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HDAC11 suppresses the thermogenic program of adipose tissue via BRD2
Open accessPublished version of a preprint
Abstract
Little is known about the biological function of histone deacetylase 11 (HDAC11), which is the lone class IV HDAC. Here, we demonstrate that deletion of HDAC11 in mice stimulates brown adipose tissue (BAT) formation and beiging of white adipose tissue (WAT). Consequently, HDAC11-deficient mice exhibit enhanced thermogenic potential and, in response to high-fat feeding, attenuated obesity, improved insulin sensitivity, and reduced hepatic steatosis. Ex vivo and cell-based assays revealed that HDAC11 catalytic activity suppresses the BAT transcriptional program, in both the basal state and in response to β-adrenergic receptor signaling, through a mechanism that is dependent on physical association with BRD2, a bromodomain and extraterminal (BET) acetyl-histone-binding protein. These findings define an epigenetic pathway for the regulation of energy homeostasis and suggest the potential for HDAC11-selective inhibitors for the treatment of obesity and diabetes.
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“These activities require the interaction of Hdac11 with the epigenetic reader BRD2 (Bagchi et al., 2018).”
From HDACs and the epigenetic plasticity of cancer cells: target the complexity (2022) · cites this paper as Bagchi et al., 2018
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Metadata
- Authors
- Bagchi, R. A., Ferguson, B. S., Stratton, M. S., Hu, T., Cavasin, M. A., Sun, L., Lin, Y.-H., Liu, D., Londono, P., Song, K., Pino, M. F., Sparks, L. M., Smith, S. R., Scherer, P. E., Collins, S., Seto, E., & McKinsey, T. A.
- Affiliations
- University of Colorado Anschutz (US)
- George Washington University (US)
- Sanford Burnham Prebys Medical Discovery Institute (US)
- Translational Research Institute for Metabolism and Diabetes (US)
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- McKinsey, Timothy A.
- ORCID
- Venue
- JCI Insight
- Published
- 2018-08-09
- Volume
- 3
- Issue
- 15
- ISSN
- 2379-3708 (ISSN-L)
- PMC
- PMC6129125
- OpenAlex
- W2794856460
- Cited by
- 110
- References
- 64
- Citations by year
- 2026: 9 · 2025: 21 · 2024: 13 · 2023: 13 · 2022: 12 · 2021: 16 · 2020: 16 · 2019: 9 · 2018: 1
- FWCI
- 7.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- JCI Insight (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (HL116848,HL127240, AG043822), T32HL007822, F32HL126354).)
- American Heart Association (16SFRN31400013, 16POST30960017)
- Canadian Institutes of Health Research (FRN-216927)
- xxx (xxx)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- HDAC11, BRD2, brown adipose tissue, thermogenesis, beta-adrenergic signaling, obesity, insulin sensitivity, hepatic steatosis, energy homeostasis, epigenetic regulation, diabetes mellitus
- MeSH terms
- Bromodomain Containing Proteins, Adult, Aged, Aged, 80 and over, Animals, Adipose Tissue, Brown, Disease Models, Animal, Energy Metabolism, Fatty Liver, Female, Gene Expression Regulation, Histone Deacetylases, Humans, Insulin Resistance, Male, Middle Aged, Obesity, Transcription Factors, Mice, Knockout, Thermogenesis, Epigenesis, Genetic, Mice, Adipose Tissue, White, Diet, High-Fat
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