Cited by 523Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorHistorical and Modern Theater Studies

The DOI matches its Crossref record; 96 of the 98 references it cites were found in a registry or an index; 9 of the 49 sources its claims cite were checked for support.

Frontostriatal Maturation Predicts Cognitive Control Failure to Appetitive Cues in Adolescents

Open access
Somerville, Leah H., Hare, Todd, Casey, B. J.·2011·Journal of Cognitive Neuroscience

Abstract

Adolescent risk-taking is a public health issue that increases the odds of poor lifetime outcomes. One factor thought to influence adolescents' propensity for risk-taking is an enhanced sensitivity to appetitive cues, relative to an immature capacity to exert sufficient cognitive control. We tested this hypothesis by characterizing interactions among ventral striatal, dorsal striatal, and prefrontal cortical regions with varying appetitive load using fMRI scanning. Child, teen, and adult participants performed a go/no-go task with appetitive (happy faces) and neutral cues (calm faces). Impulse control to neutral cues showed linear improvement with age, whereas teens showed a nonlinear reduction in impulse control to appetitive cues. This performance decrement in teens was paralleled by enhanced activity in the ventral striatum. Prefrontal cortical recruitment correlated with overall accuracy and showed a linear response with age for no-go versus go trials. Connectivity analyses identified a ventral frontostriatal circuit including the inferior frontal gyrus and dorsal striatum during no-go versus go trials. Examining recruitment developmentally showed that teens had greater between-subject ventral-dorsal striatal coactivation relative to children and adults for happy no-go versus go trials. These findings implicate exaggerated ventral striatal representation of appetitive cues in adolescents relative to an intermediary cognitive control response. Connectivity and coactivity data suggest these systems communicate at the level of the dorsal striatum differentially across development. Biased responding in this system is one possible mechanism underlying heightened risk-taking during adolescence.

Overview

Integrity signals

Registry

Crossref · 10.1162/jocn.2010.21572

Cites

96 of 96 references verified0 citation errors · 0 not checkable

Statistics

29 tests recomputed · 0 with the reported and recomputed p on opposite sides of .05

Verification

Claims the paper makes

48 Own result · 18 Own interpretation · 8 No full text of the sources · 6 Not checked yet · 3 Supported · 3 Partly supported · 3 Sources not found · 1 Supported so far · 1 Couldn’t confirm · accuracy not yet measured

Show all 68 claims

  • Probably not a substantial claim. 14
  • It may state two separate claims as one. 13
23 of 23
  • The paper relies on this without support.

    Risk-taking during adolescence is a public health concern that raises the likelihood of poor long-term outcomes.

    “Adolescent risk-taking is a public health issue that increases the odds of poor lifetime outcomes.”
  • The paper relies on this without support.

    Adolescent behavior differs qualitatively from child and adult behavior in many respects.

    “Adolescent behavior is qualitatively different from that seen in children and adults in numerous ways.”
  • The paper relies on this without support.

    Most evidence supporting these theoretical models has examined reward processing and cognitive control separately.

    “Though recent neurobiological research has largely supported this conceptualization, the majority of evidence informing these theoretical models has separately targeted either reward processing or cognitive control systems.”
  • The paper relies on this without support.

    Happy faces function as appetitive cues that signal reward and facilitate approach responses.

    “Using a task that contains salient, appetitive stimuli (e.g., happy faces) that facilitated approach responses”
  • The paper relies on this without support.

    False alarm rate on happy nogo trials is a valid index of failure to suppress approach behavior toward appetitive cues.

    “We focus on the happy condition because happy-nogo relative to happy-go trials encompass the psychological construct of suppressing approach responses toward potential rewards.”
5 of 5

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Statistics that don’t add up

Each reported p-value recomputed from its test statistic and degrees of freedom.

5 of 5

Statistics recomputed

Every reported test result, recomputed from its test statistic and degrees of freedom. A result shows as not adding up only once an independent check has confirmed it.

  • Doesn’t add upF(2, 59) = 6.77reported p < .002 · recomputed p = .002

    “F(2,59) = 6.77, p < .002”

  • Doesn’t add upF(2, 59) = 7.8reported p = .007 · recomputed p < .001

    “F(2,59) = 7.80, p = .007”

  • Doesn’t add upr(24) = 0.49reported p = .013 · recomputed p = .011

    “r(24) = 0.49, p = .013”

  • Doesn’t add upr(18) = 0.57reported p = .012 · recomputed p = .009

    “r(18) = 0.57, p = .012”

  • Doesn’t add upr(18) = 0.54reported p = .016 · recomputed p = .014

    “r(18) = 0.54, p = .016”

  • ConsistentF(1, 59) = 15.44reported p < .001 · recomputed p < .001

    “F(1,59) = 15.44, p < .001”

  • ConsistentF(2, 59) = 0.24reported p > .7 · recomputed p = .787

    “F(2,59) = .24, p > .7”

  • ConsistentF(2, 59) = 0.13reported p > .8 · recomputed p = .878

    “F(2,59) = .13, p > .8”

  • ConsistentF(2, 59) = 12.57reported p < .001 · recomputed p < .001

    “F(2,59) = 12.57, p < .001”

  • ConsistentF(2, 59) = 3.59reported p = .034 · recomputed p = .034

    “F(2,59) = 3.59, p = .034”

  • ConsistentF(1, 59) = 1.18reported p > .2 · recomputed p = .282

    “F(1,59) = 1.18, p > .2”

  • Consistentt(35) = 2.04reported p = .049 · recomputed p = .049

    “t(35) = 2.04, p = .049”

  • Consistentt(42) = 2.62reported p = .012 · recomputed p = .012

    “t(42) = 2.62, p = .012”

  • Consistentt(18) = 2.87reported p = .01 · recomputed p = .010

    “t(18) = 2.87, p = .01”

  • ConsistentF(1, 59) = 22.3reported p < .001 · recomputed p < .001

    “F(1,59) = 22.3, p < .001”

  • ConsistentF(1, 59) = 6.52reported p = .013 · recomputed p = .013

    “F(1,59) = 6.52, p = .013”

  • ConsistentF(1, 59) = 14.31reported p < .001 · recomputed p < .001

    “F(1,59) = 14.31, p < .001”

  • ConsistentF(1, 59) = 36.09reported p < .001 · recomputed p < .001

    “F(1,59) = 36.09, p < .001”

  • ConsistentF(2, 59) = 1.78reported p > .15 · recomputed p = .178

    “F(2,59) = 1.78, p > .15”

  • ConsistentF(1, 59) = 10.05reported p < .003 · recomputed p = .002

    “F(1,59) = 10.05, p < .003”

  • ConsistentF(1, 59) = 0.54reported p > .4 · recomputed p = .465

    “F(1,59) = 0.54, p > .4”

  • ConsistentF(1, 59) = 4.53reported p = .037 · recomputed p = .037

    “F(1,59) = 4.53, p = .037”

  • ConsistentF(1, 59) = 0.17reported p > .6 · recomputed p = .682

    “F(1,59) = .17, p > .6”

  • ConsistentF(2, 59) = 8.95reported p < .005 · recomputed p < .001

    “F(2,59) = 8.95, p < .005”

  • Consistentr(61) = -0.28reported p = .026 · recomputed p = .026

    “r(61) = −0.28, p = .026”

  • Consistentr(61) = 0.39reported p = .002 · recomputed p = .002

    “r(61) = 0.39, p = .002”

  • Consistentr(61) = 0.28reported p = .026 · recomputed p = .026

    “r(61) = 0.28, p = .026”

  • Consistentr(60) = 0.45reported p < .001 · recomputed p < .001

    “r(60) = 0.45, p < .001”

  • Consistentr(17) = 0.41reported p = .09 · recomputed p = .081

    “r(17) = 0.41, p = .09”

29 of 29

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

Self-check results appear here once an independent check has confirmed them.

Citations

Cites

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Metadata

Authors
Somerville, L. H., Hare, T., & Casey, B. J.
Affiliations
  • Weill Cornell Medicine (US)
  • California Institute of Technology (US)
Venue
Journal of Cognitive Neuroscience
Published
2011-09-01
Volume
23
Issue
9
Pages
2123-2134
ISSN
  • 0898-929X (ISSN-L)
  • 1530-8898
OpenAlex
W2171760615
Cited by
523
References
98
Citations by year
2026: 17 · 2025: 15 · 2024: 16 · 2023: 22 · 2022: 31 · 2021: 38 · 2020: 38 · 2019: 37 · 2018: 59 · 2017: 42 · 2016: 42 · 2015: 40 · 2014: 50 · 2013: 40 · 2012: 18
FWCI
14.72
Type
journal article
Language
en
Open access
Locations
  • Journal of Cognitive Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • CaltechAUTHORS (California Institute of Technology) (submittedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
  • Zurich Open Repository and Archive (University of Zurich)
Funders
  • College of Veterinary Medicine, Cornell University
  • Weill Cornell Medical College
  • National Institute of Mental Health (K99MH087813, P50MH079513, F31MH073265, P50MH062196)
  • National Institute on Drug Abuse (R01DA018879, T32DA007274)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
Keywords
adolescent risk-taking, appetitive cues, cognitive control, ventral striatum, dorsal striatum, prefrontal cortex, frontostriatal circuits, impulse control, go/no-go task, developmental maturation, inferior frontal gyrus, neuronal connectivity
MeSH terms
Adolescent, Adult, Analysis of Variance, Appetite, Brain Mapping, Child, Cognition Disorders, Corpus Striatum, Cues, Emotions, Female, Humans, Image Processing, Computer-Assisted, Inhibition, Psychological, Magnetic Resonance Imaging, Male, Neural Pathways, Neuropsychological Tests, Oxygen, Photic Stimulation, Predictive Value of Tests, Reaction Time, Prefrontal Cortex, Young Adult

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