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The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Human adipose beiging in response to cold and mirabegron

Finlin, Brian S., Memetimin, Hasiyet, Confides, Amy L., Kasza, Ildiko, Zhu, Beibei, Vekaria, Hemendra J., Harfmann, Brianna, Jones, Kelly A., Johnson, Zachary R., Westgate, Philip M., Alexander, Caroline M., Sullivan, Patrick G., Dupont-Versteegden, Esther E., Kern, Philip A.·2018·JCI Insight
DOI 10.1172/jci.insight.121510
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Abstract

BACKGROUND. The induction of beige adipocytes in s.c. white adipose tissue (WAT) depots of humans is postulated to improve glucose and lipid metabolism in obesity. The ability of obese, insulin-resistant humans to induce beige adipose tissue is unknown. METHODS. We exposed lean and obese research participants to cold (30-minute ice pack application each day for 10 days of the upper thigh) or treated them with the β 3 agonist mirabegron. We determined beige adipose marker expression by IHC and quantitative PCR, and we analyzed mitochondrial bioenergetics and UCP activity with an Oxytherm system. RESULTS. Cold significantly induced UCP1 and TMEM26 protein in both lean and obese subjects, and this response was not associated with age. Interestingly, these proteins increased to the same extent in s.c. WAT of the noniced contralateral leg, indicating a crossover effect. We further analyzed the bioenergetics of purified mitochondria from the abdominal s.c. WAT of cold-treated subjects and determined that repeat ice application significantly increased uncoupled respiration, consistent with the UCP1 protein induction and subsequent activation. Cold also increased State 3 and maximal respiration, and this effect on mitochondrial bioenergetics was stronger in summer than winter. Chronic treatment (10 weeks; 50 mg/day) with the β 3 receptor agonist mirabegron induces UCP1, TMEM26, CIDEA, and phosphorylation of HSL on serine 660 in obese subjects. CONCLUSION. Cold or β 3 agonists cause the induction of beige adipose tissue in human s.c. WAT; this phenomenon may be exploited to increase beige adipose in older, insulin-resistant, obese individuals. TRIAL REGISTRATION. Clinicaltrials.gov NCT02596776, NCT02919176. FUNDING. NIH (DK107646, DK112282, P20GM103527, and by CTSA grant UL1TR001998).

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Research works printed but not linked: 52

  1. 10.1016/j.cmet.2015.09.007 · DOI
  2. 10.1016/j.cell.2012.05.016 · DOI · Paper page
  3. 10.1172/JCI78362 · DOI · Paper page
  4. 10.1016/j.cmet.2008.12.014 · DOI · Paper page
  5. Porter, 2015, The Therapeutic Potential of Brown Adipocytes in Humans, Front Endocrinol (Lausanne), 6, 10.3389/fendo.2015.00156 · DOI
  6. 10.1016/j.cell.2013.12.021 · DOI
  7. 10.2337/db14-0746 · DOI · Paper page
  8. 10.1016/j.cmet.2011.06.012 · DOI · Paper page
  9. 10.1038/ijo.2013.206 · DOI
  10. 10.1172/JCI60433 · DOI · Paper page
  11. 10.1152/ajpendo.00298.2010 · DOI
  12. 10.1038/nm.4031 · DOI
  13. 10.1016/j.cmet.2012.01.004 · DOI
  14. 10.1038/nm.3891 · DOI · Paper page
  15. 10.2337/db16-1057 · DOI
  16. 10.1210/jc.2014-2440 · DOI
  17. 10.1056/NEJMoa0810780 · DOI · Paper page
  18. 10.1080/21623945.2016.1191307 · DOI
  19. 10.1016/j.cmet.2015.06.022 · DOI
  20. 10.1016/j.cmet.2014.06.011 · DOI
  21. Frontini, 2013, White-to-brown transdifferentiation of omental adipocytes in patients affected by pheochromocytoma, Biochim Biophys Acta, 1831, 950, 10.1016/j.bbalip.2013.02.005 · DOI
  22. 10.1038/nature13528 · DOI
  23. 10.1016/j.cmet.2014.12.009 · DOI · Paper page
  24. 10.1073/pnas.1207287109 · DOI · Paper page
  25. 10.1152/japplphysiol.00096.2017 · DOI
  26. 10.1073/pnas.1310261110 · DOI
  27. 10.1074/jbc.M115.637785 · DOI
  28. 10.1016/S2213-8587(14)70033-6 · DOI · Paper page
  29. 10.1016/j.ecl.2004.03.002 · DOI · Paper page
  30. Facchini, 1996, Enhanced sympathetic nervous system activity. The linchpin between insulin resistance, hyperinsulinemia, and heart rate, Am J Hypertens, 9, 1013, 10.1016/0895-7061(96)87747-8 · DOI
  31. 10.1016/0026-0495(89)90118-2 · DOI
  32. 10.1038/oby.2011.125 · DOI
  33. 10.2337/db10-0004 · DOI
  34. 10.1016/j.cmet.2016.10.023 · DOI
  35. 10.1038/nature17399 · DOI
  36. 10.1152/ajpendo.00284.2016 · DOI
  37. 10.1016/j.tem.2012.06.004 · DOI
  38. 10.1113/expphysiol.2014.081414 · DOI
  39. 10.1016/j.molmet.2015.07.001 · DOI
  40. 10.1016/j.cmet.2013.02.020 · DOI · Paper page
  41. 10.1016/j.tips.2013.04.004 · DOI
  42. 10.1210/jc.2006-1740 · DOI · Paper page
  43. 10.1016/S0014-2999(02)01421-8 · DOI
  44. 10.1111/ijcp.12433 · DOI
  45. 10.1007/s00192-013-2042-x · DOI
  46. 10.1152/ajpendo.00329.2010 · DOI · Paper page
  47. 10.2337/diabetes.54.8.2305 · DOI · Paper page
  48. 10.1210/js.2017-00202 · DOI
  49. Cannon, 1979, Mitochondria from brown adipose tissue: isolation and properties, Meth Enzymol, 55, 65, 10.1016/0076-6879(79)55010-1 · DOI
  50. 10.1089/neu.2006.3673 · DOI · Paper page
  51. 10.1002/ana.10543 · DOI
  52. 10.1002/ana.20062 · DOI · Paper page

Cited by

Metadata

Authors
Finlin, B. S., Memetimin, H., Confides, A. L., Kasza, I., Zhu, B., Vekaria, H. J., Harfmann, B., Jones, K. A., Johnson, Z. R., Westgate, P. M., Alexander, C. M., Sullivan, P. G., Dupont-Versteegden, E. E., & Kern, P. A.
Venue
JCI Insight
Publisher
American Society for Clinical Investigation
Published
2018-08-09
Volume
3
Issue
15
ISSN
2379-3708
DOI
10.1172/jci.insight.121510
Cited by
184
References
9
Language
en

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