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Cited by 345

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Fas Determines Differential Fates of Resident and Recruited Macrophages during Resolution of Acute Lung Injury

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Janssen, William J, Barthel, Lea, Muldrow, Alaina, Oberley-Deegan, Rebecca E, Kearns, Mark T, Jakubzick, Claudia, Henson, Peter M·2011·American Journal of Respiratory and Critical Care Medicine
DOI 10.1164/rccm.201011-1891oc
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Abstract

RATIONALE: During acute lung injury (ALI) the macrophage pool expands markedly as inflammatory monocytes migrate from the circulation to the airspaces. As inflammation resolves, macrophage numbers return to preinjury levels and normal tissue structure and function are restored. OBJECTIVES: To determine the fate of resident and recruited macrophages during the resolution of ALI in mice and to elucidate the mechanisms responsible for macrophage removal. METHODS: ALI was induced in mice using influenza A (H1N1; PR8) infection and LPS instillation. Dye labeling techniques, bone marrow transplantation, and surface immunophenotyping were used to distinguish resident and recruited macrophages during inflammation and to study the role of Fas in determining macrophage fate during resolving ALI. MEASUREMENTS AND MAIN RESULTS: During acute and resolving lung injury from influenza A and LPS, a high proportion of the original resident alveolar macrophages persisted. In contrast, recruited macrophages exhibited robust accumulation in early inflammation, followed by a progressive decline in their number. This decline was mediated by apoptosis with local phagocytic clearance. Recruited macrophages expressed high levels of the death receptor Fas and were rapidly depleted from the airspaces by Fas-activating antibodies. In contrast, macrophage depletion was inhibited in mice treated with Fas-blocking antibodies and in chimeras with Fas-deficient bone marrow. Caspase-8 inhibition prevented macrophage apoptosis and delayed the resolution of ALI. CONCLUSIONS: These findings indicate that Fas-induced apoptosis of recruited macrophages is essential for complete resolution of ALI.

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Metadata

Authors
Janssen, W. J., Barthel, L., Muldrow, A., Oberley-Deegan, R. E., Kearns, M. T., Jakubzick, C., & Henson, P. M.
Venue
American Journal of Respiratory and Critical Care Medicine
Publisher
Oxford University Press (OUP)
Published
2011-09-01
Volume
184
Issue
5
Pages
547-560
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
DOI
10.1164/rccm.201011-1891oc
OpenAlex
W2041189421
Cited by
345
References
7
FWCI
16.33
Type
journal article
Language
en
Open access
green

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