Absolute Coding of Stimulus Novelty in the Human Substantia Nigra/VTA
Open accessAbstract
Novelty exploration can enhance hippocampal plasticity in animals through dopaminergic neuromodulation arising in the substantia nigra/ventral tegmental area (SN/VTA). This enhancement can outlast the exploration phase by several minutes. Currently, little is known about dopaminergic novelty processing and its relationship to hippocampal function in humans. In two functional magnetic resonance imaging (fMRI) studies, SN/VTA activations in humans were indeed driven by stimulus novelty rather than other forms of stimulus salience such as rareness, negative emotional valence, or targetness of familiar stimuli, whereas hippocampal responses were less selective. SN/VTA novelty responses were scaled according to absolute rather than relative novelty in a given context, unlike adaptive SN/VTA responses recently reported for reward outcome in animal studies. Finally, novelty enhanced learning and perirhinal/parahippocampal processing of familiar items presented in the same context. Thus, the human SN/VTA can code absolute stimulus novelty and might contribute to enhancing learning in the context of novelty.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The lack of a stronger neural response to the partner under placebo indicates that a partner's neutral face is not inherently more rewarding than a novel woman of equivalent attractiveness.
“The absence of a stronger neural response to the female partner during PLC treatment indicates that the presentation of a partner's neutral expression face is not more rewarding per se than that of a novel female of equivalent attractiveness (40).”
From Oxytocin enhances brain reward system responses in men viewing the face of their female partner (2013) · cites this paper as [40]
The hippocampus and substantia nigra are key to detecting novelty and evaluating its reward value.
“The hippocampus and substantia nigra (a basal ganglia structure) are central to novelty detection and reward evaluation of novelty (Bunzeck and Düzel, 2006; Lisman and Grace, 2005).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Bunzeck and Düzel, 2006
Midbrain DA neurons in the SN/VTA respond to both novelty and reward.
“As midbrain DA neurons in the SN/VTA respond to both novelty and reward62–64, we contrasted new and rewarding stimuli against familiar and nonrewarding stimuli.”
From Acute social isolation evokes midbrain craving responses similar to hunger (2020) · cites this paper as [63]
fMRI studies confirm SN/VTA activation by associative novelty and stimulus novelty but less by other salient events such as rareness or negative emotional content.
“Indeed, fMRI studies (for examples see Box 2 Figure 1) confirm SN/VTA activation by associative novelty [60] and stimulus novelty [61] but less by other salient events such as rareness or negative emotional content [61].”
From A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP (2011) · cites this paper as [61]
Cites
Statistical parametric maps in functional imaging: A general linear approach
Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. ‐., Frith, C. D., & Frackowiak, R. S. J. (1994) · Human Brain Mapping · doi:10.1002/hbm.460020402 · Cited by 9,688 · see citing works
Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564 · see citing works
Squire, L. R., Stark, C. E. L., & Clark, R. E. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144130 · Cited by 2,680 · see citing works
THE AMYGDALA MODULATES THE CONSOLIDATION OF MEMORIES OF EMOTIONALLY AROUSING EXPERIENCES
McGaugh, J. L. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144157 · Cited by 2,296 · see citing works
Event-Related fMRI: Characterizing Differential Responses
Friston, K. J., Fletcher, P. C., Josephs, O., Holmes, A., Rugg, M. D., & Turner, R. (1998) · NeuroImage · doi:10.1006/nimg.1997.0306 · Cited by 2,017 · see citing works
The hippocampal-VTA loop: controlling the entry of information into long-term memory
Lisman, J. E., & Grace, A. A. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.002 · Cited by 1,983 · see citing works
Lang, P. J., Bradley, M. M., & Cuthbert, B. N. (1999) · Cited by 1,664 · see citing works
Recognition memory: What are the roles of the perirhinal cortex and hippocampus?
Brown, M. W., & Aggleton, J. P. (2001) · Nature reviews. Neuroscience · doi:10.1038/35049064 · Cited by 1,555 · see citing works
Adaptive Coding of Reward Value by Dopamine Neurons
Tobler, P. N., Fiorillo, C. D., & Schultz, W. (2005) · Science · doi:10.1126/science.1105370 · Cited by 1,276 · see citing works
Baxter, M. G., & Murray, E. A. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn875 · Cited by 1,200 · see citing works
Reward-motivated learning: mesolimbic activation precedes memory formation
Adcock, R. A., Thangavel, A., Whitfield-Gabrieli, S., Knutson, B., & Gabrieli, J. D. E. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.036 · Cited by 977 · see citing works
Mesolimbocortical and nigrostriatal dopamine responses to salient non-reward events
Horvitz, J. C. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00019-1 · Cited by 967 · see citing works
The Amygdala: a functional analysis
Aggleton, J. P. (2000) · Cited by 964 · see citing works
Endogenous Potentials Generated in the Human Hippocampal Formation and Amygdala by Infrequent Events
Halgren, E., Squires, N. K., Wilson, C. L., Rohrbaugh, J., Babb, T. L., & Crandall, P. H. (1980) · Science · doi:10.1126/science.7434000 · Cited by 778 · see citing works
Wittmann, B. C., Schott, B. H., Guderian, S., Frey, J. U., Heinze, H.-J., & Düzel, E. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.010 · Cited by 698 · see citing works
Self-citationSynaptic tagging: implications for late maintenance of hippocampal long-term potentiation
Frey, U., & Morris, R. G. M. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01189-2 · Cited by 615 · see citing works
Dopamine-dependent facilitation of LTP induction in hippocampal CA1 by exposure to spatial novelty
Li, S., Cullen, W. K., Anwyl, R., & Rowan, M. J. (2003) · Nature Neuroscience · doi:10.1038/nn1049 · Cited by 568 · see citing works
Novelty and Familiarity Activations in PET Studies of Memory Encoding and Retrieval
Tulving, E., Markowitsch, H. J., Craik, F. I. M., Habib, R., & Houle, S. (1996) · Cerebral Cortex · doi:10.1093/cercor/6.1.71 · Cited by 558 · see citing works
Conditioned stimulus as a determinant of the form of the Pavlovian conditioned response.
Holland, P. C. (1977) · Journal of experimental psychology. Animal behavior processes · doi:10.1037/0097-7403.3.1.77 · Cited by 553 · see citing works
Conditioned stimulus as a determinant of the form of the Pavlovian conditioned response.
Holland, P. C. (1977) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037//0097-7403.3.1.77 · Cited by 514 · see citing works
Is the short-latency dopamine response too short to signal reward error?
Redgrave, P., Prescott, T. J., & Gurney, K. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01373-3 · Cited by 506 · see citing works
Dopamine: generalization and bonuses
Kakade, S. M., & Dayan, P. (2002) · Neural Networks · doi:10.1016/s0893-6080(02)00048-5 · Cited by 477 · see citing works
Human striatal response to salient nonrewarding stimuli
Zink, C. F., Pagnoni, G., Martin, M. E., Dhamala, M., & Berns, G. S. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-22-08092.2003 · Cited by 312 · see citing works
How visual stimuli activate dopaminergic neurons at short latency
Dommett, E., Coizet, V., Blaha, C. D., Martindale, J., Lefebvre, V., Walton, N., Mayhew, J. E. W., Overton, P. G., & Redgrave, P. (2005) · Science · doi:10.1126/science.1107026 · Cited by 285 · see citing works
Brain activity evidence for recognition without recollection after early hippocampal damage
Düzel, E., Vargha‐Khadem, F., Heinze, H. –., & Mishkin, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.131205798 · Cited by 253 · see citing works
Self-citationLevodopa: Faster and better word learning in normal humans
Knecht, S., Breitenstein, C., Bushuven, S., Wailke, S., Kamping, S., Flöel, A., Zwitserlood, P., & Ringelstein, E. B. (2004) · Annals of Neurology · doi:10.1002/ana.20125 · Cited by 246 · see citing works
Schott, B. H., Seidenbecher, C. I., Fenker, D. B., Lauer, C. J., Bunzeck, N., Bernstein, H.-G., Tischmeyer, W., Gundelfinger, E. D., Heinze, H.-J., & Düzel, E. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3463-05.2006 · Cited by 214 · see citing works
Self-citationDüzel, E., Habib, R., Rotte, M., Guderian, S., Tulving, E., & Heinze, H. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-28-09439.2003 · Cited by 211 · see citing works
Self-citationRapid Prefrontal-Hippocampal Habituation to Novel Events
Yamaguchi, S. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4587-03.2004 · Cited by 207 · see citing works
Ungless, M. A. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.10.001 · Cited by 190 · see citing works
Straube, T., Korz, V., Balschun, D., & Frey, J. U. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049452 · Cited by 152 · see citing works
Eckert, T., Sailer, M., Kaufmann, J., Schrader, C., Peschel, T., Bodammer, N., Heinze, H., & Schoenfeld, M. A. (2003) · NeuroImage · doi:10.1016/j.neuroimage.2003.08.028 · Cited by 150 · see citing works
Schott, B. H., Sellner, D., Lauer, C., Habib, R., Frey, J. U., Guderian, S., Heinze, H., & Düzel, E. (2004) · Learning & Memory · doi:10.1101/lm.75004 · Cited by 130 · see citing works
Self-citationReproducibility of BOLD-based functional MRI obtained at 4 T
Tegeler, C., Strother, S. C., Anderson, J. R., & Kim, S. (1999) · Human Brain Mapping · doi:10.1002/(sici)1097-0193(1999)7:4 · Cited by 121 · see citing works
Hinrichs, H., Scholz, M., Tempelmann, C., Woldorff, M. G., Dale, A. M., & Heinze, H. (2000) · Journal of Cognitive Neuroscience · doi:10.1162/089892900564082 · Cited by 118 · see citing works
Adaptive anterior hippocampal responses to oddball stimuli
Strange, B. A., & Dolan, R. J. (2001) · Hippocampus · doi:10.1002/hipo.1084 · Cited by 117 · see citing works
Davis, C. D., Jones, F. L., & Derrick, B. E. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4970-03.2004 · Cited by 114 · see citing works
Relationship between priming and recognition in deterministic and probabilistic sequence learning.
Shanks, D. R., Wilkinson, L., & Channon, S. (2003) · Journal of Experimental Psychology Learning Memory and Cognition · doi:10.1037/0278-7393.29.2.248 · Cited by 105 · see citing works
Role of Amygdalo-Nigral Circuitry in Conditioning of a Visual Stimulus Paired with Food
Lee, H. J., Groshek, F., Petrovich, G. D., Cantalini, J. P., Gallagher, M., & Holland, P. C. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0416-05.2005 · Cited by 101 · see citing works
Phasic activation of locus ceruleus neurons by the central nucleus of the amygdala
Bouret, S., Duvel, A., Onat, S., & Sara, S. J. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03491.2003 · Cited by 84 · see citing works
Liu, Z., Richmond, B. J., Murray, E. A., Saunders, R. C., Steenrod, S. C., Stubblefield, B. K., Montague, D. M., & Ginns, E. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403639101 · Cited by 77 · see citing works
Reed, P., Mitchell, C., & Nokes, T. (1996) · Animal Learning & Behavior · doi:10.3758/bf03198952 · Cited by 59 · see citing works
Hippocampal involvement in detection of deviant auditory and visual stimuli
Crottaz‐Herbette, S., Lau, K. M., Glover, G. H., & Menon, V. (2004) · Hippocampus · doi:10.1002/hipo.20039 · Cited by 39 · see citing works
Red nucleus: role in motor control
Houk, J. (1991) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(05)80037-6 · Cited by 29 · see citing works
Worsley (1996) · doi:10.1002/(sici)1097-0193(1996)4:1
Episodic memory, semantic memory, and amnesia
Squire, L. R., & Zola, S. M. (1998) · Hippocampus · doi:10.1002/(sici)1098-1063(1998)8:3
Flagged first, then by citations
Cited by
Sorted by citations
The reward circuit: linking primate anatomy and human imaging
Haber, S. N., & Knutson, B. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.129 · Cited by 3,718 · see citing works
Lisman, J. E., Coyle, J. T., Green, R. W., Javitt, D. C., Benes, F. M., Heckers, S., & Grace, A. A. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.02.005 · Cited by 1,010 · see citing works
Consciousness without a cerebral cortex: A challenge for neuroscience and medicine
Merker, B. (2007) · Behavioral and Brain Sciences · doi:10.1017/s0140525x07000891 · Cited by 868 · see citing works
Active inference and epistemic value
Friston, K., Rigoli, F., Ognibene, D., Mathys, C., Fitzgerald, T., & Pezzulo, G. (2015) · Cognitive Neuroscience · doi:10.1080/17588928.2015.1020053 · Cited by 731 · see citing works
Hierarchically organized behavior and its neural foundations: A reinforcement learning perspective
Botvinick, M. M., Niv, Y., & Barto, A. G. (2009) · Cognition · doi:10.1016/j.cognition.2008.08.011 · Cited by 646 · see citing works
BOLD responses reflecting dopaminergic signals in the human ventral tegmental area
D'Ardenne, K., McClure, S. M., Nystrom, L. E., & Cohen, J. D. (2008) · Science · doi:10.1126/science.1150605 · Cited by 661 · see citing works
How prediction errors shape perception, attention, and motivation
den Ouden, H. E. M., Kok, P., & de Lange, F. P. (2012) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00548 · Cited by 512 · see citing works
Schott, B. H., Minuzzi, L., Krebs, R. M., Elmenhorst, D., Lang, M., Winz, O. H., Seidenbecher, C. I., Coenen, H. H., Heinze, H.-J., Zilles, K., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2058-08.2008 · Cited by 496 · see citing works
Self-citationA neoHebbian framework for episodic memory; role of dopamine-dependent late LTP
Lisman, J., Grace, A. A., & Duzel, E. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.07.006 · Cited by 465 · see citing works
Self-citationGambling near-misses enhance motivation to gamble and recruit win-related brain circuitry
Clark, L., Lawrence, A. J., Astley-Jones, F., & Gray, N. (2009) · Neuron · doi:10.1016/j.neuron.2008.12.031 · Cited by 410 · see citing works
Barto, A., Mirolli, M., & Baldassarre, G. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00907 · Cited by 397 · see citing works
“The novelty bonus idea has recently attracted much attention, and it is fostering a number of neuroimaging studies where the activation of the dopaminergic system is studied while subjects are exposed to novel stimuli (e.g., Bunzeck and Duzel, 2006; Wittmann et al., 2008; Krebs et al., 2009).”
BackgroundBrydon, L., Harrison, N. A., Walker, C., Steptoe, A., & Critchley, H. D. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.12.007 · Cited by 381 · see citing works
Hierarchical Prediction Errors in Midbrain and Basal Forebrain during Sensory Learning
Iglesias, S., Mathys, C., Brodersen, K. H., Kasper, L., Piccirelli, M., den Ouden, H. E. M., & Stephan, K. E. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.009 · Cited by 342 · see citing works
Oxytocin enhances brain reward system responses in men viewing the face of their female partner
Scheele, D., Wille, A., Kendrick, K. M., Stoffel-Wagner, B., Becker, B., Güntürkün, O., Maier, W., & Hurlemann, R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1314190110 · Cited by 345 · see citing works
Embedding reward signals into perception and cognition
Pessoa, L. (2010) · Frontiers in Neuroscience · doi:10.3389/fnins.2010.00017 · Cited by 279 · see citing works
Acute social isolation evokes midbrain craving responses similar to hunger
Tomova, L., Wang, K. L., Thompson, T., Matthews, G. A., Takahashi, A., Tye, K. M., & Saxe, R. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-00742-z · Cited by 283 · see citing works
Striatal activity underlies novelty-based choice in humans
Wittmann, B. C., Daw, N. D., Seymour, B., & Dolan, R. J. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.027 · Cited by 277 · see citing works
Dopamine modulates novelty seeking behavior during decision making.
Costa, V. D., Tran, V. L., Turchi, J., & Averbeck, B. B. (2014) · Behavioral Neuroscience · doi:10.1037/a0037128 · Cited by 263 · see citing works
Düzel, E., Bunzeck, N., Guitart-Masip, M., & Düzel, S. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.08.006 · Cited by 249 · see citing works
Self-citationThe dopaminergic midbrain encodes the expected certainty about desired outcomes
Schwartenbeck, P., FitzGerald, T. H. B., Mathys, C., Dolan, R., & Friston, K. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhu159 · Cited by 219 · see citing works
Dopaminergic basis of salience dysregulation in psychosis
Winton-Brown, T. T., Fusar-Poli, P., Ungless, M. A., & Howes, O. D. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2013.11.003 · Cited by 231 · see citing works
Post-learning hippocampal dynamics promote preferential retention of rewarding events
Gruber, M. J., Ritchey, M., Wang, S.-F., Doss, M. K., & Ranganath, C. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.017 · Cited by 212 · see citing works
Functional imaging of the human dopaminergic midbrain
Düzel, E., Bunzeck, N., Guitart-Masip, M., Wittmann, B., Schott, B. H., & Tobler, P. N. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.02.005 · Cited by 216 · see citing works
Self-citationGroppe, S. E., Gossen, A., Rademacher, L., Hahn, A., Westphal, L., Gründer, G., & Spreckelmeyer, K. N. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.12.023 · Cited by 218 · see citing works
Pain and analgesia: the value of salience circuits
Borsook, D., Edwards, R., Elman, I., Becerra, L., & Levine, J. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.02.003 · Cited by 215 · see citing works
Planning and navigation as active inference
Kaplan, R., & Friston, K. J. (2018) · Biological Cybernetics · doi:10.1007/s00422-018-0753-2 · Cited by 203 · see citing works
Guitart-Masip, M., Fuentemilla, L., Bach, D. R., Huys, Q. J. M., Dayan, P., Dolan, R. J., & Duzel, E. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6376-10.2011 · Cited by 216 · see citing works
Bhattacharyya, S. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.161 · Cited by 203 · see citing works
Solié, C., Girard, B., Righetti, B., Tapparel, M., & Bellone, C. (2022) · Nature Neuroscience · doi:10.1038/s41593-021-00972-9 · Cited by 186 · see citing works
Dooley, L. N., Kuhlman, K. R., Robles, T. F., Eisenberger, N. I., Craske, M. G., & Bower, J. E. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.006 · Cited by 176 · see citing works
Bariselli, S., Hörnberg, H., Prévost-Solié, C., Musardo, S., Hatstatt-Burklé, L., Scheiffele, P., & Bellone, C. (2018) · Nature Communications · doi:10.1038/s41467-018-05382-3 · Cited by 171 · see citing works
The role of the hippocampus in memory and mental construction
Sheldon, S., & Levine, B. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13006 · Cited by 155 · see citing works
A psychological and neuroanatomical model of obsessive-compulsive disorder
Huey, E. D., Zahn, R., Krueger, F., Moll, J., Kapogiannis, D., Wassermann, E. M., & Grafman, J. (2008) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.2008.20.4.390 · Cited by 152 · see citing works
Anterior hippocampus and goal-directed spatial decision making
Viard, A., Doeller, C. F., Hartley, T., Bird, C. M., & Burgess, N. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4640-10.2011 · Cited by 144 · see citing works
Novelty, conditioning and attentional bias to sexual rewards
Banca, P., Morris, L. S., Mitchell, S., Harrison, N. A., Potenza, M. N., & Voon, V. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.10.017 · Cited by 137 · see citing works
Krebs, R. M., Heipertz, D., Schuetze, H., & Duzel, E. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.06.038 · Cited by 135 · see citing works
Krebs, R. M., Schott, B. H., & Düzel, E. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.019 · Cited by 129 · see citing works
Role of nicotinic acetylcholine receptors in regulating dopamine neuron activity
Faure, P., Tolu, S., Valverde, S., & Naudé, J. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.05.040 · Cited by 125 · see citing works
Contextual novelty changes reward representations in the striatum
Guitart-Masip, M., Bunzeck, N., Stephan, K. E., Dolan, R. J., & Düzel, E. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5331-09.2010 · Cited by 104 · see citing works
Self-citationChoking on the money: reward-based performance decrements are associated with midbrain activity
Mobbs, D., Hassabis, D., Seymour, B., Marchant, J. L., Weiskopf, N., Dolan, R. J., & Frith, C. D. (2009) · Psychological Science · doi:10.1111/j.1467-9280.2009.02399.x · Cited by 103 · see citing works
Dopaminergic basis for signaling belief updates, but not surprise, and the link to paranoia
Nour, M. M., Dahoun, T., Schwartenbeck, P., Adams, R. A., FitzGerald, T. H. B., Coello, C., Wall, M. B., Dolan, R. J., & Howes, O. D. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1809298115 · Cited by 101 · see citing works
Novel scenes improve recollection and recall of words
Fenker, D. B., Frey, J. U., Schuetze, H., Heipertz, D., Heinze, H.-J., & Duzel, E. (2008) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2008.20086 · Cited by 94 · see citing works
Harrison, N. A., Cercignani, M., Voon, V., & Critchley, H. D. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.222 · Cited by 89 · see citing works
Hirshhorn, M., Grady, C., Rosenbaum, R. S., Winocur, G., & Moscovitch, M. (2012) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2012.08.008 · Cited by 85 · see citing works
Sleep and dreaming are for important matters
Perogamvros, L., Dang-Vu, T. T., Desseilles, M., & Schwartz, S. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00474 · Cited by 77 · see citing works
“By contrast, VTA bursting activity is elevated during REM sleep of rats, up to levels observed during reward and punisher anticipation (Carter et al., 2009) and response to stimulus novelty (Bunzeck and Duzel, 2006; Wittmann et al., 2007; Krebs et al., 2011) at wake.”
BackgroundPlace field assembly distribution encodes preferred locations
Mamad, O., Stumpp, L., McNamara, H. M., Ramakrishnan, C., Deisseroth, K., Reilly, R. B., & Tsanov, M. (2017) · PLoS Biology · doi:10.1371/journal.pbio.2002365 · Cited by 73 · see citing works
Brain structures implicated in inflammation-associated depression
Harrison, N. A. (2016) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2016_30 · Cited by 74 · see citing works
Action-specific value signals in reward-related regions of the human brain
FitzGerald, T. H. B., Friston, K. J., & Dolan, R. J. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3254-12.2012 · Cited by 68 · see citing works
Neural Circuitry of Salience and Reward Processing in Psychosis
Kesby, J. P., Murray, G. K., & Knolle, F. (2023) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2021.12.003 · Cited by 55 · see citing works
Modulation of midbrain neurocircuitry by intranasal insulin
Edwin Thanarajah, S., Iglesias, S., Kuzmanovic, B., Rigoux, L., Stephan, K. E., Brüning, J. C., & Tittgemeyer, M. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.03.050 · Cited by 55 · see citing works
Winton-Brown, T., Schmidt, A., Roiser, J. P., Howes, O. D., Egerton, A., Fusar-Poli, P., Bunzeck, N., Grace, A. A., Duzel, E., Kapur, S., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.174 · Cited by 51 · see citing works
Self-citationMeyer, B., Mann, C., Götz, M., Gerlicher, A., Saase, V., Yuen, K. S. L., Aedo-Jury, F., Gonzalez-Escamilla, G., Stroh, A., & Kalisch, R. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.3128-18.2019 · Cited by 43 · see citing works
Deficits in context-dependent adaptive coding of reward in schizophrenia
Kirschner, M., Hager, O. M., Bischof, M., Hartmann-Riemer, M. N., Kluge, A., Seifritz, E., Tobler, P. N., & Kaiser, S. (2016) · npj Schizophrenia · doi:10.1038/npjschz.2016.20 · Cited by 43 · see citing works
Altered salience processing in attention deficit hyperactivity disorder
Tegelbeckers, J., Bunzeck, N., Duzel, E., Bonath, B., Flechtner, H., & Krauel, K. (2015) · Human Brain Mapping · doi:10.1002/hbm.22755 · Cited by 42 · see citing works
Self-citationSethi, A., Voon, V., Critchley, H. D., Cercignani, M., & Harrison, N. A. (2018) · Brain · doi:10.1093/brain/awy048 · Cited by 36 · see citing works
Neural circuitry of novelty salience processing in psychosis risk: Association with clinical outcome
Modinos, G., Allen, P., Zugman, A., Dima, D., Azis, M., Samson, C., Bonoldi, I., Quinn, B., Gifford, G. W. G., Smart, S. E., et al. (2020) · Schizophrenia Bulletin · doi:10.1093/schbul/sbz089 · Cited by 31 · see citing works
Midbrain fMRI: Applications, Limitations and Challenges
Düzel, E., Guitart-Masip, M., Maass, A., Hämmerer, D., Betts, M. J., Speck, O., Weiskopf, N., & Kanowski, M. (2015) · Biological Magnetic Resonance · doi:10.1007/978-1-4899-7591-1_20 · Cited by 16 · see citing works
Self-citationNeural activations associated with feedback and retrieval success.
Wiklund-Hörnqvist, C., Andersson, M., Jonsson, B., & Nyberg, L. (2017) · npj Science of Learning · doi:10.1038/s41539-017-0013-6 · Cited by 10 · see citing works
- Authors
- Bunzeck, N., & Düzel, E.
- Affiliations
- University College London (GB)
- Corresponding author
- Düzel, Emrah
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2006-08
- Volume
- 51
- Issue
- 3
- Pages
- 369-379
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2059763388
- Cited by
- 503
- References
- 46
- Citations by year
- 2026: 17 · 2025: 28 · 2024: 45 · 2023: 29 · 2022: 23 · 2021: 25 · 2020: 40 · 2019: 21 · 2018: 29 · 2017: 28 · 2016: 24 · 2015: 30 · 2014: 21 · 2013: 26 · 2012: 24
- FWCI
- 8.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2578 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (KFO 163)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- stimulus novelty, substantia nigra, ventral tegmental area, dopaminergic modulation, hippocampal plasticity, perirhinal cortex, parahippocampal cortex, emotional valence
- MeSH terms
- Adolescent, Adult, Brain Mapping, Exploratory Behavior, Female, Humans, Learning, Male, Photic Stimulation, Psychomotor Performance, Substantia Nigra, Ventral Tegmental Area
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
