Cited by 25Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorNeural dynamics and brain function

Neurodynamics of cognitive set shifting in monkey frontal cortex and its causal impact on behavioral flexibility

Kamigaki, Tsukasa, Fukushima, Tetsuya, Tamura, Keita, Miyashita, Yasushi·2012·Journal of Cognitive Neuroscience

Abstract

Flexible behavior depends on the ability to shift an internal cognitive set as soon as external demand changes. According to neuropsychological studies in human and nonhuman primates, selective lesion to the PFC impairs flexible behavioral shifting. Our previous fMRI study demonstrated that the prefrontal regions showed transient activation related to set shifting in humans and monkeys. To investigate the underlying neural processing, we recorded single-unit activities while monkeys performed a cognitive-set-shifting task, which required shifting between shape-matching and color-matching behaviors. We identified a group of neurons in the inferior arcuate region that exhibited selective activity when the monkeys were required to shift their cognitive set. These shift-related neurons were localized in the focal area along the posterior bank of the inferior arcuate sulcus. Reversible inactivation of this area ipsilateral to the response hand with a small volume of muscimol (even with 0.5 μl) selectively impaired the performance of behavioral shifting. Moreover, this selective behavioral impairment strongly correlated with the dose of muscimol. These results demonstrated localized neural processing for cognitive set shifting and its causal role for behavioral flexibility in primates.

Integrity signals

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Crossref · 10.1162/jocn_a_00277

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47 of 47 references verified0 citation errors · 0 not checkable

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  • Goal-related information used in cognitive flexibility tasks is primarily represented in the PFC in monkeys and humans.

    “Goal-related information used in cognitive flexibility tasks is primarily represented in the PFC in monkeys (e.g. [56]) and humans [57].”

    From Linking ADHD to the Neural Circuitry of Attention (2017) · cites this paper as [56]

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Authors
Kamigaki, T., Fukushima, T., Tamura, K., & Miyashita, Y.
Affiliations
  • The University of Tokyo (JP)
  • Japan Science and Technology Agency (JP)
Venue
Journal of Cognitive Neuroscience
Publisher
MIT Press
Published
2012-11-01
Volume
24
Issue
11
Pages
2171-2185
ISSN
  • 0898-929X (ISSN-L)
  • 1530-8898
OpenAlex
W2046035408
Cited by
25
References
47
Citations by year
2025: 2 · 2024: 2 · 2022: 1 · 2020: 2 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 1 · 2014: 2 · 2013: 3
FWCI
0.98
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Cognitive Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Tokyo
  • Japan Society for the Promotion of Science (24220008)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
behavioral flexibility, prefrontal cortex, single-unit activity, muscimol inactivation, non-human primates, frontal lobe lesions
MeSH terms
Animals, Haplorhini, Choice Behavior, Cognition, Frontal Lobe, Macaca, Male, Photic Stimulation, Psychomotor Performance, Reaction Time

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