The dopaminergic midbrain participates in human episodic memory formation: evidence from genetic imaging
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Recent data from animal studies raise the possibility that dopaminergic neuromodulation promotes the encoding of novel stimuli. We investigated a possible role for the dopaminergic midbrain in human episodic memory by measuring how polymorphisms in dopamine clearance pathways affect encoding-related brain activity (functional magnetic resonance imaging) in an episodic memory task. In 51 young, healthy adults, successful episodic encoding was associated with activation of the substantia nigra. This midbrain activation was modulated by a functional variable number of tandem repeat (VNTR) polymorphism in the dopamine transporter (DAT1) gene. Despite no differences in memory performance between genotype groups, carriers of the (low expressing) 9-repeat allele of the DAT1 VNTR showed relatively higher midbrain activation when compared with subjects homozygous for the 10-repeat allele, who express DAT1 at higher levels. The catechol-O-methyl transferase (COMT) Val108/158Met polymorphism, which is known to modulate enzyme activity, affected encoding-related activity in the right prefrontal cortex (PFC) and in occipital brain regions but not in the midbrain. Moreover, subjects homozygous for the (low activity) Met allele showed stronger functional coupling between the PFC and the hippocampus during encoding. Our finding that genetic variations in the dopamine clearance pathways affect encoding-related activation patterns in midbrain and PFC provides strong support for a role of dopaminergic neuromodulation in human episodic memory formation. It also supports the hypothesis of anatomically and functionally distinct roles for DAT1 and COMT in dopamine metabolism, with DAT1 modulating rapid, phasic midbrain activity and COMT being particularly involved in prefrontal dopamine clearance.
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DAT is much less abundant in the hippocampus than in the striatum.
“The dopamine transporter (DAT), which rapidly clears dopamine from the synaptic cleft, is much less abundant in the hippocampus than in the striatum [75]”
From A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP (2011) · cites this paper as [75]
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An Introduction to the Bootstrap
Efron, B., & Tibshirani, R. J. (1993) · doi:10.1007/978-1-4899-4541-9 · Cited by 21,230 · see citing works
Episodic memory: from mind to brain
Tulving, E. (2002) · Annual Review of Psychology · doi:10.1146/annurev.psych.53.100901.135114 · Cited by 4,950 · see citing works
da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,012 · see citing works
Egan, M. F., Kojima, M., Callicott, J. H., Goldberg, T. E., Kolachana, B. S., Bertolino, A., Zaitsev, E., Gold, B., Goldman, D., Dean, M., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00035-7 · Cited by 3,888 · see citing works
Psychophysiological and Modulatory Interactions in Neuroimaging
Friston, K. J., Buechel, C., Fink, G. R., Morris, J., Rolls, E., & Dolan, R. J. (1997) · NeuroImage · doi:10.1006/nimg.1997.0291 · Cited by 3,097 · see citing works
Squire, L. R., Stark, C. E. L., & Clark, R. E. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144130 · Cited by 2,680 · see citing works
Effect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia
Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E., Goldman, D. A., & Weinberger, D. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111134598 · Cited by 2,374 · see citing works
Serotonin transporter genetic variation and the response of the human amygdala.
Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., Egan, M. F., & Weinberger, D. R. (2002) · Science · doi:10.1126/science.1071829 · Cited by 2,340 · see citing works
Region of interest analysis using an SPM toolbox
Brett, M. (2002) · NeuroImage · Cited by 2,273 · see citing works
The hippocampal-VTA loop: controlling the entry of information into long-term memory
Lisman, J. E., & Grace, A. A. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.002 · Cited by 1,983 · see citing works
Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., Egan, M. F., Mattay, V. S., Hariri, A. R., & Weinberger, D. R. (2005) · Nature Neuroscience · doi:10.1038/nn1463 · Cited by 1,980 · see citing works
Differential Effects of Early Hippocampal Pathology on Episodic and Semantic Memory
Vargha-Khadem, F., Gadian, D. G., Watkins, K. E., Connelly, A., Van Paesschen, W., & Mishkin, M. (1997) · Science · doi:10.1126/science.277.5324.376 · Cited by 1,746 · see citing works
Building Memories: Remembering and Forgetting of Verbal Experiences as Predicted by Brain Activity
Wagner, A. D., Schacter, D. L., Rotte, M., Koutstaal, W., Maril, A., Dale, A. M., Rosen, B. R., & Buckner, R. L. (1998) · Science · doi:10.1126/science.281.5380.1188 · Cited by 1,620 · see citing works
Patterns of Brain Activation in People at Risk for Alzheimer's Disease
Bookheimer, S. Y., Strojwas, M. H., Cohen, M. S., Saunders, A. M., Pericak-Vance, M. A., Mazziotta, J. C., & Small, G. W. (2000) · New England Journal of Medicine · doi:10.1056/nejm200008173430701 · Cited by 1,328 · see citing works
Lotta, T. I., Vidgren, J., Tilgmann, C., Ulmanen, I., Melén, K., Julkunen, I., & Taskinen, J. (1995) · Biochemistry · doi:10.1021/bi00013a008 · Cited by 1,167 · see citing works
Gitelman, D. R., Penny, W. D., Ashburner, J., & Friston, K. J. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00058-2 · Cited by 799 · see citing works
Profound neuronal plasticity in response to inactivation of the dopamine transporter.
Jones, S., Gainetdinov, R., Jaber, M., Giros, B., Wightman, R., & Caron, M. (1998) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.95.7.4029 · Cited by 729 · see citing works
Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter
Heinz, A., Braus, D. F., Smolka, M. N., Wrase, J., Puls, I., Hermann, D., Vollstädt‐Klein, S., Grüsser, S. M., Flor, H., Schumann, G., et al. (2004) · Nature Neuroscience · doi:10.1038/nn1366 · Cited by 700 · see citing works
Wittmann, B. C., Schott, B. H., Guderian, S., Frey, J. U., Heinze, H.-J., & Düzel, E. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.010 · Cited by 698 · see citing works
Self-citationDopaminergic innervation of the cerebral cortex: unexpected differences between rodents and primates
Berger, B., Gaspar, P., & Verney, C. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90179-x · Cited by 588 · see citing works
Sesack, S. R., Hawrylak, V. A., Matus, C., Guido, M. A., & Levey, A. I. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-07-02697.1998 · Cited by 582 · see citing works
Separate Neural Bases of Two Fundamental Memory Processes in the Human Medial Temporal Lobe
Gabrieli, J. D. E., Brewer, J. B., Desmond, J. E., & Glover, G. H. (1997) · Science · doi:10.1126/science.276.5310.264 · Cited by 569 · see citing works
Dopamine-dependent facilitation of LTP induction in hippocampal CA1 by exposure to spatial novelty
Li, S., Cullen, W. K., Anwyl, R., & Rowan, M. J. (2003) · Nature Neuroscience · doi:10.1038/nn1049 · Cited by 568 · see citing works
Bach, M. E., Barad, M., Son, H., Zhuo, M., Lü, Y.-F., Shih, R., Mansuy, I. M., Hawkins, R. D., & Kandel, E. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.5280 · Cited by 561 · see citing works
Genotype Influences In Vivo Dopamine Transporter Availability in Human Striatum
Heinz, A. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00099-8 · Cited by 538 · see citing works
Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype
Meyer-Lindenberg, A., Kohn, P. D., Kolachana, B., Kippenhan, S., McInerney-Leo, A., Nussbaum, R., Weinberger, D. R., & Berman, K. F. (2005) · Nature Neuroscience · doi:10.1038/nn1438 · Cited by 428 · see citing works
Tunbridge, E. M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1124-04.2004 · Cited by 418 · see citing works
The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression
Fuke, S., Suo, S., Takahashi, N., Koike, H., Sasagawa, N., & Ishiura, S. (2001) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500026 · Cited by 415 · see citing works
Lisman, J. E., & Otmakhova, N. A. (2001) · Hippocampus · doi:10.1002/hipo.1071 · Cited by 402 · see citing works
Dopaminergic modulation of cortical function in patients with Parkinson's disease
Mattay, V. S., Tessitore, A., Callicott, J. H., Bertolino, A., Goldberg, T. E., Chase, T. N., Hyde, T. M., & Weinberger, D. R. (2002) · Annals of Neurology · doi:10.1002/ana.10078 · Cited by 402 · see citing works
Cools, R., Stefanova, E. D., Barker, R., Robbins, T. W., & Owen, A. M. (2002) · Brain · doi:10.1093/brain/awf052 · Cited by 397 · see citing works
Otmakhova, N. A., & Lisman, J. E. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-23-07478.1996 · Cited by 377 · see citing works
Prefrontal modulation of visual processing in humans
Barceló, F., Suwazono, S., & Knight, R. T. (2000) · Nature Neuroscience · doi:10.1038/73975 · Cited by 374 · see citing works
Matsumoto, M., Weickert, C. S., Akil, M., Lipska, B. K., Hyde, T. M., Herman, M. M., Kleinman, J. E., & Weinberger, D. R. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00556-0 · Cited by 365 · see citing works
Maguire, E. A., & Mummery, C. J. (1999) · Hippocampus · doi:10.1002/(sici)1098-1063(1999)9:1 · Cited by 362 · see citing works
Karoum, F., Chrapusta, S. J., & Egan, M. F. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63030972.x · Cited by 347 · see citing works
Mill, J., Asherson, P., Browes, C., D'Souza, U., & Craig, I. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.b.10948 · Cited by 341 · see citing works
Catechol- <i>O</i> -Methyltransferase Genotype and Dopamine Regulation in the Human Brain
Akil, M., Kolachana, B. S., Rothmond, D. A., Hyde, T. M., Weinberger, D. R., & Kleinman, J. E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-06-02008.2003 · Cited by 325 · see citing works
Striatal dopamine transporters and cognitive functioning in healthy men and women
Mozley, L. H., Gur, R. C., Mozley, P. D., & Gur, R. E. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.9.1492 · Cited by 314 · see citing works
Addis, D. R., McIntosh, A. R., Moscovitch, M., Crawley, A. P., & McAndrews, M. P. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.08.007 · Cited by 305 · see citing works
Aalto, S., Brück, A., Laine, M., Någren, K., & Rinne, J. O. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2097-04.2005 · Cited by 284 · see citing works
Prediction of Dopamine Transporter Binding Availability by Genotype: A Preliminary Report
Jacobsen, L. K., Staley, J. K., Zoghbi, S. S., Seibyl, J. P., Kosten, T. R., Innis, R. B., & Gelernter, J. E. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.10.1700 · Cited by 277 · see citing works
Levodopa: Faster and better word learning in normal humans
Knecht, S., Breitenstein, C., Bushuven, S., Wailke, S., Kamping, S., Flöel, A., Zwitserlood, P., & Ringelstein, E. B. (2004) · Annals of Neurology · doi:10.1002/ana.20125 · Cited by 246 · see citing works
The dopamine transporter: A crucial component regulating dopamine transmission
Jaber, M., Jones, S. R., Bruno Giros, A., & Caron, M. G. (1997) · Movement Disorders · doi:10.1002/mds.870120502 · Cited by 232 · see citing works
Dopaminergic Modulation of Visual Attention and Working Memory in the Rodent Prefrontal Cortex
Chudasama, Y., & Robbins, T. W. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300490 · Cited by 225 · see citing works
State-related and item-related neural correlates of successful memory encoding
Otten, L. J., Henson, R. N., & Rugg, M. D. (2002) · Nature Neuroscience · doi:10.1038/nn967 · Cited by 196 · see citing works
Morrison, J. H., Foote, S. L., O’Connor, D., & Bloom, F. E. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90144-7 · Cited by 186 · see citing works
Neurotoxic methamphetamine regimen severely impairs recognition memory in rats
Schröder, N., O’Dell, S. J., & Marshall, J. F. (2003) · Synapse · doi:10.1002/syn.10210 · Cited by 179 · see citing works
Spatial memory impairment induced by lesion of the mesohippocampal dopaminergic system in the rat
Gasbarri, A., Sulli, A., Innocenzi, R., Pacitti, C., & Brioni, J. D. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00202-3 · Cited by 174 · see citing works
Pathways for fear perception: modulation of amygdala activity by thalamo-cortical systems
Das, P., Kemp, A. H., Liddell, B. J., Brown, K. J., Olivieri, G., Peduto, A. S., Gordon, E., & Williams, L. M. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.01.049 · Cited by 168 · see citing works
Eckert, T., Sailer, M., Kaufmann, J., Schrader, C., Peschel, T., Bodammer, N., Heinze, H., & Schoenfeld, M. A. (2003) · NeuroImage · doi:10.1016/j.neuroimage.2003.08.028 · Cited by 150 · see citing works
Self-citationCOMT Gene Polymorphism Is Associated with Declarative Memory in Adulthood and Old Age
de Frias, C. M., Annerbrink, K., Westberg, L., Eriksson, E., Adolfsson, R., & Nilsson, L.-G. (2004) · Behavior Genetics · doi:10.1023/b:bege.0000038491.06972.8c · Cited by 145 · see citing works
Schott, B. H., Sellner, D., Lauer, C., Habib, R., Frey, J. U., Guderian, S., Heinze, H., & Düzel, E. (2004) · Learning & Memory · doi:10.1101/lm.75004 · Cited by 130 · see citing works
Self-citationBernstein, H., Baumann, B., Dános, P., Diekmann, S., Bogerts, B., Gundelfinger, E. D., & Braunewell, K. (1999) · Journal of Neurocytology · doi:10.1023/a:1007056731551 · Cited by 113 · see citing works
Self-citationCognitive neuroscience of episodic memory encoding
Buckner, R. L., Logan, J., Donaldson, D. I., & Wheeler, M. E. (2000) · Acta Psychologica · doi:10.1016/s0001-6918(00)00057-3 · Cited by 112 · see citing works
Population genetic study of the human dopamine transporter gene (DAT1)
Doucette‐Stamm, L., Blakely, D. J., Tian, J., Mockus, S., & Mao, J. (1995) · Genetic Epidemiology · doi:10.1002/gepi.1370120307 · Cited by 85 · see citing works
Dopamine transporter: Basic aspects and neuroimaging
Piccini, P. P. (2003) · Movement Disorders · doi:10.1002/mds.10571 · Cited by 80 · see citing works
Huotari, M., Sántha, M., Lucas, L., Karayiorgou, M., Gogos, J. A., & Männistö, P. T. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.043042 · Cited by 80 · see citing works
DeMille, M. M. C., Kidd, J. R., Ruggeri, V., Palmatier, M. A., Goldman, D. A., Odunsi, A., Okonofua, F. E., Grigorenko, E. L., Schulz, L. O., Bonné, B., et al. (2002) · Human Genetics · doi:10.1007/s00439-002-0809-0 · Cited by 80 · see citing works
d -Amphetamine responses in catechol-O-methyltransferase (COMT) disrupted mice
Huotari, M., Garcia-Horsman, A., Karayiorgou, M., Gogos, J. A., & Männistö, P. T. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1627-3 · Cited by 56 · see citing works
Brevican isoforms associate with neural membranes
Seidenbecher, C. I., Smalla, K., Fischer, N., Gundelfinger, E. D., & Kreutz, M. R. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01183.x · Cited by 55 · see citing works
Self-citationBudygin, E. A., Gainetdinov, R. R., Kilpatrick, M., et al. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00084-9 · Cited by 46 · see citing works
Siciliano, R., Fornai, F., Bonaccorsi, I., et al. (1999) · Visual Neuroscience · doi:10.1017/s0952523899166045 · Cited by 27 · see citing works
Verbal learning and memory in schizophrenic and Parkinson's disease patients
van Oostrom, I., Dollfus, S., Brazo, P., Abadie, P., Halbecq, I., Théry, S., & Marie, R. (2003) · Psychiatry Research · doi:10.1016/s0165-1781(02)00302-5 · Cited by 20 · see citing works
Ciliax (1999) · doi:10.1002/(sici)1096-9861(19990621)409:1
Flagged first, then by citations
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Intermediate phenotypes and genetic mechanisms of psychiatric disorders
Meyer-Lindenberg, A., & Weinberger, D. R. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1993 · Cited by 1,216 · see citing works
BOLD responses reflecting dopaminergic signals in the human ventral tegmental area
D'Ardenne, K., McClure, S. M., Nystrom, L. E., & Cohen, J. D. (2008) · Science · doi:10.1126/science.1150605 · Cited by 661 · see citing works
Absolute Coding of Stimulus Novelty in the Human Substantia Nigra/VTA
Bunzeck, N., & Düzel, E. (2006) · Neuron · doi:10.1016/j.neuron.2006.06.021 · Cited by 503 · see citing works
Self-citationSchott, B. H., Minuzzi, L., Krebs, R. M., Elmenhorst, D., Lang, M., Winz, O. H., Seidenbecher, C. I., Coenen, H. H., Heinze, H.-J., Zilles, K., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2058-08.2008 · Cited by 496 · see citing works
Self-citationNeural substrates of pleiotropic action of genetic variation in COMT: a meta-analysis
Mier, D., Kirsch, P., & Meyer-Lindenberg, A. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.36 · Cited by 464 · see citing works
A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP
Lisman, J., Grace, A. A., & Duzel, E. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.07.006 · Cited by 465 · see citing works
Self-citationForbes, E. E., Brown, S. M., Kimak, M., Ferrell, R. E., Manuck, S. B., & Hariri, A. R. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002086 · Cited by 408 · see citing works
Variation in dopamine genes influences responsivity of the human reward system
Dreher, J.-C., Kohn, P., Kolachana, B., Weinberger, D. R., & Berman, K. F. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805517106 · Cited by 376 · see citing works
Ben-Yakov, A., & Dudai, Y. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0702-11.2011 · Cited by 238 · see citing works
Functional imaging of the human dopaminergic midbrain
Düzel, E., Bunzeck, N., Guitart-Masip, M., Wittmann, B., Schott, B. H., & Tobler, P. N. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.02.005 · Cited by 216 · see citing works
Self-citationMiedl, S. F. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.1552 · Cited by 229 · see citing works
From prediction error to psychosis: Ketamine as a pharmacological model of delusions
Corlett, P. R., Honey, G. D., & Fletcher, P. C. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881107077716 · Cited by 227 · see citing works
Lower Ventral Striatal Activation During Reward Anticipation in Adolescent Smokers
Peters, J., Bromberg, U., Schneider, S., Brassen, S., Menz, M., Banaschewski, T., Conrod, P. J., Flor, H., Gallinat, J., Garavan, H., et al. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.10071024 · Cited by 218 · see citing works
Striatal Dopamine and the Interface between Motivation and Cognition
Aarts, E., van Holstein, M., & Cools, R. (2011) · Frontiers in Psychology · doi:10.3389/fpsyg.2011.00163 · Cited by 211 · see citing works
Emotion and episodic memory in neuropsychiatric disorders
Dere, E., Pause, B. M., & Pietrowsky, R. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.03.017 · Cited by 165 · see citing works
Qin (2011) · doi:10.1016/j.neuroimage.2011.05.006 · Cited by 124 · see citing works
Krebs, R. M., Schott, B. H., & Düzel, E. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.019 · Cited by 129 · see citing works
Büchel, C., Peters, J., Banaschewski, T., Bokde, A. L. W., Bromberg, U., Conrod, P. J., Flor, H., Papadopoulos, D., Garavan, H., Gowland, P., et al. (2017) · Nature Communications · doi:10.1038/ncomms14140 · Cited by 118 · see citing works
DURSTON, S., FOSSELLA, J. A., MULDER, M. J., CASEY, B. J., ZIERMANS, T. B., VESSAZ, M. N., & VAN ENGELAND, H. (2008) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e31815a5f17 · Cited by 108 · see citing works
Influence of SLC6A3 and COMT variation on neural activation during response inhibition
Congdon, E., Constable, R. T., Lesch, K. P., & Canli, T. (2009) · Biological Psychology · doi:10.1016/j.biopsycho.2009.03.005 · Cited by 103 · see citing works
Cooperation between the hippocampus and the striatum during episodic encoding
Sadeh, T., Shohamy, D., Levy, D. R., Reggev, N., & Maril, A. (2011) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2010.21549 · Cited by 104 · see citing works
Locus Coeruleus and Dopamine-Dependent Memory Consolidation
Yamasaki, M., & Takeuchi, T. (2017) · Neural Plasticity · doi:10.1155/2017/8602690 · Cited by 91 · see citing works
Schott, B. H., Wüstenberg, T., Wimber, M., Fenker, D. B., Zierhut, K. C., Seidenbecher, C. I., Heinze, H., Walter, H., Düzel, E., & Richardson‐Klavehn, A. (2013) · Human Brain Mapping · doi:10.1002/hbm.21435 · Cited by 98 · see citing works
Self-citationNovel scenes improve recollection and recall of words
Fenker, D. B., Frey, J. U., Schuetze, H., Heipertz, D., Heinze, H.-J., & Duzel, E. (2008) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2008.20086 · Cited by 94 · see citing works
Self-citationCue-Induced Craving Increases Impulsivity via Changes in Striatal Value Signals in Problem Gamblers
Miedl, S. F., Büchel, C., & Peters, J. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.5020-13.2014 · Cited by 87 · see citing works
Positive and negative modulation of word learning by reward anticipation
Callan, D. E., & Schweighofer, N. (2008) · Human Brain Mapping · doi:10.1002/hbm.20383 · Cited by 79 · see citing works
Lahey, B. B., Rathouz, P. J., Lee, S. S., Chronis-Tuscano, A., Pelham, W. E., Waldman, I. D., & Cook, E. H. (2011) · Journal of Abnormal Psychology · doi:10.1037/a0021133 · Cited by 63 · see citing works
Relationship of DAT1 and adult ADHD to task-positive and task-negative working memory networks
Brown, A. B., Biederman, J., Valera, E., Makris, N., Doyle, A., Whitfield-Gabrieli, S., Mick, E., Spencer, T., Faraone, S., & Seidman, L. (2011) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2011.01.006 · Cited by 53 · see citing works
Yacubian, J., & Büchel, C. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.05.015 · Cited by 53 · see citing works
Schott, B. H., Niklas, C., Kaufmann, J., Bodammer, N. C., Machts, J., Schütze, H., & Düzel, E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1013287108 · Cited by 44 · see citing works
Self-citation
- Authors
- Schott, B. H., Seidenbecher, C. I., Fenker, D. B., Lauer, C. J., Bunzeck, N., Bernstein, H.-G., Tischmeyer, W., Gundelfinger, E. D., Heinze, H.-J., & Düzel, E.
- Affiliations
- University Hospital Magdeburg (DE)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2006-02-01
- Volume
- 26
- Issue
- 5
- Pages
- 1407-1417
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6675495
- OpenAlex
- W1976031744
- Cited by
- 214
- References
- 65
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 7 · 2022: 3 · 2021: 3 · 2020: 10 · 2019: 6 · 2018: 3 · 2017: 11 · 2016: 6 · 2015: 7 · 2014: 9 · 2013: 20 · 2012: 18
- FWCI
- 8.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Helmholtz-Gemeinschaft
- Deutsche Forschungsgemeinschaft
- Studienstiftung des Deutschen Volkes
- Leibniz-Gemeinschaft
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- dopaminergic midbrain, episodic memory encoding, substantia nigra, dopamine transporter gene, catechol-O-methyltransferase, COMT Val158Met polymorphism, prefrontal cortex, hippocampus, dopamine clearance, neuromodulation
- MeSH terms
- Adolescent, Adult, Behavior, Brain, Catechol O-Methyltransferase, Dopamine, Female, Genotype, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Memory, Mesencephalon, Polymorphism, Genetic, Mental Recall, Prefrontal Cortex, Tandem Repeat Sequences, Dopamine Plasma Membrane Transport Proteins
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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