was also associated with activation of the substantia nigra/ventral tegmental area of the midbrain and the hippocampus, but these activations did not correlate with contextual memory enhancement. These findings indicate remarkable parallels between contextual memory enhancement in humans and existing evidence regarding contextually enhanced hippocampal plasticity in animals. They provide specific behavioral clues to enhancing hippocampus-dependent memory in humans.
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In humans, exposure to novel photographs before weak encoding events results in a higher proportion of recollected words compared to exposure to familiar pictures.
“The result was a higher proportion of recollected (as opposed to those recognized on the basis of familiarity) words when compared to individuals who were exposed to familiar pictures prior to encoding.”
From A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP (2011) · cites this paper as [74]
Pre-exposure to familiar, emotionally very negative photographs did not cause a comparable enhancement.
“pre-exposure to familiar, but emotionally very negative, photographs did not cause a comparable enhancement.”
From A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP (2011) · cites this paper as [74]
This effect is stronger after 24 hours compared to 30 minutes after encoding.
“This effect was stronger after 24 hours as compared to 30 minutes after encoding [74].”
From A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP (2011) · cites this paper as [74]
Cites
Mesulam, M. (1998) · Brain · doi:10.1093/brain/121.6.1013 · Cited by 3,072 · see citing works
The hippocampal-VTA loop: controlling the entry of information into long-term memory
Lisman, J. E., & Grace, A. A. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.002 · Cited by 1,983 · see citing works
Differential Effects of Early Hippocampal Pathology on Episodic and Semantic Memory
Vargha-Khadem, F., Gadian, D. G., Watkins, K. E., Connelly, A., Van Paesschen, W., & Mishkin, M. (1997) · Science · doi:10.1126/science.277.5324.376 · Cited by 1,746 · see citing works
Neural mechanisms of autonomic, affective, and cognitive integration
Critchley, H. D. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20749 · Cited by 1,214 · see citing works
Floresco, S. B., West, A. R., Ash, B., Moore, H., & Grace, A. A. (2003) · Nature Neuroscience · doi:10.1038/nn1103 · Cited by 1,106 · see citing works
Reward-motivated learning: mesolimbic activation precedes memory formation
Adcock, R. A., Thangavel, A., Whitfield-Gabrieli, S., Knutson, B., & Gabrieli, J. D. E. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.036 · Cited by 977 · see citing works
Binocular Rivalry and Visual Awareness in Human Extrastriate Cortex
Tong, F., Nakayama, K., Vaughan, J. T., & Kanwisher, N. (1998) · Neuron · doi:10.1016/s0896-6273(00)80592-9 · Cited by 866 · see citing works
Neural mechanisms for detecting and remembering novel events
Ranganath, C., & Rainer, G. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1052 · Cited by 779 · see citing works
Das State-Trait-Angstinventar (STAI) : theoretische Grundlagen und Handanweisung
Laux, L. (1981) · Beltz eBooks · Cited by 750 · see citing works
Wittmann, B. C., Schott, B. H., Guderian, S., Frey, J. U., Heinze, H.-J., & Düzel, E. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.010 · Cited by 698 · see citing works
Self-citationÜber die Wirkung von Bereichsbildungen im Spurenfeld
von Restorff, H. (1933) · Psychological Research · doi:10.1007/bf02409636 · Cited by 643 · see citing works
Dopamine-dependent facilitation of LTP induction in hippocampal CA1 by exposure to spatial novelty
Li, S., Cullen, W. K., Anwyl, R., & Rowan, M. J. (2003) · Nature Neuroscience · doi:10.1038/nn1049 · Cited by 568 · see citing works
Effects of extensive temporal lobe damage or mild hypoxia on recollection and familiarity
Yonelinas, A., Kroll, N., Quamme, J., Lazzara, M. M., Sauvé, M., Widaman, K., & Knight, R. (2002) · Nature Neuroscience · doi:10.1038/nn961 · Cited by 554 · see citing works
Absolute Coding of Stimulus Novelty in the Human Substantia Nigra/VTA
Bunzeck, N., & Düzel, E. (2006) · Neuron · doi:10.1016/j.neuron.2006.06.021 · Cited by 503 · see citing works
The Relation between Remembering and Knowing as Bases for Recognition: Effects of Size Congruency
Yonelinas, A., & Jacoby, L. (1995) · Journal of Memory and Language · doi:10.1006/jmla.1995.1028 · Cited by 500 · see citing works
Bernabeu, R., Bevilaqua, L. R., Ardenghi, P. G., Bromberg, E., Schmitz, P. K., Bianchin, M. M., Izquierdo, I., & Medina, J. H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.7041 · Cited by 499 · see citing works
Recollection-like memory retrieval in rats is dependent on the hippocampus
Fortin, N. J., Wright, S. P., & Eichenbaum, H. (2004) · Nature · doi:10.1038/nature02853 · Cited by 460 · see citing works
Event-related brain potential correlates of two states of conscious awareness in memory
Düzel, E., Yonelinas, A. P., Mangun, G. R., Heinze, H., & Tulving, E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.11.5973 · Cited by 443 · see citing works
Self-citationLate-associativity, synaptic tagging, and the role of dopamine during LTP and LTD
Sajikumar, S. (2004) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2004.03.003 · Cited by 341 · see citing works
Novelty encoding networks in the human brain: positron emission tomography data.
Tulving, E., Markowitsch, H., Kapur, S., Habib, R., & Houle, S. (1994) · NeuroReport · doi:10.1097/00001756-199412000-00030 · Cited by 296 · see citing works
Novelty assessment in the brain and long-term memory encoding
Tulving, E., & Kroll, N. (1995) · Psychonomic Bulletin & Review · doi:10.3758/bf03210977 · Cited by 294 · see citing works
The central role of the prefrontal cortex in directing attention to novel events
Daffner, K. R., Mesulam, M. M., Scinto, L. F. M., Acar, D., Calvo, V., Faust, R. R., Chabrerie, A. V., Kennedy, B., & Holcomb, P. J. (2000) · Brain · doi:10.1093/brain/123.5.927 · Cited by 265 · see citing works
Brain activity evidence for recognition without recollection after early hippocampal damage
Düzel, E., Vargha‐Khadem, F., Heinze, H. –., & Mishkin, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.131205798 · Cited by 253 · see citing works
Self-citationDüzel, E., Bunzeck, N., Guitart-Masip, M., & Düzel, S. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.08.006 · Cited by 249 · see citing works
Mechanisms underlying working memory for novel information
Hasselmo, M. E., & Stern, C. E. (2006) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2006.09.005 · Cited by 249 · see citing works
Schott, B. H., Seidenbecher, C. I., Fenker, D. B., Lauer, C. J., Bunzeck, N., Bernstein, H.-G., Tischmeyer, W., Gundelfinger, E. D., Heinze, H.-J., & Düzel, E. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3463-05.2006 · Cited by 214 · see citing works
Self-citationDüzel, E., Habib, R., Rotte, M., Guderian, S., Tulving, E., & Heinze, H. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-28-09439.2003 · Cited by 211 · see citing works
Self-citationYonelinas, A. P., Dobbins, I. G., Szymanski, M. D., Dhaliwal, H. S., & King, L. (1996) · Consciousness and Cognition · doi:10.1006/ccog.1996.0026 · Cited by 211 · see citing works
Rapid Prefrontal-Hippocampal Habituation to Novel Events
Yamaguchi, S. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4587-03.2004 · Cited by 207 · see citing works
Straube, T., Korz, V., Balschun, D., & Frey, J. U. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049452 · Cited by 152 · see citing works
Self-citationAny novelty in hippocampal formation and memory?
Nyberg, L. (2005) · Current Opinion in Neurology · doi:10.1097/01.wco.0000168080.99730.1c · Cited by 136 · see citing works
Davis, C. D., Jones, F. L., & Derrick, B. E. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4970-03.2004 · Cited by 114 · see citing works
Human declarative memory formation: Segregating rhinal and hippocampal contributions
Fernández, G., Klaver, P., Fell, J., Grünwald, T., & Elger, C. E. (2002) · Hippocampus · doi:10.1002/hipo.10050 · Cited by 75 · see citing works
McGaugh, J. D. (2005) · Learning & memory (Cold Spring Harbor, N.Y.) · doi:10.1101/lm.93405 · Cited by 56 · see citing works
Neural correlates of exemplar novelty processing under different spatial attention conditions
Stoppel, C. M., Boehler, C. N., Strumpf, H., Heinze, H., Hopf, J., Düzel, E., & Schoenfeld, M. A. (2009) · Human Brain Mapping · doi:10.1002/hbm.20804 · Cited by 37 · see citing works
Self-citationFour types of novelty–familiarity responses in associative recognition memory of humans
Düzel, E., Habib, R., Guderian, S., & Heinze, H. –. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03253.x · Cited by 34 · see citing works
Self-citationCell Polarity and Subcellular RNA Localization
(2001) · Results and problems in cell differentiation · doi:10.1007/978-3-540-40025-7 · Cited by 32 · see citing works
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van Kesteren, M. T. R., Ruiter, D. J., Fernández, G., & Henson, R. N. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.02.001 · Cited by 860 · see citing works
A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP
Lisman, J., Grace, A. A., & Duzel, E. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.07.006 · Cited by 465 · see citing works
Self-citationDüzel, E., Bunzeck, N., Guitart-Masip, M., & Düzel, S. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.08.006 · Cited by 249 · see citing works
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Yamasaki, M., & Takeuchi, T. (2017) · Neural Plasticity · doi:10.1155/2017/8602690 · Cited by 91 · see citing works
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Wittmann, B. C., Dolan, R. J., & Düzel, E. (2011) · Learning & Memory · doi:10.1101/lm.1996811 · Cited by 62 · see citing works
- Authors
- Fenker, D. B., Frey, J. U., Schuetze, H., Heipertz, D., Heinze, H.-J., & Duzel, E.
- Affiliations
- Otto-von-Guericke-Universität Magdeburg (DE)
- Leibniz Institute for Neurobiology (DE)
- 3University College London, UK
- Venue
- Journal of Cognitive Neuroscience
- Publisher
- MIT Press - Journals
- Published
- 2008-07-01
- Volume
- 20
- Issue
- 7
- Pages
- 1250-1265
- ISSN
- 0898-929X (ISSN-L)
- 1530-8898
- OpenAlex
- W1988899743
- Cited by
- 94
- References
- 37
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 8 · 2021: 14 · 2020: 15 · 2019: 6 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 6 · 2014: 4 · 2012: 4
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cognitive Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- recollection, free recall, hippocampal-dependent memory, hippocampal long-term potentiation, novelty exposure, parahippocampal cortex, dorsal prefrontal cortex, substantia nigra/ventral tegmental area, attentional orienting, scene perception, word memory
- MeSH terms
- Adult, Analysis of Variance, Association Learning, Brain, Brain Mapping, Emotions, Female, Humans, Image Processing, Computer-Assisted, Language, Magnetic Resonance Imaging, Male, Oxygen, Pattern Recognition, Visual, Photic Stimulation, Reaction Time, Mental Recall, Recognition, Psychology
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