Cited by 110Adipose Tissue and MetabolismPeroxisome Proliferator-Activated ReceptorsAdipokines, Inflammation, and Metabolic Diseases

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HDAC11 suppresses the thermogenic program of adipose tissue via BRD2

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Bagchi, Rushita A., Ferguson, Bradley S., Stratton, Matthew S., Hu, Tianjing, Cavasin, Maria A., Sun, Lei, Lin, Ying-Hsi, Liu, Dianxin, Londono, Pilar, Song, Kunhua, Pino, Maria F., Sparks, Lauren M., Smith, Steven R., Scherer, Philipp E., Collins, Sheila, Seto, Edward, McKinsey, Timothy A.·2018·JCI Insight

DOI 10.1172/jci.insight.120159PMC PMC6129125

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Abstract

Little is known about the biological function of histone deacetylase 11 (HDAC11), which is the lone class IV HDAC. Here, we demonstrate that deletion of HDAC11 in mice stimulates brown adipose tissue (BAT) formation and beiging of white adipose tissue (WAT). Consequently, HDAC11-deficient mice exhibit enhanced thermogenic potential and, in response to high-fat feeding, attenuated obesity, improved insulin sensitivity, and reduced hepatic steatosis. Ex vivo and cell-based assays revealed that HDAC11 catalytic activity suppresses the BAT transcriptional program, in both the basal state and in response to β-adrenergic receptor signaling, through a mechanism that is dependent on physical association with BRD2, a bromodomain and extraterminal (BET) acetyl-histone-binding protein. These findings define an epigenetic pathway for the regulation of energy homeostasis and suggest the potential for HDAC11-selective inhibitors for the treatment of obesity and diabetes.

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Authors: Bagchi, R. A., Ferguson, B. S., Stratton, M. S., Hu, T., Cavasin, M. A., Sun, L., Lin, Y.-H., Liu, D., Londono, P., Song, K., Pino, M. F., Sparks, L. M., Smith, S. R., Scherer, P. E., Collins, S., Seto, E., & McKinsey, T. A.
Affiliations: University of Colorado Anschutz (US)
George Washington University (US)
Sanford Burnham Prebys Medical Discovery Institute (US)
Translational Research Institute for Metabolism and Diabetes (US)
The University of Texas Southwestern Medical Center (US)
Corresponding author: McKinsey, Timothy A.
ORCID: Bagchi, Rushita A.
Ferguson, Bradley S.
Stratton, Matthew S.
Hu, Tianjing
Liu, Dianxin
Londono, Pilar
Song, Kunhua
Pino, Maria F.
Sparks, Lauren M.
Smith, Steven R.
Scherer, Philipp E.
Collins, Sheila
Seto, Edward
McKinsey, Timothy A.
Venue: JCI Insight
Publisher: American Society for Clinical Investigation
Published: 2018-08-09
Volume: 3
Issue: 15
ISSN: 2379-3708 (ISSN-L)
DOI: 10.1172/jci.insight.120159
PMC: PMC6129125
OpenAlex: W2794856460
Cited by: 110
References: 64
Citations by year: 2026: 9 · 2025: 21 · 2024: 13 · 2023: 13 · 2022: 12 · 2021: 16 · 2020: 16 · 2019: 9 · 2018: 1
FWCI: 7.22
Type: journal article
Language: en
Open access: gold
doi.org
Locations: JCI Insight (publishedVersion)
bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (HL116848,HL127240, AG043822), T32HL007822, F32HL126354).)
American Heart Association (16SFRN31400013, 16POST30960017)
Canadian Institutes of Health Research (FRN-216927)
xxx (xxx)
Topics: Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: HDAC11, BRD2, brown adipose tissue, thermogenesis, beta-adrenergic signaling, obesity, insulin sensitivity, hepatic steatosis, energy homeostasis, epigenetic regulation, diabetes mellitus
MeSH terms: Bromodomain Containing Proteins, Adult, Aged, Aged, 80 and over, Animals, Adipose Tissue, Brown, Disease Models, Animal, Energy Metabolism, Fatty Liver, Female, Gene Expression Regulation, Histone Deacetylases, Humans, Insulin Resistance, Male, Middle Aged, Obesity, Transcription Factors, Mice, Knockout, Thermogenesis, Epigenesis, Genetic, Mice, Adipose Tissue, White, Diet, High-Fat

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HDAC11 suppresses the thermogenic program of adipose tissue via BRD2

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